Gene: INS (insulin)  Homo sapiens Symbol: INS Name: insulin Description: After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Type: protein-coding RefSeq Status: REVIEWED Also known as: IDDM2; ILPR; insulin; IRDN; MODY10; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519; preproinsulin; proinsulin Orthologs: Mus musculus : Ins2 (insulin II)  MGI Rattus norvegicus : Ins2 (insulin 2) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 2,114,901 - 2,116,331 - NCBI Human Genome Assembly HuRef 11 1,971,272 - 1,972,702 - NCBI Human Genome Assembly GRCh37 11 2,181,009 - 2,182,439 - NCBI Human Genome Assembly Build 36 11 2,137,585 - 2,139,015 - NCBI Human Cytogenetic Map 11 p15.5   NCBI Human Genome Assembly 11 2,137,584 - 2,139,000   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Adenoma   ISS RGD:10812 2317273 protein:increased secretion:serum RGD   Alzheimer Disease   ISS RGD:2916 2298713 mRNA:decreased expression:cerebral cortex RGD   Carcinoma, Pancreatic Ductal   IEP   2317248 Glucagon/insulin RGD   Diabetes Mellitus   IED   2317260 protein:altered localization :endoplasmic reticulum RGD   Diabetes Mellitus   IAGP   2317259 DNA, protein:missense mutations:exons:multiple RGD   Diabetes Mellitus   ISS RGD:10812 2311115 DNA:point mutation (mouse) RGD   Diabetes Mellitus   IPM   2311109   RGD   Diabetes Mellitus   IED   2317262 DNA, protein:missense mutations, altered processing:exons, endoplasmic reticulum:multiple RGD   Diabetes Mellitus, Experimental   ISS RGD:2915 4142788 protein:decreased expression:heart RGD   Diabetes Mellitus, Permanent Neonatal   IEA   7240710   OMIM   Diabetes Mellitus, Type 1   IPM   2311114   RGD   Diabetes Mellitus, Type 2   IAGP   1625120 DNA:polymorphism:promoter RGD   Diabetes Mellitus, Type 2   IGI RGD:1353354 2311111   RGD   Diabetes Mellitus, Type 2   IEP   2311112   RGD   Diabetes, Gestational   IEP   2311131 protein:increased expression:serum RGD   Diabetic Nephropathies Resistance ISS RGD:2916 6902908   RGD   Diabetic Retinopathy   IED   6902909   RGD   Fatty Liver   IEP   2311137 associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD   Hyperinsulinism   IAGP   1625121   RGD   Hyperinsulinism   IEA   7240710   OMIM   Hypertension   ISS RGD:2916 6902896   RGD   Hyperuricemia   IEP   6902897   RGD   Insulin Resistance   IEP   2311112   RGD   Insulinoma   IED   2317266 protein:altered expression:blood RGD   Insulinoma   IED   2317268 protein:altered localization:pancreas RGD   MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10   IEA   7240710   OMIM   Obesity   IAGP   1625118   RGD   Pancreatic Neoplasms Susceptibility IED   2317250 associated with Diabetes Mellitus RGD   Pancreatic Neoplasms Disease_progression IAGP   2317253 DNA:Polymorphism:promoter:-23 HphI (human) RGD   Pancreatic Neoplasms Susceptibility IED   2317247 associated with Diabetes Mellitus, Non-Insulin-Depend RGD   Pancreatic Neoplasms   ISS RGD:10812 2317245   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-adrenaline multiple interactions EXP   6480464 Butoxamine inhibits the reaction [Epinephrine results in decreased expression of INS protein]; more ... CTD PMID:6018752 (R)-adrenaline decreases expression EXP   6480464 Epinephrine results in decreased expression of INS protein CTD PMID:6018752 PMID:6314140 (R)-adrenaline multiple interactions EXP   6480464 Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein] CTD PMID:1218171 (R)-adrenaline decreases expression EXP   6480464 Epinephrine results in decreased expression of INS protein CTD PMID:6314140 PMID:6018752 (R)-lipoic acid multiple interactions EXP   6480464 Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 (S)-nicotine increases expression ISO RGD:2916 6480464 Nicotine results in increased expression of INS2 mRNA CTD PMID:20426880 17beta-estradiol multiple interactions EXP   6480464 Estradiol promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]; more ... CTD PMID:21632903 17beta-estradiol increases expression ISO RGD:2916 6480464 Estradiol results in increased expression of INS2 mRNA CTD PMID:18446233 17beta-estradiol increases expression ISO RGD:10812 6480464 Estradiol results in increased expression of INS2 protein CTD PMID:18446233 17beta-estradiol multiple interactions ISO RGD:10812 6480464 ESR1 protein affects the reaction [Estradiol results in increased expression of INS2 protein]; more ... CTD PMID:18446233 2,6-dinitrotoluene affects expression ISO RGD:2916 6480464 2,6-dinitrotoluene affects the expression of INS2 mRNA CTD PMID:21346803 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP   6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 2-deoxy-D-glucose multiple interactions EXP   6480464 SLC2A1 protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose] CTD PMID:2173694 2-deoxy-D-glucose multiple interactions ISO RGD:10812 6480464 PPARA protein promotes the reaction [GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose]] CTD PMID:21324916 2-deoxy-D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Deoxyglucose CTD PMID:16483873 PMID:21324916 2-deoxy-D-glucose multiple interactions EXP   6480464 GW 7647 promotes the reaction [INS protein results in increased uptake of Deoxyglucose] CTD PMID:21324916 2-deoxy-D-glucose multiple interactions EXP   6480464 TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]; more ... CTD PMID:16483873 2-deoxy-D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Deoxyglucose CTD PMID:16483873 2-deoxy-D-glucose increases uptake EXP   6480464 INS results in increased uptake of Deoxyglucose CTD PMID:20165829 2-deoxy-D-glucose multiple interactions EXP   6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 3-aminobenzamide multiple interactions EXP   6480464 3-aminobenzamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]]; more ... CTD PMID:16505238 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10812 6480464 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; more ... CTD PMID:22298784 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 BQ 610 affects the reaction [sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; more ... CTD PMID:23152186 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA; more ... CTD PMID:23086663 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10812 6480464 bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:2916 6480464 [INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of SOX2 mRNA; more ... CTD PMID:21350315 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 [rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA; more ... CTD PMID:20206132 4-phenylbutyric acid multiple interactions EXP   6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]] CTD PMID:20165829 5-fluorouracil decreases expression ISO RGD:10812 6480464 Fluorouracil results in decreased expression of INS2 protein CTD PMID:21296659 AACOCF3 increases secretion EXP   6480464 arachidonyltrifluoromethane results in increased secretion of INS protein CTD PMID:17192482 AACOCF3 multiple interactions EXP   6480464 arachidonyltrifluoromethane inhibits the reaction [Glucose results in increased secretion of INS protein] CTD PMID:17192482 acetic acid decreases expression ISO RGD:10812 6480464 Acetic Acid results in decreased expression of INS2 protein CTD PMID:21296659 albuterol increases expression EXP   6480464 Albuterol results in increased expression of INS CTD PMID:8098220 albuterol increases expression EXP   6480464 Albuterol results in increased expression of INS protein CTD PMID:9088585 aldehydo-D-glucosamine multiple interactions EXP   6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of INS protein CTD PMID:16473924 all-trans-retinoic acid increases secretion EXP   6480464 Tretinoin results in increased secretion of INS protein CTD PMID:16473924 all-trans-retinol multiple interactions ISO RGD:10812 6480464 [Vitamin A co-treated with INHBA protein] results in increased expression of INS2 mRNA CTD PMID:17244017 amlodipine decreases expression EXP   6480464 Amlodipine results in decreased expression of INS protein CTD PMID:19651449 ammonium chloride affects expression ISO RGD:2916 6480464 Ammonium Chloride affects the expression of INS2 mRNA CTD PMID:16483693 arachidonic acid multiple interactions EXP   6480464 Arachidonic Acid promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:17192482 arachidonic acid increases secretion EXP   6480464 Arachidonic Acid results in increased secretion of INS protein CTD PMID:17192482 aspartame increases expression EXP   6480464 Aspartame results in increased expression of INS protein CTD PMID:1805284 atenolol multiple interactions EXP   6480464 Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 baicalein multiple interactions EXP   6480464 baicalein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:17192482 baicalein increases secretion EXP   6480464 baicalein results in increased secretion of INS protein CTD PMID:17192482 beta-D-glucosamine multiple interactions EXP   6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine inhibits the reaction [INS results in increased uptake of Deoxyglucose]]; more ... CTD PMID:20165829 bezafibrate multiple interactions EXP   6480464 [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased expression of INS protein CTD PMID:20404010 bezafibrate decreases expression EXP   6480464 Bezafibrate results in decreased expression of INS protein CTD PMID:2209320 bezafibrate multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:11292061 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:10812 6480464 Diethylhexyl Phthalate promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 bisoprolol multiple interactions EXP   6480464 Bisoprolol inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:12795776 bisphenol A multiple interactions ISO RGD:10812 6480464 bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 bisphenol A decreases expression ISO RGD:2916 6480464 bisphenol A results in decreased expression of INS2 mRNA CTD PMID:23328667 bisphenol A multiple interactions ISO RGD:10812 6480464 ESR1 protein affects the reaction [bisphenol A results in increased expression of INS2 protein]; more ... CTD PMID:18446233 bisphenol A increases expression ISO RGD:10812 6480464 bisphenol A results in increased expression of INS2 protein CTD PMID:18446233 bisphenol A increases secretion EXP   6480464 bisphenol A results in increased secretion of INS protein CTD PMID:22347437 bromochloroacetic acid decreases expression ISO RGD:10812 6480464 bromochloroacetic acid results in decreased expression of INS2 protein CTD PMID:21296659 bromocriptine decreases expression EXP   6480464 Bromocriptine results in decreased expression of INS protein CTD PMID:16803851 cadmium atom decreases expression EXP   6480464 Cadmium results in decreased expression of INS protein CTD PMID:17303580 caffeine multiple interactions EXP   6480464 Caffeine inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:21081844 capsaicin multiple interactions ISO RGD:2916 6480464 [INS protein co-treated with Capsaicin] promotes the reaction [Capsaicin results in increased uptake of cobaltous chloride] CTD PMID:14622148 carvedilol decreases expression EXP   6480464 carvedilol results in decreased expression of INS protein alternative form CTD PMID:16598518 chlorpropamide