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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dihydrosanguinarine
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Accession:CHEBI:17209 term browser browse the term
Definition:A benzophenanthridine alkaloid obtained by selective hydrogenation of the 13,14-position of sanguinarine.
Synonyms:exact_synonym: 13-methyl-13,14-dihydro-2H,10H-[1,3]dioxolo[4,5-i][1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine
 related_synonym: 13,14-dihydro-13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridine;   Formula=C20H15NO4;   InChI=1S/C20H15NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-7H,8-10H2,1H3;   InChIKey=CIUHLXZTZWTVFL-UHFFFAOYSA-N;   SMILES=CN1Cc2c3OCOc3ccc2-c2ccc3cc4OCOc4cc3c12;   dihydroavicine
 alt_id: CHEBI:14161;   CHEBI:23766;   CHEBI:4584
 xref: CAS:3606-45-9;   KEGG:C05191;   KNApSAcK:C00001847;   KNApSAcK:C00024647
 xref_mesh: MESH:C501843
 xref: PMID:11488455;   PMID:11488467;   PMID:12898646;   PMID:17260290;   PMID:18309269;   PMID:18420297;   PMID:18495316;   PMID:19346183;   PMID:19578993;   PMID:19629460;   PMID:19647059;   PMID:19873781;   PMID:20226485;   PMID:20385218;   PMID:20600683;   PMID:20683512;   PMID:20686258;   PMID:21500094;   Reaxys:48770



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dihydrosanguinarine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO dihydrosanguinarine results in increased activity of CASP3 protein CTD PMID:19346183 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO dihydrosanguinarine results in increased activity of CASP9 protein CTD PMID:19346183 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases chemical synthesis EXP NQO1 protein results in increased chemical synthesis of dihydrosanguinarine CTD PMID:24300172 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19740
    role 19713
      biological role 19711
        biochemical role 19429
          metabolite 19416
            dihydrosanguinarine 3
              dihydrochelirubine 0
              dihydromacarpine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19740
    subatomic particle 19738
      composite particle 19738
        hadron 19738
          baryon 19738
            nucleon 19738
              atomic nucleus 19738
                atom 19738
                  main group element atom 19686
                    p-block element atom 19686
                      carbon group element atom 19631
                        carbon atom 19627
                          organic molecular entity 19627
                            organic molecule 19587
                              organic cyclic compound 19393
                                organic heterocyclic compound 18766
                                  organonitrogen heterocyclic compound 17995
                                    benzophenanthridine 127
                                      benzophenanthridine alkaloid 104
                                        sanguinarine 51
                                          dihydrosanguinarine 3
                                            dihydrochelirubine 0
                                            dihydromacarpine 0
paths to the root