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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:leukotriene
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Accession:CHEBI:25029 term browser browse the term
Definition:Any icosanoid from that family of C20 polyunsaturated fatty acids and their derivatives generated by leukocytes from arachidonic acid, each member having four double bonds of which three are conjugated.
Synonyms:related_synonym: Leukotrien;   leucotriene;   leucotrienes;   leukotrienes
 xref: LIPID_MAPS_class:LMFA0302;   PMID:10922142;   PMID:15794321;   PMID:3001504;   PMID:6129158;   PMID:6293196;   PMID:6311078;   PMID:8842590;   PMID:9526099;   PMID:9561094
 cyclic_relationship: is_conjugate_acid_of CHEBI:62942


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leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase increases chemical synthesis EXP ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G LTA4H leukotriene A4 hydrolase multiple interactions
increases hydrolysis		 EXP cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
leukotriene B4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle increases expression EXP
ISO		 Leukotriene B4 results in increased expression of ACTA2 protein
Leukotriene B4 results in increased expression of ACTA2 mRNA		 CTD PMID:27697457 PMID:30818366 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO AHR mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased chemical synthesis of Leukotriene B4] CTD PMID:28487374 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Leukotriene B4 inhibits the reaction [isoliquiritigenin results in decreased activity of AKT1 protein] CTD PMID:23747687 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase increases secretion
increases chemical synthesis
multiple interactions		 EXP
ISO		 ALOX5 protein results in increased secretion of Leukotriene B4
ALOX5 protein results in increased chemical synthesis of Leukotriene B4
[benoxaprofen results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [RS 43179 results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Tamoxifen results in increased expression of ALOX5 protein] which results in increased abundance of Leukotriene B4; [tenidap results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]; ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; kaempferol inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Luteolin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; quercetin 3'-sulfate inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Quercetin inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]; Resveratrol inhibits the reaction [[Hydrogen Peroxide results in increased activity of ALOX5 protein] which results in increased chemical synthesis of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]
[[A 78773 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[CMI 392 co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene B4; [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [tepoxalin results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [troglitazone results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; ALOX5 protein promotes the reaction [CXCL8 protein results in increased abundance of Leukotriene B4]; tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4]		 CTD PMID:1781415 PMID:2849922 PMID:8058773 PMID:9223651 PMID:9445378 More... NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]; L 655238 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; MK-886 inhibits the reaction [ALOX5AP protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]] CTD PMID:9609743 NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 EXP Leukotriene B4 results in decreased expression of BAX mRNA; Leukotriene B4 results in decreased expression of BAX protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]		 CTD PMID:15970427 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G C5 complement C5 multiple interactions
increases abundance		 EXP MK 0591 inhibits the reaction [C5 protein results in increased abundance of Leukotriene B4] CTD PMID:10477617 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195 		JBrowse link
G CCL13 C-C motif chemokine ligand 13 multiple interactions
increases abundance		 ISO zileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4] CTD PMID:12388339 NCBI chr17:34,356,480...34,358,610
Ensembl chr17:34,356,480...34,358,610 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases abundance
increases expression		 ISO zileuton inhibits the reaction [CCL2 protein results in increased abundance of Leukotriene B4]
Leukotriene B4 results in increased expression of CCL2 protein		 CTD PMID:12388339 PMID:19880577 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO [Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4; Dexamethasone inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4] CTD PMID:18083043 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G COL1A1 collagen type I alpha 1 chain increases expression ISO Leukotriene B4 results in increased expression of COL1A1 mRNA CTD PMID:30818366 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G CSF2 colony stimulating factor 2 increases secretion EXP Leukotriene B4 results in increased secretion of CSF2 protein CTD PMID:15136573 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases abundance