decreases expression EXP   6480464 Chlorpropamide results in decreased expression of INS protein CTD PMID:15642492 chlorpropamide increases expression EXP   6480464 Chlorpropamide results in increased expression of INS mRNA CTD PMID:15642492 chlorpropamide multiple interactions EXP   6480464 Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:15642492 ciprofibrate multiple interactions ISO RGD:2916 6480464 INS protein affects the reaction [ciprofibrate results in increased expression of CYP3A1 mRNA] CTD PMID:10215695 clofibrate affects secretion EXP   6480464 Clofibrate affects the secretion of INS protein CTD PMID:1143089 clofibrate decreases secretion EXP   6480464 Clofibrate results in decreased secretion of INS protein CTD PMID:417937 clonidine decreases secretion EXP   6480464 Clonidine results in decreased secretion of INS protein CTD PMID:707001 clonidine (amino form) decreases secretion EXP   6480464 Clonidine results in decreased secretion of INS protein CTD PMID:707001 clonidine (imino form) decreases secretion EXP   6480464 Clonidine results in decreased secretion of INS protein CTD PMID:707001 clozapine affects secretion EXP   6480464 Clozapine affects the secretion of INS protein CTD PMID:11769361 clozapine increases expression EXP   6480464 Clozapine results in increased expression of INS protein CTD PMID:16601995 co-trimoxazole increases secretion EXP   6480464 Trimethoprim-Sulfamethoxazole Combination results in increased secretion of INS protein modified form CTD PMID:14714756 cobalt dichloride multiple interactions ISO RGD:2916 6480464 Ruthenium Red inhibits the reaction [INS protein results in increased uptake of cobaltous chloride]; more ... CTD PMID:14622148 cobalt dichloride increases uptake ISO RGD:2916 6480464 INS protein results in increased uptake of cobaltous chloride CTD PMID:14622148 cocaine decreases expression EXP   6480464 Cocaine results in decreased expression of INS protein CTD PMID:18346162 copper atom multiple interactions EXP   6480464 INS protein inhibits the reaction [ATP7B protein affects the export of Copper] CTD PMID:17109627 copper atom affects transport EXP   6480464 INS protein affects the transport of Copper CTD PMID:17109627 copper(0) multiple interactions EXP   6480464 INS protein inhibits the reaction [ATP7B protein affects the export of Copper] CTD PMID:17109627 copper(0) affects transport EXP   6480464 INS protein affects the transport of Copper CTD PMID:17109627 corticotropin multiple interactions EXP   6480464 Adrenocorticotropic Hormone inhibits the reaction [INS protein results in increased secretion of GH1 protein] CTD PMID:3008584 cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7917157 more ... cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7473517 more ... cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7792821 more ... cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7917157 more ... cortisol multiple interactions EXP   6480464 Octreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein] CTD PMID:7917157 PMID:7792821 cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of INS protein CTD PMID:7473517 more ... cortisol multiple interactions EXP   6480464 Octreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein] CTD PMID:7792821 PMID:7917157 D-glucose multiple interactions ISO RGD:10812 6480464 Estradiol promotes the reaction [Glucose results in increased secretion of INS2 protein] CTD PMID:18446233 D-glucose increases uptake ISO RGD:2916 6480464 INS protein results in increased uptake of Glucose CTD PMID:18266981 D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose multiple interactions EXP   6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 D-glucose multiple interactions EXP   6480464 UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18167556 D-glucose multiple interactions ISO RGD:2916 6480464 IKBKB affects the reaction [IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; more ... CTD PMID:22558381 D-glucose increases expression ISO RGD:2916 6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 D-glucose multiple interactions ISO RGD:10812 6480464 IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; more ... CTD PMID:22558381 D-glucose increases expression ISO RGD:10812 6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 D-glucose multiple interactions EXP   6480464 MIR133A affects the reaction [Glucose results in decreased chemical synthesis of INS protein] CTD PMID:20520763 D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose decreases chemical synthesis EXP   6480464 Glucose results in decreased chemical synthesis of INS protein CTD PMID:20520763 D-glucose multiple interactions EXP   6480464 INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein] CTD PMID:22162761 D-glucose multiple interactions EXP   6480464 GW8510 promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:22242153 D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... D-glucose multiple interactions EXP   6480464 Metformin promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:15531508 D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 more ... D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:19188863 more ... D-glucose multiple interactions ISO RGD:2916 6480464 Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:21888768 D-glucose decreases secretion EXP   6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 PMID:16452552 D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:15277403 more ... D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:18347054 more ... D-glucose multiple interactions EXP   6480464 TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]; more ... CTD PMID:7956951 D-glucose multiple interactions EXP   6480464 rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose] CTD PMID:15277403 D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... D-glucose increases secretion EXP   6480464 INS protein results in increased secretion of Glucose CTD PMID:14625208 D-glucose multiple interactions EXP   6480464 IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:16204373 D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:15153144 more ... D-glucose increases activity EXP   6480464 Glucose results in increased activity of INS promoter CTD PMID:16489446 D-glucose decreases secretion EXP   6480464 Glucose results in decreased secretion of INS protein CTD PMID:16452552 PMID:15642492 D-glucose multiple interactions EXP   6480464 Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen] CTD PMID:15864539 D-glucose multiple interactions EXP   6480464 Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 D-glucose multiple interactions EXP   6480464 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; more ... CTD PMID:14625208 D-glucose decreases expression ISO RGD:2916 6480464 Glucose results in decreased expression of INS2 mRNA CTD PMID:12914525 D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 PMID:18328801 D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... D-glucose increases expression ISO RGD:2916 6480464 Glucose results in increased expression of INS mRNA CTD PMID:9142872 D-glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS protein CTD PMID:10967106 D-glucose multiple interactions ISO RGD:10812 6480464 [IL1B protein co-treated with IFNG protein] promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10967106 D-glucose multiple interactions EXP   6480464 SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:16984975 D-glucose multiple interactions EXP   6480464 Saquinavir inhibits the reaction [INS protein results in increased import of Glucose] CTD PMID:11786383 D-glucose multiple interactions EXP   6480464 NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18347054 D-glucose multiple interactions EXP   6480464 IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10430617 D-glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 D-glucose multiple interactions EXP   6480464 INS protein mutant form results in decreased uptake of and results in decreased oxidation of Glucose CTD PMID:3511099 D-glucose decreases secretion EXP   6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 D-glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... D-glucose multiple interactions EXP   6480464 [Glyburide co-treated with Glucose] results in increased expression of INS protein CTD PMID:11305519 D-glucose multiple interactions EXP   6480464 [Glucose co-treated with sodium arsenite] results in increased secretion of INS protein; more ... CTD PMID:20100676 D-glucose multiple interactions EXP   6480464 Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; more ... CTD PMID:20960276 D-glucose multiple interactions EXP   6480464 [Glucose co-treated with INS protein] affects the localization of PDX1 protein; more ... CTD PMID:11574405 D-glucose multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose] CTD PMID:18328801 D-glucose multiple interactions EXP   6480464 Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]; more ... CTD PMID:15642492 D-glucose multiple interactions EXP   6480464 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:17192482 D-glucose multiple interactions EXP   6480464 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS mRNA]; more ... CTD PMID:16505238 D-glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS2 protein CTD PMID:18446233 demethoxycurcumin increases secretion EXP   6480464 demethoxycurcumin results in increased secretion of INS protein CTD PMID:19188863 dexamethasone multiple interactions ISO RGD:10812 6480464 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of CEBPA mRNA]; more ... CTD PMID:22298784 dexamethasone multiple interactions EXP   6480464 BQ 610 affects the reaction [sodium arsenite inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]]; more ... CTD PMID:23152186 dexamethasone multiple interactions EXP   6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA; more ... CTD PMID:23086663 dexamethasone multiple interactions ISO RGD:10812 6480464 [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with [Dexamethasone co-treated with INS protein co-treated with PRL protein]] results in decreased expression of BAX protein; more ... CTD PMID:11751460 dexamethasone multiple interactions ISO RGD:2916 6480464 Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:21888768 dexamethasone multiple interactions ISO RGD:10812 6480464 [Dexamethasone co-treated with INS protein] results in increased expression of GRSF1 mRNA; more ... CTD PMID:11916924 dexamethasone multiple interactions ISO RGD:10812 6480464 bisphenol A inhibits the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 dexamethasone multiple interactions ISO RGD:2916 6480464 INS protein inhibits the reaction [Dexamethasone results in increased expression of G6PC mRNA]; more ... CTD PMID:18972406 dexamethasone multiple interactions ISO RGD:2916 6480464 [INS co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of POU5F1 mRNA; more ... CTD PMID:21350315 dexamethasone increases secretion EXP   6480464 Dexamethasone results in increased secretion of INS protein CTD PMID:8436259 dexamethasone multiple interactions EXP   6480464 [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG mRNA; more ... CTD PMID:20206132 dexamethasone