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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:actinomycin D
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Accession:CHEBI:27666 term browser browse the term
Definition:An actinomycin that has formula C62H86N12O16.
Synonyms:exact_synonym: 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide
 related_synonym: 2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide;   ActD;   Dactinomycin;   Formula=C62H86N12O16;   InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1;   InChIKey=RJURFGZVJUQBHK-IIXSONLDSA-N;   SMILES=[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C;   actinomycin C1;   actinomycin IV
 alt_id: CHEBI:22218;   CHEBI:2446
 xref: Beilstein:4173766;   CAS:50-76-0;   DrugBank:DB00970;   Drug_Central:774;   KEGG:C06770;   KEGG:D00214;   LINCS:LSM-5783
 xref_mesh: MESH:D003609
 xref: Wikipedia:Dactinomycin


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actinomycin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases response to substance
multiple interactions		 EXP
ISO		 ABCB1 protein results in decreased susceptibility to Dactinomycin
Dactinomycin inhibits the reaction [[Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [[Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] which results in increased uptake of (N-5-(4-nitrobenzofurazan-7-yl)lysyl(8))cyclosporine]; Dactinomycin inhibits the reaction [coptisine results in increased expression of ABCB1A mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Dactinomycin inhibits the reaction [tetrabromobisphenol A results in increased expression of and results in increased activity of ABCB1A protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]
Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 mRNA]; Dactinomycin inhibits the reaction [Progesterone results in increased expression of ABCB1 protein]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCB1 mRNA]		 CTD PMID:1967174 PMID:11455017 PMID:15725475 PMID:18474546 PMID:19813763 More... NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases response to substance EXP
ISO		 ABCC1 protein results in decreased susceptibility to Dactinomycin CTD PMID:11455017 PMID:12067707 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases response to substance
multiple interactions		 ISO
EXP		 ABCC2 protein results in decreased susceptibility to Dactinomycin
Dactinomycin inhibits the reaction [Bucladesine results in increased expression of ABCC2 mRNA]
Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of ABCC2 mRNA]		 CTD PMID:11408547 PMID:11455017 PMID:26049102 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) multiple interactions EXP Dactinomycin inhibits the reaction [Daunorubicin results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [Doxorubicin results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [Mitoxantrone results in increased expression of ABCG2 mRNA]; Dactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein]; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA] CTD PMID:20019844 PMID:21625222 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G ABHD3 abhydrolase domain containing 3, phospholipase increases expression EXP Dactinomycin results in increased expression of ABHD3 mRNA CTD PMID:21527772 NCBI chr18:21,650,901...21,704,774
Ensembl chr18:21,650,901...21,704,780 		JBrowse link
G ACE angiotensin I converting enzyme multiple interactions ISO Dactinomycin inhibits the reaction [Aldosterone results in increased activity of ACE protein]; Dactinomycin inhibits the reaction [Aldosterone results in increased expression of ACE mRNA] CTD PMID:15932931 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380 		JBrowse link
G ACSL6 acyl-CoA synthetase long chain family member 6 multiple interactions ISO Dactinomycin inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of ACSL6 mRNA] CTD PMID:10585473 NCBI chr 5:131,949,973...132,012,213
Ensembl chr 5:131,949,973...132,012,243 		JBrowse link
G ADAM9 ADAM metallopeptidase domain 9 multiple interactions EXP Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein] CTD PMID:17018608 NCBI chr 8:38,996,973...39,105,261
Ensembl chr 8:38,996,754...39,105,445 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of ADRB2 protein]; Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA]; Dactinomycin inhibits the reaction [Formoterol Fumarate affects the expression of ADRB2 mRNA] CTD PMID:22483689 PMID:24705868 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623 		JBrowse link
G AGRP agouti related neuropeptide multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [bisphenol A results in increased expression of AGRP mRNA]
Dactinomycin results in decreased expression of AGRP mRNA		 CTD PMID:32575098 NCBI chr16:67,482,571...67,483,547
Ensembl chr16:67,482,571...67,483,547 		JBrowse link
G AGT angiotensinogen multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [Amiodarone results in increased expression of AGT mRNA]
Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]		 CTD PMID:16705055 PMID:17214612 PMID:19292980 PMID:23288202 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [TGFB1 protein results in decreased expression of AHR mRNA]
ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]		 CTD PMID:9145908 PMID:16226227 PMID:25637755 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AICDA activation induced cytidine deaminase multiple interactions ISO [Dactinomycin co-treated with Alpha-Amanitin] inhibits the reaction [Estradiol results in increased expression of AICDA mRNA] CTD PMID:19139166 NCBI chr12:8,602,170...8,612,859
Ensembl chr12:8,602,155...8,613,242 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP [Dactinomycin co-treated with TNFSF10 protein] results in increased expression of AIFM1 protein CTD PMID:17707539 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases stability		 ISO
EXP		 PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]
Dactinomycin results in decreased stability of AKT1 mRNA
PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]; YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF2 protein affects the reaction [YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]		 CTD PMID:14640974 PMID:37061066 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G ALPI alkaline phosphatase, intestinal multiple interactions ISO Dactinomycin inhibits the reaction [Fish Oils results in increased activity of ALPI protein] CTD PMID:15599000 NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753 		JBrowse link
G ALX3 ALX homeobox 3 multiple interactions ISO Dactinomycin inhibits the reaction [Folic Acid results in increased expression of ALX3 mRNA] CTD PMID:20534379 NCBI chr 1:110,059,870...110,070,672
Ensembl chr 1:110,059,870...110,070,672 		JBrowse link
G AOC1 amine oxidase copper containing 1 multiple interactions ISO Dactinomycin inhibits the reaction [Epinephrine results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of AOC1 protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased activity of AOC1 protein] CTD PMID:2860926 PMID:6218830 NCBI chr 7:150,852,120...150,861,504
Ensembl chr 7:150,824,627...150,861,504 		JBrowse link
G AQP1 aquaporin 1 (Colton blood group) multiple interactions EXP Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of AQP1 mRNA] CTD PMID:22415096 NCBI chr 7:30,911,853...30,925,516
Ensembl chr 7:30,911,853...30,925,517 		JBrowse link
G ARHGDIB Rho GDP dissociation inhibitor beta increases expression EXP Dactinomycin results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr12:14,942,015...14,961,601
Ensembl chr12:14,942,031...14,961,728 		JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions ISO ARNT protein promotes the reaction [Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]] CTD PMID:16226227 NCBI chr 1:150,809,713...150,876,599
Ensembl chr 1:150,809,713...150,876,708 		JBrowse link
G ATF4 activating transcription factor 4 multiple interactions EXP Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Bortezomib results in increased expression of ATF4 protein]; Dactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Fenretinide results in increased expression of ATF4 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] CTD PMID:20022965 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683 		JBrowse link
G ATG7 autophagy related 7 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of ATG7 protein] CTD PMID:24095927 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G ATM ATM serine/threonine kinase multiple interactions EXP Dactinomycin results in decreased expression of and results in increased phosphorylation of ATM protein CTD PMID:31226288 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102 		JBrowse link
G AVP arginine vasopressin multiple interactions ISO Dactinomycin inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein] CTD PMID:11102496 NCBI chr20:3,082,556...3,084,724
Ensembl chr20:3,082,556...3,084,724 		JBrowse link
G AXL AXL receptor tyrosine kinase increases expression EXP Dactinomycin results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr19:41,219,223...41,261,766
Ensembl chr19:41,219,223...41,261,766 		JBrowse link
G BAG3 BAG cochaperone 3 multiple interactions EXP Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of BAG3 mRNA] CTD PMID:22020323 NCBI chr10:119,651,380...119,677,819
Ensembl chr10:119,651,380...119,677,819 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAK1 mRNA]
Dactinomycin promotes the reaction [BAK1 protein binds to BAK1 protein]		 CTD PMID:21281706 PMID:26670606 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP
ISO		 Dactinomycin results in increased expression of BAX mRNA; Dactinomycin results in increased expression of BAX protein
Dactinomycin promotes the reaction [BAX protein binds to BAX protein]
Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of BAX mRNA]
Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]		 CTD PMID:10760829 PMID:12927789 PMID:21281706 PMID:21527772 PMID:26670606 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 increases expression EXP Dactinomycin results in increased expression of BBC3 mRNA; Dactinomycin results in increased expression of BBC3 protein CTD PMID:17581298 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 EXP BCL2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [IL1B results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [Paclitaxel results in increased phosphorylation of BCL2 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Dactinomycin results in decreased expression of BCL2 mRNA; Dactinomycin results in decreased expression of BCL2 protein		 CTD PMID:11726273 PMID:11880364 PMID:12927789 PMID:16492401 PMID:17581298 More... NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions EXP BCL2A1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
increases expression		 EXP Dactinomycin results in decreased expression of BCL2L1 protein
Dexamethasone inhibits the reaction [Dactinomycin results in increased expression of BCL2L1 protein]
Dactinomycin results in increased expression of BCL2L1 protein; Dactinomycin results in increased expression of BCL2L1 protein alternative form		 CTD PMID:9326359 PMID:12430140 PMID:15592511 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of BCL2L11 mRNA] CTD PMID:16166651 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of BDNF mRNA]
