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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Acute Lung Injury
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Accession:DOID:9004610 term browser browse the term
Definition:A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Synonyms:exact_synonym: Acute Lung Injuries
 primary_id: MESH:D055371;   RDO:0007706
 xref: EFO:0004610

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Acute Lung Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 severity
treatment		 ISO human protein in a mouse model
associated with avian influenza;protein:decreased expression:lung (mouse)
associated with Escherichia coli Infections
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:16001071 PMID:25391767 PMID:27302421 PMID:29990483 RGD:32716389 RGD:40400897 RGD:40818412 NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702 		JBrowse link
G Acvr1 activin A receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21297076 NCBI chrNW_004936469:20,743,195...20,811,567
Ensembl chrNW_004936469:20,743,213...20,811,569 		JBrowse link
G Adar adenosine deaminase RNA specific treatment ISO RGD PMID:18520702 RGD:10755331 NCBI chrNW_004936580:4,183,016...4,208,341
Ensembl chrNW_004936580:4,183,079...4,203,435 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO associated with Sepsis RGD PMID:22156343 PMID:23522481 RGD:5686380 RGD:8695940 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Adra2a adrenoceptor alpha 2A ISO RGD PMID:21542970 RGD:6480481 NCBI chrNW_004936486:1,837,785...1,841,019
Ensembl chrNW_004936486:1,838,176...1,839,630 		JBrowse link
G Aff4 ALF transcription elongation factor 4 treatment ISO RGD PMID:31466050 RGD:155631268 NCBI chrNW_004936647:2,242,476...2,342,409
Ensembl chrNW_004936647:2,242,319...2,336,532 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO associated with Hyperoxia; protein:decreased expression:bronchoalveolar lavage fluid (rat) RGD PMID:23576805 RGD:7244254 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Akap12 A-kinase anchoring protein 12 ISO mRNA,protein:increased expression:lung RGD PMID:23912647 RGD:14348970 NCBI chrNW_004936489:4,237,466...4,258,408
Ensembl chrNW_004936489:4,237,439...4,261,141 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 severity ISO RGD PMID:23904165 RGD:38676478 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO RGD PMID:19752233 RGD:5509626 NCBI chrNW_004936677:3,232,183...3,241,307
Ensembl chrNW_004936677:3,232,183...3,241,253 		JBrowse link
G Apoa1 apolipoprotein A1 ISO CTD Direct Evidence: therapeutic CTD PMID:20972769 NCBI chrNW_004936542:2,111,055...2,112,626
Ensembl chrNW_004936542:2,111,052...2,112,854 		JBrowse link
G Aqp5 aquaporin 5 ISO associated with Disseminated Intravascular Coagulation;mRNA,protein:decreased expression:lung: RGD PMID:24806323 RGD:11553933 NCBI chrNW_004936512:7,639,518...7,643,242
Ensembl chrNW_004936512:7,639,668...7,642,756 		JBrowse link
G Ascl1 achaete-scute family bHLH transcription factor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:20554700 NCBI chrNW_004936492:11,315,929...11,317,166
Ensembl chrNW_004936492:11,316,417...11,317,166 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bcl2 BCL2 apoptosis regulator ISO associated with Endotoxemia RGD PMID:20663300 RGD:10054109 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G C3 complement C3 treatment ISO RGD PMID:22763771 RGD:11040808 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Casp3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:29755641 PMID:32062619 RGD:13782288 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:29755641 RGD:13782288 NCBI chrNW_004936726:554,627...596,334
Ensembl chrNW_004936726:554,758...595,922 		JBrowse link