decreases response to substance EXP   6480464 Dexamethasone results in decreased susceptibility to INS protein CTD PMID:8436259 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose] CTD PMID:18328801 diazoxide multiple interactions ISO RGD:2916 6480464 INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; more ... CTD PMID:19167487 diazoxide increases expression ISO RGD:2916 6480464 Isoproterenol results in increased expression of INS protein CTD PMID:1129332 diazoxide affects expression ISO RGD:2916 6480464 Isoproterenol affects the expression of INS protein CTD PMID:1170870 digoxin decreases response to substance EXP   6480464 INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 digoxin decreases response to substance ISO RGD:2916 6480464 INS protein results in decreased susceptibility to Digoxin CTD PMID:22562035 dimercaprol multiple interactions ISO RGD:2916 6480464 Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in decreased phosphorylation of SLC2A4 protein]] CTD PMID:8048502 disodium selenite multiple interactions EXP   6480464 INS protein inhibits the reaction [Sodium Selenite results in increased secretion of SEPP1 protein] CTD PMID:18972406 disodium selenite decreases expression ISO RGD:10812 6480464 Sodium Selenite results in decreased expression of INS2 mRNA CTD PMID:23274088 dopamine multiple interactions EXP   6480464 Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 dopamine increases secretion EXP   6480464 Dopamine results in increased secretion of INS protein CTD PMID:18645345 dopamine increases expression EXP   6480464 Dopamine results in increased expression of INS protein CTD PMID:18645345 enalaprilat dihydrate multiple interactions EXP   6480464 Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 fructose decreases response to substance EXP   6480464 Fructose results in decreased susceptibility to INS protein CTD PMID:12010179 fructose multiple interactions ISO RGD:2916 6480464 INS protein inhibits the reaction [Fructose results in increased expression of AGTR1A mRNA] CTD PMID:18360027 fulvestrant multiple interactions ISO RGD:10812 6480464 fulvestrant inhibits the reaction [bisphenol A results in increased expression of INS2 protein]; more ... CTD PMID:18446233 gatifloxacin multiple interactions ISO RGD:2916 6480464 GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 gatifloxacin decreases expression ISO RGD:2916 6480464 gatifloxacin results in decreased expression of INS2 mRNA CTD PMID:23200776 glimepiride decreases expression EXP   6480464 glimepiride results in decreased expression of INS protein CTD PMID:15642492 glucose multiple interactions ISO RGD:10812 6480464 Estradiol promotes the reaction [Glucose results in increased secretion of INS2 protein] CTD PMID:18446233 glucose increases uptake ISO RGD:2916 6480464 INS protein results in increased uptake of Glucose CTD PMID:18266981 glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose multiple interactions EXP   6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 glucose multiple interactions EXP   6480464 UCP3 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18167556 glucose multiple interactions ISO RGD:2916 6480464 IKBKB affects the reaction [IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]]; more ... CTD PMID:22558381 glucose increases expression ISO RGD:2916 6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 glucose multiple interactions ISO RGD:10812 6480464 IL1B protein inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form]; more ... CTD PMID:22558381 glucose increases expression ISO RGD:10812 6480464 Glucose results in increased expression of INS2 mRNA alternative form CTD PMID:22558381 glucose multiple interactions EXP   6480464 MIR133A affects the reaction [Glucose results in decreased chemical synthesis of INS protein] CTD PMID:20520763 glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose decreases chemical synthesis EXP   6480464 Glucose results in decreased chemical synthesis of INS protein CTD PMID:20520763 glucose multiple interactions EXP   6480464 INS protein inhibits the reaction [Glucose results in decreased expression of ATP1A1 protein] CTD PMID:22162761 glucose multiple interactions EXP   6480464 GW8510 promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:22242153 glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... glucose multiple interactions EXP   6480464 Metformin promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:15531508 glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 more ... glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:19188863 more ... glucose multiple interactions ISO RGD:2916 6480464 Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:21888768 glucose decreases secretion EXP   6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 PMID:16452552 glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:15277403 more ... glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:18347054 more ... glucose multiple interactions EXP   6480464 TNF protein inhibits the reaction [INS protein results in increased uptake of Glucose]; more ... CTD PMID:7956951 glucose multiple interactions EXP   6480464 rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose] CTD PMID:15277403 glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 more ... glucose increases secretion EXP   6480464 INS protein results in increased secretion of Glucose CTD PMID:14625208 glucose multiple interactions EXP   6480464 IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:16204373 glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:15153144 more ... glucose increases activity EXP   6480464 Glucose results in increased activity of INS promoter CTD PMID:16489446 glucose decreases secretion EXP   6480464 Glucose results in decreased secretion of INS protein CTD PMID:16452552 PMID:15642492 glucose multiple interactions EXP   6480464 Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen] CTD PMID:15864539 glucose multiple interactions EXP   6480464 Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 glucose multiple interactions EXP   6480464 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; more ... CTD PMID:14625208 glucose decreases expression ISO RGD:2916 6480464 Glucose results in decreased expression of INS2 mRNA CTD PMID:12914525 glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:19531641 PMID:18328801 glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:838844 more ... glucose increases expression ISO RGD:2916 6480464 Glucose results in increased expression of INS mRNA CTD PMID:9142872 glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS protein CTD PMID:10967106 glucose multiple interactions ISO RGD:10812 6480464 [IL1B protein co-treated with IFNG protein] promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10967106 glucose multiple interactions EXP   6480464 SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:16984975 glucose multiple interactions EXP   6480464 Saquinavir inhibits the reaction [INS protein results in increased import of Glucose] CTD PMID:11786383 glucose multiple interactions EXP   6480464 NKX6-1 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:18347054 glucose multiple interactions EXP   6480464 IRS1 protein polymorphism inhibits the reaction [Glucose results in increased secretion of INS protein] CTD PMID:10430617 glucose increases uptake EXP   6480464 INS protein results in increased uptake of Glucose CTD PMID:18328801 glucose multiple interactions EXP   6480464 INS protein mutant form results in decreased uptake of and results in decreased oxidation of Glucose CTD PMID:3511099 glucose decreases secretion EXP   6480464 Glucose results in decreased secretion of INS protein CTD PMID:15642492 glucose increases secretion EXP   6480464 Glucose results in increased secretion of INS protein CTD PMID:10430617 more ... glucose multiple interactions EXP   6480464 [Glyburide co-treated with Glucose] results in increased expression of INS protein CTD PMID:11305519 glucose multiple interactions EXP   6480464 [Glucose co-treated with sodium arsenite] results in increased secretion of INS protein; more ... CTD PMID:20100676 glucose multiple interactions EXP   6480464 Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]; more ... CTD PMID:20960276 glucose multiple interactions EXP   6480464 [Glucose co-treated with INS protein] affects the localization of PDX1 protein; more ... CTD PMID:11574405 glucose multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [INS protein results in increased uptake of Glucose] CTD PMID:18328801 glucose multiple interactions EXP   6480464 Chlorpropamide inhibits the reaction [Glucose results in decreased secretion of INS protein]; more ... CTD PMID:15642492 glucose multiple interactions EXP   6480464 alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:17192482 glucose multiple interactions EXP   6480464 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Glucose results in increased expression of INS mRNA]; more ... CTD PMID:16505238 glucose increases secretion ISO RGD:10812 6480464 Glucose results in increased secretion of INS2 protein CTD PMID:18446233 glyburide multiple interactions EXP   6480464 [Glyburide co-treated with Glucose] results in increased expression of INS protein CTD PMID:11305519 glyburide increases response to substance ISO RGD:2916 6480464 Glyburide results in increased susceptibility to INS protein CTD PMID:3116364 glyburide multiple interactions EXP   6480464 IRS1 protein polymorphism inhibits the reaction [Glyburide results in increased secretion of INS protein] CTD PMID:10430617 glyburide increases secretion EXP   6480464 Glyburide results in increased secretion of INS protein CTD PMID:10430617 glyburide increases expression EXP   6480464 Glyburide results in increased expression of INS mRNA CTD PMID:15642492 glyburide decreases expression EXP   6480464 Glyburide results in decreased expression of INS protein CTD PMID:15642492 glyburide multiple interactions EXP   6480464 Glyburide inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:15642492 glycogen multiple interactions EXP   6480464 Estradiol promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]; more ... CTD PMID:21632903 glycogen increases chemical synthesis EXP   6480464 INS protein results in increased chemical synthesis of Glycogen CTD PMID:21632903 PMID:15864539 glycogen increases chemical synthesis EXP   6480464 INS protein results in increased chemical synthesis of Glycogen CTD PMID:15864539 PMID:21632903 glycogen multiple interactions EXP   6480464 Glucose inhibits the reaction [INS protein results in increased chemical synthesis of Glycogen] CTD PMID:15864539 glycogen increases chemical synthesis EXP   6480464 INS protein results in increased chemical synthesis of Glycogen CTD PMID:21632903 hydrogen peroxide increases chemical synthesis EXP   6480464 INS protein results in increased chemical synthesis of Hydrogen Peroxide CTD PMID:22031853 hydrogen peroxide multiple interactions EXP   6480464 manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [INS protein results in increased chemical synthesis of Hydrogen Peroxide] CTD PMID:22031853 indomethacin multiple interactions EXP   6480464 [Indomethacin co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG protein; more ... CTD PMID:20206132 indomethacin multiple interactions EXP   6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of CIDEC mRNA; more ... CTD PMID:23086663 indomethacin decreases secretion EXP   6480464 Indomethacin results in decreased secretion of INS protein CTD PMID:10909992 isoprenaline multiple interactions ISO RGD:2916 6480464 INS protein inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]; more ... CTD PMID:19167487 isoprenaline increases expression ISO RGD:2916 6480464 Isoproterenol results in increased expression of INS protein CTD PMID:1129332 isoprenaline affects expression ISO RGD:2916 6480464 Isoproterenol affects the expression of INS protein CTD PMID:1170870 lanthanum atom decreases response to substance EXP   6480464 Lanthanum results in decreased susceptibility to INS protein CTD PMID:22031853 lipoic acid multiple interactions EXP   6480464 Thioctic Acid inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 lovastatin multiple interactions ISO RGD:2916 6480464 Lovastatin promotes the reaction [INS protein results in increased phosphorylation of IGF1R protein]; more ... CTD PMID:19741129 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 PMID:18359480 LY294002 multiple interactions EXP   6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:18359480 mercaptopurine decreases expression ISO RGD:2916 6480464 6-Mercaptopurine results in decreased expression of INS2 mRNA CTD PMID:23358152 metformin multiple interactions EXP   6480464 Metformin results in decreased expression of and results in decreased secretion of INS protein CTD PMID:18082302 metformin multiple interactions EXP   6480464 Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; more ... CTD PMID:15531508 metformin increases expression EXP   6480464 Metformin results in increased expression of INS mRNA CTD PMID:15531508 metformin decreases expression EXP   6480464 Metformin results in decreased expression of INS protein CTD PMID:21779873 PMID:1900072 metformin decreases expression EXP   6480464 Metformin results in decreased expression of INS protein CTD PMID:1900072 PMID:21779873 metformin decreases expression EXP   6480464 Metformin results in decreased expression of INS protein CTD PMID:1900072 methadone decreases response to substance EXP   6480464 Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 methotrexate decreases expression EXP   6480464 Methotrexate results in decreased expression of INS mRNA CTD PMID:17400583 metoclopramide multiple interactions EXP   6480464 Dopamine promotes the reaction [Metoclopramide results in increased expression of INS protein] CTD PMID:18645345 metoclopramide increases expression EXP   6480464 Metoclopramide results in increased expression of INS protein CTD PMID:18645345 N-acetyl-L-cysteine multiple interactions EXP   6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 N-acetyl-L-cysteine multiple interactions ISO RGD:2916 6480464 Acetylcysteine inhibits the reaction [Dexamethasone inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:21888768 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:10812 6480464 Ethylnitrosourea results in increased mutagenesis of INS2 gene CTD PMID:18056790 nicotinamide multiple interactions EXP   6480464 Niacinamide inhibits the reaction [Glucose results in increased expression of INS mRNA]; more ... CTD PMID:16505238 nitric oxide multiple interactions EXP   6480464 resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; more ... CTD PMID:20960276 nitric oxide increases secretion EXP   6480464 INS protein results in increased secretion of Nitric Oxide CTD PMID:20960276 olanzapine increases expression EXP   6480464 olanzapine results in increased expression of INS protein CTD PMID:16601995 more ... olanzapine increases expression EXP   6480464 olanzapine results in increased expression of INS protein CTD PMID:11927762 more ... olanzapine increases expression EXP   6480464 olanzapine results in increased expression of INS protein CTD PMID:16601995 more ... olanzapine increases expression EXP   6480464 olanzapine results in increased expression of INS protein CTD PMID:19512971 more ... olanzapine increases secretion EXP   6480464 olanzapine results in increased secretion of INS protein CTD PMID:11769361 oleic acid multiple interactions EXP   6480464 Bezafibrate inhibits the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:11292061 palmitic acid multiple interactions EXP   6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein]] CTD PMID:18155663 palmitic acid multiple interactions ISO RGD:10812 6480464 Palmitic Acid inhibits the reaction [Glucose results in increased expression of INS2 mRNA alternative form] CTD PMID:22558381 palmitic acid decreases expression EXP   6480464 Palmitic Acid results in decreased expression of INS protein CTD PMID:18155663 paroxetine multiple interactions ISO RGD:2916 6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Paroxetine affects the reaction [INS protein affects the phosphorylation of IRS1 protein]] CTD PMID:17728140 pentolinium tartrate multiple interactions EXP   6480464 Pentolinium Tartrate inhibits the reaction [Epinephrine results in decreased secretion of INS protein] CTD PMID:1218171 phenobarbital multiple interactions ISO RGD:2916 6480464 INS protein affects the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; more ... CTD PMID:10215695 potassium chloride multiple interactions EXP   6480464 sodium arsenite promotes the reaction [Potassium Chloride results in increased secretion of INS protein] CTD PMID:20100676 propranolol multiple interactions EXP   6480464 Propranolol inhibits the reaction [Epinephrine results in decreased expression of INS protein] CTD PMID:6018752 propranolol decreases expression EXP   6480464 Propranolol results in decreased expression of INS protein CTD PMID:3019152 purine-6-thiol decreases expression ISO RGD:2916 6480464 6-Mercaptopurine results in decreased expression of INS2 mRNA CTD PMID:23358152 pyridine multiple interactions ISO RGD:2916 6480464 INS protein affects the reaction [pyridine results in increased expression of CYP2B1 mRNA]; more ... CTD PMID:10215695 pyruvic acid multiple interactions ISO RGD:2916 6480464 INS protein inhibits the reaction [Pyruvic Acid results in increased secretion of GCG protein] CTD PMID:15919803 quercetin multiple interactions EXP   6480464 Quercetin inhibits the reaction [Glucose results in increased expression of INS protein] CTD PMID:16505238 quercetin multiple interactions EXP   6480464 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; more ... CTD PMID:18359480 resveratrol increases response to substance ISO RGD:10812 6480464 resveratrol results in increased susceptibility to INS protein CTD PMID:21945106 resveratrol multiple interactions EXP   6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 PMID:16626303 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of FOXO4 protein] CTD PMID:17550345 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; more ... CTD PMID:20960276 resveratrol decreases response to substance EXP   6480464 INS protein results in decreased susceptibility to resveratrol CTD PMID:20015842 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:17550345 resveratrol decreases expression ISO RGD:10812 6480464 resveratrol results in decreased expression of INS protein CTD PMID:21945106 resveratrol decreases response to substance EXP   6480464 resveratrol results in decreased susceptibility to INS protein CTD PMID:15297429 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased expression of HIF1A protein] CTD PMID:15297429 risperidone increases expression EXP   6480464 Risperidone results in increased expression of INS protein CTD PMID:11927762 PMID:16601995 risperidone increases expression EXP   6480464 Risperidone results in increased expression of INS protein CTD PMID:16601995 PMID:11927762 rosiglitazone multiple interactions EXP   6480464 [rosiglitazone co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA; more ... CTD PMID:20206132 rosiglitazone multiple interactions EXP   6480464 [rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with INS protein] results in increased expression of ADIPOQ mRNA; more ... CTD PMID:23086663 rosiglitazone increases response to substance EXP   6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:15730735 more ... rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15089784 more ... rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:20498286 more ... rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:19556978 more ... rosiglitazone increases response to substance EXP   6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:15730735 more ... rosiglitazone increases response to substance EXP   6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:16644639 more ... rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:20498286 more ... rosiglitazone multiple interactions ISO RGD:10812 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with INS protein] results in increased expression of FOSL1 mRNA; more ... CTD PMID:11916924 rosiglitazone increases expression EXP   6480464 rosiglitazone results in increased expression of INS mRNA CTD PMID:18155663 rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15089784 more ... rosiglitazone multiple interactions EXP   6480464 rosiglitazone promotes the reaction [INS protein results in increased uptake of Glucose] CTD PMID:15277403 rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction [INS protein results in increased secretion of RETN protein] CTD PMID:14671216 rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction [IAPP protein inhibits the reaction [Glucose results in increased secretion of INS protein]] CTD PMID:16204373 rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA]; more ... CTD PMID:14625208 rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction and results in increased secretion of INS protein inhibits the reaction and results in increased secretion of SERPINE1 protein CTD PMID:12940867 rosiglitazone multiple interactions EXP   6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein]] CTD PMID:18155663 rosiglitazone increases response to substance EXP   6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:19531641 more ... rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15730735 more ... rosiglitazone multiple interactions EXP   6480464 rosiglitazone inhibits the reaction [INS protein results in increased expression of NAMPT protein] CTD PMID:21694775 rosiglitazone increases response to substance EXP   6480464 rosiglitazone results in increased susceptibility to INS protein CTD PMID:15730735 PMID:16644639 rosiglitazone decreases secretion EXP   6480464 rosiglitazone results in decreased secretion of INS protein CTD PMID:18541328 rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of INS protein CTD PMID:15730735 more ... saquinavir multiple interactions EXP   6480464 Saquinavir inhibits the reaction [INS protein results in increased import of Glucose] CTD PMID:11786383 sertraline multiple interactions ISO RGD:2916 6480464 Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; more ... CTD PMID:17728140 sodium dichromate increases expression ISO RGD:10812 6480464 sodium bichromate results in increased