ABCC1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1)

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Keyword

Gene: ABCC1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1) Homo sapiens

Symbol:

ABCC1

Name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Description:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ABC29; ABCC; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13&14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25&26; DKFZp686N04233; DKFZp781G125; GS-X; leukotriene C(4) transporter; LTC4 transporter; MRP; MRP1; multidrug resistance associated protein 1; multidrug resistance protein; multidrug resistance-associated protein 1; multiple drug resistance protein 1; multiple drug resistance-associated protein; OTTHUMP00000045904

Orthologs:

Mus musculus : Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1) MGI
Rattus norvegicus : Abcc1 (ATP-binding cassette, subfamily C (CFTR/MRP), member 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	16	16,134,963 - 16,270,239	+	NCBI
Human Genome Assembly HuRef	16	15,436,705 - 15,630,893	+	NCBI
Human Genome Assembly GRCh37	16	16,043,434 - 16,236,931	+	NCBI
Human Genome Assembly Build 36	16	15,950,935 - 16,144,432	+	NCBI
Human Cytogenetic Map	16	p13.1		NCBI
Human Genome Assembly	16	15,950,934 - 16,143,774		NCBI