multiple interactions		 ISO CXCL1 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [CXCL1 protein results in increased abundance of Leukotriene B4]		 CTD PMID:12388339 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression		 EXP Leukotriene B4 inhibits the reaction [zileuton inhibits the reaction [Histamine results in increased expression of CXCL8 protein]]
Leukotriene B4 results in increased expression of CXCL8 mRNA; Leukotriene B4 results in increased expression of CXCL8 protein		 CTD PMID:9609743 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 multiple interactions ISO [LY 171883 binds to and results in decreased activity of CYSLTR1 protein] which results in decreased abundance of Leukotriene B4 CTD PMID:8014878 NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691 		JBrowse link
G FGF2 fibroblast growth factor 2 increases expression ISO Leukotriene B4 results in increased expression of FGF2 mRNA CTD PMID:30818366 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Leukotriene B4 inhibits the reaction [Zymosan results in increased expression of HMOX1 protein] CTD PMID:11454666 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases expression
decreases activity		 EXP [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone results in increased activity of HSD11B2 protein]; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]
Leukotriene B4 results in decreased expression of HSD11B2 mRNA
Leukotriene B4 results in decreased activity of HSD11B2 protein		 CTD PMID:10377029 PMID:18032417 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G IFNG interferon gamma multiple interactions ISO [Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4; Mangifera indica extract inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4]; mangiferin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Leukotriene B4] CTD PMID:15177302 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Leukotriene B4 promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein] CTD PMID:16313356 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO Leukotriene B4 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein] CTD PMID:16313356 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL13 interleukin 13 increases abundance
multiple interactions		 ISO IL13 protein results in increased abundance of Leukotriene B4
zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]		 CTD PMID:12654629 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases abundance		 EXP resveratrol inhibits the reaction [IL1B protein results in increased abundance of Leukotriene B4] CTD PMID:18759268 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL4 interleukin 4 multiple interactions EXP IL4 protein inhibits the reaction [Calcimycin results in increased metabolism of Leukotriene B4]; IL4 protein inhibits the reaction [Zymosan affects the metabolism of Leukotriene B4] CTD PMID:11861792 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G ITGAM integrin subunit alpha M multiple interactions
increases expression 		EXP Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]; LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]
LTB4 increases expression of ITGAM protein on neutrophils and monocytes		 CTD
RGD		 PMID:7473568 PMID:18064325 RGD:329901666 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGB2 integrin subunit beta 2 increases expression
multiple interactions		 ISO
EXP		 Leukotriene B4 results in increased expression of ITGB2 protein
Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]; LY 255283 analog inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 255283 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]; LY 293111 inhibits the reaction [Leukotriene B4 results in increased expression of [ITGAM protein binds to ITGB2 protein]]		 CTD PMID:7473568 PMID:14716214 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G LTA4H leukotriene A4 hydrolase multiple interactions
increases chemical synthesis		 EXP 1-(4-(benzothiazol-2-yloxy)benzyl)piperidine-4-carboxylic acid inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; cyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; Oxygen inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; propanethiol inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4] CTD PMID:2827578 PMID:17371808 NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520 		JBrowse link
G LTB4R leukotriene B4 receptor multiple interactions
affects response to substance
affects binding		 ISO
EXP		 [SC 41930 binds to and results in decreased activity of LTB4R protein] which results in decreased abundance of Leukotriene B4; Leukotriene B4 binds to and affects the activity of LTB4R1 protein
Leukotriene B4 binds to and results in increased activity of LTB4R protein; LY 255283 analog inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 255283 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]; LY 293111 inhibits the reaction [Leukotriene B4 binds to and results in increased activity of LTB4R protein]
LTB4R1 protein affects the susceptibility to Leukotriene B4
