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Gene: ARRB1 (arrestin beta 1) Homo sapiens
Symbol: ARRB1
Name: arrestin beta 1
RGD ID: 732370
Description: Exhibits several functions, including GTPase activator activity; arrestin family protein binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Localizes to chromatin; cytoplasmic vesicle; and nuclear body. Biomarker of major depressive disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ARB1; ARR1; arrestin 2; arrestin beta-1; arrestin, beta 1; beta-arrestin; beta-arrestin-1; non-visual arrestin-2
Mus musculus (house mouse) : Arrb1 (arrestin, beta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arrb1 (arrestin, beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arrb1 (arrestin beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ARRB1 (arrestin beta 1)
Canis lupus familiaris (dog) : ARRB1 (arrestin beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arrb1 (arrestin beta 1)
Sus scrofa (pig) : ARRB1 (arrestin beta 1)
Chlorocebus sabaeus (African green monkey) : ARRB1 (arrestin beta 1)
Heterocephalus glaber (naked mole-rat) : Arrb1 (arrestin beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1175,260,122 - 75,351,705 (-)EnsemblGRCh38hg38GRCh38
GRCh381175,260,122 - 75,351,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371174,971,166 - 75,062,875 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,654,130 - 74,740,521 (-)NCBINCBI36hg18NCBI36
Build 341174,654,129 - 74,740,521NCBI
Celera1172,283,036 - 72,369,427 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1171,268,798 - 71,360,118 (-)NCBIHuRef
CHM1_11174,854,770 - 74,946,464 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ARRB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732370
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.