G Cat catalase ISO CTD Direct Evidence: therapeutic CTD PMID:15612528 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Cav1 caveolin 1 treatment ISO RGD PMID:24919947 RGD:10045573 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) ISO associated with Malaria RGD PMID:18483551 RGD:6893505 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 treatment ISO associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chrNW_004936547:479,261...504,757 JBrowse link
G Ddit3 DNA damage inducible transcript 3 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chrNW_004936646:1,665,019...1,669,212 JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16625121 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20935109 RGD:5131862 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Ephx1 epoxide hydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26840748 NCBI chrNW_004936526:2,589,254...2,652,831
Ensembl chrNW_004936526:2,614,059...2,653,286 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:22051199 RGD:5688354 NCBI chrNW_004936675:350,357...392,919
Ensembl chrNW_004936675:350,342...392,551 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chrNW_004936541:4,613,197...4,705,911
Ensembl chrNW_004936541:4,617,555...4,705,866 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:22804886 RGD:7387313 NCBI chrNW_004936562:2,371,725...2,388,617
Ensembl chrNW_004936562:2,372,044...2,388,650 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased expression: respiratory system fluid/secretion RGD PMID:21964405 RGD:11341740 NCBI chrNW_004936537:4,637,028...4,647,915
Ensembl chrNW_004936537:4,636,667...4,647,916 		JBrowse link
G Fadd Fas associated via death domain treatment ISO associated with Shock, Hemorrhagic RGD PMID:24122010 RGD:11341811 NCBI chrNW_004936599:633,501...639,412
Ensembl chrNW_004936599:633,330...639,456 		JBrowse link
G Fas Fas cell surface death receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:11778176 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Fcgr1a Fc fragment of IgG receptor Ia ISO RGD PMID:19106808 RGD:5147925 NCBI chrNW_004936580:115,552...144,970
Ensembl chrNW_004936580:115,450...145,785 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa ISO RGD PMID:19106808 RGD:5147925 NCBI chrNW_004937131:15,542...22,099 JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb treatment ISO RGD PMID:19106808 RGD:5147925 NCBI chrNW_004937131:80,014...96,114 JBrowse link
G Fga fibrinogen alpha chain ISO protein:increased expression:blood (rat) RGD PMID:22804886 RGD:7387313 NCBI chrNW_004936576:1,322,406...1,329,743 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO associated with Endotoxemia RGD PMID:21528367 RGD:5684427 NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041 		JBrowse link
G Foxa1 forkhead box A1 ISO mRNA,protein:increased expression:lung RGD PMID:19649697 RGD:151665511 NCBI chrNW_004936494:11,529,546...11,535,224
Ensembl chrNW_004936494:11,529,546...11,535,224 		JBrowse link
G Gja1 gap junction protein alpha 1 treatment ISO RGD PMID:23576849 RGD:8662452 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO protein:decreased expression:lung (rat) RGD PMID:25581610 RGD:13504847 NCBI chrNW_004936636:617,376...640,424
Ensembl chrNW_004936636:617,356...640,932 		JBrowse link
G Gsr glutathione-disulfide reductase ISO RGD PMID:7896613 RGD:7257562 NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166 		JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO associated with Endotoxemia
associated with Burns
associated with Crush Injuries		 RGD PMID:19766246 PMID:23874764 PMID:30465396 RGD:10402098 RGD:34901874 RGD:4892587 NCBI chrNW_004936472:25,236,728...25,246,585
Ensembl chrNW_004936472:25,236,728...25,246,580 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO RGD PMID:16922808 RGD:5508470 NCBI chrNW_004936549:1,378,536...1,400,501