Leukotriene B4 analog binds to LTB4R1 protein		 CTD PMID:7473568 PMID:8014878 PMID:10934232 PMID:11006272 NCBI chr14:24,311,502...24,318,036
Ensembl chr14:24,311,450...24,318,036 		JBrowse link
G LTB4R2 leukotriene B4 receptor 2 affects binding EXP Leukotriene B4 binds to LTB4R2 protein CTD PMID:11006272 NCBI chr14:24,310,140...24,312,038
Ensembl chr14:24,305,734...24,312,053 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Leukotriene B4 results in increased phosphorylation of MAPK1 protein CTD PMID:19837106 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Leukotriene B4 results in increased phosphorylation of MAPK3 protein CTD PMID:19837106 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member increases expression
multiple interactions		 EXP Leukotriene B4 results in increased expression of MCL1 mRNA; Leukotriene B4 results in increased expression of MCL1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]		 CTD PMID:15970427 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene B4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene B4 results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression ISO Leukotriene B4 results in increased expression of MUC5AC protein CTD PMID:12654629 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Leukotriene B4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites] CTD PMID:11454666 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PLA2G4A phospholipase A2 group IVA multiple interactions EXP PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4]; PLA2G4A protein promotes the reaction [Zymosan analog results in increased metabolism of Leukotriene B4] CTD PMID:11741884 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions
affects binding		 EXP
ISO		 Leukotriene B4 binds to and results in increased activity of PPARA protein
Leukotriene B4 binds to PPARA protein		 CTD PMID:10403814 PMID:12009843 PMID:15491415 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G SELL selectin L increases expression ISO Leukotriene B4 results in increased expression of SELL protein CTD PMID:14716214 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression ISO Leukotriene B4 results in increased expression of TGFB1 mRNA CTD PMID:30818366 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
leukotriene B5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTB4R2 leukotriene B4 receptor 2 affects binding EXP leukotriene B5 binds to LTB4R2 protein CTD PMID:11006272 NCBI chr14:24,310,140...24,312,038
Ensembl chr14:24,305,734...24,312,053 		JBrowse link
leukotriene C4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA8 ATP binding cassette subfamily A member 8 affects transport EXP ABCA8 protein affects the transport of Leukotriene C4 CTD PMID:12379217 NCBI chr17:68,867,289...68,955,392
Ensembl chr17:68,867,289...68,955,392 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) affects transport
multiple interactions
increases uptake
decreases transport
affects binding		 EXP ABCC1 protein affects the transport of Leukotriene C4
[Nimustine results in increased expression of ABCC1 protein] which results in increased transport of Leukotriene C4; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Bilirubin inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; kaempferol inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; myricetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Quercetin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]
ABCC1 protein mutant form results in decreased transport of Leukotriene C4		 CTD PMID:9393752 PMID:11278867 PMID:11306701 PMID:15245331 PMID:15355964 More... NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases transport
multiple interactions
affects transport		 ISO
EXP		 ABCC2 protein modified form results in increased transport of Leukotriene C4
verlukast inhibits the reaction [ABCC2 protein results in increased transport of Leukotriene C4]
ABCC2 protein affects the transport of Leukotriene C4		 CTD PMID:9430713 PMID:11500505 PMID:12388192 PMID:12395335 PMID:15507541 More... NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions EXP verlukast inhibits the reaction [ABCC3 protein results in increased transport of Leukotriene C4] CTD PMID:27676153 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 affects transport EXP ABCC6 protein affects the transport of Leukotriene C4 CTD PMID:11880368 NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions EXP
ISO		 [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4
[Calcimycin results in increased activity of and results in increased localization of ALOX5 protein] which results in increased abundance of Leukotriene C4
ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]		 CTD PMID:9445378 PMID:9495842 PMID:10764316 PMID:12794006 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP [2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4; [MK-886 results in decreased activity of ALOX5AP protein] which results in decreased abundance of Leukotriene C4 CTD PMID:9113110 NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426 		JBrowse link
G AMBP alpha-1-microglobulin/bikunin precursor decreases secretion ISO AMBP protein results in decreased secretion of Leukotriene C4 CTD PMID:9579392 NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328 		JBrowse link
