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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sanguinarine
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Accession:CHEBI:17183 term browser browse the term
Definition:A botanical anti-fungal agent that has formula C20H14NO4.
Synonyms:exact_synonym: 13-methyl-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridinium
 related_synonym: 13-methyl[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium;   Formula=C20H14NO4;   InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1;   InChIKey=INVGWHRKADIJHF-UHFFFAOYSA-N;   SMILES=C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
 alt_id: CHEBI:15064;   CHEBI:26601;   CHEBI:9022
 xref: BPDB:2914;   CAS:2447-54-3;   KEGG:C06162;   KNApSAcK:C00001917;   KNApSAcK:C00024663;   LINCS:LSM-6639
 xref_mesh: MESH:C005705
 xref: PMID:19346183


show annotations for term's descendants           Sort by:
sanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP sanguinarine promotes the reaction [AHR protein binds to ARNT protein]; sanguinarine results in increased activity of and affects the localization of AHR protein; sanguinarine results in increased localization of and results in increased activity of AHR protein CTD PMID:15993743 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions EXP sanguinarine promotes the reaction [AHR protein binds to ARNT protein] CTD PMID:15993743 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 sanguinarine results in increased expression of BAX protein
sanguinarine results in increased expression of BAX mRNA; sanguinarine results in increased expression of BAX protein
NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]		 CTD PMID:22215411 PMID:24300172 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of BBC3 mRNA CTD PMID:24345465 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 sanguinarine results in decreased expression of BCL2 protein
sanguinarine results in decreased expression of BCL2 mRNA; sanguinarine results in decreased expression of BCL2 protein
NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BCL2 protein		 CTD PMID:22215411 PMID:23660334 PMID:24300172 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L14 BCL2 like 14 multiple interactions
increases expression		 EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of BCL2L14 mRNA
sanguinarine results in increased expression of BCL2L14 mRNA		 CTD PMID:24345465 NCBI chr12:12,049,861...12,099,695
Ensembl chr12:12,049,844...12,211,084 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions
increases cleavage		 EXP [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [sanguinarine results in increased cleavage of BID protein] CTD PMID:23660334 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIK BCL2 interacting killer multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of BIK mRNA CTD PMID:24345465 NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein CTD PMID:23660334 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BNIP3L BCL2 interacting protein 3 like multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of BNIP3L mRNA CTD PMID:24345465 NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636 		JBrowse link
G CARD18 caspase recruitment domain family member 18 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD18 mRNA CTD PMID:24345465 NCBI chr11:105,137,714...105,139,769
Ensembl chr11:105,137,714...105,531,697 		JBrowse link
G CARD6 caspase recruitment domain family member 6 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of CARD6 mRNA CTD PMID:24345465 NCBI chr 5:40,841,367...40,855,354
Ensembl chr 5:40,841,308...40,860,175 		JBrowse link
G CASP1 caspase 1 multiple interactions
increases expression		 EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP1 mRNA
sanguinarine results in increased expression of CASP1 mRNA		 CTD PMID:24345465 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP10 caspase 10 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP10 mRNA CTD PMID:24345465 NCBI chr 2:201,183,141...201,229,406
Ensembl chr 2:201,182,872...201,229,428 		JBrowse link
G CASP3 caspase 3 decreases expression
multiple interactions
increases activity		 EXP sanguinarine results in decreased expression of CASP3 protein alternative form
[sanguinarine co-treated with Arsenic Trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP3 protein
sanguinarine results in increased activity of CASP3 protein		 CTD PMID:19135517 PMID:19346183 PMID:20150630 PMID:22215411 PMID:23660334 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP4 caspase 4 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP4 mRNA CTD PMID:24345465 NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366 		JBrowse link
G CASP5 caspase 5 multiple interactions
increases expression		 EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of CASP5 mRNA
sanguinarine results in increased expression of CASP5 mRNA		 CTD PMID:24345465 NCBI chr11:104,994,243...105,023,168
Ensembl chr11:104,994,235...105,023,168 		JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions		 EXP sanguinarine results in increased activity of CASP8 protein
[sanguinarine co-treated with Arsenic Trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with Arsenic Trioxide] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein		 CTD PMID:19346183 PMID:23660334 PMID:24345465 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 decreases expression
multiple interactions
increases activity		 EXP sanguinarine results in decreased expression of CASP9 protein alternative form
[sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in increased activity of CASP9 protein