Ensembl chrNW_004936549:1,378,736...1,400,532 		JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO associated with Reperfusion Injury RGD PMID:20360627 PMID:20850789 RGD:4140418 RGD:4145326 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C ISO protein:altered localization:lung (mouse) RGD PMID:19029002 RGD:10054390 NCBI chrNW_004936880:368,041...425,967 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 treatment ISO associated with Crush Injuries RGD PMID:30465396 RGD:34901874 NCBI chrNW_004936487:13,348,465...13,352,717
Ensembl chrNW_004936487:13,348,465...13,352,717 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17973899 PMID:20569121 PMID:27525872 RGD:8547719 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:25278421 RGD:39939031 NCBI chrNW_004936843:658,058...672,662
Ensembl chrNW_004936843:657,979...672,700 		JBrowse link
G Ifng interferon gamma ISO RGD PMID:21767135 RGD:6480432 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Il10 interleukin 10 treatment
no_association		 ISO DNA:SNP:promoter:-1082G>A (rs1800896) (human)
DNA:SNP:promoter:rs3021097 (human)
associated with Reperfusion Injury;protein:increased expression:lung, plasma		 RGD PMID:23801594 PMID:23902576 PMID:30412745 RGD:14975158 RGD:7364984 RGD:7365008 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il13 interleukin 13 ISO mRNA:increased expression:lung RGD PMID:15461830 RGD:4145512 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il17a interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:28600744 NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008 		JBrowse link
G Il18 interleukin 18 treatment ISO associated with Myocardial Reperfusion Injury RGD PMID:24223666 RGD:8655952 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:serum
mRNA, protein:increased expression:lung
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:8613550 PMID:20153312 PMID:20663306 PMID:21767135 PMID:22982561 More... RGD:4142531 RGD:4142807 RGD:4143193 RGD:6480432 RGD:7204498 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il1rl1 interleukin 1 receptor like 1 ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:21352201 RGD:5144222 NCBI chrNW_004936713:1,020,969...1,035,012
Ensembl chrNW_004936713:1,021,044...1,035,039 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO mRNA:increased expression:lung RGD PMID:8613550 PMID:15970097 RGD:4143168 RGD:4143193 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Il2 interleukin 2 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:21767135 RGD:6480432 NCBI chrNW_004936662:1,594,953...1,599,625
Ensembl chrNW_004936662:1,594,953...1,599,625 		JBrowse link
G Il4i1 interleukin 4 induced 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36537648 NCBI chrNW_004936664:3,674,612...3,715,036
Ensembl chrNW_004936664:3,675,805...3,686,262 		JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:bronchoalveolar lavage, blood, lung (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:19995278 PMID:32062619 RGD:11062103 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 ISO mRNA, protein:increased expression:lung (mouse) RGD PMID:21577093 RGD:36049795 NCBI chrNW_004936545:4,233,353...4,284,324
Ensembl chrNW_004936545:4,233,358...4,282,806 		JBrowse link
G Itgam integrin subunit alpha M treatment ISO associated with Hemorrhagic Shock RGD PMID:1347308 PMID:16096539 RGD:329901922 RGD:329901935 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:1374449 RGD:6482199 NCBI chrNW_004936778:1,286,475...1,311,184
Ensembl chrNW_004936778:1,286,341...1,311,194 		JBrowse link
G Jak3 Janus kinase 3 ISO RGD PMID:22359619 RGD:11531100 NCBI chrNW_004936596:3,212,593...3,224,426
Ensembl chrNW_004936596:3,212,593...3,224,048 		JBrowse link
G Kdr kinase insert domain receptor ISO associated with Endotoxemia;mRNA, protein:decreased expression:lung RGD PMID:21528367 RGD:5684427 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G LOC101960095 antileukoproteinase severity
treatment		 ISO associated with Endotoxemia RGD PMID:10092827 PMID:25466948 RGD:9999422 RGD:9999425 NCBI chrNW_004936514:7,618,382...7,620,790