Dactinomycin results in decreased expression of BDNF mRNA		 CTD PMID:22982731 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BECN1 beclin 1 multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of BECN1 protein] CTD PMID:24095927 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BID BH3 interacting domain death agonist multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [vorinostat results in increased cleavage of BID protein]
Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of BID mRNA]		 CTD PMID:11535817 PMID:16166651 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions EXP BIRC3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403 		JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO [Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA; Dactinomycin inhibits the reaction [Ethanol results in increased expression of BNIP3 protein]; Dactinomycin inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:11592958 PMID:19442826 PMID:24095927 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967 		JBrowse link
G BSDC1 BSD domain containing 1 increases expression EXP Dactinomycin results in increased expression of BSDC1 mRNA CTD PMID:21527772 NCBI chr 1:32,364,633...32,394,441
Ensembl chr 1:32,364,633...32,394,731 		JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase multiple interactions EXP Dactinomycin promotes the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA]; Dactinomycin promotes the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC mRNA] CTD PMID:35561756 NCBI chr10:101,354,048...101,557,313
Ensembl chr10:101,354,033...101,557,321 		JBrowse link
G C1QBP complement C1q binding protein decreases response to substance EXP C1QBP protein results in decreased susceptibility to Dactinomycin CTD PMID:25354864 NCBI chr17:5,432,777...5,439,155
Ensembl chr17:5,432,777...5,448,830 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G multiple interactions ISO Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr17:50,560,715...50,627,474
Ensembl chr17:50,560,715...50,627,474 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H multiple interactions ISO Dactinomycin inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr16:1,153,106...1,221,768
Ensembl chr16:1,153,103...1,224,169 		JBrowse link
G CASP2 caspase 2 increases cleavage EXP Dactinomycin results in increased cleavage of CASP2 protein CTD PMID:10663630 NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
decreases expression		 EXP
ISO		 [TNF co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP3 protein; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Dactinomycin inhibits the reaction [Biological Products results in increased expression of CASP3 mRNA]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP3 protein]
Dactinomycin results in increased cleavage of and results in increased activity of CASP3 protein
[Dactinomycin co-treated with TNF protein] results in increased activity of CASP3 protein
Dactinomycin results in increased activity of CASP3 protein
Dactinomycin results in decreased expression of CASP3 mRNA		 CTD PMID:10663630 PMID:16001973 PMID:16492401 PMID:21496118 PMID:22654482 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 multiple interactions
decreases expression		 EXP [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP7 protein; [TNF co-treated with Dactinomycin] results in increased activity of CASP7 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP7 protein; Dactinomycin promotes the reaction [TNF results in increased activity of CASP7 protein]
Dactinomycin results in decreased expression of CASP7 mRNA		 CTD PMID:16001973 PMID:16492401 PMID:17707539 PMID:21496118 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 decreases expression EXP Dactinomycin results in decreased expression of CASP8 mRNA CTD PMID:16001973 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases cleavage		 EXP
ISO		 [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP9 protein
Dactinomycin results in increased cleavage of CASP9 protein		 CTD PMID:17707539 PMID:26670606 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAV1 caveolin 1 multiple interactions EXP Dactinomycin inhibits the reaction [rosiglitazone results in increased expression of CAV1 mRNA] CTD PMID:15314095 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 multiple interactions EXP Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA] CTD PMID:15531761 NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Dactinomycin inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:15531761 PMID:16705055 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCN4 cellular communication network factor 4 multiple interactions EXP Dactinomycin inhibits the reaction [2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of CCN4 mRNA] CTD PMID:19238344 NCBI chr 8:133,191,039...133,231,690
Ensembl chr 8:133,191,039...133,231,690 		JBrowse link
G CCNA2 cyclin A2 multiple interactions ISO Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA] CTD PMID:8550827 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCND1 cyclin D1 decreases stability ISO Dactinomycin results in decreased stability of CCND1 mRNA CTD PMID:15610522 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CD1D CD1d molecule multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] CTD PMID:17392484 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427 		JBrowse link
G CD28 CD28 molecule multiple interactions EXP Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD28 protein] CTD PMID:11465111 NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,475...203,738,912 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
decreases expression		 EXP 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone inhibits the reaction [Dactinomycin results in increased expression of and affects the localization of CDKN1A protein]; Dactinomycin results in increased expression of and affects the localization of CDKN1A protein
Dactinomycin results in decreased expression of CDKN1A protein		 CTD PMID:12807743 PMID:14601052 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B multiple interactions ISO CDKN1B protein affects the reaction [Dactinomycin results in increased degradation of PTGS2 mRNA] CTD PMID:23639288 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CEBPB CCAAT enhancer binding protein beta decreases expression EXP Dactinomycin results in decreased expression of CEBPB mRNA CTD PMID:16001973 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668 		JBrowse link
G CEL carboxyl ester lipase increases expression EXP Dactinomycin results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,981...133,071,861 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression EXP Dactinomycin results in decreased expression of CFLAR protein CTD PMID:11234897 PMID:14601052 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CKB creatine kinase B multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of CKB protein]; Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of CKB protein] CTD PMID:7839363 NCBI chr14:103,519,667...103,522,830
Ensembl chr14:103,519,667...103,522,833 		JBrowse link
G CLMN calmin multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of CLMN mRNA] CTD PMID:16688769 NCBI chr14:95,181,940...95,319,908
Ensembl chr14:95,181,940...95,319,908 		JBrowse link
G CNMD chondromodulin multiple interactions EXP Dactinomycin inhibits the reaction [hydroquinone results in increased expression of CNMD protein] CTD PMID:19525446 NCBI chr13:52,703,264...52,739,820
Ensembl chr13:52,703,264...52,739,820 		JBrowse link
G CNR1 cannabinoid receptor 1 multiple interactions EXP Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR1 mRNA] CTD PMID:21525939 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CNR2 cannabinoid receptor 2 multiple interactions EXP Dactinomycin inhibits the reaction [Gemcitabine results in increased expression of CNR2 mRNA] CTD PMID:21525939 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]
Dactinomycin results in decreased expression of COL1A1 mRNA		 CTD PMID:11216681 PMID:18253093 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions ISO Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G CRABP2 cellular retinoic acid binding protein 2 increases expression EXP Dactinomycin results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 1:156,699,606...156,705,784
Ensembl chr 1:156,699,606...156,705,816 		JBrowse link
G CS citrate synthase multiple interactions ISO Dactinomycin inhibits the reaction [Hydrocortisone results in decreased activity of CS protein] CTD PMID:6476976 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Reactive Oxygen Species results in increased expression of CSF2 protein]
Dactinomycin inhibits the reaction [IL1B results in increased secretion of CSF2 protein]; Dactinomycin inhibits the reaction [Particulate Matter results in increased secretion of CSF2 protein]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased secretion of CSF2 protein]		 CTD PMID:9606035 PMID:10645887 PMID:11752025 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTF1 cardiotrophin 1 multiple interactions ISO Dactinomycin promotes the reaction [Spironolactone inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]] CTD PMID:23288202 NCBI chr16:30,895,846...30,903,560
Ensembl chr16:30,896,614...30,903,547 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression		 EXP [Dactinomycin co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; Dactinomycin inhibits the reaction [arsenic trioxide promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]]; Dactinomycin inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 protein]; Dactinomycin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [sphingosine 1-phosphate results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [Zinc deficiency results in decreased expression of CXCL8 protein]]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [Zinc Oxide results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [Zinc Oxide results in increased expression of CXCL8 protein]; Dactinomycin promotes the reaction [3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8]]
Dactinomycin results in increased expression of CXCL8 mRNA		 CTD PMID:12039947 PMID:12812920 PMID:15531761 PMID:18281166 PMID:18308354 More... NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions ISO Dactinomycin inhibits the reaction [Dichlorodiphenyl Dichloroethylene results in increased expression of CYCS mRNA] CTD PMID:21281706 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYGB cytoglobin multiple interactions EXP Dactinomycin inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA] CTD PMID:25781201 NCBI chr17:76,527,356...76,551,193
Ensembl chr17:76,527,356...76,551,175 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Copper results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Lead results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [SB 203580 results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tetrandrine results in increased expression of CYP1A1 protein]; Dactinomycin promotes the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA]; Dactinomycin promotes the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]
Dactinomycin results in decreased expression of CYP1A1 mRNA
