SLC16A7 (solute carrier family 16 member 7) - Rat Genome Database

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Gene: SLC16A7 (solute carrier family 16 member 7) Homo sapiens
Analyze
Symbol: SLC16A7
Name: solute carrier family 16 member 7
RGD ID: 1346247
HGNC Page HGNC
Description: Enables lactate transmembrane transporter activity and pyruvate transmembrane transporter activity. Involved in lactate transmembrane transport and pyruvate transmembrane transport. Located in nucleoplasm and plasma membrane. Is integral component of plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MCT 2; MCT2; monocarboxylate transporter 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1259,596,029 - 59,789,855 (+)EnsemblGRCh38hg38GRCh38
GRCh381259,595,934 - 59,789,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371259,989,810 - 60,183,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361258,369,393 - 58,461,675 (+)NCBINCBI36hg18NCBI36
Build 341258,369,392 - 58,461,674NCBI
Celera1259,745,720 - 59,838,012 (+)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBIHuRef
CHM1_11259,958,039 - 60,151,803 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
obesity  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-Iodothyronamine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
chlordecone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
dibenz[a,h]anthracene  (ISO)
dieldrin  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
formaldehyde  (EXP)
geldanamycin  (EXP)
glafenine  (ISO)
heptachlor  (ISO)
hydrogen peroxide  (ISO)
isotretinoin  (EXP)
leflunomide  (ISO)
Licochalcone B  (EXP)
methapyrilene  (ISO)
methylseleninic acid  (EXP)
mirex  (ISO)
nefazodone  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
tamibarotene  (EXP)
testosterone enanthate  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)

References

Additional References at PubMed
PMID:7273846   PMID:9786900   PMID:12115955   PMID:12477932   PMID:12739169   PMID:14757520   PMID:15123239   PMID:15505343   PMID:15917240   PMID:17502341   PMID:18188595   PMID:18598673  
PMID:19834535   PMID:19876643   PMID:20035863   PMID:20379614   PMID:20454640   PMID:20827233   PMID:21177384   PMID:21680735   PMID:21787388   PMID:21873635   PMID:21988832   PMID:22131303  
PMID:22535546   PMID:22700320   PMID:22964484   PMID:23192371   PMID:24799634   PMID:25243493   PMID:25492048   PMID:25578492   PMID:25639644   PMID:26035357   PMID:26590417   PMID:28281525  
PMID:30021884   PMID:30297875   PMID:30521130   PMID:32296183   PMID:32415067   PMID:32819565   PMID:33999492  


Genomics

Comparative Map Data
SLC16A7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1259,596,029 - 59,789,855 (+)EnsemblGRCh38hg38GRCh38
GRCh381259,595,934 - 59,789,841 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371259,989,810 - 60,183,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361258,369,393 - 58,461,675 (+)NCBINCBI36hg18NCBI36
Build 341258,369,392 - 58,461,674NCBI
Celera1259,745,720 - 59,838,012 (+)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBIHuRef
CHM1_11259,958,039 - 60,151,803 (+)NCBICHM1_1
Slc16a7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910125,055,139 - 125,225,455 (-)NCBIGRCm39mm39
GRCm39 Ensembl10125,055,139 - 125,225,334 (-)Ensembl
GRCm3810125,219,270 - 125,389,586 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10125,219,270 - 125,389,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710124,664,541 - 124,765,591 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610124,630,545 - 124,731,595 (-)NCBImm8
Celera10127,630,780 - 127,731,940 (-)NCBICelera
Cytogenetic Map10D3NCBI
Slc16a7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2761,043,667 - 61,211,547 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl761,051,167 - 61,154,994 (-)Ensembl
Rnor_6.0768,438,341 - 68,606,312 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl768,446,193 - 68,549,763 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0768,633,417 - 68,801,189 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4765,210,148 - 65,313,572 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1765,230,721 - 65,390,741 (-)NCBI
Celera758,206,868 - 58,309,915 (-)NCBICelera
Cytogenetic Map7q22NCBI
Slc16a7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554587,232,886 - 7,352,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554587,232,886 - 7,352,782 (+)NCBIChiLan1.0ChiLan1.0
SLC16A7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11229,390,576 - 29,587,897 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1229,390,576 - 29,528,851 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01229,128,600 - 29,317,797 (-)NCBIMhudiblu_PPA_v0panPan3