G CCL13 C-C motif chemokine ligand 13 increases expression ISO Leukotriene C4 results in increased expression of CCL12 mRNA CTD PMID:12388339 NCBI chr17:34,356,480...34,358,610
Ensembl chr17:34,356,480...34,358,610 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Leukotriene C4 results in increased expression of CCL2 mRNA CTD PMID:12388339 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CLEC7A C-type lectin domain containing 7A multiple interactions EXP CLEC7A protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4]; CLEC7A protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4] CTD PMID:17030235 NCBI chr12:10,116,777...10,130,304
Ensembl chr12:10,116,777...10,130,258 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression ISO Leukotriene C4 results in increased expression of CXCL1 mRNA CTD PMID:12388339 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 multiple interactions
affects binding		 EXP
ISO		 [Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; CGP 57698 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]; Leukotriene C4 binds to and results in increased activity of CYSLTR1 protein; MEN91507 inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]; pobilukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]; pranlukast inhibits the reaction [Leukotriene C4 binds to CYSLTR1 protein]
CYSLTR1 protein binds to and affects the susceptibility to Leukotriene C4; Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]		 CTD PMID:8384568 PMID:10391245 PMID:10462554 PMID:10825389 PMID:11705452 More... NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 multiple interactions
increases activity		 EXP [Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene C4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene C4 binds to and results in increased activity of CYSLTR2 protein CTD PMID:10851239 PMID:11093801 NCBI chr13:48,653,929...48,711,226
Ensembl chr13:48,653,711...48,711,226 		JBrowse link
G EDN1 endothelin 1 increases expression
multiple interactions		 EXP Leukotriene C4 results in increased expression of EDN1 mRNA; Leukotriene C4 results in increased expression of EDN1 protein
zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 mRNA]; zafirlukast inhibits the reaction [Leukotriene C4 results in increased expression of EDN1 protein]		 CTD PMID:11372388 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGFR epidermal growth factor receptor increases expression ISO Leukotriene C4 results in increased expression of EGFR mRNA CTD PMID:12388339 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G GGT5 gamma-glutamyltransferase 5 multiple interactions EXP [Beclomethasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4; [Fluticasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4 CTD PMID:11447392 NCBI chr22:24,219,654...24,245,142
Ensembl chr22:24,219,654...24,245,108 		JBrowse link
G GPR17 G protein-coupled receptor 17 increases activity ISO Leukotriene C4 results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr 2:127,646,153...127,652,639
Ensembl chr 2:127,645,864...127,652,639 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO Leukotriene C4 inhibits the reaction [Zymosan results in increased expression of HMOX1 protein] CTD PMID:11454666 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IL13 interleukin 13 increases expression
multiple interactions
increases abundance		 ISO Leukotriene C4 results in increased expression of IL13 mRNA
[IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein		 CTD PMID:12388339 PMID:12654629 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL5 interleukin 5 increases secretion EXP IL5 protein results in increased secretion of Leukotriene C4 CTD PMID:9378992 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G LTC4S leukotriene C4 synthase affects chemical synthesis EXP LTC4S protein affects the chemical synthesis of Leukotriene C4 CTD PMID:10666225 NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Leukotriene C4 results in increased phosphorylation of MAPK1 protein CTD PMID:19837106 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Leukotriene C4 results in increased phosphorylation of MAPK3 protein CTD PMID:19837106 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 multiple interactions ISO Leukotriene C4 binds to and results in decreased activity of MGST1 protein; Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein] CTD PMID:9890956 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene C4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene C4 results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression
multiple interactions		 ISO Leukotriene C4 results in increased expression of MUC5AC mRNA; Leukotriene C4 results in increased expression of MUC5AC protein
[IL13 protein results in increased abundance of Leukotriene C4] which results in increased secretion of MUC5AC protein		 CTD PMID:12654629 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Leukotriene C4 inhibits the reaction [[Zymosan results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitrites] CTD PMID:11454666 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PLA2G5 phospholipase A2 group V multiple interactions EXP
ISO		 PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]
