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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene C4
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Accession:CHEBI:16978 term browser browse the term
Definition:A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
Synonyms:exact_synonym: L-gamma-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl]-L-cysteinylglycine
 related_synonym: (R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)glycine;   5S,6R-Ltc(sub 4);   5S-hydroxy,6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid;   Formula=C30H47N3O9S;   InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1;   InChIKey=GWNVDXQDILPJIG-NXOLIXFESA-N;   LTC (sub 4);   LTC4;   SMILES=CCCCC\\C=C/C\\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
 alt_id: CHEBI:14504;   CHEBI:25025;   CHEBI:6422
 xref: CAS:72025-60-6 "ChemIDplus";   CAS:72025-60-6 "KEGG COMPOUND";   HMDB:HMDB0001198;   KEGG:C02166;   LIPID_MAPS_instance:LMFA03020003 "LIPID MAPS"
 xref_mesh: MESH:D017997
 xref: MetaCyc:LEUKOTRIENE-C4;   PMID:24244016 "Europe PMC";   PMID:8415814 "Europe PMC";   PMID:9042024 "Europe PMC";   PMID:9384524 "Europe PMC";   Reaxys:4732117 "Reaxys";   Wikipedia:Leukotriene_C4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57973


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leukotriene C4 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca8 ATP binding cassette subfamily A member 8 JBrowse link 10 98,236,919 98,308,288 RGD:6480464
G Abcc1 ATP binding cassette subfamily C member 1 JBrowse link 10 549,537 672,235 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcc6 ATP binding cassette subfamily C member 6 JBrowse link 1 101,954,786 102,013,252 RGD:6480464
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:6480464
G Alox5ap arachidonate 5-lipoxygenase activating protein JBrowse link 12 6,854,930 6,879,112 RGD:6480464
G Ambp alpha-1-microglobulin/bikunin precursor JBrowse link 5 78,975,690 78,986,021 RGD:6480464
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Clec7a C-type lectin domain containing 7A JBrowse link 4 163,216,152 163,227,367 RGD:6480464
G Cxcl3 chemokine (C-X-C motif) ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Cysltr2 cysteinyl leukotriene receptor 2 JBrowse link 15 54,903,290 54,941,742 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Ggt5 gamma-glutamyltransferase 5 JBrowse link 20 13,988,444 14,001,296 RGD:6480464
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:6480464
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:6480464
G Ltc4s leukotriene C4 synthase JBrowse link 10 35,736,486 35,743,088 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mgst1 microsomal glutathione S-transferase 1 JBrowse link 4 172,119,382 172,134,609 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming JBrowse link 1 214,725,482 214,756,653 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Syk spleen associated tyrosine kinase JBrowse link 17 12,614,311 12,669,568 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pharmaceutical 19081
          drug 19081
            bronchoconstrictor agent 63
              leukotriene C4 33
                11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                11,12-dihydro-12-oxoleukotriene C4 0
                leukotriene C4 methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            organic group 18331
                              organic divalent group 18321
                                organodiyl group 18321
                                  carbonyl group 18209
                                    carbonyl compound 18209
                                      carboxylic acid 17908
                                        monocarboxylic acid 17245
                                          fatty acid 15807
                                            unsaturated fatty acid 888
                                              polyunsaturated fatty acid 646
                                                fatty acid 20:4 309
                                                  icosatetraenoic acid 309
                                                    icosa-7,9,11,14-tetraenoic acid 44
                                                      leukotriene C4 33
                                                        11,12-dihydro-(12R)-hydroxyleukotriene C4 0
                                                        11,12-dihydro-12-oxoleukotriene C4 0
                                                        leukotriene C4 methyl ester 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.