SLC16A7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1103,333,000 - 3,500,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl103,334,126 - 3,496,150 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha103,398,668 - 3,564,721 (+)NCBI
ROS_Cfam_1.0103,356,472 - 3,522,599 (+)NCBI
UMICH_Zoey_3.1103,323,639 - 3,489,625 (+)NCBI
UNSW_CanFamBas_1.0103,565,685 - 3,731,591 (+)NCBI
UU_Cfam_GSD_1.0103,691,746 - 3,857,780 (+)NCBI
Slc16a7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494555,219,046 - 55,388,105 (-)NCBI
SpeTri2.0NW_0049366463,482,148 - 3,647,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl524,713,267 - 24,875,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1524,713,009 - 24,871,891 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2526,710,139 - 26,864,757 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11155,541,313 - 55,709,102 (+)NCBI
ChlSab1.1 Ensembl1155,645,129 - 55,708,356 (+)Ensembl
Vero_WHO_p1.0NW_023666037190,169,996 - 190,345,973 (-)NCBI
Slc16a7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248028,015,061 - 8,191,031 (-)NCBI

Position Markers
STS-N34486  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,175,257 - 60,175,455UniSTSGRCh37
Build 361258,461,524 - 58,461,722RGDNCBI36
Celera1259,837,861 - 59,838,059RGD
Cytogenetic Map12q13UniSTS
HuRef1257,223,723 - 57,223,921UniSTS
GeneMap99-GB4 RH Map12263.57UniSTS
NCBI RH Map12463.3UniSTS
RH123615  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,119,241 - 60,119,562UniSTSGRCh37
Build 361258,405,508 - 58,405,829RGDNCBI36
Celera1259,781,837 - 59,782,158RGD
Cytogenetic Map12q13UniSTS
HuRef1257,167,701 - 57,168,022UniSTS
TNG Radiation Hybrid Map1228661.0UniSTS
D12S1169E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,168,558 - 60,168,640UniSTSGRCh37
Build 361258,454,825 - 58,454,907RGDNCBI36
Celera1259,831,162 - 59,831,244RGD
Cytogenetic Map12q13UniSTS
HuRef1257,217,024 - 57,217,106UniSTS
SHGC-153727  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,083,137 - 60,083,442UniSTSGRCh37
Build 361258,369,404 - 58,369,709RGDNCBI36
Celera1259,745,731 - 59,746,036RGD
Cytogenetic Map12q13UniSTS
HuRef1257,131,593 - 57,131,898UniSTS
TNG Radiation Hybrid Map1228618.0UniSTS
SLC16A7_1419  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,173,301 - 60,174,081UniSTSGRCh37
Build 361258,459,568 - 58,460,348RGDNCBI36
Celera1259,835,905 - 59,836,685RGD
HuRef1257,221,767 - 57,222,547UniSTS
UniSTS:461933  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,168,448 - 60,168,978UniSTSGRCh37
Build 361258,454,715 - 58,455,245RGDNCBI36
Celera1259,831,052 - 59,831,582RGD
HuRef1257,216,914 - 57,217,444UniSTS
UniSTS:461934  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371260,168,448 - 60,168,664UniSTSGRCh37
Build 361258,454,715 - 58,454,931RGDNCBI36
Celera1259,831,052 - 59,831,268RGD
HuRef1257,216,914 - 57,217,130UniSTS
AL033784  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q13UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic MapXq12UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3049
Count of miRNA genes:1098
Interacting mature miRNAs:1334
Transcripts:ENST00000261187, ENST00000543448, ENST00000546459, ENST00000547379, ENST00000547801, ENST00000548444, ENST00000548610, ENST00000549033, ENST00000549305, ENST00000549465, ENST00000549588, ENST00000549928, ENST00000550062, ENST00000551877, ENST00000552024, ENST00000552405, ENST00000552432
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 56 206 40 13 158 13 177 144 36 58 23 132 3 227 39
Low 2230 2511 1557 531 1524 372 3900 1772 3082 311 1269 1384 165 977 2504 2 1
Below cutoff 121 273 121 78 263 78 275 276 591 46 122 85 5 1 245

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005269231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC079905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC119793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF049608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF058056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC394954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR000391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261187   ⟹   ENSP00000261187
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,337 - 59,789,855 (+)Ensembl
RefSeq Acc Id: ENST00000546459   ⟹   ENSP00000449229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,348 - 59,768,223 (+)Ensembl
RefSeq Acc Id: ENST00000547379   ⟹   ENSP00000448071
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,596,029 - 59,789,841 (+)Ensembl
RefSeq Acc Id: ENST00000547801