PLA2G5 protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4]		 CTD PMID:9495842 PMID:14761945 NCBI chr 1:20,028,408...20,091,911
Ensembl chr 1:20,028,179...20,091,911 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene C4] CTD PMID:25432964 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G RALBP1 ralA binding protein 1 multiple interactions
affects transport		 EXP Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4]; Colchicine inhibits the reaction [RALBP1 protein affects the transport of Leukotriene C4] CTD PMID:15386349 NCBI chr18:9,475,009...9,538,114
Ensembl chr18:9,475,009...9,538,114 		JBrowse link
G SELP selectin P increases expression EXP Leukotriene C4 results in increased expression of SELP protein CTD PMID:9152370 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SYK spleen associated tyrosine kinase multiple interactions EXP SYK protein promotes the reaction [Peptidoglycan results in increased metabolism of Leukotriene C4]; SYK protein promotes the reaction [Zymosan results in increased metabolism of Leukotriene C4] CTD PMID:17030235 NCBI chr 9:90,801,600...90,898,549
Ensembl chr 9:90,801,787...90,898,549 		JBrowse link
leukotriene D4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase increases abundance
multiple interactions		 EXP
ISO		 ALOX5 protein results in increased abundance of Leukotriene D4
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4
ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]		 CTD PMID:10764316 PMID:12629151 PMID:12794006 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G ARRB1 arrestin beta 1 multiple interactions EXP Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB1 protein] CTD PMID:33288675 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRB2 arrestin beta 2 multiple interactions EXP Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB2 protein] CTD PMID:33288675 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP Leukotriene D4 promotes the reaction [CSF2 protein results in increased expression of TGFB1 protein] CTD PMID:15947480 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein] CTD PMID:18704935 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 multiple interactions
affects binding
increases activity
increases response to substance		 EXP
ISO		 [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein; [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; BAY u9773 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; BAY u9773 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; CGP 57698 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]; iralukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein; LY 171883 inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; MEN91507 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; montelukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; montelukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; pobilukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; pobilukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; pobilukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; pranlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; pranlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]; pranlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; verlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; verlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of CXCL8 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]; zafirlukast inhibits the reaction [CYSLTR1 protein promotes the reaction [Leukotriene D4 results in increased abundance of Calcium]]; zafirlukast inhibits the reaction [CYSLTR1 protein results in increased susceptibility to Leukotriene D4]; zafirlukast inhibits the reaction [Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
[Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; CYSLTR1 protein binds to and affects the susceptibility to Leukotriene D4; Leukotriene C4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; Leukotriene D4 binds to and results in increased activity of CYSLTR1 protein; Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]		 CTD PMID:8014876 PMID:8384568 PMID:9620942 PMID:9647482 PMID:10391245 More... NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 multiple interactions EXP [Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased chemical synthesis of inositol 1-phosphate; [Leukotriene D4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; BAY u9773 inhibits the reaction [[Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium]; Leukotriene D4 binds to and results in increased activity of CYSLTR2 protein; Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB1 protein]; Leukotriene D4 promotes the reaction [CYSLTR2 protein binds to ARRB2 protein]; montelukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]; pranlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]; verlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein]; zafirlukast inhibits the reaction [Leukotriene D4 binds to CYSLTR2 protein] CTD PMID:10851239 PMID:11093801 PMID:33288675 NCBI chr13:48,653,929...48,711,226