expression of INS2 mRNA CTD PMID:22155349 staurosporine multiple interactions ISO RGD:2916 6480464 Staurosporine inhibits the reaction [INS protein results in increased uptake of cobaltous chloride] CTD PMID:14622148 streptozocin multiple interactions EXP   6480464 INS inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; more ... CTD PMID:19136650 streptozocin decreases expression ISO RGD:2916 6480464 Streptozocin results in decreased expression of INS protein CTD PMID:11216864 streptozocin multiple interactions ISO RGD:2916 6480464 INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA]; more ... CTD PMID:20219977 streptozocin multiple interactions EXP   6480464 INS protein inhibits the reaction [Streptozocin results in decreased expression of NES mRNA] CTD PMID:19388005 sucrose increases expression EXP   6480464 Sucrose results in increased expression of INS protein CTD PMID:1805284 sulpiride increases expression EXP   6480464 Sulpiride results in increased expression of INS protein CTD PMID:16601995 tacrolimus hydrate decreases expression EXP   6480464 Tacrolimus results in decreased expression of INS protein CTD PMID:17391142 telmisartan decreases expression EXP   6480464 telmisartan results in decreased expression of INS protein CTD PMID:15892894 terbutaline multiple interactions EXP   6480464 Atenolol inhibits the reaction [Terbutaline results in increased expression of INS protein]; more ... CTD PMID:12795776 terbutaline multiple interactions EXP   6480464 SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217 terbutaline increases expression EXP   6480464 Terbutaline results in increased expression of INS protein CTD PMID:12795776 more ... testosterone multiple interactions EXP   6480464 Testosterone promotes the reaction [INS protein results in increased chemical synthesis of Glycogen]; more ... CTD PMID:21632903 testosterone increases expression EXP   6480464 Testosterone results in increased expression of INS protein CTD PMID:9851674 tolbutamide increases secretion EXP   6480464 Tolbutamide results in increased secretion of INS protein CTD PMID:9568693 PMID:9032110 tolbutamide increases secretion EXP   6480464 Tolbutamide results in increased secretion of INS protein CTD PMID:9032110 PMID:9568693 tolbutamide multiple interactions EXP   6480464 ABCC8 gene SNP inhibits the reaction [Tolbutamide results in increased secretion of INS protein] CTD PMID:9568693 trans-resveratrol increases response to substance ISO RGD:10812 6480464 resveratrol results in increased susceptibility to INS protein CTD PMID:21945106 trans-resveratrol multiple interactions EXP   6480464 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]] CTD PMID:21163946 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 PMID:16626303 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of FOXO4 protein] CTD PMID:17550345 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]; more ... CTD PMID:20960276 trans-resveratrol decreases response to substance EXP   6480464 INS protein results in decreased susceptibility to resveratrol CTD PMID:20015842 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:17550345 trans-resveratrol decreases expression ISO RGD:10812 6480464 resveratrol results in decreased expression of INS protein CTD PMID:21945106 trans-resveratrol decreases response to substance EXP   6480464 resveratrol results in decreased susceptibility to INS protein CTD PMID:15297429 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [INS protein results in increased expression of HIF1A protein] CTD PMID:15297429 tributylstannane multiple interactions ISO RGD:10812 6480464 tributyltin promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased abundance of Triglycerides]; more ... CTD PMID:22197818 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS protein CTD PMID:10406828 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS protein CTD PMID:10406828 more ... troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS protein CTD PMID:21779873 more ... troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS protein CTD PMID:8772734 more ... troglitazone multiple interactions EXP   6480464 troglitazone promotes the reaction [[Oleic Acid co-treated with INS protein] results in increased expression of SERPINE1 mRNA]; more ... CTD PMID:11292061 troglitazone increases response to substance EXP   6480464 troglitazone results in increased susceptibility to INS protein CTD PMID:8772734 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS protein CTD PMID:21779873 more ... troglitazone multiple interactions EXP   6480464 troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased expression of CEBPA mRNA]]; more ... CTD PMID:7956951 troglitazone decreases expression ISO RGD:2916 6480464 troglitazone results in decreased expression of INS2 mRNA CTD PMID:12914525 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of INS protein CTD PMID:21779873 PMID:10406828 troglitazone multiple interactions EXP   6480464 troglitazone inhibits the reaction [TNF protein inhibits the reaction [INS protein results in increased uptake of Deoxyglucose]] CTD PMID:16483873 wortmannin multiple interactions EXP   6480464 [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein] CTD PMID:11574405 wortmannin multiple interactions EXP   6480464 wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids] CTD PMID:20015842 wortmannin multiple interactions ISO RGD:2916 6480464 wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:17728140 wortmannin multiple interactions EXP   6480464 wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] CTD PMID:17550345 yohimbine increases expression EXP   6480464 Yohimbine results in increased expression of INS protein CTD PMID:1972139 zinc atom affects binding EXP   6480464 Zinc binds to INS protein CTD PMID:16969698 zinc atom affects binding EXP   6480464 Zinc binds to INS protein binds to INS protein CTD PMID:16362452 zinc(0) affects binding EXP   6480464 Zinc binds to INS protein CTD PMID:16969698 zinc(0) affects binding EXP   6480464 Zinc binds to INS protein binds to INS protein CTD PMID:16362452 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of protein kinase B activity   IDA   2290271 PMID:8702995 BHF-UCL PMID:8702995 acute-phase response   IDA   2290271 PMID:14739855 BHF-UCL PMID:14739855 alpha-beta T cell activation   IDA   2290271 PMID:10604997 UniProtKB PMID:10604997 cell-cell signaling   IC GO:0005158 2290271 PMID:7556975 UniProtKB PMID:7556975 cellular protein metabolic process   TAS   2290271 Reactome:REACT_17015 Reactome Reactome:REACT_17015 endocrine pancreas development   TAS   2290271 Reactome:REACT_13698 Reactome Reactome:REACT_13698 endocrine pancreas development   TAS   2290271 Reactome:REACT_13819 Reactome Reactome:REACT_13819 energy reserve metabolic process   TAS   2290271 Reactome:REACT_1505 Reactome Reactome:REACT_1505 fatty acid homeostasis   IMP   2290271 PMID:1184755 BHF-UCL PMID:1184755 G-protein coupled receptor signaling pathway   IDA   2290271 PMID:9092559 BHF-UCL PMID:9092559 glucose homeostasis   IMP   2290271 PMID:381941 BHF-UCL PMID:381941 glucose metabolic process   IEA UniProtKB-KW:KW-0313 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 glucose metabolic process   IEA UniProtKB-KW:KW-0313 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 glucose transport   IDA   2290271 PMID:14615391 UniProtKB PMID:14615391 glucose transport   IDA   2290271 PMID:15792832 UniProtKB PMID:15792832 insulin receptor signaling pathway   TAS   2290271 Reactome:REACT_498 Reactome Reactome:REACT_498 MAPK cascade   IDA   2290271 PMID:11278339 BHF-UCL PMID:11278339 negative regulation of acute inflammatory response   IDA   2290271 PMID:11443198 BHF-UCL PMID:11443198 negative regulation of apoptotic process   NAS   2290271 PMID:16604263 BHF-UCL PMID:16604263 negative regulation of fatty acid metabolic process   IMP   2290271 PMID:1184755 BHF-UCL PMID:1184755 negative regulation of feeding behavior   IDA   2290271 PMID:17957153 DFLAT PMID:17957153 negative regulation of gluconeogenesis   NAS   2290271 PMID:11742412 BHF-UCL PMID:11742412 negative regulation of glycogen catabolic process   IMP   2290271 PMID:381941 BHF-UCL PMID:381941 negative regulation of lipid catabolic process   NAS   2290271 PMID:11742412 BHF-UCL PMID:11742412 negative regulation of NAD(P)H oxidase activity   IDA   2290271 PMID:11443198 BHF-UCL PMID:11443198 negative regulation of protein catabolic process   IDA   2290271 PMID:15185208 UniProtKB PMID:15185208 negative regulation of protein oligomerization   IDA   2290271 PMID:9830016 UniProtKB PMID:9830016 negative regulation of protein secretion   IDA   2290271 PMID:14739855 BHF-UCL PMID:14739855 negative regulation of proteolysis   IMP   2290271 PMID:3553851 BHF-UCL PMID:3553851 negative regulation of respiratory burst involved in inflammatory response   IDA   2290271 PMID:11443198 BHF-UCL PMID:11443198 negative regulation of vasodilation   NAS   2290271 PMID:12946932 UniProtKB PMID:12946932 positive regulation of brown fat cell differentiation   TAS   2290271 PMID:11387233 BHF-UCL PMID:11387233 positive regulation of cell differentiation   NAS   2290271 PMID:11742412 BHF-UCL PMID:11742412 positive regulation of cell growth   NAS   2290271 PMID:11742412 BHF-UCL PMID:11742412 positive regulation of cell migration   ISS UniProtKB:P01315 2290271 PMID:12138094 BHF-UCL PMID:12138094 positive regulation of cell proliferation   IDA   2290271 PMID:17925406 BHF-UCL PMID:17925406 positive regulation of cellular protein metabolic process   IMP   2290271 PMID:3553851 BHF-UCL PMID:3553851 positive regulation of cytokine secretion   IDA   2290271 PMID:15473891 UniProtKB PMID:15473891 positive regulation of DNA replication   IDA   2290271 PMID:7688386 BHF-UCL PMID:7688386 positive regulation of glucose import   IDA   2290271 PMID:14615391 BHF-UCL PMID:14615391 positive regulation of glycogen biosynthetic process   IDA   2290271 PMID:17925406 BHF-UCL PMID:17925406 positive regulation of glycolysis   IMP   2290271 PMID:381941 BHF-UCL PMID:381941 positive regulation of glycolysis   IDA   2290271 PMID:7688386 BHF-UCL PMID:7688386 positive regulation of insulin receptor signaling pathway   IDA   2290271 PMID:7688386 BHF-UCL PMID:7688386 positive regulation of lipid biosynthetic process   NAS   2290271 PMID:11742412 BHF-UCL PMID:11742412 positive regulation of MAPK cascade   IDA   2290271 PMID:11500939 BHF-UCL PMID:11500939 positive regulation of mitosis   IDA   2290271 PMID:10644978 UniProtKB PMID:10644978 positive regulation of mitosis   IDA   2290271 PMID:11500939 BHF-UCL PMID:11500939 positive regulation of NF-kappaB transcription factor activity   IDA   2290271 PMID:19727662 BHF-UCL PMID:19727662 positive regulation of nitric oxide biosynthetic process   NAS   2290271 PMID:14615391 UniProtKB PMID:14615391 positive regulation of nitric-oxide synthase activity   NAS   2290271 PMID:12135947 UniProtKB PMID:12135947 positive regulation of peptide hormone secretion   TAS   2290271 PMID:11387233 BHF-UCL PMID:11387233 positive regulation of peptidyl-tyrosine phosphorylation   IDA   2290271 PMID:11278339 BHF-UCL PMID:11278339 positive regulation of phosphatidylinositol 3-kinase cascade   IDA   2290271 PMID:7688386 BHF-UCL PMID:7688386 positive regulation of protein autophosphorylation   