Dactinomycin inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [NSC 674495 results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [Sunitinib results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [T-2 Toxin results in increased expression of CYP1A1 mRNA]; Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA]		 CTD PMID:1934297 PMID:10359656 PMID:11577022 PMID:11752201 PMID:16093525 More... NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP Dactinomycin inhibits the reaction [cryptotanshinone results in increased expression of CYP1A2 mRNA]; Dactinomycin inhibits the reaction [dihydrotanshinone I results in increased expression of CYP1A2 mRNA]; Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA] CTD PMID:21262253 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions
decreases expression		 EXP
ISO		 Dactinomycin inhibits the reaction [NSC 674495 results in increased expression of CYP1B1 mRNA]
Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of CYP1B1 protein]
Dactinomycin results in decreased expression of CYP1B1 mRNA
Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]		 CTD PMID:11577022 PMID:11752201 PMID:21867498 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 increases stability
multiple interactions		 ISO Dactinomycin results in increased stability of CYP2A5 mRNA
Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]; Dactinomycin inhibits the reaction [Cyclic AMP results in increased expression of CYP2A5 mRNA]; Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP2A5 mRNA]		 CTD PMID:12754101 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions ISO Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP2B10 mRNA] CTD PMID:9007836 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2F1 cytochrome P450 family 2 subfamily F member 1 multiple interactions EXP Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] CTD PMID:20187624 NCBI chr19:41,114,432...41,128,381
Ensembl chr19:41,114,432...41,128,381 		JBrowse link
G CYP2S1 cytochrome P450 family 2 subfamily S member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA] CTD PMID:17277313 NCBI chr19:41,193,219...41,207,539
Ensembl chr19:41,193,210...41,207,539 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA]; Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A4 mRNA]
Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [Phenobarbital results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]		 CTD PMID:11181506 PMID:15795092 PMID:24819614 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A5 mRNA] CTD PMID:24819614 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 multiple interactions EXP Dactinomycin inhibits the reaction [U 0126 results in increased expression of CYP3A7 mRNA] CTD PMID:24819614 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G DDAH2 DDAH family member 2, ADMA-independent multiple interactions EXP Dactinomycin inhibits the reaction [Nebivolol results in increased expression of DDAH2 mRNA] CTD PMID:17977009 NCBI chr 6:31,727,040...31,730,263
Ensembl chr 6:31,727,038...31,730,617 		JBrowse link
G DIO3 iodothyronine deiodinase 3 multiple interactions ISO Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased activity of DIO3 protein] CTD PMID:18420745 NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452 		JBrowse link
G DPYSL4 dihydropyrimidinase like 4 increases expression EXP Dactinomycin results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr10:132,186,948...132,205,759
Ensembl chr10:132,186,948...132,205,759 		JBrowse link
G EDN1 endothelin 1 multiple interactions EXP Dactinomycin inhibits the reaction [EDN1 protein results in increased expression of ADRB2 mRNA] CTD PMID:22483689 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EDNRA endothelin receptor type A multiple interactions ISO [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA; [Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA protein; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein] CTD PMID:20561571 NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954 		JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO Dactinomycin inhibits the reaction [Cyclosporine results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Dimethyl Sulfoxide results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB mRNA]; Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [Smoke analog results in increased expression of EDNRB protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA] CTD PMID:20561571 PMID:20716444 PMID:22207076 PMID:25772258 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529 		JBrowse link
G EFNB2 ephrin B2 multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of EFNB2 mRNA] CTD PMID:16688769 NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662 		JBrowse link
G EGF epidermal growth factor multiple interactions ISO Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of EGFR protein]; Dactinomycin inhibits the reaction [Methoxychlor results in increased expression of EGFR protein] CTD PMID:8888411 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EGR1 early growth response 1 multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of EGR1 mRNA] CTD PMID:1717835 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G ELOVL3 ELOVL fatty acid elongase 3 multiple interactions ISO Dactinomycin inhibits the reaction [Norepinephrine results in increased expression of ELOVL3 mRNA]; Dactinomycin inhibits the reaction [rosiglitazone results in increased expression of ELOVL3 mRNA] CTD PMID:17726147 NCBI chr10:102,224,767...102,229,589
Ensembl chr10:102,226,299...102,229,589 		JBrowse link
G EMP1 epithelial membrane protein 1 increases expression EXP Dactinomycin results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr12:13,196,726...13,219,941
Ensembl chr12:13,196,723...13,219,941 		JBrowse link
G EMP3 epithelial membrane protein 3 (MAM blood group) increases expression EXP Dactinomycin results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr19:48,325,552...48,330,553
Ensembl chr19:48,321,509...48,330,553 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 increases stability ISO Dactinomycin results in increased stability of EPAS1 protein CTD PMID:23545307 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [indoleacetic acid results in increased expression of F3 mRNA]
Dactinomycin results in decreased expression of F3 mRNA		 CTD PMID:30324315 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G FADD Fas associated via death domain decreases expression EXP Dactinomycin results in decreased expression of FADD mRNA CTD PMID:16001973 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FADS3 fatty acid desaturase 3 increases expression EXP Dactinomycin results in increased expression of FADS3 mRNA CTD PMID:21527772 NCBI chr11:61,873,526...61,892,224
Ensembl chr11:61,873,519...61,892,051 		JBrowse link
G FBL fibrillarin affects localization EXP Dactinomycin analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr19:39,834,458...39,846,379
Ensembl chr19:39,834,458...39,846,379 		JBrowse link
G FCAR Fc alpha receptor multiple interactions EXP Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of FCAR mRNA] CTD PMID:21911031 NCBI chr19:54,874,235...54,891,420
Ensembl chr19:54,874,235...54,891,420 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions
decreases expression		 EXP
ISO		 Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
Dactinomycin inhibits the reaction [FGF2 protein results in increased expression of SNCA protein]
Dactinomycin results in decreased expression of FGF2 mRNA		 CTD PMID:12562524 PMID:26800359 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 multiple interactions ISO Dactinomycin inhibits the reaction [Triiodothyronine results in increased expression of FGFR1 mRNA] CTD PMID:12805413 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G FHL1 four and a half LIM domains 1 multiple interactions ISO Dactinomycin promotes the reaction [25-hydroxycholesterol results in increased expression of FHL1 mRNA] CTD PMID:17161435 NCBI chr  X:136,146,702...136,211,359
Ensembl chr  X:136,146,702...136,211,359 		JBrowse link
G FLNC filamin C increases expression EXP Dactinomycin results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 7:128,830,406...128,859,272
Ensembl chr 7:128,830,406...128,859,274 		JBrowse link
G FN1 fibronectin 1 multiple interactions EXP Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 NCBI chr 2:215,360,865...215,436,068
Ensembl chr 2:215,360,440...215,436,073 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]
Dactinomycin inhibits the reaction [Hemin results in increased expression of FOS mRNA]
Dactinomycin results in decreased expression of FOS mRNA
Dactinomycin inhibits the reaction [[Cycloheximide co-treated with Cadmium] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA]		 CTD PMID:1696944 PMID:7564102 PMID:10381381 PMID:11123204 PMID:11353138 More... NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [Particulate Matter results in increased expression of FOSL1 mRNA]; Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of FOSL1 mRNA]
Dactinomycin results in decreased expression of FOSL1 mRNA		 CTD PMID:14565943 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573 		JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO Dactinomycin inhibits the reaction [Isoproterenol results in increased activity of G6PD protein] CTD PMID:1978808 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,517,825...154,547,572 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha multiple interactions
increases expression		 EXP Dactinomycin inhibits the reaction [arsenite results in increased expression of GADD45A mRNA]
Dactinomycin results in increased expression of GADD45A mRNA		 CTD PMID:17616671 PMID:21527772 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GALM galactose mutarotase multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of GALM mRNA] CTD PMID:18052213 NCBI chr 2:38,666,114...38,734,765
Ensembl chr 2:38,666,081...38,741,237 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Dactinomycin results in increased expression of GAPDH mRNA CTD PMID:16001973 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G GAS6 growth arrest specific 6 multiple interactions
increases degradation		 EXP Phosphates promotes the reaction [Dactinomycin results in increased degradation of GAS6 mRNA] CTD PMID:20048160 NCBI chr13:113,820,549...113,864,076
Ensembl chr13:113,820,549...113,864,076 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Vitamin K 3 results in increased expression of GCLC mRNA]
Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]		 CTD PMID:11972604 PMID:24437944 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970 		JBrowse link
G GDF15 growth differentiation factor 15 multiple interactions EXP Dactinomycin inhibits the reaction [resveratrol results in increased expression of GDF15 mRNA] CTD PMID:17257620 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176 		JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of GDNF mRNA]
Dactinomycin results in decreased expression of GDNF mRNA		 CTD PMID:22982731 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G GFER growth factor, augmenter of liver regeneration increases secretion
multiple interactions		 ISO Dactinomycin results in increased secretion of GFER protein
