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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:leukotriene A4
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Accession:CHEBI:15651 term browser browse the term
Definition:A leukotriene that is the (5S,6S)-epoxy derivative of (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid.
Synonyms:exact_synonym: (5S,6S,7E,9E,11Z,14Z)-5,6-epoxyicosa-7,9,11,14-tetraenoic acid
 related_synonym: (7E,9E,11Z,14Z)-(5S,6S)-5,6-Epoxyeicosa-7,9,11,14-tetraenoic acid;   5(S)-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid;   5S,6S-epoxy-7E,9E,11Z,14Z-eicosatetraenoic acid;   5S,6S-leukotriene A4;   Formula=C20H30O3;   InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1;   InChIKey=UFPQIRYSPUYQHK-WAQVJNLQSA-N;   LTA4;   Oxiranebutanoic acid, 3-(1,3,5,8-tetradecatetraenyl)-, (2S-(2alpha,3beta(1E,3Z,5Z,8Z)))-;   SMILES=CCCCC\\C=C/C\\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O
 alt_id: CHEBI:10937;   CHEBI:14503;   CHEBI:25023;   CHEBI:6420
 xref: CAS:72059-45-1;   HMDB:HMDB0001337;   KEGG:C00909;   KNApSAcK:C00053424;   LIPID_MAPS_instance:LMFA03020023
 xref_mesh: MESH:D017572
 xref: PDBeChem:DJ3;   PMID:1667967;   PMID:19531649;   PMID:20120015;   PMID:22913921;   PMID:28827365;   PMID:33896285;   PMID:8017792;   Reaxys:5756170;   Wikipedia:Leukotriene_A4
 cyclic_relationship: is_conjugate_acid_of CHEBI:57463



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leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase increases chemical synthesis ISO ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases hydrolysis
ISO cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          metabolite 19623
            eukaryotic metabolite 19326
              plant metabolite 17657
                leukotriene A4 3
                  4,5-leukotriene A4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        monocarboxylic acid 17840
                                          fatty acid 16464
                                            unsaturated fatty acid 956
                                              polyunsaturated fatty acid 693
                                                fatty acid 20:4 333
                                                  icosatetraenoic acid 333
                                                    icosa-7,9,11,14-tetraenoic acid 46
                                                      leukotriene A4 3
                                                        4,5-leukotriene A4 0
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