Ensembl chrNW_004936514:7,618,261...7,620,912 		JBrowse link
G LOC101961846 neutrophil elastase treatment ISO protein:increased expression:perfusate:
associated with Shock, Hemorrhagic;		 RGD PMID:15257085 PMID:17203197 PMID:18283562 RGD:10450548 RGD:10450585 RGD:10450587 NCBI chrNW_004936588:345,678...347,420
Ensembl chrNW_004936588:345,678...347,413 		JBrowse link
G LOC101964209 C-C chemokine receptor type 1 ISO associated with Pancreatitis RGD PMID:17312463 RGD:5688151 NCBI chrNW_004936596:177,774...183,186
Ensembl chrNW_004936596:177,812...183,186 		JBrowse link
G LOC101964975 interleukin-8 disease_progression ISO associated with sepsis;protein:increased expression:blood serum (human) RGD PMID:28506137 RGD:40925937 NCBI chrNW_004936598:1,779,471...1,781,353
Ensembl chrNW_004936598:1,779,471...1,781,353 		JBrowse link
G LOC101968921 angiotensin-converting enzyme treatment ISO associated wit Escherichia coli Infections RGD PMID:29990483 RGD:40400897 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO mRNA:increased expression:lung RGD PMID:16882535 PMID:18367723 RGD:5135235 RGD:5147744 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G Ltb4r2 leukotriene B4 receptor 2 severity ISO associated with Endotoxemia RGD PMID:27703200 RGD:40903067 NCBI chrNW_004936722:239,811...242,050 JBrowse link
G Mfn1 mitofusin 1 ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chrNW_004936566:3,737,315...3,775,894
Ensembl chrNW_004936566:3,737,315...3,775,693 		JBrowse link
G Mfn2 mitofusin 2 ISO mRNA, protein:increased expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:23040778 RGD:13207316 NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851 		JBrowse link
G Mmp7 matrix metallopeptidase 7 ISO associated with Sepsis RGD PMID:21567117 RGD:9685338 NCBI chrNW_004936551:5,388,456...5,395,071
Ensembl chrNW_004936551:5,388,459...5,395,071 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:23040778 RGD:13207316 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Mpo myeloperoxidase ISO associated with Kidney Reperfusion Injury; protein:increased activity:lung RGD PMID:22092133 RGD:6909173 NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070 		JBrowse link
G Mylk myosin light chain kinase ISO associated with Sepsis
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16399953 PMID:19374788 RGD:1581052 NCBI chrNW_004936725:1,418,930...1,594,697
Ensembl chrNW_004936725:1,424,130...1,592,840 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:24812154 NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262 		JBrowse link
G Ngf nerve growth factor ISO RGD PMID:17673270 RGD:5144065 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Nlrp3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33012731 NCBI chrNW_004936864:709,693...732,119
Ensembl chrNW_004936864:709,709...731,718 		JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 treatment ISO associated with Sepsis RGD PMID:22575870 RGD:8547530 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:16882535 RGD:5147744 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:23422200 RGD:7247713 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment ISO RGD PMID:24669282 PMID:28065220 RGD:11035223 RGD:13442501 NCBI chrNW_004936475:19,771,384...19,785,034
Ensembl chrNW_004936475:19,769,488...19,785,311 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase ISO mRNA, protein:altered expression:lung (rat) RGD PMID:25560372 RGD:12437080 NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847 		JBrowse link
G P2ry12 purinergic receptor P2Y12 ISO associated with Shock, Hemorrhagic RGD PMID:21841533 RGD:6480522 NCBI chrNW_004936758:1,581,828...1,624,332
Ensembl chrNW_004936758:1,581,897...1,592,222 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO DNA:hypermethylation RGD PMID:23546543 RGD:11533951 NCBI chrNW_004936498:6,001,126...6,135,663
