Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:leukotriene A4
go back to main search page
Accession:CHEBI:15651 term browser browse the term
Definition:A leukotriene that is the (5S,6S)-epoxy derivative of (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid.
Synonyms:exact_synonym: (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoic acid
 related_synonym: (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoic acid;   5(S)-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid;   5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid;   5S,6S-leukotriene A4;   Formula=C20H30O3;   InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1;   InChIKey=UFPQIRYSPUYQHK-WAQVJNLQSA-N;   LTA4;   Oxiranebutanoic acid, 3-(1,3,5,8-tetradecatetraenyl)-, (2S-(2alpha,3beta(1E,3Z,5Z,8Z)))-;   SMILES=CCCCC\\C=C/C\\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O
 alt_id: CHEBI:10937;   CHEBI:14503;   CHEBI:25023;   CHEBI:6420
 xref: CAS:72059-45-1;   HMDB:HMDB0001337;   KEGG:C00909;   KNApSAcK:C00053424;   LIPID_MAPS_instance:LMFA03020023
 xref_mesh: MESH:D017572
 xref: PDBeChem:DJ3;   PMID:1667967;   PMID:19531649;   PMID:20120015;   PMID:22913921;   PMID:28827365;   PMID:33896285;   PMID:8017792;   Reaxys:5756170;   Wikipedia:Leukotriene_A4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57463



show annotations for term's descendants           Sort by:
leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase increases chemical synthesis ISO ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases hydrolysis
ISO cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            eukaryotic metabolite 19387
              plant metabolite 17985
                leukotriene A4 3
                  4,5-leukotriene A4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        monocarboxylic acid 17984
                                          fatty acid 16709
                                            unsaturated fatty acid 1095
                                              polyunsaturated fatty acid 839
                                                fatty acid 20:4 360
                                                  icosatetraenoic acid 360
                                                    icosa-7,9,11,14-tetraenoic acid 46
                                                      leukotriene A4 3
                                                        4,5-leukotriene A4 0
paths to the root