HK2 (hexokinase 2) - Rat Genome Database

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Gene: HK2 (hexokinase 2) Homo sapiens
Analyze
Symbol: HK2
Name: hexokinase 2
RGD ID: 733090
HGNC Page HGNC:4923
Description: Enables glucokinase activity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; and protein localization to mitochondrion. Acts upstream of or within apoptotic mitochondrial changes. Located in centrosome; cytosol; and mitochondrial outer membrane. Implicated in obesity and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp686M1669; hexokinase type II; hexokinase-2; hexokinase-2, muscle; hexokinase-B; HK II; HKII; HXK2; muscle form hexokinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HK2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,834,127 - 74,893,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,834,127 - 74,893,359 (+)EnsemblGRCh38hg38GRCh38
GRCh37275,061,254 - 75,120,486 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,913,290 - 74,973,989 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,971,436 - 75,032,134NCBI
Celera274,890,867 - 74,951,557 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef274,796,877 - 74,857,297 (+)NCBIHuRef
CHM1_1274,989,111 - 75,049,797 (+)NCBICHM1_1
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-adrenaline  (EXP,ISO)
(S)-naringenin  (EXP)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-deoxy-D-glucose  (EXP)
2-ethoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-bromopyruvic acid  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-chlorobiphenyl  (EXP)
4-phenylbutyric acid  (EXP)
5-fluorouracil  (EXP)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alpha-cyano-4-hydroxycinnamic acid  (EXP)
AP20187  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
ATP  (ISO)
Azaspiracid  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoates  (EXP)
betulinic acid  (EXP)
bicalutamide  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bruceine D  (EXP)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
carteolol  (EXP)
CCCP  (EXP)
celastrol  (ISO)
celecoxib  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chloroprene  (ISO)
chloroquine  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
clotrimazole  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cobalt(2+) sulfate  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
dimercaprol  (EXP)
dimethylarsinic acid  (ISO)
dimethylselenide  (EXP)
dinophysistoxin 1  (EXP)
Diosbulbin B  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
fulvestrant  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glutathione  (EXP)
heptachlor  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP,ISO)
ionomycin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
josamycin  (EXP)
L-methionine  (ISO)
lead(0)  (EXP)
leflunomide  (EXP)
leptomycin B  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
mercury dichloride  (ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
microcystin-LR  (ISO)
mirex  (ISO)
myricetin  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP)
ochratoxin A  (EXP)
okadaic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
promethazine  (ISO)
propanal  (EXP)
prostaglandin E2  (ISO)
quercetin  (EXP)
quizartinib  (EXP)
rac-lactic acid  (EXP)
radon atom  (EXP)
radon(0)  (EXP)
resveratrol  (EXP)
rotenone  (EXP,ISO)
roxadustat  (EXP)
SB 431542  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
sotorasib  (EXP)
sunitinib  (EXP)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tolfenamic acid  (EXP)
trametinib  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
Tungsten carbide  (EXP)
tunicamycin  (EXP,ISO)
ubiquinone-0  (EXP)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vorinostat  (EXP)
Yessotoxin  (EXP)
zearalenone  (EXP)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Reduced expression of hexokinase II in insulin-resistant diabetes. Braithwaite SS, etal., Diabetes. 1995 Jan;44(1):43-8.
2. Evolution and regulatory role of the hexokinases. Cardenas ML, etal., Biochim Biophys Acta. 1998 Mar 5;1401(3):242-64.
3. Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes. Cusi KJ, etal., Metabolism. 2001 May;50(5):602-6.
4. Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats. Ferrer-Martinez A, etal., Lipids. 2006 Jan;41(1):55-62.
5. Effects of Tianshu Capsule on Spontaneously Hypertensive Rats as Revealed by 1H-NMR-Based Metabolic Profiling. Gao J, etal., Front Pharmacol. 2019 Sep 11;10:989. doi: 10.3389/fphar.2019.00989. eCollection 2019.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for type II hexokinase. Mathupala SP, etal., J Biol Chem 1995 Jul 14;270(28):16918-25.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Chronic hypoxia enhances expression and activity of mitochondrial creatine kinase and hexokinase in the rat ventricular myocardium. Waskova-Arnostova P, etal., Cell Physiol Biochem. 2014;33(2):310-20. doi: 10.1159/000356671. Epub 2014 Jan 31.
