RGD Reference Report - miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation. - Rat Genome Database

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miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation.

Authors: Zhang, Y  Chen, M  Zhang, Y  Peng, P  Li, J  Xin, X 
Citation: Zhang Y, etal., Blood Coagul Fibrinolysis. 2014 Oct;25(7):731-7. doi: 10.1097/MBC.0000000000000133.
RGD ID: 11553933
Pubmed: PMID:24806323   (View Abstract at PubMed)
DOI: DOI:10.1097/MBC.0000000000000133   (Journal Full-text)

Disseminated intravascular coagulation (DIC) is a severe clinical condition that can lead to or aggravate the development of multiple organ dysfunction syndrome. Of all types of organ damage, lung damage is the most frequent and most severe. In DIC patients, lung damage is primarily characterized by pulmonary edema. Aquaporin (AQP) 5 is the chief AQP in the lungs and it plays a key role in many processes, including water transport in normal and abnormal lungs. Here we demonstrate that expression of AQP5 and two microRNAs, miR-96 and miR-330, in rat lung of lipopolysaccharide (LPS)-induced DIC. We also show that both miR-96 and miR-330 can regulate the expression of AQP5 by binding with its 3'-untranslated region (UTR) by luciferase activity assay. These results suggest that microRNAs are involved in lung damage in LPS-induced rat DIC and can be a potential target for molecular therapy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AQP5HumanAcute Lung Injury  ISOAqp5 (Rattus norvegicus)associated with Disseminated Intravascular Coagulation more ...RGD 
Aqp5RatAcute Lung Injury  IEP associated with Disseminated Intravascular Coagulation more ...RGD 
Aqp5MouseAcute Lung Injury  ISOAqp5 (Rattus norvegicus)associated with Disseminated Intravascular Coagulation more ...RGD 
MIR330HumanAcute Lung Injury  ISOMir330 (Rattus norvegicus)associated with Disseminated Intravascular Coagulation and RNA:increased expression:lung:RGD 
MIR96HumanAcute Lung Injury  ISOMir96 (Rattus norvegicus)associated with Disseminated Intravascular Coagulation and RNA:increased expression:lung:RGD 
Mir330RatAcute Lung Injury  IEP associated with Disseminated Intravascular Coagulation and RNA:increased expression:lung:RGD 
Mir96MouseAcute Lung Injury  ISOMir96 (Rattus norvegicus)associated with Disseminated Intravascular Coagulation and RNA:increased expression:lung:RGD 
Mir96RatAcute Lung Injury  IEP associated with Disseminated Intravascular Coagulation and RNA:increased expression:lung:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp5  (aquaporin 5)
Mir330  (microRNA 330)
Mir96  (microRNA 96)

Genes (Mus musculus)
Aqp5  (aquaporin 5)
Mir96  (microRNA 96)

Genes (Homo sapiens)
AQP5  (aquaporin 5)
MIR330  (microRNA 330)
MIR96  (microRNA 96)


Additional Information