ARRB1 (arrestin beta 1) - Rat Genome Database

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Gene: ARRB1 (arrestin beta 1) Homo sapiens
Analyze
Symbol: ARRB1
Name: arrestin beta 1
RGD ID: 732370
HGNC Page HGNC:711
Description: Enables several functions, including GTPase activator activity; arrestin family protein binding activity; and signaling receptor binding activity. Involved in several processes, including regulation of gene expression; regulation of protein modification process; and regulation of signal transduction. Located in chromatin; cytoplasmic vesicle; and nuclear body. Biomarker of major depressive disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ARB1; ARR1; arrestin 2; arrestin beta-1; arrestin, beta 1; beta-arrestin; beta-arrestin-1; non-visual arrestin-2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,260,122 - 75,351,661 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1175,260,122 - 75,351,705 (-)EnsemblGRCh38hg38GRCh38
GRCh371174,971,166 - 75,062,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,654,130 - 74,740,521 (-)NCBINCBI36Build 36hg18NCBI36
Build 341174,654,129 - 74,740,521NCBI
Celera1172,283,036 - 72,369,427 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,268,798 - 71,360,118 (-)NCBIHuRef
CHM1_11174,854,770 - 74,946,464 (-)NCBICHM1_1
T2T-CHM13v2.01175,189,729 - 75,281,255 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-arachidonoylglycerol  (EXP)
2-butoxyethanol  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
AH23848  (EXP)
alprenolol  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bortezomib  (EXP)
butanal  (EXP)
caffeine  (EXP)
carbon nanotube  (EXP,ISO)
carvedilol  (EXP,ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (EXP)
diazinon  (ISO)
dioxygen  (ISO)
dobutamine  (EXP)
dopamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
entinostat  (EXP)
ethanol  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (EXP)
isoprenaline  (EXP)
leukotriene D4  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (EXP)
mesalamine  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
metoprolol  (EXP)
N-nitrosodiethylamine  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
O-methyleugenol  (EXP)
ouabain  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
pentanal  (EXP)
phenethyl caffeate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (EXP)
propiconazole  (ISO)
protein kinase inhibitor  (EXP)
quercetin  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
tamoxifen  (ISO)
thioacetamide  (ISO)
trichostatin A  (EXP)
Triptolide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (EXP)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
endocytosis  (ISO)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor internalization  (IBA,IMP)
G protein-coupled receptor signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of catalytic activity  (IEA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of interleukin-6 production  (IDA)
negative regulation of interleukin-8 production  (IDA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (IDA)
negative regulation of Notch signaling pathway  (IBA,IMP)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (IDA)
negative regulation of signal transduction  (IEA)
phototransduction  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA,IDA,ISO)
positive regulation of histone acetylation  (IMP)
positive regulation of histone H4 acetylation  (IMP)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of receptor internalization  (IMP)
positive regulation of Rho protein signal transduction  (IMP)
positive regulation of smooth muscle cell apoptotic process  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IMP)
protein transport  (IEA)
protein transport  (IEA)
protein ubiquitination  (IMP)
regulation of apoptotic process  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (IMP)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
signal transduction  (IEA)
signal transduction  (IEA)
stress fiber assembly  (IMP)
ubiquitin-dependent protein catabolic process  (IMP)
visual perception  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Beta-arrestin-1 levels: reduced in leukocytes of patients with depression and elevated by antidepressants in rat brain. Avissar S, etal., Am J Psychiatry. 2004 Nov;161(11):2066-72.
2. Beta-arrestins: multifunctional cellular mediators. Barki-Harrington L and Rockman HA, Physiology (Bethesda). 2008 Feb;23:17-22.
3. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
4. Gender related alterations of beta-adrenoceptor mechanisms in heart failure due to arteriovenous fistula. Dent MR, etal., J Cell Physiol. 2011 Oct 20. doi: 10.1002/jcp.23058.
5. GRK mythology: G-protein receptor kinases in cardiovascular disease. Dorn GW 2nd J Mol Med (Berl). 2009 May;87(5):455-63. Epub 2009 Feb 20.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets. Hauger RL, etal., CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79.
8. [Pathogenetic mechanism of beta-arrestin1 in experimental colitis of rats and intervention effects of oxymatrine]. Liao Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Oct;30(10):1067-72.