Dactinomycin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of GFER protein]; lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [Dactinomycin results in increased secretion of GFER protein]		 CTD PMID:23073658 NCBI chr16:1,984,193...1,987,749
Ensembl chr16:1,984,193...1,987,749 		JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO Dactinomycin promotes the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GJA1 mRNA] CTD PMID:36863560 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GPR137B G protein-coupled receptor 137B increases expression EXP Dactinomycin results in increased expression of GPR137B mRNA CTD PMID:21527772 NCBI chr 1:236,142,539...236,208,907
Ensembl chr 1:236,142,505...236,221,865 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Dactinomycin inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 multiple interactions ISO Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]; Dactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein] CTD PMID:11665859 NCBI chr11:88,504,642...89,065,982
Ensembl chr11:88,504,576...89,065,982 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions EXP Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of GSTA1 mRNA] CTD PMID:28483492 NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860 		JBrowse link
G GSTA5 glutathione S-transferase alpha 5 multiple interactions ISO Dactinomycin inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA] CTD PMID:16243960 NCBI chr 6:52,831,692...52,846,245
Ensembl chr 6:52,831,655...52,840,843 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases response to substance ISO GSTP1 protein results in decreased susceptibility to Dactinomycin CTD PMID:11455017 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G H2AX H2A.X variant histone increases expression EXP Dactinomycin results in increased expression of H2AX protein CTD PMID:31226288 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HBEGF heparin binding EGF like growth factor multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA]
Dactinomycin results in decreased expression of HBEGF mRNA		 CTD PMID:26800359 NCBI chr 5:140,332,843...140,346,603
Ensembl chr 5:140,332,843...140,346,603 		JBrowse link
G HGF hepatocyte growth factor multiple interactions EXP Dactinomycin inhibits the reaction [Berberine results in increased expression of HGF protein] CTD PMID:29408570 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:12479793 PMID:19958256 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
decreases expression		 EXP
ISO		 Dactinomycin inhibits the reaction [Ammonium Chloride results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Lipid Peroxides results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Nitroprusside results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Oxygen results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]; Dactinomycin results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]
Dactinomycin results in decreased expression of HMOX1 protein
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [cobaltous chloride results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of HMOX1 mRNA]
Dactinomycin inhibits the reaction [fisetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [puerarin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]		 CTD PMID:8764571 PMID:9747510 PMID:9808084 PMID:11880364 PMID:12763371 More... NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 affects localization
multiple interactions		 ISO Dactinomycin affects the localization of HNRNPA1 protein
Dactinomycin affects the reaction [HNRNPA1 protein binds to CYP2A5 mRNA]		 CTD PMID:12754101 NCBI chr12:54,280,726...54,287,087
Ensembl chr12:54,280,193...54,287,088 		JBrowse link
G HOMER3 homer scaffold protein 3 increases expression EXP Dactinomycin results in increased expression of HOMER3 mRNA CTD PMID:21527772 NCBI chr19:18,929,201...18,941,217
Ensembl chr19:18,929,201...18,941,261 		JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions EXP Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] CTD PMID:9345283 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions EXP Dactinomycin inhibits the reaction [Bexarotene results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [tributyltin results in increased expression of HSD11B2 mRNA]; Dactinomycin inhibits the reaction [triphenyltin chloride results in increased expression of HSD11B2 mRNA] CTD PMID:31927052 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G HSF1 heat shock transcription factor 1 multiple interactions EXP Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of HSF1 protein] CTD PMID:30309986 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Dactinomycin inhibits the reaction [Dithiothreitol results in increased expression of HSP90B1 mRNA] CTD PMID:34244458 NCBI chr12:103,930,410...103,947,926
Ensembl chr12:103,930,107...103,953,931 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression		 ISO
EXP		 Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [lead acetate results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]
[Arsenic Trioxide co-treated with Dactinomycin] results in decreased expression of HSPA5 mRNA; [Arsenic Trioxide co-treated with Dactinomycin] results in increased expression of HSPA5 protein
Dactinomycin results in decreased expression of HSPA5 mRNA		 CTD PMID:17915553 PMID:34560123 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G HTR3A 5-hydroxytryptamine receptor 3A multiple interactions ISO Dactinomycin promotes the reaction [Dronabinol results in decreased activity of HTR3A protein] CTD PMID:20800662 NCBI chr11:113,975,108...113,990,313
Ensembl chr11:113,975,075...113,990,313 		JBrowse link
G ID1 inhibitor of DNA binding 1 multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of ID1 mRNA] CTD PMID:16494909 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515 		JBrowse link
G IER3 immediate early response 3 multiple interactions EXP Dactinomycin inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA] CTD PMID:16849584 NCBI chr 6:30,743,199...30,744,547
Ensembl chr 6:30,743,199...30,744,548 		JBrowse link
G IER5 immediate early response 5 increases expression EXP Dactinomycin results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr 1:181,088,700...181,092,900
Ensembl chr 1:181,088,700...181,092,900 		JBrowse link
G IFNA1 interferon alpha 1 multiple interactions EXP Dactinomycin inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA] CTD PMID:15937643 NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316 		JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA] CTD PMID:15937643 NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IFNG interferon gamma multiple interactions EXP [Dactinomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA]; Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]] CTD PMID:15937643 PMID:16085646 PMID:26278786 PMID:29594315 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IGF1 insulin like growth factor 1 decreases response to substance ISO IGF1 protein results in decreased susceptibility to Dactinomycin CTD PMID:9525472 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IL10 interleukin 10 multiple interactions ISO Dactinomycin inhibits the reaction [Zymosan results in increased expression of IL10 mRNA] CTD PMID:17458858 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL11 interleukin 11 multiple interactions EXP Dactinomycin inhibits the reaction [Formaldehyde results in increased expression of IL11 mRNA] CTD PMID:22138297 NCBI chr19:55,364,382...55,370,463
Ensembl chr19:55,364,382...55,370,463 		JBrowse link
G IL17A interleukin 17A multiple interactions ISO Dactinomycin inhibits the reaction [Glucose results in increased secretion of IL17A protein] CTD PMID:18310510 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO Dactinomycin inhibits the reaction [IL1A protein results in increased expression of FOS mRNA] CTD PMID:7564102 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Dinoprostone]; Dactinomycin inhibits the reaction [IL1B results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [IL1B results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [IL1B results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [IL1B results in increased secretion of CSF2 protein]
Dactinomycin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]
Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA]		 CTD PMID:9606035 PMID:11286988 PMID:12512699 PMID:16338976 PMID:16365456 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP [Dactinomycin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL27RA interleukin 27 receptor subunit alpha increases expression EXP Dactinomycin results in increased expression of IL27RA mRNA CTD PMID:21527772 NCBI chr19:14,031,762...14,053,218
Ensembl chr19:14,031,762...14,053,218 		JBrowse link
G IL6 interleukin 6 decreases secretion EXP Dactinomycin results in decreased secretion of IL6 protein CTD PMID:11216681 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS insulin multiple interactions ISO Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with alitretinoin] results in increased expression of SLC27A1 mRNA] CTD PMID:10777552 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Dactinomycin inhibits the reaction [bisphenol A results in increased secretion of INS1 protein]; Dactinomycin inhibits the reaction [nonylphenol results in increased secretion of INS1 protein] CTD PMID:15778011 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G IRF1 interferon regulatory factor 1 multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin promotes the reaction [IFNG protein results in increased expression of IRF1 protein]]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of IRF1 mRNA] CTD PMID:16085646 PMID:16636311 NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719 		JBrowse link
G ITGA2B integrin subunit alpha 2b increases expression EXP Dactinomycin results in increased expression of ITGA2B mRNA CTD PMID:21527772 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649 		JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 multiple interactions EXP Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]; Dactinomycin inhibits the reaction [linsidomine results in increased expression of ITPR1 mRNA] CTD PMID:17241155 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506 		JBrowse link
G JAK2 Janus kinase 2 multiple interactions ISO Dactinomycin inhibits the reaction [Aldosterone results in increased phosphorylation of JAK2 protein] CTD PMID:15932931 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Dactinomycin results in decreased expression of JUN mRNA
Dactinomycin inhibits the reaction [Cadmium results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Fructose results in increased expression of JUN mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of JUN mRNA]		 CTD PMID:1696944 PMID:11123204 PMID:11353138 PMID:11568973 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KIF1A kinesin family member 1A increases expression EXP Dactinomycin results in increased expression of KIF1A mRNA CTD PMID:21527772 NCBI chr 2:240,713,767...240,821,403
Ensembl chr 2:240,713,761...240,824,293 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase multiple interactions EXP Dactinomycin inhibits the reaction [[KRAS protein mutant form affects the susceptibility to vemurafenib] which results in increased expression of TNFRSF10B mRNA] CTD PMID:27222248 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936 		JBrowse link