sanguinarine results in increased activity of CASP9 protein		 CTD PMID:19135517 PMID:19346183 PMID:22215411 PMID:23660334 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of CAT protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of CAT protein CTD PMID:20691676 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression ISO sanguinarine results in increased expression of CDKN1A protein CTD PMID:15981203 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CLDN2 claudin 2 decreases expression EXP sanguinarine results in decreased expression of CLDN2 protein CTD PMID:19063874 NCBI chr  X:106,900,164...106,930,861
Ensembl chr  X:106,900,164...106,930,861 		JBrowse link
G CLDN3 claudin 3 decreases expression EXP sanguinarine results in decreased expression of CLDN3 protein CTD PMID:19063874 NCBI chr 7:73,768,997...73,770,270
Ensembl chr 7:73,768,997...73,770,270 		JBrowse link
G CLDN4 claudin 4 decreases expression EXP sanguinarine results in decreased expression of CLDN4 protein CTD PMID:19063874 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,690 		JBrowse link
G CLDN5 claudin 5 decreases expression EXP sanguinarine results in decreased expression of CLDN5 protein CTD PMID:19063874 NCBI chr22:19,523,024...19,525,337
Ensembl chr22:19,523,024...19,527,545 		JBrowse link
G CRYZ crystallin zeta multiple interactions
decreases activity		 ISO sanguinarine inhibits the reaction [Methylcholanthrene results in increased activity of CRYZ protein]
sanguinarine results in decreased activity of CRYZ protein		 CTD PMID:19788401 NCBI chr 1:74,705,486...74,733,050
Ensembl chr 1:74,705,482...74,733,408 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
multiple interactions
increases expression
increases activity		 EXP
ISO		 sanguinarine results in decreased activity of CYP1A1 protein
sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A1 protein]; sanguinarine results in decreased expression of and results in decreased activity of CYP1A1 protein
sanguinarine results in increased expression of CYP1A1 mRNA; sanguinarine results in increased expression of CYP1A1 protein
sanguinarine results in increased activity of CYP1A1 protein		 CTD PMID:15993743 PMID:19788401 PMID:24300172 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO sanguinarine inhibits the reaction [Methylcholanthrene results in increased expression of and results in increased activity of CYP1A2 protein]; sanguinarine results in decreased expression of and results in decreased activity of CYP1A2 protein CTD PMID:19788401 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression
increases activity		 EXP sanguinarine results in increased expression of CYP1B1 mRNA
sanguinarine results in increased activity of CYP1B1 protein		 CTD PMID:15993743 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions ISO sanguinarine results in decreased expression of and results in decreased activity of CYP2E1 protein CTD PMID:19788401 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G DEDD2 death effector domain containing 2 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of DEDD2 mRNA CTD PMID:24345465 NCBI chr19:42,198,598...42,220,134
Ensembl chr19:42,198,598...42,220,140 		JBrowse link
G EGR1 early growth response 1 multiple interactions
increases expression
decreases expression		 EXP sanguinarine promotes the reaction [Reactive Oxygen Species results in increased activity of EGR1 protein]
sanguinarine results in increased expression of EGR1 protein
sanguinarine results in decreased expression of EGR1 protein		 CTD PMID:23660334 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of FAS mRNA CTD PMID:24345465 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of FASLG mRNA CTD PMID:24345465 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 increases expression ISO sanguinarine results in increased expression of GGT1 protein CTD PMID:15981203 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,594,811...24,629,005 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of GSR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of GSR protein CTD PMID:20691676 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GSTA3 glutathione S-transferase alpha 3 multiple interactions EXP sanguinarine inhibits the reaction [GSTA3 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 6:52,896,646...52,909,698
Ensembl chr 6:52,896,639...52,909,698 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions
increases expression		 EXP
ISO		 sanguinarine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]; sanguinarine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA]; sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA]
sanguinarine results in increased expression of GSTP1 protein		 CTD PMID:15313406 PMID:15981203 PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HAL histidine ammonia-lyase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein CTD PMID:20691676 NCBI chr12:95,972,662...95,996,344
Ensembl chr12:95,972,662...95,996,365 		JBrowse link
G HPGDS hematopoietic prostaglandin D synthase decreases activity EXP sanguinarine results in decreased activity of HPGDS protein CTD PMID:25603235 NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876 		JBrowse link
G LTB lymphotoxin beta increases expression
multiple interactions		 EXP sanguinarine results in increased expression of LTB mRNA
[sanguinarine co-treated with arsenic trioxide] results in increased expression of LTB mRNA		 CTD PMID:24345465 NCBI chr 6:31,580,558...31,582,425
