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Gene: CAMK2A (calcium/calmodulin dependent protein kinase II alpha) Homo sapiens
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Symbol: CAMK2A
Name: calcium/calmodulin dependent protein kinase II alpha
Description: Exhibits calmodulin binding activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including generation of neurons; peptidyl-threonine autophosphorylation; and positive regulation of NF-kappaB transcription factor activity. Localizes to the calcium- and calmodulin-dependent protein kinase complex and dendritic spine. Implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Biomarker of Alzheimer's disease and malignant glioma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II alpha subunit; caM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; caMK-II subunit alpha; CAMKA; CaMKIIalpha; CaMKIINalpha; KIAA0968; MRD53; MRT63
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385150,219,491 - 150,290,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375149,599,054 - 149,669,403 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,579,248 - 149,649,529 (-)NCBINCBI36hg18NCBI36
Build 345149,579,247 - 149,649,529NCBI
Celera5145,680,447 - 145,750,799 (-)NCBI
Cytogenetic Map5q32NCBI
HuRef5144,747,170 - 144,817,356 (-)NCBIHuRef
CHM1_15149,031,647 - 149,101,993 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CAMK2A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736752
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.