ISS UniProtKB:P01315 2290271 PMID:3518947 BHF-UCL PMID:3518947 positive regulation of protein kinase B signaling cascade   IDA   2290271 PMID:11500939 BHF-UCL PMID:11500939 positive regulation of respiratory burst   IDA   2290271 PMID:9092559 BHF-UCL PMID:9092559 positive regulation of vasodilation   NAS   2290271 PMID:14744991 UniProtKB PMID:14744991 regulation of cellular amino acid metabolic process   IMP   2290271 PMID:3553851 BHF-UCL PMID:3553851 regulation of insulin secretion   TAS   2290271 Reactome:REACT_18325 Reactome Reactome:REACT_18325 regulation of protein localization   IDA   2290271 PMID:14615391 BHF-UCL PMID:14615391 regulation of protein secretion   IDA   2290271 PMID:15591776 UniProtKB PMID:15591776 regulation of transcription, DNA-dependent   NAS   2290271 PMID:12881524 BHF-UCL PMID:12881524 regulation of transmembrane transporter activity   IDA   2290271 PMID:14615391 BHF-UCL PMID:14615391 small molecule metabolic process   TAS   2290271 Reactome:REACT_111217 Reactome Reactome:REACT_111217 wound healing   IDA   2290271 PMID:9498508 BHF-UCL PMID:9498508 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) endoplasmic reticulum lumen   TAS   2290271 Reactome:REACT_15454 Reactome Reactome:REACT_15454 endoplasmic reticulum lumen   TAS   2290271 Reactome:REACT_15512 Reactome Reactome:REACT_15512 endosome lumen   TAS   2290271 Reactome:REACT_134 Reactome Reactome:REACT_134 endosome lumen   TAS   2290271 Reactome:REACT_599 Reactome Reactome:REACT_599 endosome lumen   TAS   2290271 Reactome:REACT_1355 Reactome Reactome:REACT_1355 extracellular region   IC GO:0005158 2290271 PMID:7556975 UniProtKB PMID:7556975 extracellular region   IEA UniProtKB-SubCell:SL-0243 2290271 GO_REF:0000040 UniProtKB GO_REF:0000040 extracellular region   TAS   2290271 Reactome:REACT_75905 Reactome Reactome:REACT_75905 extracellular region   TAS   2290271 Reactome:REACT_75876 Reactome Reactome:REACT_75876 extracellular region   TAS   2290271 Reactome:REACT_599 Reactome Reactome:REACT_599 extracellular region   TAS   2290271 Reactome:REACT_596 Reactome Reactome:REACT_596 extracellular region   TAS   2290271 Reactome:REACT_562 Reactome Reactome:REACT_562 extracellular region   TAS   2290271 Reactome:REACT_509 Reactome Reactome:REACT_509 extracellular region   TAS   2290271 Reactome:REACT_342 Reactome Reactome:REACT_342 extracellular region   TAS   2290271 Reactome:REACT_2211 Reactome Reactome:REACT_2211 extracellular region   TAS   2290271 Reactome:REACT_2120 Reactome Reactome:REACT_2120 extracellular region   TAS   2290271 Reactome:REACT_2015 Reactome Reactome:REACT_2015 extracellular region   TAS   2290271 Reactome:REACT_1459 Reactome Reactome:REACT_1459 extracellular region   TAS   2290271 Reactome:REACT_106 Reactome Reactome:REACT_106 extracellular space   IDA   2290271 PMID:9667398 BHF-UCL PMID:9667398 Golgi lumen   TAS   2290271 Reactome:REACT_15362 Reactome Reactome:REACT_15362 Golgi lumen   TAS   2290271 Reactome:REACT_15512 Reactome Reactome:REACT_15512 Golgi lumen   TAS   2290271 Reactome:REACT_15499 Reactome Reactome:REACT_15499 secretory granule lumen   TAS   2290271 Reactome:REACT_15374 Reactome Reactome:REACT_15374 secretory granule lumen   TAS   2290271 Reactome:REACT_15362 Reactome Reactome:REACT_15362 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) hormone activity   NAS   2290271 PMID:14986111 UniProtKB PMID:14986111 hormone activity   IEA UniProtKB-KW:KW-0372 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 hormone activity   IEA InterPro:IPR004825|InterPro:IPR016179 2290271 GO_REF:0000002 InterPro GO_REF:0000002 hormone activity   IC GO:0005158 2290271 PMID:9667398 BHF-UCL PMID:9667398 hormone activity   IMP   2290271 PMID:381941 BHF-UCL PMID:381941 insulin receptor binding   IDA   2290271 PMID:7556975 UniProtKB PMID:7556975 insulin receptor binding   IDA   2290271 PMID:9667398 BHF-UCL PMID:9667398 insulin receptor binding   IPI UniProtKB:P06213 2290271 PMID:8452530 BHF-UCL PMID:8452530 insulin-like growth factor receptor binding   IPI UniProtKB:P08069 2290271 PMID:8452530 BHF-UCL PMID:8452530 protease binding   IPI UniProtKB:P14735 2290271 PMID:20082125 UniProtKB PMID:20082125 protein binding   IPI UniProtKB:P17936 2290271 PMID:9388210 BHF-UCL PMID:9388210 protein binding   IPI UniProtKB:P98164 2290271 PMID:9773776 UniProtKB PMID:9773776 protein binding   IPI UniProtKB:Q16270 2290271 PMID:9388210 BHF-UCL PMID:9388210 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) aldosterone signaling pathway   IEA RGD:731056 6907045   KEGG hsa:04960 altered insulin signaling pathway   TAS   2313694   RGD   autophagy pathway   IEA RGD:731056 6907045   KEGG hsa:04140 forkhead class A signaling pathway   EXP   6484113   PID PID:200226 forkhead class A signaling pathway   EXP   6484113   PID PID:200087 insulin responsive facilitative sugar transporter mediated glucose transport pathway   EXP   6484113   PID PID:200196 insulin signaling pathway   TAS   1625124   RGD   insulin signaling pathway   IEA RGD:731056 6907045   KEGG hsa:04910 insulin signaling pathway   EXP   6484113   PID PID:200014 maturity onset diabetes of the young pathway   IEA RGD:731056 6907045   KEGG hsa:04950 mTOR signaling pathway   IEA RGD:731056 6907045   KEGG hsa:04150 prostate cancer pathway   IEA RGD:731056 6907045   KEGG hsa:05215 type 1 diabetes mellitus pathway   IEA RGD:731056 6907045   KEGG hsa:04940 type 2 diabetes mellitus pathway   TAS   2313694   RGD   type 2 diabetes mellitus pathway   IEA RGD:731056 6907045   KEGG hsa:04930 External Database Links KEGG Pathway Aldosterone-regulated sodium reabsorption HIF-1 signaling pathway Insulin secretion Insulin signaling pathway Maturity onset diabetes of the young mTOR signaling pathway Oocyte meiosis PI3K-Akt signaling pathway Progesterone-mediated oocyte maturation Prostate cancer Regulation of actin cytoskeleton Regulation of autophagy Type I diabetes mellitus Type II diabetes mellitus Pathway Interaction Database Arf6 trafficking events (PID:200057) ATF-2 transcription factor network (PID:200135) FOXA1 transcription factor network (PID:200226) FOXA2 and FOXA3 transcription factor networks (PID:200087) Insulin Pathway (PID:200014) Insulin-mediated glucose transport (PID:200196) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) increased susceptibility to age related obesity   IAGP   1625118   RGD   obese   IAGP   1625118   RGD   Disease Annotations Adenoma  (ISS) Alzheimer Disease  (ISS) Carcinoma, Pancreatic Ductal  (IEP) Diabetes Mellitus  (IAGP,IED,IPM,ISS) Diabetes Mellitus, Experimental  (ISS) Diabetes Mellitus, Permanent Neonatal  (IEA) Diabetes Mellitus, Type 1  (IPM) Diabetes Mellitus, Type 2  (IAGP,IEP,IGI) Diabetes, Gestational  (IEP) Diabetic Nephropathies  (ISS) Diabetic Retinopathy  (IED) Fatty Liver  (IEP) Hyperinsulinism  (IAGP,IEA) Hypertension  (ISS) Hyperuricemia  (IEP) Insulin Resistance  (IEP) Insulinoma  (IED) MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10  (IEA) Obesity  (IAGP) Pancreatic Neoplasms  (IAGP,IED,ISS) Gene-Chemical Interaction Annotations (R)-adrenaline  (EXP) (R)-lipoic acid  (EXP) (S)-nicotine  (ISO) 17beta-estradiol  (EXP,ISO) 2,6-dinitrotoluene  (ISO) 2-amino-2-deoxy-D-glucopyranose  (EXP) 2-deoxy-D-glucose  (EXP,ISO) 3-aminobenzamide  (EXP) 3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO) 4-phenylbutyric acid  (EXP) 5-fluorouracil  (ISO) AACOCF3  (EXP) acetic acid  (ISO) albuterol  (EXP) aldehydo-D-glucosamine  (EXP) all-trans-retinoic acid  (EXP) all-trans-retinol  (ISO) amlodipine  (EXP) ammonium chloride  (ISO) arachidonic acid  (EXP) aspartame  (EXP) atenolol  (EXP) baicalein  (EXP) beta-D-glucosamine  (EXP) bezafibrate  (EXP) bis(2-ethylhexyl) phthalate  (ISO) bisoprolol  (EXP) bisphenol A  (EXP,ISO) bromochloroacetic acid  (ISO) bromocriptine  (EXP) cadmium atom  (EXP) caffeine  (EXP) capsaicin  (ISO) carvedilol  (EXP) chlorpropamide  (EXP) ciprofibrate  (ISO) clofibrate  (EXP) clonidine  (EXP) clonidine (amino form)  (EXP) clonidine (imino form)  (EXP) clozapine  (EXP) co-trimoxazole  (EXP) cobalt dichloride  (ISO) cocaine  (EXP) copper atom  (EXP) copper(0)  (EXP) corticotropin  (EXP) cortisol  (EXP) D-glucose  (EXP,ISO) demethoxycurcumin  (EXP) dexamethasone  (EXP,ISO) diazoxide  (ISO) digoxin  (EXP,ISO) dimercaprol  (ISO) disodium selenite  (EXP,ISO) dopamine  (EXP) enalaprilat dihydrate  (EXP) fructose  (EXP,ISO) fulvestrant  (ISO) gatifloxacin  (ISO) glimepiride  (EXP) glucose  (EXP,ISO) glyburide  (EXP,ISO) glycogen  (EXP) hydrogen peroxide  (EXP) indomethacin  (EXP) isoprenaline  (ISO) lanthanum atom  (EXP) lipoic acid  (EXP) lovastatin  (ISO) LY294002  (EXP) mercaptopurine  (ISO) metformin  (EXP) methadone  (EXP) methotrexate  (EXP) metoclopramide  (EXP) N-acetyl-L-cysteine  (EXP,ISO) N-ethyl-N-nitrosourea  (ISO) nicotinamide  (EXP) nitric oxide  (EXP) olanzapine  (EXP) oleic acid  (EXP) palmitic acid  (EXP,ISO) paroxetine  (ISO) pentolinium tartrate  (EXP) phenobarbital  (ISO) potassium chloride  (EXP) propranolol  (EXP) purine-6-thiol  (ISO) pyridine  (ISO) pyruvic acid  (ISO) quercetin  (EXP) resveratrol  (EXP,ISO) risperidone  (EXP) rosiglitazone  (EXP,ISO) saquinavir  (EXP) sertraline  (ISO) sodium dichromate  (ISO) staurosporine  (ISO) streptozocin  (EXP,ISO) sucrose  (EXP) sulpiride  (EXP) tacrolimus hydrate  (EXP) telmisartan  (EXP) terbutaline  (EXP) testosterone  (EXP) tolbutamide  (EXP) trans-resveratrol  (EXP,ISO) tributylstannane  (ISO) troglitazone  (EXP,ISO) wortmannin  (EXP,ISO) yohimbine  (EXP) zinc atom  (EXP) zinc(0)  (EXP) Gene Ontology Annotations Biological Process activation of protein kinase B activity  (IDA) acute-phase response  (IDA) alpha-beta T cell activation  (IDA) cell-cell signaling  (IC) cellular protein metabolic process  (TAS) endocrine pancreas development  (TAS) energy reserve metabolic process  (TAS) fatty acid homeostasis  (IMP) G-protein coupled receptor signaling pathway  (IDA) glucose homeostasis  (IMP) glucose metabolic process  (IEA) glucose transport  (IDA) insulin receptor signaling pathway  (TAS) MAPK cascade  (IDA) negative regulation of acute inflammatory response  (IDA) negative regulation of apoptotic process  (NAS) negative regulation of fatty acid metabolic process  (IMP) negative regulation of feeding behavior  (IDA) negative regulation of gluconeogenesis  (NAS) negative regulation of glycogen catabolic process  (IMP) negative regulation of lipid catabolic process  (NAS) negative regulation of NAD(P)H oxidase activity  (IDA) negative regulation of protein catabolic process  (IDA) negative regulation of protein oligomerization  (IDA) negative regulation of protein secretion  (IDA) negative regulation of proteolysis  (IMP) negative regulation of respiratory burst involved in inflammatory response  (IDA) negative regulation of vasodilation  (NAS) positive regulation of brown fat cell differentiation  (TAS) positive regulation of cell differentiation  (NAS) positive regulation of cell growth  (NAS) positive regulation of cell migration  (ISS) positive regulation of cell proliferation  (IDA) positive regulation of cellular protein metabolic process  (IMP) positive regulation of cytokine secretion  (IDA) positive regulation of DNA replication  (IDA) positive regulation of glucose import  (IDA) positive regulation of glycogen