9. Adrenal beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. Lymperopoulos A, etal., J Am Coll Cardiol. 2011 Jan 18;57(3):356-65.
10. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Pi M, etal., Mol Endocrinol. 2005 Apr;19(4):1078-87. Epub 2005 Jan 6.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Shenoy SK and Lefkowitz RJ, Sci STKE. 2005 Nov 22;2005(311):cm14.
14. Biased agonism of the calcium-sensing receptor. Thomsen AR, etal., Cell Calcium. 2012 Feb;51(2):107-16. doi: 10.1016/j.ceca.2011.11.009. Epub 2011 Dec 20.
15. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
16. The expression change of beta-arrestins in fibroblast-like synoviocytes from rats with collagen-induced arthritis and the effect of total glucosides of paeony. Wang QT, etal., J Ethnopharmacol. 2011 Jan 27;133(2):511-6. Epub 2010 Oct 19.
17. Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, etal., Immunobiology. 2011 Jul;216(7):854-61. doi: 10.1016/j.imbio.2010.11.005. Epub 2010 Dec 3.
18. Role of ssarrestins in bradykinin B2 receptor-mediated signalling. Zimmerman B, etal., Cell Signal. 2011 Apr;23(4):648-59. doi: 10.1016/j.cellsig.2010.11.016. Epub 2010 Dec 8.
Additional References at PubMed
PMID:2163110   PMID:7896272   PMID:8486659   PMID:8885248   PMID:8889548   PMID:9169477   PMID:9388255   PMID:9501202   PMID:9668034   PMID:9827808   PMID:9924018   PMID:10196135  
PMID:10347142   PMID:10347182   PMID:10521508   PMID:10644702   PMID:10753943   PMID:10770944   PMID:10823817   PMID:10862778   PMID:10973280   PMID:11031247   PMID:11170396   PMID:11252894  
PMID:11259507   PMID:11278883   PMID:11356842   PMID:11533043   PMID:11579203   PMID:11588219   PMID:11694590   PMID:11723231   PMID:11726668   PMID:11729201   PMID:11742073   PMID:11777907  
PMID:11867621   PMID:12020767   PMID:12065593   PMID:12105416   PMID:12220636   PMID:12393857   PMID:12399592   PMID:12464600   PMID:12477932   PMID:12538596   PMID:12582207   PMID:14500724  
PMID:14709160   PMID:14711824   PMID:15084596   PMID:15125834   PMID:15173580   PMID:15489220   PMID:15489334   PMID:15498833   PMID:15611106   PMID:15699339   PMID:15878855   PMID:16051150  
PMID:16181421   PMID:16189514   PMID:16280323   PMID:16319069   PMID:16325578   PMID:16344560   PMID:16378096   PMID:16407241   PMID:16412099   PMID:16432186   PMID:16492667   PMID:16524428  
PMID:16580177   PMID:16611986   PMID:16670094   PMID:16709866   PMID:16778767   PMID:17008309   PMID:17207965   PMID:17272726   PMID:17353931   PMID:17377064   PMID:17436063   PMID:17498700  
PMID:17500066   PMID:17579607   PMID:17620599   PMID:17623778   PMID:17846866   PMID:17855543   PMID:17890288   PMID:17900862   PMID:17947233   PMID:18276584   PMID:18534983   PMID:18544533  
PMID:18678875   PMID:18703513   PMID:18729826   PMID:18768750   PMID:18775329   PMID:18787115   PMID:18940181   PMID:19153083   PMID:19202075   PMID:19262695   PMID:19279230   PMID:19306926  
PMID:19363159   PMID:19404096   PMID:19453261   PMID:19509284   PMID:19609003   PMID:19661922   PMID:19782076   PMID:19879840   PMID:20086095   PMID:20353754   PMID:20353998   PMID:20360068  
PMID:20379614   PMID:20448034   PMID:20505072   PMID:20650893   PMID:20717968   PMID:20725137   PMID:20801186   PMID:20855896   PMID:20936779   PMID:20956518   PMID:21044950   PMID:21081496  
PMID:21212384   PMID:21233215   PMID:21243522   PMID:21378163   PMID:21466165   PMID:21479985   PMID:21502318   PMID:21589858   PMID:21642958   PMID:21685944   PMID:21795688   PMID:21857681  
PMID:21873635   PMID:21988832   PMID:22101011   PMID:22106258   PMID:22267743   PMID:22457824   PMID:22487268   PMID:22871966   PMID:22961449   PMID:23208497   PMID:23208550   PMID:23236378  
PMID:23242524   PMID:23302795   PMID:23317236   PMID:23341447   PMID:23353685   PMID:23400010   PMID:23418490   PMID:23449980   PMID:23582260   PMID:23589893   PMID:23633677   PMID:23818521  
PMID:23886940   PMID:24069330   PMID:24147004   PMID:24169548   PMID:24265322   PMID:24334028   PMID:24452472   PMID:24502978   PMID:24530737   PMID:24658140   PMID:24692549   PMID:24723693  
PMID:24837709   PMID:24867953   PMID:24898255   PMID:24937675   PMID:24939178   PMID:25109335   PMID:25134464   PMID:25294870   PMID:25377471   PMID:25401222   PMID:25402006   PMID:25416956  
PMID:25519916   PMID:25600647   PMID:25766502   PMID:25820700   PMID:26077142   PMID:26097560   PMID:26119788   PMID:26211463   PMID:26269596   PMID:26293896   PMID:26347956   PMID:26399832  