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,362 - 59,768,309 (+)Ensembl
RefSeq Acc Id: ENST00000548444   ⟹   ENSP00000447814
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,769,059 - 59,775,035 (+)Ensembl
RefSeq Acc Id: ENST00000548610   ⟹   ENSP00000446722
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,664,677 - 59,779,548 (+)Ensembl
RefSeq Acc Id: ENST00000549033   ⟹   ENSP00000447459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,353 - 59,779,696 (+)Ensembl
RefSeq Acc Id: ENST00000549305   ⟹   ENSP00000448870
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,371 - 59,761,146 (+)Ensembl
RefSeq Acc Id: ENST00000549465   ⟹   ENSP00000447555
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,596,162 - 59,720,194 (+)Ensembl
RefSeq Acc Id: ENST00000549588
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,345 - 59,764,077 (+)Ensembl
RefSeq Acc Id: ENST00000549928   ⟹   ENSP00000449167
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,370 - 59,779,689 (+)Ensembl
RefSeq Acc Id: ENST00000550062   ⟹   ENSP00000450133
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,345 - 59,735,982 (+)Ensembl
RefSeq Acc Id: ENST00000551877   ⟹   ENSP00000449972
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,362 - 59,734,085 (+)Ensembl
RefSeq Acc Id: ENST00000552024   ⟹   ENSP00000448742
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,597,059 - 59,779,685 (+)Ensembl
RefSeq Acc Id: ENST00000552405
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,689,353 - 59,768,225 (+)Ensembl
RefSeq Acc Id: ENST00000552432   ⟹   ENSP00000449547
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1259,596,067 - 59,780,213 (+)Ensembl
RefSeq Acc Id: NM_001270622   ⟹   NP_001257551
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,596,029 - 59,789,841 (+)NCBI
GRCh371259,989,821 - 60,183,636 (+)NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBI
CHM1_11259,958,039 - 60,151,803 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270623   ⟹   NP_001257552
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,596,029 - 59,789,841 (+)NCBI
GRCh371259,989,821 - 60,183,636 (+)NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBI
CHM1_11259,958,039 - 60,151,803 (+)NCBI
Sequence:
RefSeq Acc Id: NM_004731   ⟹   NP_004722
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,370 - 59,789,841 (+)NCBI
GRCh371259,989,821 - 60,183,636 (+)NCBI
Build 361258,369,393 - 58,461,675 (+)NCBI Archive
HuRef1257,038,268 - 57,232,240 (+)NCBI
CHM1_11260,051,279 - 60,151,803 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073055
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,370 - 59,789,841 (+)NCBI
GRCh371259,989,821 - 60,183,636 (+)NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBI
CHM1_11260,051,279 - 60,151,803 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073056
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,370 - 59,789,841 (+)NCBI
GRCh371259,989,821 - 60,183,636 (+)NCBI
HuRef1257,038,268 - 57,232,240 (+)NCBI
CHM1_11260,051,279 - 60,151,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005269231   ⟹   XP_005269288
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,664,874 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538989   ⟹   XP_011537291
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,595,934 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538990   ⟹   XP_011537292
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,175 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538991   ⟹   XP_011537293
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,664,852 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538992   ⟹   XP_011537294
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,663,819 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538993   ⟹   XP_011537295
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,209 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538995   ⟹   XP_011537297
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,733,744 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017020224   ⟹   XP_016875713
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,348 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017020225   ⟹   XP_016875714
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,348 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017020226   ⟹   XP_016875715
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,704,963 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017020227   ⟹   XP_016875716
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,348 - 59,789,841 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024449276   ⟹   XP_024305044