Ensembl chrNW_004936498:6,001,014...6,086,614 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO associated with Pancreatitis, Experimental, Acute RGD PMID:16127429 RGD:11075069 NCBI chrNW_004936526:3,102,468...3,147,601
Ensembl chrNW_004936526:3,102,039...3,147,642 		JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO mRNA,protein:increased expression:lung,blood vessel: RGD PMID:17136598 RGD:9835397 NCBI chrNW_004936698:650,225...746,593
Ensembl chrNW_004936698:650,953...747,057 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:22592748 RGD:6483494 NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ISO associated with Endotoxemia;mRNA, protein:increased expression:lung (mouse) RGD PMID:31167111 RGD:41410778 NCBI chrNW_004936484:8,356,523...8,434,529
Ensembl chrNW_004936484:8,356,487...8,434,925 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO associated with endotoxemia RGD PMID:11714830 PMID:22198681 RGD:38599213 RGD:6482677 NCBI chrNW_004936479:17,084,006...17,112,264
Ensembl chrNW_004936479:17,084,920...17,112,258 		JBrowse link
G Pla2g2a phospholipase A2 group IIA severity ISO RGD PMID:19235614 RGD:6482722 NCBI chrNW_004936474:6,091,978...6,095,961
Ensembl chrNW_004936474:6,091,941...6,096,057 		JBrowse link
G Plau plasminogen activator, urokinase treatment ISO associated with Endotoxemia RGD PMID:21473829 PMID:23324284 RGD:5147760 RGD:7241552 NCBI chrNW_004936521:5,238,128...5,243,829
Ensembl chrNW_004936521:5,238,093...5,243,877 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO protein:decreased expression:lung (rat)
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:16083301 PMID:21153920 RGD:8553030 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Prdm1 PR/SET domain 1 ISO CTD Direct Evidence: therapeutic CTD PMID:33109608 NCBI chrNW_004936564:2,594,362...2,690,680
Ensembl chrNW_004936564:2,667,660...2,690,683 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO RGD PMID:21595935 RGD:6484539 NCBI chrNW_004936518:1,817,051...1,843,376
Ensembl chrNW_004936518:1,804,969...1,843,380 		JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO associated with Pseudomonas Infections
associated with Intestinal Reperfusion Injury		 RGD PMID:16553944 PMID:18367148 RGD:11100043 RGD:11250405 NCBI chrNW_004936469:43,841,989...43,850,322
Ensembl chrNW_004936469:43,841,989...43,850,304 		JBrowse link
G Procr protein C receptor treatment ISO RGD PMID:20095324 RGD:13515130 NCBI chrNW_004936561:5,557,640...5,562,981
Ensembl chrNW_004936561:5,557,630...5,563,030 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:lung RGD PMID:19567182 PMID:20926798 RGD:5135287 RGD:5135496 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO protein:decreased expression:lung RGD PMID:16226776 PMID:18420837 RGD:5143982 RGD:5144142 NCBI chrNW_004936581:798,738...801,614
Ensembl chrNW_004936581:798,739...801,633 		JBrowse link
G Serpinc1 serpin family C member 1 treatment ISO associated with Endotoxemia RGD PMID:17940748 RGD:11035256 NCBI chrNW_004936481:13,981,014...13,993,750
Ensembl chrNW_004936481:13,981,019...13,993,634 		JBrowse link
G Serpine1 serpin family E member 1 treatment ISO associated with Shock, Hemorrhagic;mRNA:increased expression:lung (rat)
associated with Sepsis		 RGD PMID:10745022 PMID:18182560 PMID:25934465 RGD:11075078 RGD:11080962 RGD:11080967 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Serping1 serpin family G member 1 treatment ISO RGD PMID:11685347 RGD:8661650 NCBI chrNW_004936581:4,911,403...4,924,484
Ensembl chrNW_004936581:4,908,458...4,924,645 		JBrowse link
G Sftpb surfactant protein B treatment ISO RGD PMID:22295533 RGD:151667443 NCBI chrNW_004936712:1,614,979...1,621,207
Ensembl chrNW_004936712:1,614,979...1,622,466 		JBrowse link
G Sftpd surfactant protein D ISO CTD Direct Evidence: therapeutic CTD PMID:30060251 NCBI chrNW_004936716:60,754...73,010