Additional References at PubMed
PMID:7518342   PMID:7883120   PMID:7883122   PMID:7883123   PMID:8250948   PMID:8307259   PMID:8567628   PMID:8786021   PMID:8889548   PMID:9056853   PMID:9278438   PMID:9447955  
PMID:11068878   PMID:11688991   PMID:12477932   PMID:12663490   PMID:14672622   PMID:14747281   PMID:15489334   PMID:15710218   PMID:15967114   PMID:16189514   PMID:16396496   PMID:16551620  
PMID:16712791   PMID:16713569   PMID:16751776   PMID:17785433   PMID:18271924   PMID:18350175   PMID:18535403   PMID:18579725   PMID:18772588   PMID:19003546   PMID:19033437   PMID:19049977  
PMID:19322201   PMID:19554504   PMID:19558793   PMID:19579598   PMID:19681047   PMID:19723875   PMID:19770592   PMID:19946888   PMID:20346347   PMID:20347420   PMID:20453422   PMID:20845004  
PMID:20845477   PMID:20846459   PMID:20877624   PMID:20958264   PMID:21242296   PMID:21279699   PMID:21411499   PMID:21600799   PMID:21726646   PMID:21873635   PMID:21909686   PMID:22087292  
PMID:22174317   PMID:22230325   PMID:22268729   PMID:22334075   PMID:22354042   PMID:22398711   PMID:22469988   PMID:22593586   PMID:22623428   PMID:22691140   PMID:22825642   PMID:22863883  
PMID:22901702   PMID:22939629   PMID:23071593   PMID:23123787   PMID:23185017   PMID:23349798   PMID:23414517   PMID:23500080   PMID:23503661   PMID:23629924   PMID:23869589   PMID:23874603  
PMID:23962723   PMID:24033605   PMID:24051093   PMID:24136222   PMID:24363061   PMID:24390321   PMID:24780297   PMID:24797263   PMID:24890811   PMID:24939624   PMID:25060325   PMID:25381201  
PMID:25416956   PMID:25609649   PMID:25766729   PMID:25801897   PMID:25921289   PMID:26059508   PMID:26097593   PMID:26106078   PMID:26116768   PMID:26134042   PMID:26182367   PMID:26247723  
PMID:26323688   PMID:26344197   PMID:26346032   PMID:26496610   PMID:26607110   PMID:26740252   PMID:26802651   PMID:26827442   PMID:26848773   PMID:26855992   PMID:26972000   PMID:26985301  
PMID:26986252   PMID:27132509   PMID:27260001   PMID:27314295   PMID:27315591   PMID:27342126   PMID:27351131   PMID:27363977   PMID:27499296   PMID:27544294   PMID:27588472   PMID:27926482  
PMID:28025745   PMID:28054552   PMID:28098871   PMID:28174335   PMID:28184935   PMID:28347233   PMID:28378594   PMID:28380382   PMID:28429188   PMID:28432222   PMID:28445971   PMID:28478957  
PMID:28488541   PMID:28498475   PMID:28514442   PMID:28515276   PMID:28596599   PMID:28602700   PMID:28641488   PMID:28935467   PMID:28980855   PMID:29114069   PMID:29169422   PMID:29220380  
PMID:29247711   PMID:29298880   PMID:29335581   PMID:29384225   PMID:29414774   PMID:29440331   PMID:29467282   PMID:29507755   PMID:29559564   PMID:29568061   PMID:29631677   PMID:29663500  
PMID:29695690   PMID:29763606   PMID:29864898   PMID:29985480   PMID:30015920   PMID:30037846   PMID:30070319   PMID:30144070   PMID:30365936   PMID:30528266   PMID:30585266   PMID:30619736  
PMID:30650008   PMID:30825877   PMID:30833792   PMID:30875800   PMID:30877036   PMID:30920655   PMID:30948266   PMID:31073040   PMID:31091453   PMID:31201299   PMID:31267705   PMID:31270843  
PMID:31409639   PMID:31486135   PMID:31504727   PMID:31506393   PMID:31512042   PMID:31519767   PMID:31524259   PMID:31530094   PMID:31560931   PMID:31586073   PMID:31709769   PMID:31723608  
PMID:31742336   PMID:31742425   PMID:31918722   PMID:31932471   PMID:31991125   PMID:31994339   PMID:32021252   PMID:32279420   PMID:32383545   PMID:32410389   PMID:32508321   PMID:32533646  
PMID:32564010   PMID:32694731   PMID:32733938   PMID:32737775   PMID:32786267   PMID:32877691   PMID:33067267   PMID:33099572   PMID:33144569   PMID:33187984   PMID:33253711   PMID:33309838  
PMID:33378974   PMID:33420213   PMID:33594203   PMID:33602893   PMID:33742100   PMID:33753739   PMID:33760124   PMID:33836566   PMID:33922649   PMID:33924293   PMID:33946854   PMID:33961781  
PMID:33979737   PMID:34079125   PMID:34083717   PMID:34146942   PMID:34160468   PMID:34227742   PMID:34236032   PMID:34345220   PMID:34378321   PMID:34382305   PMID:34591612   PMID:34650057  
PMID:34847775   PMID:34857952   PMID:35013556   PMID:35032548   PMID:35173161   PMID:35255118   PMID:35256949   PMID:35260660   PMID:35265223   PMID:35271311   PMID:35328104   PMID:35470850  
PMID:35509820   PMID:35546050   PMID:35563538   PMID:35603967   PMID:35831314   PMID:35914373   PMID:35944360   PMID:35953860   PMID:35975322   PMID:35982398   PMID:36042519   PMID:36057605  
PMID:36064706   PMID:36075458   PMID:36114006   PMID:36215168   PMID:36289463   PMID:36320008   PMID:36335239   PMID:36370492   PMID:36416387   PMID:36437337   PMID:36538041   PMID:36546770  
PMID:36548909   PMID:36708044   PMID:36793034   PMID:36799474   PMID:36809521   PMID:36960858   PMID:37120454   PMID:37349598   PMID:37377974   PMID:37524692   PMID:37616343   PMID:37817462  