Ensembl chr13:48,653,711...48,711,226 		JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Leukotriene D4 results in decreased expression of FAS protein CTD PMID:15990778 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G GPR17 G protein-coupled receptor 17 increases activity
multiple interactions		 ISO Leukotriene D4 results in increased activity of GPR17 protein
montelukast inhibits the reaction [Leukotriene D4 results in increased activity of GPR17 protein]		 CTD PMID:18974869 NCBI chr 2:127,646,153...127,652,639
Ensembl chr 2:127,645,864...127,652,639 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP Leukotriene D4 promotes the reaction [ICAM1 protein results in increased expression of TGFB1 protein] CTD PMID:15947480 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL12A interleukin 12A multiple interactions EXP BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]] CTD PMID:19118273 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL13 interleukin 13 increases abundance
multiple interactions		 ISO IL13 protein results in increased abundance of Leukotriene D4
[IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein		 CTD PMID:12654629 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL5 interleukin 5 multiple interactions EXP Leukotriene D4 promotes the reaction [IL5 protein results in increased expression of TGFB1 protein] CTD PMID:15947480 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion		 EXP [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein; BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of IL6 protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein] CTD PMID:18704935 PMID:19118273 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation ISO Leukotriene D4 results in increased phosphorylation of MAPK1 protein CTD PMID:19837106 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation ISO Leukotriene D4 results in increased phosphorylation of MAPK3 protein CTD PMID:19837106 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene D4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Leukotriene D4 results in increased expression of MMP9 protein]; SB 203580 inhibits the reaction [Leukotriene D4 results in increased expression of MMP9 protein] CTD PMID:19837106 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming multiple interactions
increases expression		 ISO [IL13 protein results in increased abundance of Leukotriene D4] which results in increased secretion of MUC5AC protein; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC mRNA]; verlukast inhibits the reaction [Leukotriene D4 results in increased expression of MUC5AC protein]
Leukotriene D4 results in increased expression of MUC5AC mRNA; Leukotriene D4 results in increased expression of MUC5AC protein		 CTD PMID:12654629 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G PDGFRB platelet derived growth factor receptor beta multiple interactions EXP 6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]; bisindolylmaleimide I inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]; Leukotriene D4 promotes the reaction [SRC protein binds to PDGFRB protein]; Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein; lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]; pobilukast inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein] CTD PMID:12223454 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene D4] CTD PMID:25432964 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G SELP selectin P increases expression EXP Leukotriene D4 results in increased expression of SELP protein CTD PMID:9152370 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Leukotriene D4 promotes the reaction [SRC protein binds to PDGFRB protein]; Leukotriene D4 results in increased phosphorylation of and results in increased activity of SRC protein; pobilukast inhibits the reaction [Leukotriene D4 results in increased activity of SRC protein] CTD PMID:12223454 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP Leukotriene D4 promotes the reaction [CSF2 protein results in increased expression of TGFB1 protein]; Leukotriene D4 promotes the reaction [ICAM1 protein results in increased expression of TGFB1 protein]; Leukotriene D4 promotes the reaction [IL5 protein results in increased expression of TGFB1 protein] CTD PMID:15947480 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion		 EXP [Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein; BAY u9773 inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]; montelukast inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]; zafirlukast inhibits the reaction [[Leukotriene D4 results in increased activity of CYSLTR1 protein] which results in increased expression of TNF protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein] CTD PMID:18704935 PMID:19118273 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
leukotriene E4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase multiple interactions ISO
EXP		 ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4		 CTD PMID:8621850 PMID:10764316 PMID:12794006 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 affects binding
multiple interactions		 EXP
ISO		 Leukotriene E4 binds to CYSLTR1 protein
[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]		 CTD PMID:8384568 PMID:9620942 PMID:10462554 PMID:11705452 PMID:12853847 NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 multiple interactions