PMID:26449263   PMID:26522724   PMID:26708616   PMID:26871637   PMID:26927499   PMID:27155323   PMID:27188791   PMID:27195676   PMID:27493245   PMID:27502035   PMID:27620488   PMID:27789711  
PMID:27895162   PMID:28004760   PMID:28035404   PMID:28062183   PMID:28153854   PMID:28341744   PMID:28425985   PMID:28427767   PMID:28432343   PMID:28442265   PMID:28514442   PMID:28515276  
PMID:28581517   PMID:28611215   PMID:28651823   PMID:28716052   PMID:28733085   PMID:28749339   PMID:28947386   PMID:28986522   PMID:29116339   PMID:29305604   PMID:29330504   PMID:29335412  
PMID:29439204   PMID:29463778   PMID:29507755   PMID:29581292   PMID:29676828   PMID:29734363   PMID:29999490   PMID:30078843   PMID:30216111   PMID:30365090   PMID:30480076   PMID:30554943  
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PMID:31527615   PMID:31530642   PMID:31685794   PMID:31822496   PMID:31857195   PMID:32027601   PMID:32296183   PMID:32413442   PMID:32439801   PMID:32445435   PMID:32505358   PMID:32544529  
PMID:32555462   PMID:32753481   PMID:32916203   PMID:32920979   PMID:32978402   PMID:33129195   PMID:33158816   PMID:33173959   PMID:33296703   PMID:33611816   PMID:33710266   PMID:33844281  
PMID:33888704   PMID:33961781   PMID:34225700   PMID:34450275   PMID:34507982   PMID:34627424   PMID:34830362   PMID:35226379   PMID:35256949   PMID:35831314   PMID:35944360   PMID:36161910  
PMID:36209675   PMID:36215168   PMID:36250246   PMID:36717550  


Genomics

Comparative Map Data
ARRB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,260,122 - 75,351,661 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1175,260,122 - 75,351,705 (-)EnsemblGRCh38hg38GRCh38
GRCh371174,971,166 - 75,062,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,654,130 - 74,740,521 (-)NCBINCBI36Build 36hg18NCBI36
Build 341174,654,129 - 74,740,521NCBI
Celera1172,283,036 - 72,369,427 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,268,798 - 71,360,118 (-)NCBIHuRef
CHM1_11174,854,770 - 74,946,464 (-)NCBICHM1_1
T2T-CHM13v2.01175,189,729 - 75,281,255 (-)NCBIT2T-CHM13v2.0
Arrb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,184,356 - 99,255,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,184,673 - 99,255,978 (+)EnsemblGRCm39 Ensembl
GRCm38799,535,147 - 99,606,772 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,535,466 - 99,606,771 (+)EnsemblGRCm38mm10GRCm38
MGSCv377106,683,996 - 106,755,281 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,409,569 - 99,480,854 (+)NCBIMGSCv36mm8
Celera799,859,615 - 99,932,041 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.09NCBI
Arrb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,837,964 - 153,912,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,838,078 - 153,904,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,833,965 - 161,899,728 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01169,014,116 - 169,079,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01161,887,644 - 161,953,403 (+)NCBIRnor_WKY
Rnor_6.01164,502,099 - 164,573,947 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,502,389 - 164,593,139 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,705,795 - 170,777,617 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,871,564 - 156,937,540 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,949,969 - 157,015,946 (+)NCBI
Celera1151,924,752 - 151,989,492 (+)NCBICelera
Cytogenetic Map1q32NCBI
Arrb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,478,843 - 16,562,135 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541416,478,843 - 16,568,050 (+)NCBIChiLan1.0ChiLan1.0
ARRB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11173,624,254 - 73,670,495 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1173,630,276 - 73,654,155 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01170,319,935 - 70,411,276 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ARRB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,261,020 - 23,304,448 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,235,711 - 23,297,786 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,990,721 - 23,068,006 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,428,040 - 23,505,333 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,428,093 - 23,507,491 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,226,359 - 23,303,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,422,622 - 23,499,929 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,340,581 - 23,417,904 (+)NCBIUU_Cfam_GSD_1.0