biosynthetic process  (IDA) positive regulation of glycolysis  (IDA,IMP) positive regulation of insulin receptor signaling pathway  (IDA) positive regulation of lipid biosynthetic process  (NAS) positive regulation of MAPK cascade  (IDA) positive regulation of mitosis  (IDA) positive regulation of NF-kappaB transcription factor activity  (IDA) positive regulation of nitric oxide biosynthetic process  (NAS) positive regulation of nitric-oxide synthase activity  (NAS) positive regulation of peptide hormone secretion  (TAS) positive regulation of peptidyl-tyrosine phosphorylation  (IDA) positive regulation of phosphatidylinositol 3-kinase cascade  (IDA) positive regulation of protein autophosphorylation  (ISS) positive regulation of protein kinase B signaling cascade  (IDA) positive regulation of respiratory burst  (IDA) positive regulation of vasodilation  (NAS) regulation of cellular amino acid metabolic process  (IMP) regulation of insulin secretion  (TAS) regulation of protein localization  (IDA) regulation of protein secretion  (IDA) regulation of transcription, DNA-dependent  (NAS) regulation of transmembrane transporter activity  (IDA) small molecule metabolic process  (TAS) wound healing  (IDA) Cellular Component endoplasmic reticulum lumen  (TAS) endosome lumen  (TAS) extracellular region  (IC,IEA,TAS) extracellular space  (IDA) Golgi lumen  (TAS) secretory granule lumen  (TAS) Molecular Function hormone activity  (IC,IEA,IMP,NAS) insulin receptor binding  (IDA,IPI) insulin-like growth factor receptor binding  (IPI) protease binding  (IPI) protein binding  (IPI) Molecular Pathway Annotations aldosterone signaling pathway  (IEA) altered insulin signaling pathway  (TAS) autophagy pathway  (IEA) forkhead class A signaling pathway  (EXP) insulin responsive facilitative sugar transporter mediated glucose transport pathway  (EXP) insulin signaling pathway  (EXP,IEA,TAS) maturity onset diabetes of the young pathway  (IEA) mTOR signaling pathway  (IEA) prostate cancer pathway  (IEA) type 1 diabetes mellitus pathway  (IEA) type 2 diabetes mellitus pathway  (IEA,TAS) External Database Links KEGG Pathway Aldosterone-regulated sodium reabsorption HIF-1 signaling pathway Insulin secretion Insulin signaling pathway Maturity onset diabetes of the young mTOR signaling pathway Oocyte meiosis PI3K-Akt signaling pathway Progesterone-mediated oocyte maturation Prostate cancer Regulation of actin cytoskeleton Regulation of autophagy Type I diabetes mellitus Type II diabetes mellitus Pathway Interaction Database Arf6 trafficking events (PID:200057) ATF-2 transcription factor network (PID:200135) FOXA1 transcription factor network (PID:200226) FOXA2 and FOXA3 transcription factor networks (PID:200087) Insulin Pathway (PID:200014) Insulin-mediated glucose transport (PID:200196) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Phenotype Annotations increased susceptibility to age related obesity  (IAGP) obese  (IAGP) References - curated 1. Brands MW, etal., Hypertension. 1997 Apr;29(4):1014-9. 2. Collinet M, etal., Eur J Pediatr. 1998 Jun;157(6):456-60. 3. Colombo C, etal., J Clin Invest. 2008 Jun;118(6):2148-56. 4. Crabtree JS, etal., Mol Cell Biol. 2003 Sep;23(17):6075-85. 5. Currie CJ, etal., Diabetologia. 2009 Sep;52(9):1766-77. Epub 2009 Jul 2. 6. Fang D, etal., Endocr J. 2012;59(1):81-90. Epub 2011 Nov 9. 7. Fort PE, etal., PLoS One. 2011;6(10):e26498. Epub 2011 Oct 26. 8. Gastinger MJ, etal., Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3143-50. 9. GOA_HUMAN data from the GO Consortium 10. Grunblatt E, etal., J Neurochem. 2007 May;101(3):757-70. 11. Holmkvist J, etal., PLoS One. 2009 Jun 11;4(6):e5872. 12. Hompesch M, etal., Diabetes Technol Ther. 2009 May;11(5):307-13. 13. Hunter SJ and Garvey WT, Am J Med. 1998 Oct;105(4):331-45. 14. Jiang Y and Steinle JJ, Can J Physiol Pharmacol. 2010 May;88(5):553-61. 15. Kao PC, etal., J Clin Endocrinol Metab. 1994 May;78(5):1048-51. 16. Kolb A, etal., Cancer Biol Ther. 2009 Aug;8(16):1527-33. Epub 2009 Aug 13. 17. Krechler T, etal., Neoplasma. 2009;56(1):26-32. 18. Le Stunff C, etal., Nat Genet. 2000 Dec;26(4):444-6. 19. Li D, etal., Gastroenterology. 2009 Aug;137(2):482-8. Epub 2009 Apr 16. 20. Lu H, etal., J Gastroenterol Hepatol. 2009 Feb;24(2):228-32. Epub 2008 Aug 17. 21. Navaneethan SD and Beddhu S, Nephrol Dial Transplant. 2009 Apr;24(4):1260-6. Epub 2008 Nov 25. 22. Olansky L, etal., J Clin Invest. 1992 May;89(5):1596-602. 23. Park SY, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1449-54. Epub 2009 Dec 23. 24. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 25. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 26. RGD automated import pipeline for gene-chemical interactions 27. RGD Automated Pipelines 28. Roth J, etal., Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;56(5):287-92. 29. Skyler JS, etal., Diabetes Res Clin Pract. 2008 Nov;82(2):238-46. Epub 2008 Sep 27. 30. Stoy J, etal., Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15040-4. Epub 2007 Sep 12. 31. Ward WK, etal., Diabetologia. 1987 Sep;30(9):698-702. 32. Yilmaz O, etal., J Diabetes Complications. 2009 Mar 6. 33. Youngren JF Cell Mol Life Sci. 2007 Apr;64(7-8):873-91. 34. Zyromski NJ, etal., Surgery. 2009 Aug;146(2):258-63. References - uncurated PubMed 10084601   10383393   10497219   10604997   10644978   10909971   10938588   10966857   10969839   11140838   11145591   11278339   11347740   11376336   11387233   11398136   11443198   11500939   11502799   11511079   11606170   11738155   11739440   11742412   11779231   11779865   11800057   1184755   11866509   11912547   11937112   11953210   11978629   12021212   12029093   12032154   12047362   12051853   12072386   12079889   12086926   12101177   12111440   12133430   12135947   12138094   12182905   12186542   12189018   12364457   12378388   12392301   12404181   12441313   12477932   12479880   12529491   12589110   12610512   12620428   12624089   12631734   12637980   12639765   12654724   12660731   12709672   12715715   12721156   12750767   12803245   12821730   12881524   12930990   12946932   12952878   13658959   1406615   1433291   14426955   14551916   14607844   14615391   14616883   14633852   14647005   14651526   14657411   14659752   14671163   14671189   14671204   14679083   14693412   14707040   14715866   14739855   14744991   14749349   14979729   14986111   15028719   15046555   15047631   15070567   15095040   15111508   15126243   15161800   15163889   15170498   15185208   15194403   15220197   15220214   15230641   15237706   15240646   15265780   15277396   15305767   15342556   15351621   15367890   15473891   15489334   15529622   15538935   15561961   15581831   15583859   15589123   15591776   15610006   15613433   15616007   15632182   15678496   15684637   15699505   15705595   15705917   15792832   15834700   15880482   15889096   15919610   15920061   15922332   15928253   15929679   15936461   15949705   15956217   15956745   15983206   16006430   1601997   16025255   16025839   16081366   16123374   16246845   16251897   16276008   16307231   16344718   16344925   16362283   16380501   16390390   16418171   1646635   16497805   16519889   16531418   16552513   16595598   16604263   16608900   16614815   16629714   16691379   16731532   16731859   16736556   16741735   16751187   16799400   16800793   16835468   16866381   16868061   16885156   16949073   16951936   16996478   17011062   17011566   17051221   17052889   17053071   17065334   17068290   17103462   17105729   17116217   17127405   17130532   17157312   17192475   17192483   17242212   17279313   17284223   17291451   17299081   17310371   17311896   17327422   17327454   17337306   17341563   17342078   17344504   17348446   17416760   17433504   17437081   17461431   17464100   17468256   17471492   17473382   17479246   17487982   17497031   17506723   17513702   17520407   17553505   17554260   17586504   17616349   17620332   17632545   17652220   17667841   17675047   17698984   17700581   17726611   17805200   17828388   17846745   17890489   17898179   17901401   17914103   17920639   17923791   17925406   17937736   17957153   17972051   17993259   18029081   18029348   18039179   18039812   18040865   18057381   18070774   18072146   18077505   18083784   18085551   18090240   18093308   18157793   18162506   18171712   18192540   18198306   18198311   18211635   18216377   18220656   18279373   18283245   18283256   18283260   18284601   18292987   18294642   18305020   18307789   18310307   18375961   18388898   18404969   18417529   18441389   18483566   1851182   18520331   18582564   18620562   18660489   18662362   18692115   18716398   18719673   18834984   18839133   18840770   18853485   18940880   18951876   18981553   18983503   18996102   19000139   19000992   19020323   19025443   19037607   19051206   19052261   19064572   19073905   19073967   19094425   19115062   19141582   19146426   19188433   19188609   19190820   19214176   19247282   19249902   19321435   19321436   19321446   19324891   19336408   19338578   19367319   19430480   19434426   19445897   19463742   19466592   19491387   19556358   19578600   19578796   195962   1959628   19602055   19680231   19683528   19688775   19709092   19727662   19742322   19767753   19769745   19778377   19785038   19833889   19845278   19885595   19898946   19913026   19913121   19935854   19948072   19950226   20007936   20033399   20054344   20098959   20106974   20119675   20133622   20133841   20138117   20142200   20190549   20203524   20208155   20226046   20232313   20301620   20332111   20345871   20357092   20357430   20361993   2036420   20378605   20391195   20455999   20468064   20535137   20564319   20566319   20587420   20607677   20628086   20628762   20647273   20655470   20679359   20724178   20734064   20738396   20739464   20805278   20808760   20849903   20863361   20938745   21036154   21054880   21059249   21073664   21094141   21193298   21193618   21203453   21203503   21251282   21281583   21302286   21308844   21336277   21352425   21361910   21412422   21427225   21437235   21442164   21448434   21454690   21454697   21462967   21473587   21507316   21544516   21559376   21566073   21574953   21592955   21646299   21660954   21707690   21711374   21724851   21813805   21816162   21823539   21829393   21832049   21867683   21871813   21887289   21900206   21906630   21911493   2196279   22003494   22005517   22033917   22065208   22065581   22068552   22082268   22095122   22132167   22132232   22167125   22167126   22193626   22229322   22235272   22242132   22253890   22290178   22297303   22307032   22315413   22319034   22357962   22359667   22378730   22379117   22383948   22393448   22403629   22465905   22468791   22547909   22567146   22577092   2271664   22718751   22739332   22748134   22751690   22763970   22883454   22918957   22949029   22967498   22967500   22972030   22982989   23018458   23043361   23092880   23133528   23223446   23275337   23302862   23321478   2550426   3470784   3511099   3518947   3537011   3553851   381941   4019786   4443293   4698553   4698555   4803504   503234   5101771   5560404   6243748   6248962   6253909   6312455   6351842   6382002   6424111   6927840   