increases activity		 EXP [Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein CTD PMID:10851239 PMID:11093801 NCBI chr13:48,653,929...48,711,226
Ensembl chr13:48,653,711...48,711,226 		JBrowse link
G GPR17 G protein-coupled receptor 17 increases activity ISO Leukotriene E4 results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr 2:127,646,153...127,652,639
Ensembl chr 2:127,645,864...127,652,639 		JBrowse link
G IL13 interleukin 13 increases abundance ISO IL13 protein results in increased abundance of Leukotriene E4 CTD PMID:12654629 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene E4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr12:16,347,115...16,593,331
Ensembl chr12:16,347,142...16,609,259 		JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression ISO Leukotriene E4 results in increased expression of MUC5AC protein CTD PMID:12654629 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4] CTD PMID:25432964 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26504
    chemical entity 26484
      atom 26480
        nonmetal atom 25743
          carbon atom 25625
            organic molecular entity 25625
              lipid 21397
                fatty acid derivative 9355
                  icosanoid 478
                    leukotriene 68
                      (12R)-hydroxy-10,11-dihydroleukotriene E4 0
                      (5S,6S)-dihydroxy-(7E,9E,11Z,14Z)-icosatetraenoic acid 0
                      10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                      10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                      10,11-dihydroleukotriene B4 0
                      11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                      11,12-dihydro-12-oxoleukotriene C4 0
                      11-trans-LTD4 0
                      11-trans-LTE4 0
                      12-Oxo-20-trihydroxy-leukotriene B4 0
                      12-dehydro-leukotriene B4 0
                      12-epi-leukotriene B4 0
                      12-oxo-20-dihydroxy-leukotriene B4 0
                      12-oxo-20-hydroxyleukotriene B4 0
                      12-oxo-6-trans-leukotriene B4 0
                      14,15-dehydro-LTB4 0
                      18-hydroxyleukotriene B4 0
                      19-hydroxyleukotriene B4 0
                      20,20,20-trihydroxyleukotriene B4 0
                      20,20-dihydroxyleukotriene B4 0
                      20-carboxyleukotriene E4 0
                      20-hydroxy-20-oxoleukotriene B4 + 0
                      20-hydroxy-20-oxoleukotriene B4-20-(beta-D-glucuronide) 0
                      20-hydroxy-6-trans-leukotriene B4 0
                      20-oxoleukotriene B4 0
                      20-oxoleukotriene E4 0
                      20-trifluoro-LTB4 0
                      4,5-leukotriene A4 0
                      5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid 0
                      5,6-Epoxy-18R-HEPE 0
                      5-Oxo-6-trans-leukotriene B4 0
                      5S,12S-DiHETE 0
                      6-trans-leukotriene B4 + 0
                      DG(10:0/LTE4/0:0) 0
                      DG(20:0/LTE4/0:0) 0
                      Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                      Delta(6)-trans-12-epi-leukotriene B4 0
                      MG(LTE4/0:0/0:0) 0
                      N-acetylleukotriene E4 0
                      PE(24:0/LTE4) 0
                      PE(24:1(15Z)/LTE4) 0
                      PE(P-16:0/LTE4) 0
                      PG(LTE4/a-21:0) 0
                      PG(a-25:0/LTE4) 0
                      PI(16:0/LTE4) 0
                      PI(16:2(9Z,12Z)/LTE4) 0
                      PS(20:2(11Z,14Z)/LTE4) 0
                      PS(LTE4/22:5(4Z,7Z,10Z,13Z,16Z)) 0
                      eoxin A4 0
                      eoxin C4 0
                      eoxin D4 0
                      eoxin E4 0
                      leukotriene A4 + 3
                      leukotriene B4 + 40
                      leukotriene B5 1
                      leukotriene C3 0
                      leukotriene C4 + 33
                      leukotriene C4 methyl ester 0
                      leukotriene D3 0
                      leukotriene D4 26
                      leukotriene E3 + 0
                      leukotriene E4 + 8
                      leukotriene E4 methyl ester 0
                      leukotriene F4 0
                      omega-Carboxy-N-acetyl-LTE4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26504
    subatomic particle 26480
      composite particle 26480
        hadron 26480
          baryon 26480
            nucleon 26480
              atomic nucleus 26480
                atom 26480
                  main group element atom 26218
                    p-block element atom 26218
                      carbon group element atom 25663
                        carbon atom 25625
                          organic molecular entity 25625
                            heteroorganic entity 25011
                              organochalcogen compound 24601
                                organooxygen compound 24196
                                  carbon oxoacid 22812