Arrb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,490,018 - 62,573,146 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,094,893 - 4,172,755 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364984,089,621 - 4,172,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,516,947 - 9,597,976 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,516,944 - 9,597,446 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,659,892 - 10,767,092 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,489,358 - 66,580,167 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,490,102 - 66,580,154 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604359,230,347 - 59,326,828 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arrb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,750,156 - 1,823,309 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,750,448 - 1,828,399 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARRB1
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5		 pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh37/hg19 11q13.4(chr11:74580424-75099464)x3 copy number gain See cases [RCV000448058] Chr11:74580424..75099464 [GRCh37]
Chr11:11q13.4		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11q13.4-13.5(chr11:74839014-75366449) copy number gain not specified [RCV002052937] Chr11:74839014..75366449 [GRCh37]
Chr11:11q13.4-13.5		 uncertain significance
NC_000011.9:g.(?_71146421)_(75283128_?)dup duplication 3-methylglutaconic aciduria with cataracts, neurologic involvement and neutropenia [RCV003122786] Chr11:71146421..75283128 [GRCh37]
Chr11:11q13.4-13.5		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_004041.5(ARRB1):c.386T>G (p.Leu129Arg) single nucleotide variant Inborn genetic diseases [RCV002883033] Chr11:75281990 [GRCh38]
Chr11:74993034 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_004041.5(ARRB1):c.244G>A (p.Ala82Thr) single nucleotide variant Inborn genetic diseases [RCV002682908] Chr11:75283397 [GRCh38]
Chr11:74994441 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_004041.5(ARRB1):c.934C>T (p.Arg312Cys) single nucleotide variant Inborn genetic diseases [RCV002774496] Chr11:75272959 [GRCh38]
Chr11:74984003 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_004041.5(ARRB1):c.263C>T (p.Pro88Leu) single nucleotide variant Inborn genetic diseases [RCV002915113] Chr11:75283378 [GRCh38]
Chr11:74994422 [GRCh37]
Chr11:11q13.4		 uncertain significance
NM_004041.5(ARRB1):c.244G>T (p.Ala82Ser) single nucleotide variant Inborn genetic diseases [RCV002679650] Chr11:75283397 [GRCh38]
Chr11:74994441 [GRCh37]
Chr11:11q13.4		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4536
Count of miRNA genes:1097
Interacting mature miRNAs:1378
Transcripts:ENST00000360025, ENST00000393505, ENST00000420843, ENST00000524400, ENST00000527385, ENST00000529280, ENST00000529741, ENST00000530086, ENST00000531012, ENST00000532447, ENST00000532525, ENST00000533255, ENST00000533609
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D17S1790  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13UniSTS
Marshfield Genetic Map17105.68RGD
Marshfield Genetic Map17105.68UniSTS
Genethon Genetic Map17106.9UniSTS
D11S1007  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371175,002,599 - 75,002,777UniSTSGRCh37
Build 361174,680,247 - 74,680,425RGDNCBI36
Celera1172,309,149 - 72,309,327RGD
Cytogenetic Map11q13UniSTS
HuRef1171,300,229 - 71,300,407UniSTS
STS-M78804  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,972,313 - 74,972,384UniSTSGRCh37
Build 361174,649,961 - 74,650,032RGDNCBI36
Celera1172,278,867 - 72,278,938RGD
Cytogenetic Map11q13UniSTS
HuRef1171,269,943 - 71,270,014UniSTS
GeneMap99-GB4 RH Map11273.98UniSTS
NCBI RH Map11631.8UniSTS
G31124  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,974,644 - 74,974,777UniSTSGRCh37
Build 361174,652,292 - 74,652,425RGDNCBI36
Celera1172,281,198 - 72,281,331RGD
Cytogenetic Map11q13UniSTS
HuRef1171,272,274 - 71,272,407UniSTS
A009B14  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,973,632 - 74,973,738UniSTSGRCh37
Build 361174,651,280 - 74,651,386RGDNCBI36
Celera1172,280,186 - 72,280,292RGD
Cytogenetic Map11q13UniSTS
HuRef1171,271,262 - 71,271,368UniSTS
GeneMap99-GB4 RH Map11271.99UniSTS
WI-20596  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,974,459 - 74,974,735UniSTSGRCh37
