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Gene: AURKB (aurora kinase B) Homo sapiens
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Symbol: AURKB
Name: aurora kinase B
RGD ID: 731309
Description: Exhibits kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including mitotic spindle midzone assembly; positive regulation of DNA metabolic process; and positive regulation of cell cycle process. Localizes to several cellular components, including chromosome passenger complex; chromosome, centromeric region; and midbody. Biomarker of endometrial carcinoma and prostate carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB; aurkb-sv1; aurkb-sv2; aurora 1; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; IPL1; PPP1R48; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
Orthologs:
Mus musculus (house mouse) : Aurkb (aurora kinase B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Aurkb (aurora kinase B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aurkb (aurora kinase B)
Pan paniscus (bonobo/pygmy chimpanzee) : AURKB (aurora kinase B)
Canis lupus familiaris (dog) : AURKB (aurora kinase B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aurkb (aurora kinase B)
Sus scrofa (pig) : AURKB (aurora kinase B)
Chlorocebus sabaeus (African green monkey) : AURKB (aurora kinase B)
Heterocephalus glaber (naked mole-rat) : Aurkb (aurora kinase B)
more info ...
Related Pseudogenes: AURKBP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl178,204,733 - 8,210,600 (-)EnsemblGRCh38hg38GRCh38
GRCh38178,204,731 - 8,210,767 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37178,108,049 - 8,113,944 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,048,774 - 8,054,608 (-)NCBINCBI36hg18NCBI36
Build 34178,048,781 - 8,054,604NCBI
Celera178,136,501 - 8,142,334 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef178,003,833 - 8,009,723 (-)NCBIHuRef
CHM1_1178,117,184 - 8,123,078 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
 
More on AURKB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731309
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.