PMID:37827155   PMID:37846677   PMID:37930472   PMID:38325141  


Genomics

Comparative Map Data
HK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,834,127 - 74,893,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,834,127 - 74,893,359 (+)EnsemblGRCh38hg38GRCh38
GRCh37275,061,254 - 75,120,486 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,913,290 - 74,973,989 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,971,436 - 75,032,134NCBI
Celera274,890,867 - 74,951,557 (+)NCBICelera
Cytogenetic Map2p12NCBI
HuRef274,796,877 - 74,857,297 (+)NCBIHuRef
CHM1_1274,989,111 - 75,049,797 (+)NCBICHM1_1
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBIT2T-CHM13v2.0
Hk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,702,004 - 82,751,437 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,702,006 - 82,751,435 (-)EnsemblGRCm39 Ensembl
GRCm38682,725,025 - 82,774,454 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,725,025 - 82,774,454 (-)EnsemblGRCm38mm10GRCm38
MGSCv37682,675,019 - 82,724,448 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,690,705 - 82,740,117 (-)NCBIMGSCv36mm8
Celera684,700,692 - 84,750,369 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Hk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,792,258 - 116,841,275 (-)NCBIGRCr8
mRatBN7.24115,234,509 - 115,283,530 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,234,509 - 115,283,530 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,703,515 - 120,752,497 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,478,737 - 116,527,715 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,100,199 - 115,149,197 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,559,396 - 113,609,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,559,427 - 113,610,243 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04178,237,866 - 178,288,251 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,925,725 - 116,975,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14117,170,205 - 117,219,692 (-)NCBI
Celera4104,230,959 - 104,279,831 (-)NCBICelera
Cytogenetic Map4q34NCBI
Hk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,897,485 - 10,966,025 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542410,897,528 - 10,966,025 (-)NCBIChiLan1.0ChiLan1.0
HK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,498,596 - 51,561,239 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,501,345 - 51,563,782 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,897,914 - 74,957,234 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,400,240 - 76,460,881 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,400,240 - 76,460,874 (+)Ensemblpanpan1.1panPan2
HK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,287,367 - 48,329,470 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,289,272 - 48,348,663 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,929,800 - 47,991,763 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,149,327 - 49,211,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,149,338 - 49,211,264 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,164,479 - 48,226,250 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,228,923 - 48,290,663 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,791,741 - 48,853,532 (-)NCBIUU_Cfam_GSD_1.0
Hk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,624,471 - 9,683,753 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,054,021 - 1,113,450 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,054,143 - 1,113,425 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,153,835 - 68,231,615 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,155,656 - 68,231,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,331,772 - 71,407,448 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,385,237 - 32,443,864 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,385,249 - 32,442,403 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,732,113 - 79,789,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,618,030 - 28,689,794 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,618,146 - 28,718,852 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HK2
48 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000189.4(HK2):c.1629C>T (p.Val543=) single nucleotide variant Malignant melanoma [RCV000065687] Chr2:74881769 [GRCh38]
Chr2:75108896 [GRCh37]
Chr2:74962404 [NCBI36]
Chr2:2p12
not provided
NM_000189.4(HK2):c.1630C>T (p.Arg544Cys) single nucleotide variant Malignant melanoma [RCV000065688] Chr2:74881770 [GRCh38]
Chr2:75108897 [GRCh37]
Chr2:74962405 [NCBI36]
Chr2:2p12
not provided
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2
pathogenic
GRCh38/hg38 2p13.1-12(chr2:74690966-74875121)x3 copy number gain See cases [RCV000136705] Chr2:74690966..74875121 [GRCh38]
Chr2:74918093..75102248 [GRCh37]