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,663,826 - 59,789,841 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004722   ⟸   NM_004731
- UniProtKB: O60669 (UniProtKB/Swiss-Prot),   A0A024RBB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257552   ⟸   NM_001270623
- UniProtKB: O60669 (UniProtKB/Swiss-Prot),   A0A024RBB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257551   ⟸   NM_001270622
- UniProtKB: O60669 (UniProtKB/Swiss-Prot),   A0A024RBB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005269288   ⟸   XM_005269231
- Peptide Label: isoform X2
- UniProtKB: O60669 (UniProtKB/Swiss-Prot),   A0A024RBB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011537291   ⟸   XM_011538989
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011537294   ⟸   XM_011538992
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011537293   ⟸   XM_011538991
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011537295   ⟸   XM_011538993
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011537292   ⟸   XM_011538990
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011537297   ⟸   XM_011538995
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016875713   ⟸   XM_017020224
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016875714   ⟸   XM_017020225
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016875716   ⟸   XM_017020227
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016875715   ⟸   XM_017020226
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024305044   ⟸   XM_024449276
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000449229   ⟸   ENST00000546459
RefSeq Acc Id: ENSP00000448071   ⟸   ENST00000547379
RefSeq Acc Id: ENSP00000446722   ⟸   ENST00000548610
RefSeq Acc Id: ENSP00000447814   ⟸   ENST00000548444
RefSeq Acc Id: ENSP00000449167   ⟸   ENST00000549928
RefSeq Acc Id: ENSP00000448870   ⟸   ENST00000549305
RefSeq Acc Id: ENSP00000447459   ⟸   ENST00000549033
RefSeq Acc Id: ENSP00000447555   ⟸   ENST00000549465
RefSeq Acc Id: ENSP00000450133   ⟸   ENST00000550062
RefSeq Acc Id: ENSP00000261187   ⟸   ENST00000261187
RefSeq Acc Id: ENSP00000449972   ⟸   ENST00000551877
RefSeq Acc Id: ENSP00000448742   ⟸   ENST00000552024
RefSeq Acc Id: ENSP00000449547   ⟸   ENST00000552432
Protein Domains
MFS

Promoters
RGD ID:7224633
Promoter ID:EPDNEW_H18062
Type:initiation region
Name:SLC16A7_1
Description:solute carrier family 16 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18063  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,596,080 - 59,596,140EPDNEW
RGD ID:7224635
Promoter ID:EPDNEW_H18063
Type:initiation region
Name:SLC16A7_2
Description:solute carrier family 16 member 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18062  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381259,689,372 - 59,689,432EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q13.3-14.2(chr12:57013355-63042498)x1 copy number loss See cases [RCV000052813] Chr12:57013355..63042498 [GRCh38]
Chr12:57407139..63436278 [GRCh37]
Chr12:55693406..61722545 [NCBI36]
Chr12:12q13.3-14.2
pathogenic
GRCh38/hg38 12q13.3-14.1(chr12:57041158-60273934)x1 copy number loss See cases [RCV000052814] Chr12:57041158..60273934 [GRCh38]
Chr12:57434942..60667715 [GRCh37]
Chr12:55721209..58953982 [NCBI36]
Chr12:12q13.3-14.1
pathogenic
NM_004731.4(SLC16A7):c.122C>T (p.Thr41Ile) single nucleotide variant Malignant melanoma [RCV000070147] Chr12:59704923 [GRCh38]
Chr12:60098704 [GRCh37]
Chr12:58384971 [NCBI36]
Chr12:12q14.1
not provided
NM_001270622.1(SLC16A7):c.-109-19827G>C single nucleotide variant Lung cancer [RCV000111141] Chr12:59635325 [GRCh38]
Chr12:60029106 [GRCh37]
Chr12:12q14.1
uncertain significance
NM_001270622.1(SLC16A7):c.-11+2863C>T single nucleotide variant Lung cancer [RCV000111142] Chr12:59658113 [GRCh38]
Chr12:60051894 [GRCh37]
Chr12:12q14.1
uncertain significance
GRCh38/hg38 12q14.1(chr12:59353117-60085960)x1 copy number loss See cases [RCV000138218] Chr12:59353117..60085960 [GRCh38]
Chr12:59746898..60479741 [GRCh37]
Chr12:58033165..58766008 [NCBI36]
Chr12:12q14.1
uncertain significance
GRCh38/hg38 12q14.1(chr12:59042021-60965796)x1 copy number loss See cases [RCV000139874] Chr12:59042021..60965796 [GRCh38]
Chr12:59435802..61359577 [GRCh37]
Chr12:57722069..59645844 [NCBI36]
Chr12:12q14.1
uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q14.1(chr12:58802649-59703763)x3 copy number gain See cases [RCV000143275] Chr12:58802649..59703763 [GRCh38]
Chr12:59196431..60097544 [GRCh37]
Chr12:57482698..58383811 [NCBI36]
Chr12:12q14.1
