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Gene: CAMK2A (calcium/calmodulin dependent protein kinase II alpha) Homo sapiens
Symbol: CAMK2A
Name: calcium/calmodulin dependent protein kinase II alpha
Description: Exhibits calmodulin binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; peptidyl-threonine autophosphorylation; and positive regulation of NF-kappaB transcription factor activity. Localizes to the calcium- and calmodulin-dependent protein kinase complex and dendritic spine. Implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Biomarker of Alzheimer's disease and malignant glioma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; caM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; caMK-II subunit alpha; CAMKA; CaMKIIalpha; CaMKIINalpha; KIAA0968; MRD53; MRT63
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385150,219,491 - 150,290,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375149,599,054 - 149,669,403 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,579,248 - 149,649,529 (-)NCBINCBI36hg18NCBI36
Build 345149,579,247 - 149,649,529NCBI
Celera5145,680,447 - 145,750,799 (-)NCBI
Cytogenetic Map5q32NCBI
HuRef5144,747,170 - 144,817,356 (-)NCBIHuRef
CHM1_15149,031,647 - 149,101,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CAMK2A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736752
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.