Tacr1 (tachykinin receptor 1) - Rat Genome Database

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Gene: Tacr1 (tachykinin receptor 1) Ictidomys tridecemlineatus
Analyze
Symbol: Tacr1
Name: tachykinin receptor 1
RGD ID: 12665877
Description: ENCODES a protein that exhibits substance P receptor activity (ortholog); INVOLVED IN aggressive behavior (ortholog); angiotensin-mediated drinking behavior (ortholog); associative learning (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); acute necrotizing pancreatitis (ortholog); alcohol use disorder (ortholog); FOUND IN cell body (ortholog); cell surface (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: substance-P receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,315,839 - 9,471,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,266,613 - 1,421,275 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,266,621 - 1,421,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aggressive behavior  (ISO)
angiotensin-mediated drinking behavior  (ISO)
associative learning  (ISO)
behavioral response to pain  (ISO)
eating behavior  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
learning or memory  (ISO)
long-term memory  (ISO)
operant conditioning  (ISO)
positive regulation of action potential  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of flagellated sperm motility  (IEA)
positive regulation of hormone secretion  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of lymphocyte proliferation  (ISO)
positive regulation of ossification  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
positive regulation of synaptic transmission, GABAergic  (ISO)
positive regulation of uterine smooth muscle contraction  (ISO)
positive regulation of vascular permeability  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of blood pressure  (ISO)
regulation of smooth muscle cell migration  (ISO)
regulation of smooth muscle cell proliferation  (ISO)
regulation of uterine smooth muscle contraction  (IEA)
response to auditory stimulus  (ISO)
response to electrical stimulus  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hormone  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to ozone  (ISO)
response to pain  (IEA,ISO)
response to progesterone  (ISO)
smooth muscle contraction involved in micturition  (ISO)
sperm ejaculation  (ISO)
tachykinin receptor signaling pathway  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tacr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244062929,315,839 - 9,471,281 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365561,266,613 - 1,421,275 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365561,266,621 - 1,421,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TACR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38275,046,463 - 75,199,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl275,046,463 - 75,199,520 (-)EnsemblGRCh38hg38GRCh38
GRCh37275,273,590 - 75,426,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36275,129,738 - 75,279,781 (-)NCBINCBI36Build 36hg18NCBI36
Build 34275,189,817 - 75,337,838NCBI
Celera275,104,880 - 75,257,954 (-)NCBICelera
Cytogenetic Map2p12NCBI
HuRef275,010,440 - 75,164,411 (-)NCBIHuRef
CHM1_1275,202,888 - 75,356,007 (-)NCBICHM1_1
T2T-CHM13v2.0275,055,302 - 75,208,694 (-)NCBIT2T-CHM13v2.0
Tacr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39682,378,990 - 82,537,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl682,379,315 - 82,537,085 (+)EnsemblGRCm39 Ensembl
GRCm38682,402,003 - 82,560,104 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl682,402,334 - 82,560,104 (+)EnsemblGRCm38mm10GRCm38
MGSCv37682,352,469 - 82,510,098 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36682,368,133 - 82,525,757 (+)NCBIMGSCv36mm8
Celera684,384,420 - 84,542,486 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Tacr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84116,478,617 - 116,647,492 (+)NCBIGRCr8
mRatBN7.24114,920,844 - 115,089,733 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4120,383,645 - 120,552,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,158,843 - 116,327,453 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04114,778,790 - 114,948,892 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04113,247,236 - 113,416,139 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04177,926,094 - 178,095,041 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44116,610,595 - 116,780,394 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14116,855,058 - 117,024,964 (+)NCBI
Celera4103,918,032 - 104,086,347 (+)NCBICelera
Cytogenetic Map4q34NCBI
Tacr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542410,614,340 - 10,761,872 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542410,614,340 - 10,761,872 (+)NCBIChiLan1.0ChiLan1.0
TACR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,188,457 - 51,344,443 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,191,211 - 51,347,197 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A75,111,339 - 75,267,320 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A76,614,478 - 76,771,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A76,614,478 - 76,771,018 (-)Ensemblpanpan1.1panPan2
TACR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,038,010 - 48,178,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,038,010 - 48,178,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1747,681,510 - 47,821,826 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01748,900,538 - 49,041,473 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1748,899,743 - 49,044,192 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11747,916,025 - 48,056,577 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01747,980,726 - 48,121,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01748,542,868 - 48,683,479 (+)NCBIUU_Cfam_GSD_1.0
TACR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl367,839,411 - 68,021,724 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1367,839,367 - 68,021,733 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TACR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,080,319 - 32,236,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,083,615 - 32,233,596 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,940,541 - 80,098,197 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tacr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474928,243,640 - 28,455,086 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474928,243,667 - 28,455,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005329393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010001352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000011076   ⟹   ENSSTOP00000009937
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365561,266,613 - 1,421,275 (-)Ensembl
RefSeq Acc Id: XM_005329393   ⟹   XP_005329450
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244062929,315,839 - 9,471,281 (+)NCBI
SpeTri2.0NW_0049365561,266,621 - 1,421,271 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005329450 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000009937.2
GenBank Protein KAG3266992 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005329450   ⟸   XM_005329393
- UniProtKB: I3MGM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000009937   ⟸   ENSSTOT00000011076
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000011077 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000011076.3 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Neurokn_rcpt UniProtKB/TrEMBL
  NK1_rcpt UniProtKB/TrEMBL
NCBI Gene Tacr1 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED UniProtKB/TrEMBL
  SUBSTANCE-P RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  NEUROKININ1R UniProtKB/TrEMBL
  NEUROKININR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt I3MGM6 ENTREZGENE, UniProtKB/TrEMBL