                                    carboxylic acid 22793
                                      monocarboxylic acid 21791
                                        fatty acid 19174
                                          fatty acid derivative 9355
                                            icosanoid 478
                                              leukotriene 68
                                                (12R)-hydroxy-10,11-dihydroleukotriene E4 0
                                                (5S,6S)-dihydroxy-(7E,9E,11Z,14Z)-icosatetraenoic acid 0
                                                10,11-dihydro-20,20,20-trihydroxyleukotriene B4 0
                                                10,11-dihydro-20,20-dihydroxyleukotriene B4 0
                                                10,11-dihydroleukotriene B4 0
                                                11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                                                11,12-dihydro-12-oxoleukotriene C4 0
                                                11-trans-LTD4 0
                                                11-trans-LTE4 0
                                                12-Oxo-20-trihydroxy-leukotriene B4 0
                                                12-dehydro-leukotriene B4 0
                                                12-epi-leukotriene B4 0
                                                12-oxo-20-dihydroxy-leukotriene B4 0
                                                12-oxo-20-hydroxyleukotriene B4 0
                                                12-oxo-6-trans-leukotriene B4 0
                                                14,15-dehydro-LTB4 0
                                                18-hydroxyleukotriene B4 0
                                                19-hydroxyleukotriene B4 0
                                                20,20,20-trihydroxyleukotriene B4 0
                                                20,20-dihydroxyleukotriene B4 0
                                                20-carboxyleukotriene E4 0
                                                20-hydroxy-20-oxoleukotriene B4 + 0
                                                20-hydroxy-20-oxoleukotriene B4-20-(beta-D-glucuronide) 0
                                                20-hydroxy-6-trans-leukotriene B4 0
                                                20-oxoleukotriene B4 0
                                                20-oxoleukotriene E4 0
                                                20-trifluoro-LTB4 0
                                                4,5-leukotriene A4 0
                                                5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid 0
                                                5,6-Epoxy-18R-HEPE 0
                                                5-Oxo-6-trans-leukotriene B4 0
                                                5S,12S-DiHETE 0
                                                6-trans-leukotriene B4 + 0
                                                DG(10:0/LTE4/0:0) 0
                                                DG(20:0/LTE4/0:0) 0
                                                Delta(6)-trans,Delta(8)-cis-leukotriene B4 0
                                                Delta(6)-trans-12-epi-leukotriene B4 0
                                                MG(LTE4/0:0/0:0) 0
                                                N-acetylleukotriene E4 0
                                                PE(24:0/LTE4) 0
                                                PE(24:1(15Z)/LTE4) 0
                                                PE(P-16:0/LTE4) 0
                                                PG(LTE4/a-21:0) 0
                                                PG(a-25:0/LTE4) 0
                                                PI(16:0/LTE4) 0
                                                PI(16:2(9Z,12Z)/LTE4) 0
                                                PS(20:2(11Z,14Z)/LTE4) 0
                                                PS(LTE4/22:5(4Z,7Z,10Z,13Z,16Z)) 0
                                                eoxin A4 0
                                                eoxin C4 0
                                                eoxin D4 0
                                                eoxin E4 0
                                                leukotriene A4 + 3
                                                leukotriene B4 + 40
                                                leukotriene B5 1
                                                leukotriene C3 0
                                                leukotriene C4 + 33
                                                leukotriene C4 methyl ester 0
                                                leukotriene D3 0
                                                leukotriene D4 26
                                                leukotriene E3 + 0
                                                leukotriene E4 + 8
                                                leukotriene E4 methyl ester 0
                                                leukotriene F4 0
                                                omega-Carboxy-N-acetyl-LTE4 0
paths to the root