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Gene: E2F8 (E2F transcription factor 8) Homo sapiens
Symbol: E2F8
Name: E2F transcription factor 8
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and sprouting angiogenesis. Localizes to cytosol; nucleolus; and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E2F family member 8; E2F-8; FLJ23311; transcription factor E2F8
Mus musculus (house mouse) : E2f8 (E2F transcription factor 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : E2f8 (E2F transcription factor 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : E2f8 (E2F transcription factor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : E2F8 (E2F transcription factor 8)
Canis lupus familiaris (dog) : E2F8 (E2F transcription factor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : E2f8 (E2F transcription factor 8)
Sus scrofa (pig) : E2F8 (E2F transcription factor 8)
Chlorocebus sabaeus (African green monkey) : E2F8 (E2F transcription factor 8)
Heterocephalus glaber (naked mole-rat) : E2f8 (E2F transcription factor 8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1119,224,063 - 19,241,620 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,224,063 - 19,241,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371119,245,610 - 19,263,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,202,186 - 19,219,083 (-)NCBINCBI36hg18NCBI36
Celera1119,378,036 - 19,394,995 (-)NCBI
Cytogenetic Map11p15.1NCBI
HuRef1118,929,541 - 18,947,128 (-)NCBIHuRef
CHM1_11119,244,897 - 19,262,487 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on E2F8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1605946
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.