Chr2:74771601..74955756 [NCBI36]
Chr2:2p13.1-12
uncertain significance
GRCh38/hg38 2p13.1-12(chr2:74432069-75181627)x3 copy number gain See cases [RCV000136651] Chr2:74432069..75181627 [GRCh38]
Chr2:74659196..75408753 [GRCh37]
Chr2:74512704..75262261 [NCBI36]
Chr2:2p13.1-12
likely benign|uncertain significance
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh38/hg38 2p13.1-12(chr2:74375779-75517520)x1 copy number loss See cases [RCV000143456] Chr2:74375779..75517520 [GRCh38]
Chr2:74602906..75744646 [GRCh37]
Chr2:74456414..75598154 [NCBI36]
Chr2:2p13.1-12
likely pathogenic
GRCh37/hg19 2p13.1-12(chr2:74901369-75196822)x3 copy number gain See cases [RCV000447094] Chr2:74901369..75196822 [GRCh37]
Chr2:2p13.1-12
likely benign
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74365484-89129064)x1 copy number loss See cases [RCV000510763] Chr2:74365484..89129064 [GRCh37]
Chr2:2p13.1-11.2
pathogenic
NM_000189.5(HK2):c.45C>G (p.Asn15Lys) single nucleotide variant Inborn genetic diseases [RCV003240035] Chr2:74834625 [GRCh38]
Chr2:75061752 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.783G>C (p.Trp261Cys) single nucleotide variant Inborn genetic diseases [RCV003267250] Chr2:74874357 [GRCh38]
Chr2:75101484 [GRCh37]
Chr2:2p12
uncertain significance
GRCh37/hg19 2p13.1-11.2(chr2:74527522-89125488)x1 copy number loss not provided [RCV000682167] Chr2:74527522..89125488 [GRCh37]
Chr2:2p13.1-11.2
pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
Single allele duplication not provided [RCV000677942] Chr2:63671346..85698002 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p12(chr2:75050732-75307296)x1 copy number loss not provided [RCV000753020] Chr2:75050732..75307296 [GRCh37]
Chr2:2p12
benign
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_000189.5(HK2):c.912G>A (p.Glu304=) single nucleotide variant not provided [RCV000966141] Chr2:74877202 [GRCh38]
Chr2:75104329 [GRCh37]
Chr2:2p12
benign
GRCh37/hg19 2p13.1-12(chr2:74972080-83043893)x1 copy number loss not provided [RCV000846568] Chr2:74972080..83043893 [GRCh37]
Chr2:2p13.1-12
pathogenic
GRCh37/hg19 2p13.1-12(chr2:74928349-77095981)x3 copy number gain not provided [RCV000849780] Chr2:74928349..77095981 [GRCh37]
Chr2:2p13.1-12
uncertain significance
GRCh37/hg19 2p12(chr2:75073452-75145041)x3 copy number gain not provided [RCV000848366] Chr2:75073452..75145041 [GRCh37]
Chr2:2p12
uncertain significance
GRCh37/hg19 2p13.1-12(chr2:74895347-75829809)x3 copy number gain not provided [RCV000849901] Chr2:74895347..75829809 [GRCh37]
Chr2:2p13.1-12
uncertain significance
GRCh37/hg19 2p13.1-12(chr2:74892913-75231341)x3 copy number gain not provided [RCV001005287] Chr2:74892913..75231341 [GRCh37]
Chr2:2p13.1-12
likely benign
NM_000189.5(HK2):c.2113G>A (p.Val705Met) single nucleotide variant Inborn genetic diseases [RCV003241707] Chr2:74886567 [GRCh38]
Chr2:75113694 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.375+7C>A single nucleotide variant not provided [RCV000932411] Chr2:74867791 [GRCh38]
Chr2:75094918 [GRCh37]
Chr2:2p12
likely benign
NM_000189.5(HK2):c.1545C>T (p.Tyr515=) single nucleotide variant not provided [RCV000963603] Chr2:74880544 [GRCh38]
Chr2:75107671 [GRCh37]
Chr2:2p12
benign
NM_000189.5(HK2):c.1176C>T (p.Ala392=) single nucleotide variant not provided [RCV000906473] Chr2:74878832 [GRCh38]
Chr2:75105959 [GRCh37]
Chr2:2p12
likely benign
NM_000189.5(HK2):c.1762T>C (p.Tyr588His) single nucleotide variant Inborn genetic diseases [RCV003276158] Chr2:74882162 [GRCh38]
Chr2:75109289 [GRCh37]
Chr2:2p12
uncertain significance
GRCh37/hg19 2p13.1-12(chr2:74825161-75308974)x3 copy number gain not provided [RCV001260150] Chr2:74825161..75308974 [GRCh37]
Chr2:2p13.1-12
likely benign
GRCh37/hg19 2p13.1-12(chr2:74780969-75444113)x3 copy number gain not provided [RCV001260151] Chr2:74780969..75444113 [GRCh37]
Chr2:2p13.1-12
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_000189.5(HK2):c.112G>A (p.Glu38Lys) single nucleotide variant Inborn genetic diseases [RCV003276746] Chr2:74854341 [GRCh38]
Chr2:75081468 [GRCh37]
Chr2:2p12
uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13
pathogenic
NM_000189.5(HK2):c.2150G>T (p.Cys717Phe) single nucleotide variant Inborn genetic diseases [RCV003286626] Chr2:74886604 [GRCh38]
Chr2:75113731 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2606C>T (p.Pro869Leu) single nucleotide variant Inborn genetic diseases [RCV002907048] Chr2:74889475 [GRCh38]
Chr2:75116602 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1894G>T (p.Asp632Tyr) single nucleotide variant Inborn genetic diseases [RCV002793984] Chr2:74885548 [GRCh38]
Chr2:75112675 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1391C>T (p.Ala464Val) single nucleotide variant Inborn genetic diseases [RCV002778066] Chr2:74880390 [GRCh38]
