Il13 (interleukin 13) - Rat Genome Database
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Gene: Il13 (interleukin 13) Ictidomys tridecemlineatus
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Symbol: Il13
Name: interleukin 13
RGD ID: 12518816
Description: ENCODES a protein that exhibits interleukin-13 receptor binding (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); alcoholic hepatitis (ortholog); allergic conjunctivitis (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: interleukin-13
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
chlamydia  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diffuse scleroderma  (ISO)
drug allergy  (ISO)
Eczema  (ISO)
egg allergy  (ISO)
Endotoxemia  (ISO)
esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fibrosis  (ISO)
food allergy  (ISO)
Fungal Lung Diseases  (ISO)
Graves' disease  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperplasia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
Kawasaki disease  (ISO)
lipoid nephrosis  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
mastocytosis  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
milk allergy  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
non-alcoholic fatty liver disease  (ISO)
occupational dermatitis  (ISO)
onchocerciasis  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
peanut allergy  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
Picornaviridae Infections  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumonia  (ISO)
prostatic hypertrophy  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
purpura  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
Respiratory Tract Infections  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Schistosomiasis Mansoni  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
T-Cell Lymphoma  (ISO)
Transplant Rejection  (ISO)
uveitis  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cytokine stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
inflammatory response  (ISO)
macrophage activation  (ISO)
microglial cell activation  (ISO)
negative regulation of complement-dependent cytotoxicity  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of connective tissue growth factor production  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of ion transport  (ISO)
positive regulation of macrophage activation  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of pancreatic stellate cell proliferation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of proton transport  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Il13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5132,656,263 - 132,661,110 (+)EnsemblGRCh38hg38GRCh38
GRCh385132,656,522 - 132,661,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,992,214 - 131,996,802 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,021,764 - 132,024,700 (+)NCBINCBI36hg18NCBI36
Build 345132,021,763 - 132,024,700NCBI
Celera5128,123,995 - 128,126,931 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,186,169 - 127,189,105 (+)NCBIHuRef
CHM1_15131,427,162 - 131,430,098 (+)NCBICHM1_1
Il13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,522,150 - 53,525,529 (-)NCBIGRCm39mm39
GRCm39 Ensembl1153,522,151 - 53,525,529 (-)Ensembl
GRCm381153,631,323 - 53,634,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,631,324 - 53,634,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,444,825 - 53,448,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv361153,474,747 - 53,478,125 (-)NCBImm8
Celera1158,210,849 - 58,214,228 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
Il13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21037,790,130 - 37,792,687 (-)NCBI
Rnor_6.0 Ensembl1038,982,909 - 38,985,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01038,982,909 - 38,985,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01038,764,639 - 38,767,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,093,512 - 39,096,069 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11039,102,758 - 39,105,316 (-)NCBI
Celera1037,134,342 - 37,136,897 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,046,406 - 4,049,795 (+)NCBIChiLan1.0ChiLan1.0
IL13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15134,235,788 - 134,240,548 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,235,788 - 134,240,548 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05128,073,863 - 128,078,453 (+)NCBIMhudiblu_PPA_v0panPan3
IL13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1120,958,464 - 20,961,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11120,957,870 - 20,961,391 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
IL13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,972,623 - 134,975,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,972,099 - 134,976,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,441,025 - 140,444,068 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL13
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,475,762 - 35,479,419 (+)NCBI
ChlSab1.1 Ensembl2335,476,490 - 35,478,869 (+)Ensembl
Il13
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473339,427,189 - 39,430,019 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005335814   ⟹   XP_005335871
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021733550   ⟹   XP_021589225
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366472,529,933 - 2,532,373 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005335871 (Get FASTA)   NCBI Sequence Viewer  
  XP_021589225 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005335871   ⟸   XM_005335814
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021589225   ⟸   XM_021733550
- Peptide Label: isoform X2
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007967 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000007125 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007961 ENTREZGENE, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-13 UniProtKB/TrEMBL
  IL-4/IL-13 UniProtKB/TrEMBL
NCBI Gene Il13 ENTREZGENE
Pfam IL13 UniProtKB/TrEMBL
PRINTS INTRLEUKIN13 UniProtKB/TrEMBL
SMART IL4_13 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt I3MAR4_ICTTR UniProtKB/TrEMBL