G KRT80 keratin 80 increases expression EXP Dactinomycin results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr12:52,168,996...52,192,014
Ensembl chr12:52,168,996...52,192,014 		JBrowse link
G LAMC2 laminin subunit gamma 2 increases expression EXP Dactinomycin results in increased expression of LAMC2 mRNA CTD PMID:21527772 NCBI chr 1:183,186,264...183,258,968
Ensembl chr 1:183,186,238...183,245,127 		JBrowse link
G LDLR low density lipoprotein receptor decreases expression
multiple interactions		 EXP Dactinomycin results in decreased expression of LDLR mRNA
Ascorbic Acid inhibits the reaction [Dactinomycin results in decreased expression of LDLR mRNA]		 CTD PMID:32913121 NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820 		JBrowse link
G LEP leptin multiple interactions ISO Dactinomycin inhibits the reaction [LEP protein results in increased expression of COL1A2 mRNA] CTD PMID:12704794 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LGALS3 galectin 3 multiple interactions EXP Dactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein] CTD PMID:21821001 NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423 		JBrowse link
G LGALS7 galectin 7 increases expression EXP Dactinomycin results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr19:38,770,968...38,773,517
Ensembl chr19:38,789,200...38,791,754
Ensembl chr19:38,789,200...38,791,754 		JBrowse link
G LMNB1 lamin B1 decreases expression EXP Dactinomycin results in decreased expression of LMNB1 mRNA CTD PMID:16001973 NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO Dactinomycin inhibits the reaction [Ethanol results in increased expression of MAP1LC3B protein] CTD PMID:24095927 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 decreases expression EXP Dactinomycin results in decreased expression of MAP2K4 mRNA CTD PMID:16001973 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 decreases expression EXP Dactinomycin results in decreased expression of MAP3K7 mRNA CTD PMID:16001973 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases expression		 EXP
ISO		 PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]
Dactinomycin results in increased expression of MAPK1 protein		 CTD PMID:14640974 PMID:15959627 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases expression		 EXP
ISO		 PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]
Dactinomycin results in increased expression of MAPK3 protein
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]		 CTD PMID:14640974 PMID:15959627 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 EXP Dactinomycin results in decreased expression of MCL1 mRNA
Dactinomycin inhibits the reaction [IL1B results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of MCL1 protein]; Quercetin promotes the reaction [Dactinomycin results in decreased expression of MCL1 mRNA]		 CTD PMID:16492401 PMID:21750559 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MIR21 microRNA 21 multiple interactions EXP Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [Estradiol results in decreased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA] CTD PMID:19264808 PMID:23052036 PMID:25969534 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MIR22 microRNA 22 multiple interactions EXP [Dactinomycin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA; Dactinomycin promotes the reaction [Dehydroepiandrosterone results in increased expression of MIR22 mRNA] CTD PMID:25969534 NCBI chr17:1,713,903...1,713,987
Ensembl chr17:1,713,903...1,713,987 		JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor increases expression EXP Dactinomycin results in increased expression of MLLT11 mRNA CTD PMID:21527772 NCBI chr 1:151,060,397...151,069,544
Ensembl chr 1:151,060,397...151,069,544 		JBrowse link
G MMP1 matrix metallopeptidase 1 multiple interactions EXP Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein] CTD PMID:19136476 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of MMP9 mRNA]
Dactinomycin results in decreased expression of MMP9 mRNA		 CTD PMID:24956101 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MN1 MN1 proto-oncogene, transcriptional regulator multiple interactions EXP Dactinomycin inhibits the reaction [Calcitriol results in increased expression of MN1 mRNA] CTD PMID:15890672 NCBI chr22:27,748,277...27,801,756
Ensembl chr22:27,748,277...27,801,756 		JBrowse link
G MRPL41 mitochondrial ribosomal protein L41 multiple interactions EXP Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein] CTD PMID:16024796 NCBI chr 9:137,551,879...137,552,555
Ensembl chr 9:137,551,879...137,552,555 		JBrowse link
G MT1X metallothionein 1X multiple interactions ISO Dactinomycin inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]]; Dactinomycin inhibits the reaction [Paraquat results in increased expression of MT1 mRNA] CTD PMID:8966720 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196 		JBrowse link
G MT2A metallothionein 2A multiple interactions EXP Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA] CTD PMID:17234632 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497 		JBrowse link
G MTTP microsomal triglyceride transfer protein multiple interactions ISO Dactinomycin inhibits the reaction [pirinixic acid results in increased expression of MTTP mRNA] CTD PMID:15537571 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 EXP
ISO		 Dactinomycin results in decreased expression of MYC mRNA
Dactinomycin inhibits the reaction [Cadmium results in increased expression of MYC mRNA]
Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of MYC mRNA]		 CTD PMID:1696944 PMID:11353138 PMID:16001973 PMID:21527772 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein] CTD PMID:15701621 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332 		JBrowse link
G NAV2 neuron navigator 2 multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of NAV2 mRNA] CTD PMID:16688769 NCBI chr11:19,345,236...20,121,601
Ensembl chr11:19,350,724...20,121,601 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions EXP Dactinomycin inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA] CTD PMID:19559082 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315 		JBrowse link
G NDRG1 N-myc downstream regulated 1 multiple interactions ISO [nickel chloride co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA; [Oxygen deficiency co-treated with Dactinomycin] results in increased stability of NDRG1 mRNA CTD PMID:10646848 NCBI chr 8:133,237,175...133,297,252
Ensembl chr 8:133,237,175...133,302,022 		JBrowse link
G NEDD9 neural precursor cell expressed, developmentally down-regulated 9 multiple interactions EXP Dactinomycin inhibits the reaction [Tretinoin results in increased expression of NEDD9 mRNA] CTD PMID:16688769 NCBI chr 6:11,183,298...11,382,348
Ensembl chr 6:11,183,298...11,382,348 		JBrowse link
G NETO2 neuropilin and tolloid like 2 increases expression EXP Dactinomycin results in increased expression of NETO2 mRNA CTD PMID:21527772 NCBI chr16:47,077,703...47,143,945
Ensembl chr16:47,077,703...47,143,945 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Dactinomycin inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of NFE2L2 mRNA] CTD PMID:22019695 PMID:24632381 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression
multiple interactions		 EXP Dactinomycin results in decreased expression of NFKB1 mRNA
[RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]		 CTD PMID:11880364 PMID:16001973 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]] CTD PMID:11880364 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NGF nerve growth factor multiple interactions
decreases expression		 ISO Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA]; Dactinomycin inhibits the reaction [NEPP11 compound results in increased expression of NGF mRNA]
Dactinomycin results in decreased expression of NGF mRNA		 CTD PMID:22982731 NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions EXP Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA] CTD PMID:23937860 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]
Dactinomycin inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]		 CTD PMID:11286988 PMID:28138957 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPPC natriuretic peptide C multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of NPPC mRNA] CTD PMID:9435603 NCBI chr 2:231,921,809...231,926,396
Ensembl chr 2:231,921,809...231,926,396 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO Dactinomycin inhibits the reaction [Biological Products results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Ketoconazole results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Lead results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Mercury results in increased expression of NQO1 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Dactinomycin promotes the reaction [Chromium inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]
Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]		 CTD PMID:16243960 PMID:17923278 PMID:18474416 PMID:22570534 PMID:24437944 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR0B1 nuclear receptor subfamily 0 group B member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Bucladesine results in decreased expression of NR0B1 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of NR0B1 mRNA] CTD PMID:18787026 NCBI chr  X:30,304,206...30,309,390
Ensembl chr  X:30,304,206...30,309,390 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 multiple interactions EXP Dactinomycin inhibits the reaction [Fenofibrate results in increased expression of NR0B2 mRNA] CTD PMID:19593819 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP Dactinomycin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Clofibrate results in increased expression of NR1I2 protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of NR1I2 mRNA]; Dactinomycin inhibits the reaction [perfluorodecanoic acid results in increased expression of NR1I2 protein]
Dactinomycin inhibits the reaction [ochratoxin A results in decreased expression of NR1I2 mRNA]		 CTD PMID:15826607 PMID:20599767 PMID:26341324 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Dexamethasone affects the localization of NR3C1 protein]; Dactinomycin inhibits the reaction [Dexamethasone binds to NR3C1 protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased degradation of NR3C1 protein] CTD PMID:21569845 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512 		JBrowse link
G NTHL1 nth like DNA glycosylase 1 decreases expression EXP Dactinomycin results in decreased expression of NTHL1 mRNA CTD PMID:21527772 NCBI chr16:2,039,820...2,047,834
Ensembl chr16:2,039,815...2,047,866 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions ISO Dactinomycin inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of OPA1 protein alternative form] CTD PMID:20678484 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811 		JBrowse link
G PAPPA pappalysin 1 multiple interactions EXP Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA] CTD PMID:16338976 NCBI chr 9:116,153,791...116,402,321
Ensembl chr 9:116,153,791...116,402,321 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP
ISO		 [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein; Dactinomycin promotes the reaction [TNF results in increased cleavage of PARP1 protein]; PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]
PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]		 CTD PMID:14640974 PMID:16492401 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO Dactinomycin inhibits the reaction [Hydrocortisone results in increased activity of PCK1 protein] CTD PMID:6476976 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO
EXP		 Dactinomycin results in decreased expression of PCNA protein
Dactinomycin inhibits the reaction [Vitamin K 3 results in decreased expression of PCNA protein]		 CTD PMID:15959627 PMID:21533478 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PLAT plasminogen activator, tissue type multiple interactions EXP Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]; Dactinomycin inhibits the reaction [Resveratrol results in increased expression of PLAT mRNA] CTD PMID:11236827 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709 		JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions
increases expression		 EXP Dactinomycin inhibits the reaction [Catechin results in increased expression of PLAU mRNA]; Dactinomycin inhibits the reaction [Quercetin results in increased expression of PLAU mRNA]; Dactinomycin inhibits the reaction [resveratrol results in increased expression of PLAU mRNA]
Dactinomycin results in increased expression of PLAU mRNA		 CTD PMID:11236827 PMID:21527772 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PLD1 phospholipase D1 multiple interactions EXP PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]; PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:14640974 NCBI chr 3:171,600,404...171,810,483
Ensembl chr 3:171,600,404...171,810,950 		JBrowse link
G PLD2 phospholipase D2 multiple interactions ISO PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PARP1 protein]; PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of AKT1 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:14640974 NCBI chr17:4,807,152...4,823,430
Ensembl chr17:4,807,152...4,823,434 		JBrowse link
G POLH DNA polymerase eta multiple interactions EXP Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA] CTD PMID:25125662 NCBI chr 6:43,576,185...43,620,523
Ensembl chr 6:43,576,185...43,620,523 		JBrowse link
G POLR2A RNA polymerase II subunit A decreases phosphorylation
increases phosphorylation
multiple interactions		 EXP Dactinomycin results in decreased phosphorylation of POLR2A protein
Dactinomycin results in increased phosphorylation of POLR2A protein
[Dactinomycin co-treated with sodium arsenite] results in increased phosphorylation of POLR2A protein		 CTD PMID:8126066 NCBI chr17:7,484,366...7,514,616
Ensembl chr17:7,484,366...7,514,616 		JBrowse link
G POMT1 protein O-mannosyltransferase 1 increases expression EXP Dactinomycin results in increased expression of POMT1 mRNA CTD PMID:21527772 NCBI chr 9:131,502,918...131,523,799
Ensembl chr 9:131,502,789...131,523,806 		JBrowse link
G PRDX1 peroxiredoxin 1 multiple interactions ISO Dactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 mRNA]; Dactinomycin inhibits the reaction [sodium arsenate results in increased expression of PRDX1 protein] CTD PMID:11796722 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732 		JBrowse link
G PRDX6 peroxiredoxin 6 multiple interactions ISO Dactinomycin inhibits the reaction [Hydrogen Peroxide results in increased expression of PRDX6 mRNA]; Dactinomycin inhibits the reaction [Paraquat results in increased expression of PRDX6 mRNA] CTD PMID:12851211 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815 		JBrowse link
G PRKCD protein kinase C delta multiple interactions EXP
ISO		 PLD1 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]
PLD2 protein inhibits the reaction [Dactinomycin results in increased cleavage of PRKCD protein]		 CTD PMID:14640974 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PRL prolactin multiple interactions ISO Dactinomycin inhibits the reaction [PRL protein results in increased expression of SLC30A2 mRNA] CTD PMID:19494234 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PROCR protein C receptor increases expression EXP Dactinomycin results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240 		JBrowse link
G PROM1 prominin 1 multiple interactions
decreases expression		 EXP Dactinomycin results in decreased expression of and affects the localization of PROM1 protein
Dactinomycin results in decreased expression of PROM1 mRNA		 CTD PMID:31226288 NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases degradation
decreases expression		 EXP
ISO		 Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Sodium Fluoride results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Zinc results in increased expression of PTGS2 protein]
Dactinomycin results in increased degradation of PTGS2 mRNA
CDKN1B protein affects the reaction [Dactinomycin results in increased degradation of PTGS2 mRNA]; Dactinomycin inhibits the reaction [nickel chloride results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [nickel sulfide results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]
Dactinomycin results in decreased expression of PTGS2 mRNA
Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 mRNA]; Dactinomycin inhibits the reaction [Corticosterone results in increased expression of PTGS2 protein]; Dactinomycin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]		 CTD PMID:9576062 PMID:11286988 PMID:16894348 PMID:17065197 PMID:18513776 More... NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTK2 protein tyrosine kinase 2 decreases expression ISO Dactinomycin results in decreased expression of PTK2 protein CTD PMID:15959627 NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216 		JBrowse link
G RAD51 RAD51 recombinase decreases expression
multiple interactions		 EXP Dactinomycin results in decreased expression of RAD51 mRNA
tetrachlorobenzoquinone promotes the reaction [Dactinomycin results in decreased expression of RAD51 mRNA]		 CTD PMID:27989139 NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO Dactinomycin results in decreased expression of RAF1 protein CTD PMID:15959627 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit multiple interactions EXP [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP [RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; RELA protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G REN renin multiple interactions EXP Dactinomycin inhibits the reaction [Dobutamine results in increased secretion of REN protein]; Dactinomycin inhibits the reaction [Terbutaline results in increased secretion of REN protein] CTD PMID:9203624 NCBI chr 1:204,154,819...204,166,337
Ensembl chr 1:204,154,819...204,190,324 		JBrowse link
G RETSAT retinol saturase increases expression EXP Dactinomycin results in increased expression of RETSAT mRNA CTD PMID:21527772 NCBI chr 2:85,341,955...85,354,528
Ensembl chr 2:85,341,955...85,354,531 		JBrowse link
G RHOB ras homolog family member B multiple interactions ISO Dactinomycin inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB mRNA]; Dactinomycin inhibits the reaction [cytotoxic necrotizing factor type 1 results in increased expression of RHOB protein] CTD PMID:23732113 NCBI chr 2:20,447,074...20,449,440
Ensembl chr 2:20,447,074...20,449,440 		JBrowse link
G RIPPLY3 ripply transcriptional repressor 3 increases expression EXP Dactinomycin results in increased expression of RIPPLY3 mRNA CTD PMID:21527772 NCBI chr21:37,006,150...37,019,662
Ensembl chr21:37,006,150...37,019,662 		JBrowse link
G RNF213 ring finger protein 213 multiple interactions EXP Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA] CTD PMID:26278786 NCBI chr17:80,260,852...80,398,794
Ensembl chr17:80,260,852...80,398,794 		JBrowse link
G RNY1 RNA, Ro60-associated Y1 increases degradation EXP Dactinomycin results in increased degradation of RNY1 mRNA CTD PMID:10455152 NCBI chr 7:148,987,136...148,987,248
Ensembl chr 7:148,987,136...148,987,248 		JBrowse link
G RNY3 RNA, Ro60-associated Y3 increases degradation EXP Dactinomycin results in increased degradation of RNY3 mRNA CTD PMID:10455152 NCBI chr 7:148,983,755...148,983,856
Ensembl chr 7:148,983,755...148,983,856 		JBrowse link
G RNY4 RNA, Ro60-associated Y4 increases degradation EXP Dactinomycin results in increased degradation of RNY4 mRNA CTD PMID:10455152 NCBI chr 7:148,963,315...148,963,410
Ensembl chr 7:148,963,315...148,963,410 		JBrowse link
G RNY5 RNA, Ro60-associated Y5 increases degradation EXP Dactinomycin results in increased degradation of RNY5 mRNA CTD PMID:10455152 NCBI chr 7:148,941,488...148,941,571 JBrowse link
G ROS1 ROS proto-oncogene 1, receptor tyrosine kinase increases expression EXP Dactinomycin results in increased expression of ROS1 mRNA CTD PMID:16001973 NCBI chr 6:117,287,353...117,425,942
Ensembl chr 6:117,287,353...117,425,942 		JBrowse link
G RPL34 ribosomal protein L34 increases expression EXP Dactinomycin results in increased expression of RPL34 mRNA CTD PMID:21527772 NCBI chr 4:108,620,576...108,630,484
Ensembl chr 4:108,620,569...108,630,412 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP
ISO		 PLD1 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
PLD2 protein promotes the reaction [Dactinomycin results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]		 CTD PMID:14640974 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G RRAS RAS related increases expression EXP Dactinomycin results in increased expression of RRAS mRNA CTD PMID:21527772 NCBI chr19:49,635,292...49,640,143
Ensembl chr19:49,635,292...49,640,143 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 multiple interactions EXP Dactinomycin inhibits the reaction [N(1),N(11)-diethylnorspermine results in increased expression of SAT1 mRNA] CTD PMID:16637064 NCBI chr  X:23,783,173...23,786,210
Ensembl chr  X:23,783,173...23,786,210 		JBrowse link
G SCD stearoyl-CoA desaturase multiple interactions EXP Dactinomycin inhibits the reaction [ciprofibrate results in increased expression of SCD1 mRNA] CTD PMID:11172741 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826 		JBrowse link
G SCNN1B sodium channel epithelial 1 subunit beta multiple interactions EXP Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1B mRNA] CTD PMID:10942727 NCBI chr16:23,278,231...23,381,294
Ensembl chr16:23,278,231...23,381,294 		JBrowse link
G SCNN1G sodium channel epithelial 1 subunit gamma multiple interactions EXP Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of SCNN1G mRNA] CTD PMID:10942727 NCBI chr16:23,182,745...23,216,883
Ensembl chr16:23,182,745...23,216,883 		JBrowse link
G SDC3 syndecan 3 multiple interactions ISO Dactinomycin inhibits the reaction [Estradiol results in increased expression of SDC3 mRNA] CTD PMID:11024013 NCBI chr 1:30,869,466...30,909,735
Ensembl chr 1:30,869,466...30,908,758 		JBrowse link
G SESN2 sestrin 2 multiple interactions EXP Dactinomycin inhibits the reaction [erastin results in increased expression of SESN2 mRNA] CTD PMID:31323261 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491 		JBrowse link