Chr2:75107517 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.196A>G (p.Thr66Ala) single nucleotide variant Inborn genetic diseases [RCV002776715] Chr2:74854425 [GRCh38]
Chr2:75081552 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2278G>A (p.Asp760Asn) single nucleotide variant Inborn genetic diseases [RCV002992718] Chr2:74887961 [GRCh38]
Chr2:75115088 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1073G>A (p.Arg358Gln) single nucleotide variant Inborn genetic diseases [RCV002968684] Chr2:74878729 [GRCh38]
Chr2:75105856 [GRCh37]
Chr2:2p12
uncertain significance
GRCh37/hg19 2p12(chr2:75042935-75308974)x1 copy number loss not provided [RCV002475710] Chr2:75042935..75308974 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1118G>A (p.Arg373Gln) single nucleotide variant Inborn genetic diseases [RCV002738069] Chr2:74878774 [GRCh38]
Chr2:75105901 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.124C>T (p.Arg42Trp) single nucleotide variant Inborn genetic diseases [RCV002737862] Chr2:74854353 [GRCh38]
Chr2:75081480 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1440C>A (p.Ser480Arg) single nucleotide variant Inborn genetic diseases [RCV002757535] Chr2:74880439 [GRCh38]
Chr2:75107566 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1298G>A (p.Arg433Gln) single nucleotide variant Inborn genetic diseases [RCV002798757] Chr2:74880297 [GRCh38]
Chr2:75107424 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1219C>T (p.Arg407Cys) single nucleotide variant Inborn genetic diseases [RCV002694711] Chr2:74878875 [GRCh38]
Chr2:75106002 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.862C>T (p.Pro288Ser) single nucleotide variant Inborn genetic diseases [RCV002931298] Chr2:74874436 [GRCh38]
Chr2:75101563 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.328C>A (p.Gln110Lys) single nucleotide variant Inborn genetic diseases [RCV002875230] Chr2:74867737 [GRCh38]
Chr2:75094864 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2576G>T (p.Gly859Val) single nucleotide variant Inborn genetic diseases [RCV002826918] Chr2:74889445 [GRCh38]
Chr2:75116572 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2179G>A (p.Val727Met) single nucleotide variant Inborn genetic diseases [RCV002788410] Chr2:74886633 [GRCh38]
Chr2:75113760 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.554T>C (p.Val185Ala) single nucleotide variant Inborn genetic diseases [RCV002875273] Chr2:74873334 [GRCh38]
Chr2:75100461 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.677T>C (p.Ile226Thr) single nucleotide variant Inborn genetic diseases [RCV002743350] Chr2:74873929 [GRCh38]
Chr2:75101056 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2104C>T (p.Arg702Trp) single nucleotide variant Inborn genetic diseases [RCV002697909] Chr2:74886558 [GRCh38]
Chr2:75113685 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1322G>A (p.Arg441His) single nucleotide variant Inborn genetic diseases [RCV002831440] Chr2:74880321 [GRCh38]
Chr2:75107448 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.790T>C (p.Phe264Leu) single nucleotide variant Inborn genetic diseases [RCV003010874] Chr2:74874364 [GRCh38]
Chr2:75101491 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2512A>C (p.Met838Leu) single nucleotide variant Inborn genetic diseases [RCV002878683] Chr2:74889381 [GRCh38]
Chr2:75116508 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1306C>T (p.Pro436Ser) single nucleotide variant Inborn genetic diseases [RCV002808760] Chr2:74880305 [GRCh38]
Chr2:75107432 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1688C>T (p.Pro563Leu) single nucleotide variant Inborn genetic diseases [RCV002792214] Chr2:74881828 [GRCh38]
Chr2:75108955 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2512A>T (p.Met838Leu) single nucleotide variant Inborn genetic diseases [RCV002678615] Chr2:74889381 [GRCh38]
Chr2:75116508 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.962G>A (p.Gly321Glu) single nucleotide variant Inborn genetic diseases [RCV002657405] Chr2:74877252 [GRCh38]
Chr2:75104379 [GRCh37]
Chr2:2p12
uncertain significance
GRCh37/hg19 2p13.1-12(chr2:73716761-75347894)x1 copy number loss not provided [RCV003223078] Chr2:73716761..75347894 [GRCh37]
Chr2:2p13.1-12
uncertain significance
NM_000189.5(HK2):c.1186C>T (p.Arg396Cys) single nucleotide variant Inborn genetic diseases [RCV003180346] Chr2:74878842 [GRCh38]
Chr2:75105969 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1748C>T (p.Ala583Val) single nucleotide variant Inborn genetic diseases [RCV003211628] Chr2:74882148 [GRCh38]
Chr2:75109275 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1094A>G (p.Gln365Arg) single nucleotide variant Inborn genetic diseases [RCV003195761] Chr2:74878750 [GRCh38]
Chr2:75105877 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1624C>G (p.Leu542Val) single nucleotide variant Inborn genetic diseases [RCV003196988] Chr2:74881764 [GRCh38]