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q14.1-15(chr12:59495114-70574966)x1 copy number loss See cases [RCV000447164] Chr12:59495114..70574966 [GRCh37]
Chr12:12q14.1-15
pathogenic
GRCh37/hg19 12q14.1(chr12:59167152-60244566)x3 copy number gain See cases [RCV000445904] Chr12:59167152..60244566 [GRCh37]
Chr12:12q14.1
likely benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q14.1(chr12:60161907-60415132)x1 copy number loss not provided [RCV000683411] Chr12:60161907..60415132 [GRCh37]
Chr12:12q14.1
likely benign
GRCh37/hg19 12q14.1(chr12:60173814-60610476)x3 copy number gain not provided [RCV000683433] Chr12:60173814..60610476 [GRCh37]
Chr12:12q14.1
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q14.1(chr12:59840189-60971215)x1 copy number loss not provided [RCV000750427] Chr12:59840189..60971215 [GRCh37]
Chr12:12q14.1
uncertain significance
GRCh37/hg19 12q14.1(chr12:60082506-60103822)x1 copy number loss not provided [RCV000750432] Chr12:60082506..60103822 [GRCh37]
Chr12:12q14.1
benign
GRCh37/hg19 12q14.1(chr12:60164408-60187843)x1 copy number loss not provided [RCV000750433] Chr12:60164408..60187843 [GRCh37]
Chr12:12q14.1
benign
NM_001270623.2(SLC16A7):c.105A>G (p.Ala35=) single nucleotide variant not provided [RCV000947468] Chr12:59704906 [GRCh38]
Chr12:60098687 [GRCh37]
Chr12:12q14.1
benign
NM_001270623.2(SLC16A7):c.602A>G (p.Asn201Ser) single nucleotide variant not provided [RCV000947469] Chr12:59774897 [GRCh38]
Chr12:60168678 [GRCh37]
Chr12:12q14.1
benign
GRCh37/hg19 12q14.1(chr12:59659908-60004443)x3 copy number gain not provided [RCV001006507] Chr12:59659908..60004443 [GRCh37]
Chr12:12q14.1
uncertain significance
NM_001270623.2(SLC16A7):c.510T>C (p.Asn170=) single nucleotide variant not provided [RCV000923042] Chr12:59774805 [GRCh38]
Chr12:60168586 [GRCh37]
Chr12:12q14.1
likely benign
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1
pathogenic
GRCh37/hg19 12q14.1(chr12:59136522-62410625)x1 copy number loss not provided [RCV001259616] Chr12:59136522..62410625 [GRCh37]
Chr12:12q14.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10928 AgrOrtholog
COSMIC SLC16A7 COSMIC
Ensembl Genes ENSG00000118596 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000261187 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000446722 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000447459 UniProtKB/TrEMBL
  ENSP00000447555 UniProtKB/TrEMBL
  ENSP00000447814 UniProtKB/TrEMBL
  ENSP00000448071 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000448742 UniProtKB/Swiss-Prot
  ENSP00000448870 UniProtKB/TrEMBL
  ENSP00000449167 UniProtKB/TrEMBL
  ENSP00000449229 UniProtKB/TrEMBL
  ENSP00000449547 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000449972 UniProtKB/TrEMBL
  ENSP00000450133 UniProtKB/TrEMBL
Ensembl Transcript ENST00000261187 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000546459 UniProtKB/TrEMBL
  ENST00000547379 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000548444 UniProtKB/TrEMBL
  ENST00000548610 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000549033 UniProtKB/TrEMBL
  ENST00000549305 UniProtKB/TrEMBL
  ENST00000549465 UniProtKB/TrEMBL
  ENST00000549928 UniProtKB/TrEMBL
  ENST00000550062 UniProtKB/TrEMBL
  ENST00000551877 UniProtKB/TrEMBL
  ENST00000552024 UniProtKB/Swiss-Prot
  ENST00000552432 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000118596 GTEx
HGNC ID HGNC:10928 ENTREZGENE
Human Proteome Map SLC16A7 Human Proteome Map
InterPro MCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MCT2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:9194 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9194 ENTREZGENE
OMIM 603654 OMIM
PANTHER PTHR11360:SF25 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA35819 PharmGKB
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs 2A0113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RBB2 ENTREZGENE, UniProtKB/TrEMBL
  F8VQS4_HUMAN UniProtKB/TrEMBL
  F8VS95_HUMAN UniProtKB/TrEMBL
  F8VVU7_HUMAN UniProtKB/TrEMBL
  F8VXG4_HUMAN UniProtKB/TrEMBL
  F8VYZ2_HUMAN UniProtKB/TrEMBL
  F8W0N3_HUMAN UniProtKB/TrEMBL
  F8W0U4_HUMAN UniProtKB/TrEMBL
  F8W1M4_HUMAN UniProtKB/TrEMBL
  MOT2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8NEM3 UniProtKB/Swiss-Prot
  Q9UPB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 SLC16A7  solute carrier family 16 member 7    solute carrier family 16 (monocarboxylate transporter), member 7  Symbol and/or name change 5135510 APPROVED
2013-07-23 SLC16A7  solute carrier family 16 (monocarboxylate transporter), member 7    solute carrier family 16, member 7 (monocarboxylic acid transporter 2)  Symbol and/or name change 5135510 APPROVED