G SFN stratifin increases expression EXP Dactinomycin results in increased expression of SFN mRNA CTD PMID:21527772 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456 		JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 multiple interactions EXP Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 mRNA]; Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of SGK1 protein] CTD PMID:25128767 NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112 		JBrowse link
G SHH sonic hedgehog signaling molecule multiple interactions EXP Dactinomycin inhibits the reaction [SHH protein alternative form results in increased expression of ABCG2 protein] CTD PMID:21625222 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP
ISO		 Dactinomycin affects the reaction [antimony trichloride results in decreased expression of SIRT1 mRNA]
TAF15 mRNA inhibits the reaction [Dactinomycin results in decreased expression of SIRT1 mRNA]		 CTD PMID:30055241 PMID:35307376 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC25A14 solute carrier family 25 member 14 multiple interactions EXP Dactinomycin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SLC25A14 mRNA]; Dactinomycin inhibits the reaction [Dopamine results in increased expression of SLC25A14 mRNA] CTD PMID:20600837 NCBI chr  X:130,339,919...130,373,357
Ensembl chr  X:130,339,888...130,373,361 		JBrowse link
G SLC27A1 solute carrier family 27 member 1 multiple interactions ISO Dactinomycin inhibits the reaction [[[Dexamethasone co-treated with INS protein co-treated with 1-Methyl-3-isobutylxanthine] co-treated with alitretinoin] results in increased expression of SLC27A1 mRNA]
Dactinomycin inhibits the reaction [alitretinoin results in increased expression of SLC27A1 mRNA]		 CTD PMID:10777552 NCBI chr19:17,468,767...17,506,168
Ensembl chr19:17,468,769...17,506,168 		JBrowse link
G SLC2A2 solute carrier family 2 member 2 multiple interactions ISO Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A2 mRNA]; Dactinomycin inhibits the reaction [Glucose results in increased expression of SLC2A2 mRNA] CTD PMID:12787936 NCBI chr 3:170,996,347...171,026,720
Ensembl chr 3:170,996,347...171,026,743 		JBrowse link
G SLC2A5 solute carrier family 2 member 5 multiple interactions ISO Dactinomycin inhibits the reaction [Fructose promotes the reaction [SLC2A5 protein results in increased uptake of Fructose]]; Dactinomycin inhibits the reaction [Fructose results in increased expression of SLC2A5 mRNA] CTD PMID:11123204 NCBI chr 1:9,035,106...9,094,195
Ensembl chr 1:9,035,106...9,088,478 		JBrowse link
G SLC30A2 solute carrier family 30 member 2 multiple interactions ISO Dactinomycin inhibits the reaction [PRL protein results in increased expression of SLC30A2 mRNA] CTD PMID:19494234 NCBI chr 1:26,037,252...26,046,118
Ensembl chr 1:26,037,252...26,046,118 		JBrowse link
G SLC30A5 solute carrier family 30 member 5 multiple interactions EXP Dactinomycin inhibits the reaction [zinc chloride results in decreased expression of SLC30A5 mRNA] CTD PMID:17234632 NCBI chr 5:69,094,014...69,131,069
Ensembl chr 5:69,093,991...69,131,069 		JBrowse link
G SLC39A10 solute carrier family 39 member 10 multiple interactions ISO Dactinomycin inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA] CTD PMID:21738690 NCBI chr 2:195,613,029...195,737,700
Ensembl chr 2:195,575,977...195,737,702 		JBrowse link
G SLC39A4 solute carrier family 39 member 4 multiple interactions ISO Dactinomycin inhibits the reaction [Zinc deficiency results in increased expression of SLC39A4 mRNA]; Dactinomycin inhibits the reaction [Zinc results in decreased expression of SLC39A4 mRNA] CTD PMID:18020946 NCBI chr 8:144,412,414...144,416,844
Ensembl chr 8:144,409,742...144,416,844 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 multiple interactions EXP Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of SLC3A2 mRNA] CTD PMID:26621329 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC40A1 solute carrier family 40 member 1 multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA] CTD PMID:20090884 NCBI chr 2:189,560,590...189,580,786
Ensembl chr 2:189,560,590...189,583,758 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 decreases expression EXP Dactinomycin results in decreased expression of SLC7A11 protein CTD PMID:31226288 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 multiple interactions EXP Dactinomycin inhibits the reaction [Vehicle Emissions results in increased expression of SLC7A5 mRNA] CTD PMID:26621329 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 multiple interactions EXP Dactinomycin inhibits the reaction [diethyl maleate results in increased expression of SMPD1 mRNA] CTD PMID:25762726 NCBI chr11:6,390,474...6,394,996
Ensembl chr11:6,390,440...6,394,998 		JBrowse link
G SNCA synuclein alpha multiple interactions ISO Dactinomycin inhibits the reaction [FGF2 protein results in increased expression of SNCA protein] CTD PMID:12562524 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 multiple interactions ISO Dactinomycin inhibits the reaction [Cycloheximide results in increased expression of SOCS3 mRNA] CTD PMID:23237828 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Paclitaxel results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [SOD2 protein results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vinblastine results in increased expression of SOD2 mRNA]; Dactinomycin inhibits the reaction [Vincristine results in increased expression of SOD2 mRNA]; SOD2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]
Dactinomycin inhibits the reaction [polysaccharide-K results in increased expression of SOD2]
Dactinomycin inhibits the reaction [[2,2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA]		 CTD PMID:9852137 PMID:11154046 PMID:11880364 PMID:12031898 PMID:14996425 More... NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression EXP Dactinomycin results in decreased expression of SOS1 mRNA CTD PMID:16001973 NCBI chr 2:38,981,549...39,124,868
Ensembl chr 2:38,962,206...39,124,345 		JBrowse link
G SOX17 SRY-box transcription factor 17 decreases localization EXP Dactinomycin results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 8:54,457,935...54,460,892
Ensembl chr 8:54,457,935...54,460,892 		JBrowse link
G SPATA18 spermatogenesis associated 18 increases expression EXP Dactinomycin results in increased expression of SPATA18 mRNA CTD PMID:21527772 NCBI chr 4:52,051,304...52,097,299
Ensembl chr 4:52,051,304...52,097,299 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]
Dactinomycin inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone results in increased expression of SQSTM1 mRNA]		 CTD PMID:24095927 PMID:25301941 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 increases expression EXP Dactinomycin results in increased expression of STAT1 mRNA CTD PMID:16001973 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STMN3 stathmin 3 increases expression EXP Dactinomycin results in increased expression of STMN3 mRNA CTD PMID:21527772 NCBI chr20:63,639,712...63,653,424
Ensembl chr20:63,639,705...63,657,682 		JBrowse link
G STOM stomatin increases expression EXP Dactinomycin results in increased expression of STOM mRNA CTD PMID:21527772 NCBI chr 9:121,338,987...121,370,250
Ensembl chr 9:121,338,987...121,370,304 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 multiple interactions EXP Dactinomycin inhibits the reaction [Gallic Acid results in increased expression of SULT1A1 mRNA] CTD PMID:16308312 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G TAF15 TATA-box binding protein associated factor 15 multiple interactions ISO TAF15 mRNA inhibits the reaction [Dactinomycin results in decreased expression of SIRT1 mRNA] CTD PMID:35307376 NCBI chr17:35,809,484...35,847,242
Ensembl chr17:35,809,482...35,864,615 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member increases expression EXP Dactinomycin results in increased expression of TAP1 mRNA CTD PMID:21527772 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816 		JBrowse link
G TAT tyrosine aminotransferase multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Dexamethasone results in increased activity of TAT protein]; Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Dactinomycin inhibits the reaction [Ursodeoxycholic Acid promotes the reaction [Dexamethasone results in increased activity of TAT protein]] CTD PMID:9398635 PMID:20599767 PMID:28483492 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092 		JBrowse link
G TBX3 T-box transcription factor 3 multiple interactions EXP actinomycin D inhibits the reaction [all-trans-retinoic acid increases expression of TBX3 mRNA in melanoma cells] RGD PMID:22535523 RGD:151361117 NCBI chr12:114,670,255...114,684,175
Ensembl chr12:114,670,255...114,684,175 		JBrowse link
G TCF4 transcription factor 4 multiple interactions ISO Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of TCF4 mRNA] CTD PMID:20459685 NCBI chr18:55,222,185...55,635,957
Ensembl chr18:55,222,185...55,664,787 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase affects activity ISO Dactinomycin affects the activity of TDO2 protein CTD PMID:7306070 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP Dactinomycin inhibits the reaction [IL1B protein results in increased expression of TGFB1 mRNA]; Dactinomycin inhibits the reaction [IL1B protein results in increased secretion of TGFB1 protein]; Dactinomycin inhibits the reaction [TGFB1 protein results in decreased expression of AHR mRNA] CTD PMID:9145908 PMID:16365456 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFB2 transforming growth factor beta 2 multiple interactions EXP Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of COL1A1 mRNA]; Dactinomycin inhibits the reaction [TGFB2 protein results in increased expression of FN1 mRNA] CTD PMID:18253093 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619 		JBrowse link
G THRA thyroid hormone receptor alpha multiple interactions ISO Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Dactinomycin inhibits the reaction [IL1B protein results in decreased expression of THRA mRNA] CTD PMID:17641275 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867 		JBrowse link
G TIPARP TCDD inducible poly(ADP-ribose) polymerase multiple interactions ISO Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 3:156,674,590...156,706,770
Ensembl chr 3:156,673,235...156,706,770 		JBrowse link
G TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 multiple interactions EXP Dactinomycin inhibits the reaction [Dihydrotestosterone results in increased expression of TMEFF2 mRNA] CTD PMID:23405127 NCBI chr 2:191,949,046...192,194,933
Ensembl chr 2:191,949,043...192,194,933 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases response to substance		 ISO
EXP		 [Dactinomycin co-treated with TNF protein] results in increased expression of BNIP3 mRNA; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]
[Dactinomycin co-treated with TNF protein] results in increased activity of CASP3 protein; Dactinomycin inhibits the reaction [TNF protein results in increased expression of EDNRB mRNA]