Chr2:75108891 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1640A>C (p.Asn547Thr) single nucleotide variant Inborn genetic diseases [RCV003176017] Chr2:74881780 [GRCh38]
Chr2:75108907 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1402C>T (p.Arg468Cys) single nucleotide variant Inborn genetic diseases [RCV003200184] Chr2:74880401 [GRCh38]
Chr2:75107528 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1214G>A (p.Arg405Gln) single nucleotide variant Inborn genetic diseases [RCV003208277] Chr2:74878870 [GRCh38]
Chr2:75105997 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.754G>A (p.Glu252Lys) single nucleotide variant Inborn genetic diseases [RCV003265994] Chr2:74874328 [GRCh38]
Chr2:75101455 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1676T>C (p.Ile559Thr) single nucleotide variant Inborn genetic diseases [RCV003262079] Chr2:74881816 [GRCh38]
Chr2:75108943 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.130C>T (p.Arg44Cys) single nucleotide variant Inborn genetic diseases [RCV003339387] Chr2:74854359 [GRCh38]
Chr2:75081486 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2729G>A (p.Arg910His) single nucleotide variant Inborn genetic diseases [RCV003350570] Chr2:74890916 [GRCh38]
Chr2:75118043 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.566T>A (p.Ile189Asn) single nucleotide variant Inborn genetic diseases [RCV003362196] Chr2:74873346 [GRCh38]
Chr2:75100473 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.2687G>A (p.Gly896Asp) single nucleotide variant Inborn genetic diseases [RCV003366093] Chr2:74890874 [GRCh38]
Chr2:75118001 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1535T>A (p.Leu512Gln) single nucleotide variant Inborn genetic diseases [RCV003363757] Chr2:74880534 [GRCh38]
Chr2:75107661 [GRCh37]
Chr2:2p12
uncertain significance
NM_000189.5(HK2):c.1307C>T (p.Pro436Leu) single nucleotide variant Inborn genetic diseases [RCV003378356] Chr2:74880306 [GRCh38]
Chr2:75107433 [GRCh37]
Chr2:2p12
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR125B1hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22593586
MIR143hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22354042
MIR143hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22593586
MIR143hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23376635
MIR143hsa-miR-143-3pOncomiRDBexternal_infoNANA22691140
MIR143hsa-miR-143-3pOncomiRDBexternal_infoNANA22593586
MIR143hsa-miR-143-3pOncomiRDBexternal_infoNANA22469988
MIR125B2hsa-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22593586
MIR125Ahsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22593586

Predicted Target Of
Summary Value
Count of predictions:2045
Count of miRNA genes:750
Interacting mature miRNAs:854
Transcripts:ENST00000290573, ENST00000409174, ENST00000472302
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH65294  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,120,214 - 75,120,348UniSTSGRCh37
GRCh37X79,825,067 - 79,825,199UniSTSGRCh37
Build 36X79,711,723 - 79,711,855RGDNCBI36
Celera274,951,290 - 74,951,424UniSTS
CeleraX80,065,194 - 80,065,326RGD
Cytogenetic Map2p13UniSTS
Cytogenetic MapXq21.1UniSTS
HuRef274,857,030 - 74,857,164UniSTS
HuRefX73,406,838 - 73,406,970UniSTS
RH120627  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,110,342 - 75,110,667UniSTSGRCh37
Build 36274,963,850 - 74,964,175RGDNCBI36
Celera274,941,418 - 74,941,743RGD
Cytogenetic Map2p13UniSTS
HuRef274,847,158 - 74,847,483UniSTS
TNG Radiation Hybrid Map246695.0UniSTS
GDB:271353  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,112,857 - 75,113,078UniSTSGRCh37
Build 36274,966,365 - 74,966,586RGDNCBI36
Celera274,943,933 - 74,944,154RGD
Cytogenetic Map2p13UniSTS
HuRef274,849,673 - 74,849,894UniSTS
GDB:451610  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,120,079 - 75,120,201UniSTSGRCh37
GRCh37X79,825,218 - 79,825,334UniSTSGRCh37
Build 36X79,711,874 - 79,711,990RGDNCBI36
Celera274,951,155 - 74,951,277UniSTS
CeleraX80,065,345 - 80,065,461RGD
Cytogenetic Map2p13UniSTS
Cytogenetic MapXq21.1UniSTS
HuRef274,856,895 - 74,857,017UniSTS
HuRefX73,406,989 - 73,407,105UniSTS
GDB:631172  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,109,683 - 75,109,791UniSTSGRCh37
Build 36274,963,191 - 74,963,299RGDNCBI36
Celera274,940,759 - 74,940,867RGD
Cytogenetic Map2p13UniSTS
HuRef274,846,499 - 74,846,607UniSTS
D2S2601  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,118,089 - 75,118,423UniSTSGRCh37
Build 36274,971,597 - 74,971,931RGDNCBI36
Celera274,949,165 - 74,949,499RGD
Cytogenetic Map2p13UniSTS
HuRef274,854,905 - 74,855,239UniSTS
GeneMap99-GB4 RH Map2232.29UniSTS
Whitehead-RH Map2322.6UniSTS
Whitehead-YAC Contig Map2 UniSTS
GeneMap99-G3 RH Map23161.0UniSTS
