RGD Reference Report - Insulin reduces LPS-induced lethality and lung injury in rats. - Rat Genome Database

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Insulin reduces LPS-induced lethality and lung injury in rats.

Authors: Liu, ML  Dong, HY  Zhang, B  Zheng, WS  Zhao, PT  Liu, Y  Niu, W  Xu, DQ  Li, ZC 
Citation: Liu ML, etal., Pulm Pharmacol Ther. 2012 Dec;25(6):472-7. doi: 10.1016/j.pupt.2012.09.002. Epub 2012 Sep 13.
RGD ID: 7204498
Pubmed: PMID:22982561   (View Abstract at PubMed)
DOI: DOI:10.1016/j.pupt.2012.09.002   (Journal Full-text)

Insulin is a main glucose homeostatic hormone in the body. Previous reports showed that insulin also exerted anti-inflammatory actions and attenuated systemic inflammatory response. Here, we observed the effects and the underlying mechanisms of insulin on lipopolysaccharide (LPS)-induced acute lung injury (ALI). As revealed by survival study, insulin reduced mortality of rats and prolonged their survival time. Meanwhile, insulin significantly reduced the levels of inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and high mobility group box 1 (HMGB1) in bronchoalveolar lavage fluid (BALF). Besides, insulin markedly inhibited the expression of toll-like receptor 2 (TLR2), toll-like receptor 4 (TLR4) and nuclear factor-kappaB (NF-kappaB). Taken together, these data provided information that insulin attenuated LPS-induced ALI may attribute partly to the inhibition of the production of cytokines, and the expression of TLR2, TLR4 and NF-kappaB.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumanAcute Lung Injury  ISOIl1b (Rattus norvegicus) RGD 
Il1bRatAcute Lung Injury  IDA  RGD 
Il1bMouseAcute Lung Injury  ISOIl1b (Rattus norvegicus) RGD 
TLR2HumanAcute Lung Injury treatmentISOTlr2 (Rattus norvegicus)associated with EndotoxemiaRGD 
TLR4HumanAcute Lung Injury treatmentISOTlr4 (Rattus norvegicus)associated with EndotoxemiaRGD 
Tlr2RatAcute Lung Injury treatmentIEP associated with EndotoxemiaRGD 
Tlr2MouseAcute Lung Injury treatmentISOTlr2 (Rattus norvegicus)associated with EndotoxemiaRGD 
Tlr4RatAcute Lung Injury treatmentIEP associated with EndotoxemiaRGD 
Tlr4MouseAcute Lung Injury treatmentISOTlr4 (Rattus norvegicus)associated with EndotoxemiaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)
Tlr2  (toll-like receptor 2)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)
TLR2  (toll like receptor 2)
TLR4  (toll like receptor 4)


Additional Information