Ensembl chrNW_004936716:60,656...73,099 		JBrowse link
G Sirt2 sirtuin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32063085 NCBI chrNW_004936661:1,828,868...1,849,892
Ensembl chrNW_004936661:1,828,831...1,850,000 		JBrowse link
G Tac1 tachykinin precursor 1 ISO RGD PMID:19797759 RGD:5147812 NCBI chrNW_004936585:2,932,783...2,941,141
Ensembl chrNW_004936585:2,932,727...2,941,384 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO mRNA:increased expression:lung RGD PMID:18523300 RGD:5147819 NCBI chrNW_004936556:1,266,621...1,421,271
Ensembl chrNW_004936556:1,266,613...1,421,275 		JBrowse link
G Tgfb1 transforming growth factor beta 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16100012 PMID:25278421 RGD:39939031 NCBI chrNW_004936661:3,742,080...3,758,266
Ensembl chrNW_004936661:3,742,066...3,758,272 		JBrowse link
G Thbd thrombomodulin treatment ISO associated with Endotoxemia RGD PMID:19342415 PMID:19536047 PMID:20095324 RGD:13515130 RGD:5131887 RGD:5685372 NCBI chrNW_004936620:2,563,900...2,568,117 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 severity ISO RGD PMID:10092827 RGD:9999422 NCBI chrNW_004936594:3,232,433...3,244,241
Ensembl chrNW_004936594:3,232,355...3,244,241 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:19567182 RGD:5135496 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnf tumor necrosis factor treatment
no_association		 ISO mRNA, protein:increased expression:lung
DNA:SNP:promoter:-308G>A (rs1800629) (human)
protein:increased expression:respiratory system fluid/secretion
associated with Liver Reperfusion Injury
DNA:SNP:promoter:rs1799964 (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:11129814 PMID:19106808 PMID:21767135 PMID:30412745 PMID:34390737 RGD:14975158 RGD:14995473 RGD:5147925 RGD:6480432 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: therapeutic CTD PMID:26313688 NCBI chrNW_004936469:26,129,339...26,145,464
Ensembl chrNW_004936469:26,129,331...26,145,422 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 ameliorates
exacerbates		 ISO RGD PMID:26832696 RGD:127284840 NCBI chrNW_004936476:18,577,825...18,583,675
Ensembl chrNW_004936476:18,574,381...18,583,647 		JBrowse link
G Txn thioredoxin ISO CTD Direct Evidence: therapeutic CTD PMID:16298680 NCBI chrNW_004936559:2,811,786...2,822,528
Ensembl chrNW_004936559:2,811,782...2,822,528 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 ISO CTD Direct Evidence: therapeutic CTD PMID:33930521 NCBI chrNW_004936807:1,090,928...1,116,166
Ensembl chrNW_004936807:1,090,882...1,114,770 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Endotoxemia;mRNA, protein:altered expression:lung, plasma RGD PMID:21528367 RGD:5684427 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Vip vasoactive intestinal peptide ISO CTD Direct Evidence: therapeutic
associated with Endotoxemia		 CTD
RGD		 PMID:8643465 PMID:20441697 RGD:4145303 NCBI chrNW_004936489:5,425,778...5,434,483
Ensembl chrNW_004936489:5,425,726...5,434,785 		JBrowse link
G Xdh xanthine dehydrogenase treatment ISO RGD PMID:9655743 RGD:13209002 NCBI chrNW_004936493:1,762,814...1,824,501
Ensembl chrNW_004936493:1,762,869...1,823,238 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A severity ISO associated with toxic shock syndrome RGD PMID:23422584 RGD:39938961 NCBI chrNW_004936474:19,714,145...19,722,512
Ensembl chrNW_004936474:19,714,153...19,722,528 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14637
    Wounds and Injuries 904
      Thoracic Injuries 266
        Lung Injury 262
          Acute Lung Injury 124
Path 2
Term Annotations click to browse term
  disease 14637
    disease of anatomical entity 14326
      respiratory system disease 4639
        lower respiratory tract disease 2083
          lung disease 2044
            Lung Injury 262
              Acute Lung Injury 124
paths to the root