Build 361174,652,107 - 74,652,383RGDNCBI36
Celera1172,281,013 - 72,281,289RGD
Cytogenetic Map11q13UniSTS
HuRef1171,272,089 - 71,272,365UniSTS
GeneMap99-GB4 RH Map11274.08UniSTS
Whitehead-RH Map11371.8UniSTS
NCBI RH Map11628.0UniSTS
WI-15243  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,971,189 - 74,971,338UniSTSGRCh37
Build 361174,648,837 - 74,648,986RGDNCBI36
Celera1172,277,745 - 72,277,894RGD
Cytogenetic Map11q13UniSTS
HuRef1171,268,821 - 71,268,970UniSTS
GeneMap99-GB4 RH Map11274.08UniSTS
Whitehead-RH Map11371.8UniSTS
NCBI RH Map11631.8UniSTS
D11S4555  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371175,025,259 - 75,025,385UniSTSGRCh37
Build 361174,702,907 - 74,703,033RGDNCBI36
Celera1172,331,812 - 72,331,938RGD
Cytogenetic Map11q13UniSTS
HuRef1171,322,873 - 71,322,999UniSTS
WI-16137  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,975,428 - 74,975,555UniSTSGRCh37
Build 361174,653,076 - 74,653,203RGDNCBI36
Celera1172,281,982 - 72,282,109RGD
Cytogenetic Map11q13UniSTS
HuRef1171,273,058 - 71,273,185UniSTS
GeneMap99-GB4 RH Map11274.08UniSTS
Whitehead-RH Map11370.6UniSTS
NCBI RH Map11631.8UniSTS
WI-21016  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,976,814 - 74,977,078UniSTSGRCh37
Build 361174,654,462 - 74,654,726RGDNCBI36
Celera1172,283,368 - 72,283,632RGD
Cytogenetic Map11q13UniSTS
HuRef1171,274,444 - 71,274,708UniSTS
GeneMap99-GB4 RH Map11273.87UniSTS
Whitehead-RH Map11371.8UniSTS
NCBI RH Map11631.8UniSTS
G32376  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371174,973,632 - 74,973,738UniSTSGRCh37
Celera1172,280,186 - 72,280,292UniSTS
Cytogenetic Map11q13UniSTS
HuRef1171,271,262 - 71,271,368UniSTS
L17877  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map2p13.1UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic MapYp11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map1q23.1UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map6p22UniSTS
Cytogenetic Map6q14.1UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map10p14UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map5q31.3UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic MapXq21.1UniSTS
Cytogenetic Map15q22UniSTS
Cytogenetic Map1p36.22UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map18q21.31UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map20pter-q12UniSTS
Cytogenetic Map12q13.11-q14.3UniSTS
Cytogenetic Map9q21.3UniSTS
Cytogenetic Map20q11.22-q11.23UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map11q12.2UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map8q13.2UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map11p15.5UniSTS
Cytogenetic Map19qUniSTS
Cytogenetic Map4p16UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map16p13.11UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map18q12.2UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map17q25.3UniSTS
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map13q14.1-q14.3UniSTS
Cytogenetic Map3q22-q24UniSTS
Cytogenetic Map3q13.1-q13.2UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map17p13.1-p12UniSTS
Cytogenetic Map18q21.33UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map4q21.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map17p12-p11.2UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map1q24UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map2q32UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map2q33UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map14q31-q32UniSTS
Cytogenetic Map5p15.33UniSTS
Cytogenetic Map1q23.2UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map4p14UniSTS
Cytogenetic Map2q32.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map4q32.2UniSTS
Cytogenetic Map10q23UniSTS
Cytogenetic Map5q14.2UniSTS
Cytogenetic Map4q32.1UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map11q14.1UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map18p11.31UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic MapYp11.2UniSTS
Cytogenetic Map13q13.1UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map18q12UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map3q27.2UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map5p15.2UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map1q42UniSTS
Cytogenetic Map14q32.11UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map5q32-q34UniSTS
Cytogenetic Map15q14UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map6q25.3UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map13q14.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map10p12UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map14q21.3UniSTS
Cytogenetic Map8p22-p21UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map12q21.33UniSTS
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Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2382 1031 573 158 1229 48 2661 955 3035 165 843 1225 115 1201 1320 3
Low 57 1958 1152 466 603 417 1694 1238 692 252 616 376 59 1 3 1468 3 2
Below cutoff 2 73 1 4 7 2 1 11 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF084040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF084940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL157484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP001972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM681392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ883950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU594296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX402200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB853136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD365891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR735690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA358665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ314865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ348262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L04685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000360025   ⟹   ENSP00000353124
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,265,599 - 75,351,705 (-)Ensembl
RefSeq Acc Id: ENST00000420843   ⟹   ENSP00000409581
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,260,122 - 75,351,661 (-)Ensembl
RefSeq Acc Id: ENST00000524400   ⟹   ENSP00000434196
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,278,677 - 75,312,155 (-)Ensembl
RefSeq Acc Id: ENST00000527385   ⟹   ENSP00000433137
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,278,716 - 75,303,670 (-)Ensembl
RefSeq Acc Id: ENST00000529280
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,281,614 - 75,284,313 (-)Ensembl
RefSeq Acc Id: ENST00000529741
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,272,786 - 75,276,911 (-)Ensembl
RefSeq Acc Id: ENST00000530086
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,281,006 - 75,282,132 (-)Ensembl
RefSeq Acc Id: ENST00000531012
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,270,930 - 75,274,938 (-)Ensembl
RefSeq Acc Id: ENST00000532447   ⟹   ENSP00000436530
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,266,116 - 75,278,699 (-)Ensembl
RefSeq Acc Id: ENST00000532525   ⟹   ENSP00000433171
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,274,200 - 75,306,709 (-)Ensembl
RefSeq Acc Id: ENST00000533255
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,281,878 - 75,351,660 (-)Ensembl
RefSeq Acc Id: ENST00000533609   ⟹   ENSP00000436352
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1175,278,711 - 75,312,124 (-)Ensembl
RefSeq Acc Id: NM_004041   ⟹   NP_004032
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,351,661 (-)NCBI
GRCh371174,971,166 - 75,062,875 (-)ENTREZGENE
GRCh371174,971,166 - 75,062,875 (-)NCBI
Build 361174,654,130 - 74,740,521 (-)NCBI Archive
HuRef1171,268,798 - 71,360,118 (-)ENTREZGENE
CHM1_11174,854,770 - 74,946,464 (-)NCBI
T2T-CHM13v2.01175,189,729 - 75,281,255 (-)NCBI
Sequence:
RefSeq Acc Id: NM_020251   ⟹   NP_064647
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,351,661 (-)NCBI
GRCh371174,971,166 - 75,062,875 (-)ENTREZGENE
GRCh371174,971,166 - 75,062,875 (-)NCBI
Build 361174,654,130 - 74,740,521 (-)NCBI Archive
HuRef1171,268,798 - 71,360,118 (-)ENTREZGENE
CHM1_11174,854,770 - 74,946,464 (-)NCBI
T2T-CHM13v2.01175,189,729 - 75,281,255 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011545034   ⟹   XP_011543336
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,312,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011545035   ⟹   XP_011543337
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,312,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017750   ⟹   XP_016873239
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,312,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017751   ⟹   XP_016873240
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,312,108 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017752   ⟹   XP_016873241
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,351,661 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017753   ⟹   XP_016873242
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,306,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017754   ⟹   XP_016873243
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,260,122 - 75,351,661 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064647   ⟸   NM_020251
- Peptide Label: isoform B
- UniProtKB: P49407 (UniProtKB/Swiss-Prot),   B7Z1Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_004032   ⟸   NM_004041
- Peptide Label: isoform A
- UniProtKB: Q9BTK8 (UniProtKB/Swiss-Prot),   P49407 (UniProtKB/Swiss-Prot),   B7Z1Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011543337   ⟸   XM_011545035
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011543336   ⟸   XM_011545034
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016873243   ⟸   XM_017017754
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_016873241   ⟸   XM_017017752
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_016873240   ⟸   XM_017017751
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016873239   ⟸   XM_017017750
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016873242   ⟸   XM_017017753
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSP00000353124   ⟸   ENST00000360025
RefSeq Acc Id: ENSP00000436530   ⟸   ENST00000532447
RefSeq Acc Id: ENSP00000433171   ⟸   ENST00000532525
RefSeq Acc Id: ENSP00000436352   ⟸   ENST00000533609
RefSeq Acc Id: ENSP00000434196   ⟸   ENST00000524400
RefSeq Acc Id: ENSP00000433137   ⟸   ENST00000527385
RefSeq Acc Id: ENSP00000409581   ⟸   ENST00000420843
Protein Domains
Arrestin C-terminal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49407-F1-model_v2 AlphaFold P49407 1-418 view protein structure

Promoters
RGD ID:6788496
Promoter ID:HG_KWN:13738
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000393505,   NM_004041,   NM_020251
Position:
Human AssemblyChrPosition (strand)Source
Build 361174,740,506 - 74,741,012 (-)MPROMDB
RGD ID:7221563
Promoter ID:EPDNEW_H16527
Type:initiation region
Name:ARRB1_1
Description:arrestin beta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,351,660 - 75,351,720EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:711 AgrOrtholog
COSMIC ARRB1 COSMIC
Ensembl Genes ENSG00000137486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000353124 ENTREZGENE
  ENSP00000353124.3 UniProtKB/Swiss-Prot
  ENSP00000409581 ENTREZGENE
  ENSP00000409581.2 UniProtKB/Swiss-Prot
  ENSP00000433137.1 UniProtKB/TrEMBL
  ENSP00000433171.1 UniProtKB/TrEMBL
  ENSP00000434196.1 UniProtKB/TrEMBL
  ENSP00000436352.1 UniProtKB/TrEMBL
  ENSP00000436530.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000360025 ENTREZGENE
  ENST00000360025.7 UniProtKB/Swiss-Prot
  ENST00000420843 ENTREZGENE
  ENST00000420843.7 UniProtKB/Swiss-Prot
  ENST00000524400.5 UniProtKB/TrEMBL
  ENST00000527385.1 UniProtKB/TrEMBL
  ENST00000532447.5 UniProtKB/TrEMBL
  ENST00000532525.1 UniProtKB/TrEMBL
  ENST00000533609.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.640 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000137486 GTEx
HGNC ID HGNC:711 ENTREZGENE
Human Proteome Map ARRB1 Human Proteome Map
InterPro Arrestin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:408 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 408 ENTREZGENE
OMIM 107940 OMIM
PANTHER BETA-ARRESTIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11792 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arrestin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA59 PharmGKB
PRINTS ARRESTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARRESTINS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Arrestin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ARRB1_HUMAN UniProtKB/Swiss-Prot
  B7Z1Q3 ENTREZGENE, UniProtKB/TrEMBL
  E9PM35_HUMAN UniProtKB/TrEMBL
  H0YD81_HUMAN UniProtKB/TrEMBL
  H0YDS1_HUMAN UniProtKB/TrEMBL
  H0YEQ2_HUMAN UniProtKB/TrEMBL
  H0YET9_HUMAN UniProtKB/TrEMBL
  P49407 ENTREZGENE
  Q9BTK8 ENTREZGENE
UniProt Secondary B6V9G8 UniProtKB/Swiss-Prot
  O75625 UniProtKB/Swiss-Prot
  O75630 UniProtKB/Swiss-Prot
  Q2PP20 UniProtKB/Swiss-Prot
  Q9BTK8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-04 ARRB1  arrestin beta 1    arrestin, beta 1  Symbol and/or name change 5135510 APPROVED