CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dihydrosanguinarine
Accession: CHEBI:17209
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Definition: A benzophenanthridine alkaloid obtained by selective hydrogenation of the 13,14-position of sanguinarine.
Synonyms: exact_synonym: 13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine
related_synonym: 13,14-dihydro-13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine; Formula=C20H15NO4; InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3; InChIKey=CIUHLXZTZWTVFL-UHFFFAOYSA-N; SMILES=CN1Cc2c3OCOc3ccc2-c2ccc3cc4OCOc4cc3c12; dihydroavicine
alt_id: CHEBI:14161; CHEBI:23766; CHEBI:4584
xref: CAS:3606-45-9; KEGG:C05191; KNApSAcK:C00001847; KNApSAcK:C00024647
xref_mesh: MESH:C501843
xref: PMID:11488455; PMID:11488467; PMID:12898646; PMID:17260290; PMID:18309269; PMID:18420297; PMID:18495316; PMID:19346183; PMID:19578993; PMID:19629460; PMID:19647059; PMID:19873781; PMID:20226485; PMID:20385218; PMID:20600683; PMID:20683512; PMID:20686258; PMID:21500094; Reaxys:48770
G
Casp3
caspase 3
increases activity
ISO
dihydrosanguinarine results in increased activity of CASP3 protein
CTD
PMID:19346183
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp9
caspase 9
increases activity
ISO
dihydrosanguinarine results in increased activity of CASP9 protein
CTD
PMID:19346183
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases chemical synthesis
EXP
NQO1 protein results in increased chemical synthesis of dihydrosanguinarine
CTD
PMID:24300172
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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