Ensembl chr 6:31,580,525...31,582,522 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP sanguinarine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:19135517 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein]; pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK3 protein] CTD PMID:19135517 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation		 EXP pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK8 protein] CTD PMID:19135517 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP pyrazolanthrone inhibits the reaction [sanguinarine results in increased phosphorylation of MAPK9 protein] CTD PMID:19135517 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MMP2 matrix metallopeptidase 2 decreases expression EXP sanguinarine results in decreased expression of MMP2 mRNA; sanguinarine results in decreased expression of MMP2 protein CTD PMID:19063874 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP sanguinarine results in decreased expression of MMP9 mRNA; sanguinarine results in decreased expression of MMP9 protein CTD PMID:19063874 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NFKBIZ NFKB inhibitor zeta increases expression EXP sanguinarine results in increased expression of NFKBIZ mRNA CTD PMID:24345465 NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022 		JBrowse link
G NLRP1 NLR family pyrin domain containing 1 multiple interactions
increases expression		 EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of NLRP1 mRNA
sanguinarine results in increased expression of NLRP1 mRNA		 CTD PMID:24345465 NCBI chr17:5,501,396...5,584,509
Ensembl chr17:5,499,415...5,619,424 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
increases reduction
multiple interactions		 EXP
ISO		 sanguinarine results in decreased expression of NQO1 mRNA; sanguinarine results in decreased expression of NQO1 protein
NQO1 protein results in increased reduction of sanguinarine
NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in decreased expression of BCL2 protein]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX mRNA]; NQO1 protein inhibits the reaction [sanguinarine results in increased expression of BAX protein]		 CTD PMID:22021338 PMID:24300172 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of PMAIP1 mRNA CTD PMID:24345465 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305 		JBrowse link
G POR cytochrome p450 oxidoreductase multiple interactions
decreases activity		 ISO sanguinarine inhibits the reaction [Phenobarbital results in increased activity of POR protein]; sanguinarine promotes the reaction [Methylcholanthrene results in decreased activity of POR protein]
sanguinarine results in decreased activity of POR protein		 CTD PMID:19788401 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of PYCARD mRNA CTD PMID:24345465 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G SNAI1 snail family transcriptional repressor 1 decreases expression EXP sanguinarine results in decreased expression of SNAI1 protein CTD PMID:19063874 NCBI chr20:49,982,980...49,988,886
Ensembl chr20:49,982,980...49,988,886 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP sanguinarine inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] CTD PMID:15313406 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF10B mRNA; [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF10B protein CTD PMID:24345465 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B multiple interactions EXP [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFRSF1B mRNA CTD PMID:24345465 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions
increases expression		 EXP [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [sanguinarine co-treated with arsenic trioxide co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sanguinarine co-treated with arsenic trioxide] results in increased expression of TNFSF10 mRNA; [sanguinarine co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [sanguinarine co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; TNFSF10 protein results in increased susceptibility to [arsenic trioxide co-treated with sanguinarine]
sanguinarine results in increased expression of TNFSF10 mRNA		 CTD PMID:24345465 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TYR tyrosinase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of TYR protein; [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of TYR protein CTD PMID:20691676 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP [sanguinarine results in increased chemical synthesis of Reactive Oxygen Species] which results in decreased expression of XIAP protein CTD PMID:23660334 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
dihydrosanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP dihydrosanguinarine results in increased activity of CASP3 protein CTD PMID:19346183 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 increases activity EXP dihydrosanguinarine results in increased activity of CASP9 protein CTD PMID:19346183 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases chemical synthesis ISO NQO1 protein results in increased chemical synthesis of dihydrosanguinarine CTD PMID:24300172 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        antimicrobial agent 21917
          alkaloid antibiotic 356
            sanguinarine 60
              10-hydroxydihydrosanguinarine 0
              chelirubine + 0
              dihydrosanguinarine + 3
              macarpine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            organic molecule 25223
                              organic cyclic compound 24277
                                organic heterocyclic compound 22320
                                  organonitrogen heterocyclic compound 20332
                                    benzophenanthridine 141
                                      benzophenanthridine alkaloid 119
                                        sanguinarine 60
                                          10-hydroxydihydrosanguinarine 0
                                          chelirubine + 0
                                          dihydrosanguinarine + 3
                                          macarpine 0
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