Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: MAP3K1 (mitogen-activated protein kinase kinase kinase 1) Homo sapiens
Analyze
Symbol: MAP3K1
Name: mitogen-activated protein kinase kinase kinase 1
Description: Exhibits protein kinase binding activity and protein serine/threonine kinase activity. Involved in cellular response to mechanical stimulus. Predicted to localize to cytoplasm. Implicated in 46,XY sex reversal 6 and breast cancer. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; MEKK1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; SRXY6
Orthologs:
Mus musculus (house mouse) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Canis lupus familiaris (dog) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)
Sus scrofa (pig) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Chlorocebus sabaeus (African green monkey) : MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Heterocephalus glaber (naked mole-rat) : Map3k1 (mitogen-activated protein kinase kinase kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl556,815,549 - 56,896,152 (+)EnsemblGRCh38hg38GRCh38
GRCh38556,815,543 - 56,896,152 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37556,110,900 - 56,191,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36556,146,657 - 56,227,736 (+)NCBINCBI36hg18NCBI36
Celera553,065,179 - 53,146,179 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef553,082,897 - 53,163,892 (+)NCBIHuRef
CHM1_1556,113,966 - 56,195,023 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants