Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit) Homo sapiens
Analyze
Symbol: CHRNA1
Name: cholinergic receptor nicotinic alpha 1 subunit
Description: Exhibits acetylcholine-gated cation-selective channel activity. Predicted to contribute to acetylcholine binding activity; acetylcholine receptor activity; and extracellular ligand-gated ion channel activity. Involved in several processes, including muscle cell cellular homeostasis; neuronal action potential; and skeletal muscle tissue growth. Localizes to the cell surface; neuromuscular junction; and plasma membrane. Implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acetylcholine receptor subunit alpha; acetylcholine receptor, nicotinic, alpha 1 (muscle); ACHRA; ACHRD; cholinergic receptor, nicotinic alpha 1; cholinergic receptor, nicotinic, alpha 1 (muscle); cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle); CHRNA; CMS1A; CMS1B; CMS2A; FCCMS; muscle nicotinic acetylcholine receptor; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1; SCCMS
Orthologs:
Mus musculus (house mouse) : Chrna1 (cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle))  MGI  Alliance
Rattus norvegicus (Norway rat) : Chrna1 (cholinergic receptor nicotinic alpha 1 subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrna1 (cholinergic receptor nicotinic alpha 1 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100986268 (acetylcholine receptor subunit alpha)
Canis lupus familiaris (dog) : CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrna1 (cholinergic receptor nicotinic alpha 1 subunit)
Sus scrofa (pig) : CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit)
Chlorocebus sabaeus (green monkey) : CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit)
Heterocephalus glaber (naked mole-rat) : Chrna1 (cholinergic receptor nicotinic alpha 1 subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2174,747,592 - 174,787,935 (-)Ensembl
GRCh382174,747,592 - 174,764,472 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372175,612,320 - 175,629,200 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362175,320,566 - 175,337,427 (-)NCBINCBI36hg18NCBI36
Build 342175,438,113 - 175,454,677NCBI
Celera2169,225,856 - 169,242,726 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2167,492,831 - 167,509,717 (-)NCBIHuRef
CHM1_12175,618,423 - 175,635,290 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CHRNA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732599
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.