7027261   7350438   7477119   7556975   7688386   7716547   7818556   8358440   8421693   8452530   8496180   8524413   8702995   8971927   9092559   9141561   9235985   9388210   9498508   9631292   9773776   9830016 RGD Disease Portals INS has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Biological Process Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Biological Process Respiratory Pathways Genomics Comparative Map Data INS   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 2,114,901 - 2,116,331 - NCBI Human Genome Assembly HuRef 11 1,971,272 - 1,972,702 - NCBI Human Genome Assembly GRCh37 11 2,181,009 - 2,182,439 - NCBI Human Genome Assembly Build 36 11 2,137,585 - 2,139,015 - NCBI Human Cytogenetic Map 11 p15.5   NCBI Human Genome Assembly 11 2,137,584 - 2,139,000   NCBI Ins2   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 7 142,678,656 - 142,679,708 - NCBI Mouse cM Map 7 88.0   NCBI Mouse Celera Assembly 7 142,434,985 - 142,436,037 - NCBI Mouse Genome Assembly Build 37 7 149,864,561 - 149,865,613 - NCBI Mouse Genome Assembly Build 36.1 7 149,864,566 - 149,865,613 - NCBI Mouse Cytogenetic Map 7 F5   NCBI Ins2   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 1 q41   NCBI RGSC Genome Assembly v5.0 1 222,751,786 - 222,752,853 - NCBI RGSC Genome Assembly v3.4 1 202,935,548 - 202,936,379 - NCBI Rat Celera Assembly 1 195,461,309 - 195,462,376 - NCBI Genome Assembly 3.1 1 203,123,613 - 203,124,445 - NCBI Position Markers RH75852   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,122 - 1,971,310   UniSTS Human Genome Assembly GRCh37 11 2,180,859 - 2,181,047   UniSTS Human Celera Assembly 11 2,217,366 - 2,217,554   RGD Human Genome Assembly Build 36 11 2,137,435 - 2,137,623   RGD Human Cytogenetic Map 11 p15.5   UniSTS G44339   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,972,377 - 1,972,593   UniSTS Human Genome Assembly GRCh37 11 2,182,114 - 2,182,330   UniSTS Human Celera Assembly 11 2,218,621 - 2,218,837   RGD Human Genome Assembly Build 36 11 2,138,690 - 2,138,906   RGD Human Cytogenetic Map 11 p15.5   UniSTS GDB:179433   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,272 - 1,971,490   UniSTS Human Genome Assembly GRCh37 11 2,181,009 - 2,181,227   UniSTS Human Celera Assembly 11 2,217,516 - 2,217,734   RGD Human Genome Assembly Build 36 11 2,137,585 - 2,137,803   RGD Human Cytogenetic Map 11 p15.5   UniSTS GDB:180498   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,196 - 1,971,416   UniSTS Human Genome Assembly GRCh37 11 2,180,933 - 2,181,153   UniSTS Human Celera Assembly 11 2,217,440 - 2,217,660   RGD Human Genome Assembly Build 36 11 2,137,509 - 2,137,729   RGD Human Cytogenetic Map 11 p15.5   UniSTS GDB:181496   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,972,338 - 1,972,687   UniSTS Human Genome Assembly GRCh37 11 2,182,075 - 2,182,424   UniSTS Human Celera Assembly 11 2,218,582 - 2,218,931   RGD Human Genome Assembly Build 36 11 2,138,651 - 2,139,000   RGD Human Cytogenetic Map 11 p15.5   UniSTS GDB:197907   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,541 - 1,971,980   UniSTS Human Genome Assembly GRCh37 11 2,181,278 - 2,181,717   UniSTS Human Celera Assembly 11 2,217,785 - 2,218,224   RGD Human Genome Assembly Build 36 11 2,137,854 - 2,138,293   RGD Human Cytogenetic Map 11 p15.5   UniSTS GDB:316225   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,972,880 - 1,973,695   UniSTS Human Genome Assembly GRCh37 11 2,182,617 - 2,183,430   UniSTS Human Celera Assembly 11 2,219,124 - 2,220,023   RGD Human Genome Assembly Build 36 11 2,139,193 - 2,140,006   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD01817   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,271 - 1,972,123   UniSTS Human Genome Assembly GRCh37 11 2,181,008 - 2,181,860   UniSTS Human Celera Assembly 11 2,217,515 - 2,218,367   RGD Human Genome Assembly Build 36 11 2,137,584 - 2,138,436   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD03418   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,973,565 - 1,974,361   UniSTS Human Genome Assembly GRCh37 11 2,183,300 - 2,184,096   UniSTS Human Celera Assembly 11 2,219,893 - 2,220,689   RGD Human Genome Assembly Build 36 11 2,139,876 - 2,140,672   RGD Human Cytogenetic Map 11 p15.5   UniSTS ECD04020   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,972,260 - 1,973,037   UniSTS Human Genome Assembly GRCh37 11 2,181,997 - 2,182,774   UniSTS Human Celera Assembly 11 2,218,504 - 2,219,281   RGD Human Genome Assembly Build 36 11 2,138,573 - 2,139,350   RGD Human Cytogenetic Map 11 p15.5   UniSTS REN117096   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,972,373 - 1,972,639   UniSTS Human Genome Assembly GRCh37 11 2,182,110 - 2,182,376   UniSTS Human Celera Assembly 11 2,218,617 - 2,218,883   RGD Human Genome Assembly Build 36 11 2,138,686 - 2,138,952   RGD Human Cytogenetic Map 11 p15.5   UniSTS PMC24644P6   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,352 - 1,972,326   UniSTS Human Genome Assembly GRCh37 11 2,181,089 - 2,182,063   UniSTS Human Celera Assembly 11 2,217,596 - 2,218,570   RGD Human Genome Assembly Build 36 11 2,137,665 - 2,138,639   RGD Human Cytogenetic Map 11 p15.5   UniSTS PMC123023P3   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,346 - 1,972,464   UniSTS Human Genome Assembly GRCh37 11 2,181,083 - 2,182,201   UniSTS Human Celera Assembly 11 2,217,590 - 2,218,708   UniSTS Ins1   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,347 - 1,972,445   UniSTS Human Genome Assembly GRCh37 11 2,181,084 - 2,182,182   UniSTS Human Celera Assembly 11 2,217,591 - 2,218,689   UniSTS Ins2   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,366 - 1,972,452   UniSTS Human Genome Assembly GRCh37 11 2,181,103 - 2,182,189   UniSTS Human Celera Assembly 11 2,217,610 - 2,218,696   UniSTS PMC21231P1   Map Chr Position Strand Source Human Genome Assembly HuRef 11 1,971,369 - 1,972,456   UniSTS Human Genome Assembly GRCh37 11 2,181,106 - 2,182,193   UniSTS Human Celera Assembly 11 2,217,613 - 2,218,700   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 2289212 BW357_H Body weight QTL 357 (human) .0365 Body fat amount percent fat 11 1 17539910 Human 2316722 GLUCO278_H Glucose level QTL 278 (human) 1.25 .01371 Glucose level 11 1 18988104 Human 2314986 INSUL33_H Insulin level QTL 33 (human) 1.9 Insulin level 11 1566810 4539970 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_007114 (Get FASTA) Search GEO for Microarray Profiles   NM_000207 (Get FASTA) Search GEO for Microarray Profiles   NM_001185097 (Get FASTA) Search GEO for Microarray Profiles   NM_001185098 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide ABBA01032100 (Get FASTA) Search GEO for Microarray Profiles   AC132217 (Get FASTA) Search GEO for Microarray Profiles   AJ009655 (Get FASTA) Search GEO for Microarray Profiles   AMYH01003319 (Get FASTA) Search GEO for Microarray Profiles   AY138590 (Get FASTA) Search GEO for Microarray Profiles   AY899304 (Get FASTA) Search GEO for Microarray Profiles   BC005255 (Get FASTA) Search GEO for Microarray Profiles   BM510347 (Get FASTA) Search GEO for Microarray Profiles   BM510748 (Get FASTA) Search GEO for Microarray Profiles   BP322143 (Get FASTA) Search GEO for Microarray Profiles   BT006808 (Get FASTA) Search GEO for Microarray Profiles   CH471158 (Get FASTA) Search GEO for Microarray Profiles   J00265 (Get FASTA) Search GEO for Microarray Profiles   JF909299 (Get FASTA) Search GEO for Microarray Profiles   JQ951950 (Get FASTA) Search GEO for Microarray Profiles   L15440 (Get FASTA) Search GEO for Microarray Profiles   M10039 (Get FASTA) Search GEO for Microarray Profiles   V00565 (Get FASTA) Search GEO for Microarray Profiles   X70508 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_000207 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_000198 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 2,114,901 - 2,116,331 - NCBI Human Genome Assembly HuRef 11 1,971,272 - 1,972,702 - ENTREZGENE Human Genome Assembly GRCh37 11 2,181,009 - 2,182,439 - ENTREZGENE Human Genome Assembly Build 36 11 2,137,585 - 2,139,015 - NCBI Archive RefSeq Acc Id: NM_001185097 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001172026 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 2,114,901 - 2,116,331 - NCBI Human Genome Assembly HuRef 11 1,971,272 - 1,972,702 - ENTREZGENE Human Genome Assembly GRCh37 11 2,181,009 - 2,182,439 - ENTREZGENE RefSeq Acc Id: NM_001185098 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001172027 Peptide Label: preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 11 2,114,901 - 2,116,331 - NCBI Human Genome Assembly HuRef 11 1,971,272 - 1,972,702 - ENTREZGENE Human Genome Assembly GRCh37 11 2,181,009 - 2,182,439 - ENTREZGENE Protein Sequences Protein RefSeqs NP_000198 (Get FASTA)   NP_001172026 (Get FASTA)   NP_001172027 (Get FASTA) GenBank Protein AAA59172 (Get FASTA)   AAA59173 (Get FASTA)   AAA59179 (Get FASTA)   AAH05255 (Get FASTA)   AAN39451 (Get FASTA)   AAP35454 (Get FASTA)   AAW83741 (Get FASTA)   ABM83966 (Get FASTA)   ABM87282 (Get FASTA)   AEG19452 (Get FASTA)   AFK93533 (Get FASTA)   CAA08766 (Get FASTA)   CAA23828 (Get FASTA)   CAA49913 (Get FASTA)   EAX02488 (Get FASTA)   EAX02489 (Get FASTA)   P01308 (Get FASTA) Promoters RGD ID: 6850046 Promoter ID: EP07109 Type: single initiation site Name: HS_INS Description: Insulin, INS gene. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Notes: homology_group=Homology group 45; Mammalian insulin. Tissues & Cell Lines: pancreas islet cells Experiment Methods: RNA sequencing by primer extension Position: Map Chr Position Strand Source Human Genome Assembly Build 36 11 2,139,015 - 2,139,075   EPD Additional Information External Database Links Database Acc Id Source(s) COSMIC INS COSMIC Ensembl Genes ENSG00000254647 ENTREZGENE Ensembl Protein ENSP00000250971 ENTREZGENE   ENSP00000380432 ENTREZGENE Ensembl Transcript ENST00000250971 ENTREZGENE   ENST00000397262 ENTREZGENE Entrez Gene 3630 ENTREZGENE Gene3D-CATH Ins/IGF/relaxin UniProtKB/Swiss-Prot Germonline ENSG00000129965 HGNC ID 6081 ENTREZGENE HomoloGene Group ID 173 ENTREZGENE HPRD ID 01455 ENTREZGENE InterPro Insulin UniProtKB/Swiss-Prot   Insulin-like UniProtKB/Swiss-Prot   Insulin_CS UniProtKB/Swiss-Prot   Insulin_family UniProtKB/Swiss-Prot IPI IPI00001508 UniProtKB/Swiss-Prot   IPI00853225 UniProtKB/TrEMBL   IPI00853573 UniProtKB/TrEMBL KEGG Report hsa:3630 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 176730 OMIM   606176 OMIM   613370 OMIM Pfam Insulin UniProtKB/Swiss-Prot PharmGKB PA201 PharmGKB PRINTS INSULIN UniProtKB/Swiss-Prot   INSULINFAMLY UniProtKB/Swiss-Prot PROSITE INSULIN UniProtKB/Swiss-Prot SMART IlGF UniProtKB/Swiss-Prot Superfamily-SCOP Insulin-like UniProtKB/Swiss-Prot UniGene Hs.272259 ENTREZGENE UniProt A6XGL2_HUMAN UniProtKB/TrEMBL   C9JNR5_HUMAN UniProtKB/TrEMBL   I3WAC9_HUMAN UniProtKB/TrEMBL   INS_HUMAN UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 INS  insulin  INS  insulin  Symbol and/or name change 39860 APPROVED 2011-07-27 INS  insulin  INS  insulin  Symbol and/or name change 39860 APPROVED

More on INS Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 731056 Created: 2003-12-10 Species: Homo sapiens Last Modified: 2013-05-14 Status: ACTIVE