HK2_8401  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,119,699 - 75,120,508UniSTSGRCh37
Build 36274,973,207 - 74,974,016RGDNCBI36
Celera274,950,775 - 74,951,584RGD
HuRef274,856,515 - 74,857,324UniSTS
SHGC-57291  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37275,059,884 - 75,059,990UniSTSGRCh37
Build 36274,913,392 - 74,913,498RGDNCBI36
Celera274,890,969 - 74,891,075RGD
Cytogenetic Map2p13UniSTS
HuRef274,796,979 - 74,797,085UniSTS
TNG Radiation Hybrid Map246710.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 1
Medium 852 1588 499 181 1536 56 3056 708 323 200 1036 1186 139 1017 1702 3
Low 1552 1339 1074 296 411 263 1297 1425 3086 177 409 421 32 187 1084 1
Below cutoff 28 56 149 144 144 2 60 299 40 3 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001371525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005264280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011532807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047444085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054341643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC019069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC104135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF086198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF148512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF148513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI085541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI278414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW134604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY623118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM706373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM912287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB160837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D25412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ871602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC935073 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000290573   ⟹   ENSP00000290573
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,834,127 - 74,893,359 (+)Ensembl
RefSeq Acc Id: ENST00000409174   ⟹   ENSP00000387140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,835,170 - 74,893,359 (+)Ensembl
RefSeq Acc Id: ENST00000472302
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,854,333 - 74,867,907 (+)Ensembl
RefSeq Acc Id: NM_000189   ⟹   NP_000180
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,834,127 - 74,893,359 (+)NCBI
GRCh37275,059,782 - 75,120,481 (+)ENTREZGENE
Build 36274,913,290 - 74,973,989 (+)NCBI Archive
HuRef274,796,877 - 74,857,297 (+)ENTREZGENE
CHM1_1274,989,111 - 75,049,797 (+)NCBI
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001371525   ⟹   NP_001358454
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,835,170 - 74,893,359 (+)NCBI
T2T-CHM13v2.0274,844,026 - 74,902,233 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005264280   ⟹   XP_005264337
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,834,127 - 74,893,359 (+)NCBI
GRCh37275,059,782 - 75,120,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011532807   ⟹   XP_011531109
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,834,127 - 74,893,359 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003945   ⟹   XP_016859434
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,834,127 - 74,893,359 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047444084   ⟹   XP_047300040
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,835,170 - 74,893,359 (+)NCBI
RefSeq Acc Id: XM_047444085   ⟹   XP_047300041
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,845,653 - 74,893,359 (+)NCBI
RefSeq Acc Id: XM_054341640   ⟹   XP_054197615
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBI
RefSeq Acc Id: XM_054341641   ⟹   XP_054197616
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0274,844,026 - 74,902,233 (+)NCBI
RefSeq Acc Id: XM_054341642   ⟹   XP_054197617
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBI
RefSeq Acc Id: XM_054341643   ⟹   XP_054197618
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0274,842,983 - 74,902,233 (+)NCBI
Protein Sequences
Protein RefSeqs NP_000180 (Get FASTA)   NCBI Sequence Viewer  
  NP_001358454 (Get FASTA)   NCBI Sequence Viewer  
  XP_005264337 (Get FASTA)   NCBI Sequence Viewer  
  XP_011531109 (Get FASTA)   NCBI Sequence Viewer  
  XP_016859434 (Get FASTA)   NCBI Sequence Viewer  
  XP_047300040 (Get FASTA)   NCBI Sequence Viewer  
  XP_047300041 (Get FASTA)   NCBI Sequence Viewer  
  XP_054197615 (Get FASTA)   NCBI Sequence Viewer  
  XP_054197616 (Get FASTA)   NCBI Sequence Viewer  
  XP_054197617 (Get FASTA)   NCBI Sequence Viewer  
  XP_054197618 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD30174 (Get FASTA)   NCBI Sequence Viewer  
  AAH21116 (Get FASTA)   NCBI Sequence Viewer  
