Ngf (nerve growth factor) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ngf (nerve growth factor) Ictidomys tridecemlineatus
Analyze
Symbol: Ngf
Name: nerve growth factor
RGD ID: 12618847
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); death receptor agonist activity (ortholog); transmembrane receptor protein tyrosine kinase activator activity (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adult locomotory behavior (ortholog); aging (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); Alzheimer's disease (ortholog); amnestic disorder (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: beta-nerve growth factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,803,009 - 13,853,189 (+)NCBI
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
bacterial meningitis  (ISO)
bladder disease  (ISO)
bladder neck obstruction  (ISO)
Bronchial Hyperreactivity  (ISO)
Burns  (ISO)
Charcot-Marie-Tooth disease  (ISO)
chronic kidney disease  (ISO)
Chronic Pancreatitis  (ISO)
chronic ulcer of skin  (ISO)
Cocaine-Related Disorders  (ISO)
Congenital Pain Insensitivity  (ISO)
corneal ulcer  (ISO)
coronary artery disease  (ISO)
cystitis  (ISO)
degenerative disc disease  (ISO)
diabetic encephalopathy  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
hereditary sensory and autonomic neuropathy type 5  (ISO)
hereditary sensory neuropathy  (ISO)
heroin dependence  (ISO)
Hyperalgesia  (ISO)
hyperhomocysteinemia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
interstitial cystitis  (ISO)
interstitial lung disease  (ISO)
interstitial nephritis  (ISO)
Lewy body dementia  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myofascial pain syndrome  (ISO)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Neurobehavioral Manifestations  (ISO)
neurodegenerative disease  (ISO)
neurogenic bladder  (ISO)
Neurogenic Inflammation  (ISO)
obstructive sleep apnea  (ISO)
Overactive Urinary Bladder  (ISO)
Pain  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinitis pigmentosa  (ISO)
rhinitis  (ISO)
Rib Fractures  (ISO)
sciatic neuropathy  (ISO)
sensorineural hearing loss  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adult locomotory behavior  (ISO)
aging  (ISO)
axon extension  (ISO)
circadian rhythm  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
inflammatory response  (ISO)
memory  (ISO)
negative regulation of endopeptidase activity  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
nerve growth factor signaling pathway  (ISO)
neuron apoptotic process  (ISO)
neuron projection development  (ISO)
neuron projection morphogenesis  (IEA,ISO)
peripheral nervous system development  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of collateral sprouting  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotrophin TRK receptor signaling pathway  (ISO)
positive regulation of protein autophosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of stem cell proliferation  (ISO)
protein phosphorylation  (ISO)
regulation of neuron differentiation  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
response to electrical stimulus  (ISO)
response to glucocorticoid  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to ozone  (ISO)
response to peptide hormone  (ISO)
response to radiation  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Ngf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505813,803,009 - 13,853,189 (+)NCBI
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NGF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381115,285,917 - 115,338,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1115,285,904 - 115,338,770 (-)EnsemblGRCh38hg38GRCh38
GRCh371115,828,538 - 115,880,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361115,630,060 - 115,682,380 (-)NCBINCBI36hg18NCBI36
Build 341115,540,580 - 115,592,899NCBI
Celera1114,057,456 - 114,109,776 (-)NCBI
Cytogenetic Map1p13.2NCBI
HuRef1113,686,915 - 113,739,240 (-)NCBIHuRef
CHM1_11115,943,440 - 115,995,752 (-)NCBICHM1_1
T2T-CHM13v2.01115,297,082 - 115,349,408 (-)NCBI
Ngf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393102,377,235 - 102,428,329 (+)NCBIGRCm39mm39
GRCm39 Ensembl3102,377,235 - 102,428,329 (+)Ensembl
GRCm383102,469,919 - 102,521,013 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3102,469,919 - 102,521,013 (+)EnsemblGRCm38mm10GRCm38
MGSCv373102,273,851 - 102,324,936 (+)NCBIGRCm37mm9NCBIm37
MGSCv363102,598,989 - 102,650,066 (+)NCBImm8
Celera3104,674,123 - 104,724,621 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map345.25NCBI
Ngf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22189,901,058 - 189,954,452 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2189,901,058 - 189,954,452 (+)Ensembl
Rnor_6.02204,886,158 - 204,939,523 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,886,202 - 204,940,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02224,316,210 - 224,369,663 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42197,621,726 - 197,632,960 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2182,322,945 - 182,375,918 (+)NCBICelera
RH 3.4 Map21294.4RGD
Cytogenetic Map2q34NCBI
Ngf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543518,581,808 - 18,601,059 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543518,581,889 - 18,633,330 (-)NCBIChiLan1.0ChiLan1.0
NGF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11122,272,750 - 122,325,909 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0187,223,597 - 87,276,759 (+)NCBIMhudiblu_PPA_v0panPan3
NGF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11752,900,647 - 52,901,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1752,900,647 - 52,901,607 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1752,550,068 - 52,550,845 (-)NCBI
ROS_Cfam_1.01753,781,750 - 53,834,593 (-)NCBI
ROS_Cfam_1.0 Ensembl1753,781,750 - 53,782,527 (-)Ensembl
UMICH_Zoey_3.11752,820,833 - 52,821,610 (-)NCBI
UNSW_CanFamBas_1.01752,855,816 - 52,856,593 (-)NCBI
UU_Cfam_GSD_1.01753,428,944 - 53,429,721 (-)NCBI
NGF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4105,256,749 - 105,307,837 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14105,256,691 - 105,307,843 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24115,436,784 - 115,446,393 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NGF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12018,361,795 - 18,413,987 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2018,413,108 - 18,413,833 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603821,083,578 - 21,157,325 (+)NCBIVero_WHO_p1.0
Ngf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477211,010,845 - 11,070,017 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462477211,009,765 - 11,070,050 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005334910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005334910   ⟹   XP_005334967
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505813,803,009 - 13,853,189 (+)NCBI
SpeTri2.0NW_004936627635,784 - 641,290 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005334967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3281213 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005334967   ⟸   XM_005334910
- UniProtKB: A0A287DBS0 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
NGF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005518 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000015304.2 UniProtKB/TrEMBL
  ENSSTOP00000030580.1 UniProtKB/TrEMBL
  ENSSTOP00000031015 ENTREZGENE
  ENSSTOP00000031015.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005508.3 UniProtKB/TrEMBL
  ENSSTOT00000037768.1 UniProtKB/TrEMBL
  ENSSTOT00000038987.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/TrEMBL
  Nerve_growth_factor_bsu UniProtKB/TrEMBL
  Nerve_growth_factor_bsu_mml UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/TrEMBL
NCBI Gene Ngf ENTREZGENE
PANTHER PTHR11589 UniProtKB/TrEMBL
Pfam NGF UniProtKB/TrEMBL
PIRSF NGF UniProtKB/TrEMBL
PRINTS MAMLNGFBETA UniProtKB/TrEMBL
  NGF UniProtKB/TrEMBL
  NGFBETA UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/TrEMBL
SMART NGF UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A287DAJ6_ICTTR UniProtKB/TrEMBL
  A0A287DBS0 ENTREZGENE, UniProtKB/TrEMBL
  I3MT59_ICTTR UniProtKB/TrEMBL