[RELA protein co-treated with NFKB1 protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [RELA protein co-treated with REL protein] inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; [TNF co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF co-treated with Dactinomycin] results in increased activity of CASP7 protein; [TNF co-treated with Dactinomycin] results in increased cleavage of PARP1 protein; [TNF protein co-treated with Dactinomycin] results in decreased expression of TP53 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP3 protein; [TNF protein co-treated with Dactinomycin] results in increased activity of CASP7 protein; BCL2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; BCL2A1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; BIRC3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; Dactinomycin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of RNF213 mRNA]; Dactinomycin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL11 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of MYLK protein]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of PAPPA mRNA]; Dactinomycin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Dactinomycin inhibits the reaction [TNF results in increased abundance of Nitric Oxide]; Dactinomycin inhibits the reaction [TNF results in increased expression of BCL2 protein]; Dactinomycin inhibits the reaction [TNF results in increased expression of MCL1 protein]; Dactinomycin inhibits the reaction [Zinc deficiency promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF protein]]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP3 protein]; Dactinomycin promotes the reaction [TNF results in increased activity of CASP7 protein]; Dactinomycin promotes the reaction [TNF results in increased cleavage of PARP1 protein]; HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; NFKBIA protein inhibits the reaction [HMOX1 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]]; RELA protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; SOD2 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]; TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein]		 CTD PMID:9576062 PMID:10100995 PMID:11592958 PMID:11880364 PMID:12479793 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions EXP TNFAIP3 protein inhibits the reaction [Dactinomycin results in increased susceptibility to TNF protein] CTD PMID:11880364 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a multiple interactions ISO Dactinomycin inhibits the reaction [tetrachlorobenzoquinone results in increased expression of TNFRSF10B mRNA] CTD PMID:27484784 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b decreases expression
multiple interactions		 EXP Dactinomycin results in decreased expression of TNFRSF10B mRNA
Dactinomycin inhibits the reaction [[KRAS protein mutant form affects the susceptibility to Vemurafenib] which results in increased expression of TNFRSF10B mRNA]; Dactinomycin inhibits the reaction [Celecoxib results in increased expression of TNFRSF10B mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of TNFRSF10B mRNA]		 CTD PMID:15572759 PMID:27222248 PMID:32506763 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFSF10 TNF superfamily member 10 multiple interactions EXP [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP7 protein; [Dactinomycin co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; [Dactinomycin co-treated with TNFSF10 protein] results in increased expression of AIFM1 protein CTD PMID:17707539 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TNFSF9 TNF superfamily member 9 increases expression EXP Dactinomycin results in increased expression of TNFSF9 mRNA CTD PMID:21527772 NCBI chr19:6,531,026...6,535,924
Ensembl chr19:6,531,026...6,535,924 		JBrowse link
G TOP1 DNA topoisomerase I increases activity ISO Dactinomycin results in increased activity of TOP1 protein CTD PMID:2164630 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases activity
increases expression		 EXP [TNF protein co-treated with Dactinomycin] results in decreased expression of TP53 protein; Cadmium Chloride inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Cadmium inhibits the reaction [Dactinomycin results in increased expression of and results in increased activity of TP53 protein]; Dactinomycin promotes the reaction [MRPL41 protein results in increased stability of and affects the localization of TP53 protein]; Dactinomycin results in increased expression of and affects the localization of TP53 protein; Dactinomycin results in increased expression of and results in increased activity of TP53 protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]
Actinomycin D inhibits the reaction [Sunitinib increases expression of TP53 mRNA and protein in breast epithelium]
Dactinomycin results in increased activity of TP53 protein
Dactinomycin results in increased expression of TP53 protein; Dactinomycin results in increased expression of TP53 protein modified form		 CTD
RGD		 PMID:10531375 PMID:12807743 PMID:12869419 PMID:12927789 PMID:16024796 More... RGD:150537096 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TP53I11 tumor protein p53 inducible protein 11 multiple interactions
decreases expression		 EXP Dactinomycin inhibits the reaction [arsenic trioxide results in increased expression of TP53I11 mRNA]
Dactinomycin results in decreased expression of TP53I11 mRNA		 CTD PMID:19333544 NCBI chr11:44,932,348...44,951,306
Ensembl chr11:44,885,903...44,951,306 		JBrowse link
G TRPV6 transient receptor potential cation channel subfamily V member 6 multiple interactions EXP Dactinomycin inhibits the reaction [1,25-dihydroxyvitamin D results in increased expression of TRPV6 mRNA] CTD PMID:16362534 NCBI chr 7:142,871,208...142,885,745
Ensembl chr 7:142,871,208...142,885,745 		JBrowse link
G TUBA4A tubulin alpha 4a increases expression EXP Dactinomycin results in increased expression of TUBA4A mRNA CTD PMID:21527772 NCBI chr 2:219,249,710...219,254,740
Ensembl chr 2:219,249,710...219,277,902 		JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions EXP Dactinomycin inhibits the reaction [Acrolein results in increased expression of TXNRD1 mRNA]; Dactinomycin inhibits the reaction [sulforaphane results in increased expression of TXNRD1 mRNA] CTD PMID:12663510 PMID:15652504 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G TYMP thymidine phosphorylase multiple interactions EXP Dactinomycin inhibits the reaction [IFNA1 protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [IFNB1 protein results in increased expression of TYMP mRNA]; Dactinomycin inhibits the reaction [IFNG protein results in increased expression of TYMP mRNA]; Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]; tanespimycin inhibits the reaction [Dactinomycin promotes the reaction [salinomycin results in increased expression of TYMP mRNA]] CTD PMID:15937643 PMID:30796972 NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032 		JBrowse link
G TYR tyrosinase multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein]
Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein]		 CTD PMID:14717847 PMID:15278367 NCBI chr11:89,177,875...89,295,759
Ensembl chr11:89,177,875...89,295,759 		JBrowse link
G UBE2L3 ubiquitin conjugating enzyme E2 L3 multiple interactions ISO Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of UBE2L3 mRNA] CTD PMID:26318284 NCBI chr22:21,549,447...21,624,034
Ensembl chr22:21,549,447...21,624,034 		JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO Dactinomycin inhibits the reaction [Mevinphos results in increased expression of UCHL1 protein] CTD PMID:15545831 NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions ISO
EXP		 Dactinomycin inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]
Dactinomycin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]		 CTD PMID:10100995 PMID:12892526 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP
ISO		 Dactinomycin inhibits the reaction [oxaliplatin results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of VEGFA mRNA]
Dactinomycin inhibits the reaction [Cobalt results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA alternative form]; Dactinomycin inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]; Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]		 CTD PMID:8344219 PMID:10751333 PMID:11641398 PMID:16386082 PMID:18790786 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VIM vimentin multiple interactions EXP Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of VIM mRNA] CTD PMID:9044050 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
G VMP1 vacuole membrane protein 1 multiple interactions
decreases expression		 EXP [Dactinomycin co-treated with fludioxonil] results in decreased expression of VMP1 mRNA; Dactinomycin inhibits the reaction [Dehydroepiandrosterone results in increased expression of VMP1 mRNA]; Dactinomycin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of VMP1 mRNA]
Dactinomycin results in decreased expression of VMP1 mRNA		 CTD PMID:23052036 PMID:25969534 NCBI chr17:59,707,654...59,842,255
Ensembl chr17:59,707,192...59,842,255 		JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP Dactinomycin results in decreased expression of XIAP protein CTD PMID:12430140 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G YTHDF1 YTH N6-methyladenosine RNA binding protein F1 multiple interactions EXP YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]; YTHDF2 protein affects the reaction [YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]] CTD PMID:37061066 NCBI chr20:63,195,429...63,216,131
Ensembl chr20:63,195,429...63,216,139 		JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 multiple interactions EXP YTHDF1 protein affects the reaction [YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]]; YTHDF2 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]; YTHDF2 protein affects the reaction [YTHDF1 protein affects the reaction [Dactinomycin results in decreased stability of AKT1 mRNA]] CTD PMID:37061066 NCBI chr 1:28,736,624...28,769,775
Ensembl chr 1:28,736,621...28,769,775 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26046
    role 25962
      biological role 25941
        aetiopathogenetic role 24604
          genotoxin 20132
            mutagen 19901
              actinomycin D 314
Path 2
Term Annotations click to browse term
  CHEBI ontology 26046
    subatomic particle 26021
      composite particle 26021
        hadron 26021
          baryon 26021
            nucleon 26021
              atomic nucleus 26021
                atom 26021
                  main group element atom 25846
                    p-block element atom 25846
                      carbon group element atom 25443
                        carbon atom 25401
                          organic molecular entity 25401
                            heteroorganic entity 24779
                              organochalcogen compound 24391
                                organooxygen compound 24069
                                  carbon oxoacid 22771
                                    carboxylic acid 22751
                                      carboacyl group 20074
                                        univalent carboacyl group 20074
                                          carbamoyl group 19588
                                            carboxamide 19588
                                              peptide 11628
                                                peptide antibiotic 1812
                                                  chromopeptide 314
                                                    actinomycin 314
                                                      actinomycin D 314
paths to the root