  AAH64369 (Get FASTA)   NCBI Sequence Viewer  
  AAT38114 (Get FASTA)   NCBI Sequence Viewer  
  AAX93084 (Get FASTA)   NCBI Sequence Viewer  
  AAY24209 (Get FASTA)   NCBI Sequence Viewer  
  ABI49509 (Get FASTA)   NCBI Sequence Viewer  
  BAA04999 (Get FASTA)   NCBI Sequence Viewer  
  BAF83046 (Get FASTA)   NCBI Sequence Viewer  
  CAA86476 (Get FASTA)   NCBI Sequence Viewer  
  CAA86482 (Get FASTA)   NCBI Sequence Viewer  
  CAH18060 (Get FASTA)   NCBI Sequence Viewer  
  CBF63160 (Get FASTA)   NCBI Sequence Viewer  
  CBU88036 (Get FASTA)   NCBI Sequence Viewer  
  EAW99601 (Get FASTA)   NCBI Sequence Viewer  
  EAW99602 (Get FASTA)   NCBI Sequence Viewer  
  EAW99603 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000290573
  ENSP00000290573.2
  ENSP00000387140
  ENSP00000387140.1
GenBank Protein P52789 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_000180   ⟸   NM_000189
- Peptide Label: isoform 1
- UniProtKB: Q8WU87 (UniProtKB/Swiss-Prot),   D6W5J2 (UniProtKB/Swiss-Prot),   Q9UN82 (UniProtKB/Swiss-Prot),   P52789 (UniProtKB/Swiss-Prot),   A8K2U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005264337   ⟸   XM_005264280
- Peptide Label: isoform X1
- UniProtKB: A8K2U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011531109   ⟸   XM_011532807
- Peptide Label: isoform X3
- UniProtKB: A8K2U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859434   ⟸   XM_017003945
- Peptide Label: isoform X4
- UniProtKB: A8K2U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001358454   ⟸   NM_001371525
- Peptide Label: isoform 2
- UniProtKB: E9PB90 (UniProtKB/TrEMBL),   Q68E10 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000387140   ⟸   ENST00000409174
RefSeq Acc Id: ENSP00000290573   ⟸   ENST00000290573
RefSeq Acc Id: XP_047300040   ⟸   XM_047444084
- Peptide Label: isoform X2
- UniProtKB: Q68E10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047300041   ⟸   XM_047444085
- Peptide Label: isoform X2
- UniProtKB: Q68E10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054197615   ⟸   XM_054341640
- Peptide Label: isoform X1
- UniProtKB: A8K2U2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054197617   ⟸   XM_054341642
- Peptide Label: isoform X3
- UniProtKB: A8K2U2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054197618   ⟸   XM_054341643
- Peptide Label: isoform X4
- UniProtKB: A8K2U2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054197616   ⟸   XM_054341641
- Peptide Label: isoform X2
- UniProtKB: Q68E10 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52789-F1-model_v2 AlphaFold P52789 1-917 view protein structure

Promoters
RGD ID:6860810
Promoter ID:EPDNEW_H3570
Type:initiation region
Name:HK2_1
Description:hexokinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,834,127 - 74,834,187EPDNEW
RGD ID:6797587
Promoter ID:HG_KWN:33369
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000252238
Position:
Human AssemblyChrPosition (strand)Source
Build 36274,913,666 - 74,914,882 (+)MPROMDB
RGD ID:6797288
Promoter ID:HG_KWN:33370
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000409174
Position:
Human AssemblyChrPosition (strand)Source
Build 36274,915,524 - 74,916,024 (+)MPROMDB
RGD ID:6797586
Promoter ID:HG_KWN:33371
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000328638
Position:
Human AssemblyChrPosition (strand)Source
Build 36274,934,616 - 74,935,367 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4923 AgrOrtholog
COSMIC HK2 COSMIC
Ensembl Genes ENSG00000159399 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000290573 ENTREZGENE
  ENST00000290573.7 UniProtKB/Swiss-Prot
  ENST00000409174 ENTREZGENE
  ENST00000409174.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.367.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000159399 GTEx
HGNC ID HGNC:4923 ENTREZGENE
Human Proteome Map HK2 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3099 UniProtKB/Swiss-Prot
NCBI Gene 3099 ENTREZGENE
OMIM 601125 OMIM
PANTHER HEXOKINASE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19443 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hexokinase_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexokinase_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29301 PharmGKB
PRINTS HEXOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEXOKINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEXOKINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K2U2 ENTREZGENE, UniProtKB/TrEMBL
  D6W5J2 ENTREZGENE
  E9PB90 ENTREZGENE, UniProtKB/TrEMBL
  HXK2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53QX9_HUMAN UniProtKB/TrEMBL
  Q53SG7_HUMAN UniProtKB/TrEMBL
  Q68E10 ENTREZGENE, UniProtKB/TrEMBL
  Q8WU87 ENTREZGENE
  Q9UN82 ENTREZGENE
UniProt Secondary D6W5J2 UniProtKB/Swiss-Prot
  Q8WU87 UniProtKB/Swiss-Prot
  Q9UN82 UniProtKB/Swiss-Prot