Mylk (myosin light chain kinase) - Rat Genome Database

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Gene: Mylk (myosin light chain kinase) Ictidomys tridecemlineatus
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Symbol: Mylk
Name: myosin light chain kinase
RGD ID: 12536094
Description: ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN cellular response to calcium ion (ortholog); cellular response to potassium ion (ortholog); cellular response to xenobiotic stimulus (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); alkaptonuria (ortholog); FOUND IN cell-cell junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myosin light chain kinase, smooth muscle; myosin light chain kinase, transcript variant X1; myosin light chain kinase, transcript variant X2; myosin light chain kinase, transcript variant X3; myosin light chain kinase, transcript variant X4; myosin light chain kinase, transcript variant X5; myosin light chain kinase, transcript variant X6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602127,510,307 - 127,686,249 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367251,424,130 - 1,592,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
prostaglandin I2 signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mylk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602127,510,307 - 127,686,249 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367251,424,130 - 1,592,840 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383123,610,049 - 123,884,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3123,610,049 - 123,884,332 (-)EnsemblGRCh38hg38GRCh38
GRCh373123,328,896 - 123,603,179 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363124,813,833 - 125,085,839 (-)NCBINCBI36Build 36hg18NCBI36
Build 343124,813,834 - 124,822,220NCBI
Celera3121,738,078 - 122,010,598 (-)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3120,704,092 - 120,976,941 (-)NCBIHuRef
CHM1_13123,294,136 - 123,566,156 (-)NCBICHM1_1
T2T-CHM13v2.03126,330,173 - 126,610,461 (-)NCBIT2T-CHM13v2.0
Mylk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391634,565,569 - 34,822,806 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1634,565,580 - 34,822,790 (+)EnsemblGRCm39 Ensembl
GRCm381634,745,199 - 35,002,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1634,745,210 - 35,002,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv371634,785,036 - 35,002,520 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361634,704,668 - 34,920,359 (+)NCBIMGSCv36mm8
Celera1635,252,169 - 35,470,294 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1624.49NCBI
Mylk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81179,288,243 - 79,535,450 (-)NCBIGRCr8
mRatBN7.21165,783,008 - 66,030,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1165,783,008 - 66,030,261 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1174,604,614 - 74,815,083 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,267,069 - 67,477,427 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01166,297,014 - 66,507,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01169,013,060 - 69,260,039 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1169,013,050 - 69,223,158 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,103,710 - 72,350,517 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41167,602,540 - 67,848,794 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11167,661,997 - 67,920,369 (-)NCBI
Celera1165,239,196 - 65,448,599 (-)NCBICelera
Cytogenetic Map11q22NCBI
Mylk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542722,762,221 - 22,970,508 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542722,760,432 - 23,008,432 (-)NCBIChiLan1.0ChiLan1.0
MYLK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22121,568,257 - 121,839,962 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13121,573,032 - 121,844,737 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03120,711,705 - 120,983,432 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13127,612,369 - 127,831,009 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3127,614,173 - 127,793,261 (-)Ensemblpanpan1.1panPan2
MYLK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13326,663,991 - 26,867,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3326,664,800 - 26,843,181 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3326,685,793 - 26,889,011 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03326,897,335 - 27,100,530 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3326,897,335 - 27,166,289 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13326,692,727 - 26,872,402 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03326,737,402 - 26,940,787 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03327,349,403 - 27,553,330 (-)NCBIUU_Cfam_GSD_1.0
MYLK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13136,509,755 - 136,809,668 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113136,509,878 - 136,809,674 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213146,205,306 - 146,232,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYLK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12257,032,264 - 57,259,253 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2257,065,331 - 57,257,464 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041109,093,851 - 109,369,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mylk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249121,953,838 - 2,172,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249121,952,053 - 2,213,196 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000000046   ⟹   ENSSTOP00000000040
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367251,424,130 - 1,592,840 (+)Ensembl
RefSeq Acc Id: XM_021735631   ⟹   XP_021591306
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,510,500 - 127,686,249 (+)NCBI
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735632   ⟹   XP_021591307
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,510,499 - 127,686,249 (+)NCBI
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735633   ⟹   XP_021591308
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,510,500 - 127,686,249 (+)NCBI
SpeTri2.0NW_0049367251,418,930 - 1,594,697 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735635   ⟹   XP_021591310
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,582,725 - 127,686,249 (+)NCBI
SpeTri2.0NW_0049367251,491,074 - 1,594,697 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040270264   ⟹   XP_040126198
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,510,307 - 127,686,249 (+)NCBI
RefSeq Acc Id: XM_040270266   ⟹   XP_040126200
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,510,501 - 127,686,249 (+)NCBI
RefSeq Acc Id: XM_040270267   ⟹   XP_040126201
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,678,892 - 127,686,249 (+)NCBI
RefSeq Acc Id: XM_040270268   ⟹   XP_040126202
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405602127,678,890 - 127,686,249 (+)NCBI
RefSeq Acc Id: XP_021591306   ⟸   XM_021735631
- Peptide Label: isoform X1
- UniProtKB: I3LVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591307   ⟸   XM_021735632
- Peptide Label: isoform X2
- UniProtKB: I3LVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591308   ⟸   XM_021735633
- Peptide Label: isoform X3
- UniProtKB: I3LVW2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591310   ⟸   XM_021735635
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_040126198   ⟸   XM_040270264
- Peptide Label: isoform X1
- UniProtKB: I3LVW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040126200   ⟸   XM_040270266
- Peptide Label: isoform X4
- UniProtKB: I3LVW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040126202   ⟸   XM_040270268
- Peptide Label: isoform X7
RefSeq Acc Id: XP_040126201   ⟸   XM_040270267
- Peptide Label: isoform X6
RefSeq Acc Id: ENSSTOP00000000040   ⟸   ENSSTOT00000000046

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000046 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000046.3 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  MLCK1_kinase_dom UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mylk ENTREZGENE
PANTHER IMMUNOGLOBULIN UniProtKB/TrEMBL
  MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE UniProtKB/TrEMBL
Pfam 23ISL UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  I-set UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
  IGc2 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3LVW2 ENTREZGENE, UniProtKB/TrEMBL