Hnrnpc (heterogeneous nuclear ribonucleoprotein C)

Gene: Hnrnpc (heterogeneous nuclear ribonucleoprotein C) Ictidomys tridecemlineatus

Analyze

Symbol:

Hnrnpc

Name:

heterogeneous nuclear ribonucleoprotein C

RGD ID:

12523922

Description:

ENCODES a protein that exhibits deaminase binding (ortholog); enzyme inhibitor activity (ortholog); identical protein binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); mRNA splicing, via spliceosome (ortholog); negative regulation of mRNA modification (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); atherosclerosis (ortholog); Autosomal Dominant Intellectual Developmental Disorder 74 (ortholog); FOUND IN actin cytoskeleton (ortholog); catalytic step 2 spliceosome (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

heterogeneous nuclear ribonucleoprotein C (C1/C2); heterogeneous nuclear ribonucleoproteins C1/C2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	32,458,661 - 32,516,597 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936880	368,041 - 425,967 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

atherosclerosis (ISO)

Autosomal Dominant Intellectual Developmental Disorder 74 (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

cervical cancer (ISO)

cone-rod dystrophy 13 (ISO)

genetic disease (ISO)

purine nucleoside phosphorylase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

3'-UTR-mediated mRNA stabilization (ISO)

mRNA splicing, via spliceosome (ISO)

negative regulation of mRNA modification (ISO)

negative regulation of telomere maintenance via telomerase (ISO)

Cellular Component

actin cytoskeleton (ISO)

catalytic step 2 spliceosome (ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleoplasmic periphery of the nuclear pore complex (ISO)

nucleus (IEA)

pronucleus (ISO)

protein-containing complex (ISO)

spliceosomal complex (ISO)

telomerase holoenzyme complex (ISO)

Molecular Function

deaminase binding (ISO)

enzyme inhibitor activity (ISO)

identical protein binding (ISO)

mRNA 3'-UTR binding (ISO)

mRNA binding (ISO)

N6-methyladenosine-containing RNA reader activity (ISO)

poly(U) RNA binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

ribonucleoprotein complex binding (ISO)

RNA binding (IEA)

telomerase RNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Hnrnpc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	32,458,661 - 32,516,597 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936880	368,041 - 425,967 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HNRNPC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	21,209,147 - 21,269,442 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	21,209,136 - 21,269,494 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	21,677,306 - 21,737,601 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	20,747,135 - 20,807,478 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	20,748,554 - 20,807,422	NCBI
Celera	14	1,537,857 - 1,598,198 (-)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	1,797,516 - 1,858,479 (-)	NCBI		HuRef
CHM1_1	14	21,679,085 - 21,739,357 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	15,406,559 - 15,466,855 (-)	NCBI		T2T-CHM13v2.0

Hnrnpc
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	52,310,834 - 52,341,462 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	52,310,834 - 52,341,485 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	52,073,377 - 52,104,039 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	52,073,377 - 52,104,028 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	52,693,055 - 52,723,703 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	50,996,750 - 51,025,933 (-)	NCBI		MGSCv36	mm8
Celera	14	49,053,955 - 49,085,339 (-)	NCBI		Celera
Cytogenetic Map	14	C2	NCBI
cM Map	14	26.79	NCBI

Hnrnpc
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	27,253,098 - 27,282,779 (-)	NCBI		GRCr8
mRatBN7.2	15	24,779,593 - 24,809,213 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,779,450 - 24,809,183 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	27,550,657 - 27,580,436 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	28,506,410 - 28,536,024 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,759,342 - 26,788,962 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	28,486,605 - 28,517,353 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	28,486,617 - 28,517,353 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	32,296,829 - 32,327,619 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	27,516,839 - 27,546,646 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	27,532,538 - 27,562,346 (-)	NCBI
Celera	15	25,083,705 - 25,113,041 (-)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

Hnrnpc
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955550	1,949,975 - 2,002,297 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955550	1,949,975 - 2,002,297 (-)	NCBI	ChiLan1.0	ChiLan1.0

HNRNPC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	22,660,425 - 22,721,136 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	21,877,303 - 21,937,623 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	2,022,280 - 2,083,215 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	20,103,594 - 20,163,824 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

LOC475399
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	18,239,810 - 18,299,065 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	18,724,388 - 18,783,435 (-)	NCBI		Dog10K_Boxer_Tasha

HNRNPC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	77,921,145 - 77,973,078 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	77,921,098 - 77,978,550 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

HNRNPC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	21,677,871 - 21,737,607 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	21,678,559 - 21,731,430 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	24,696,803 - 24,758,618 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hnrnpc
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	7,205,292 - 7,276,889 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	7,198,387 - 7,276,936 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021720938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_021720938 ⟹ XP_021576613

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	32,458,661 - 32,516,597 (-)	NCBI
SpeTri2.0	NW_004936880	368,041 - 425,967 (-)	NCBI

Sequence:

show sequence

GAGGAGACTCGGGGGCCATTTTGTGAAGAGACGAAGGCTGAGCGGTTGCGGCCGCCTTCCTGAC
CTCGAGCAGCGGTCGACTTCTTCATATAGAATCTGGGAGTAGGAGATTCAGAATCGAATCTCTT
CTCCCTCCCCCTCCTGGTTACAAATCACTTGAAATATTTAAGTTAGTGGATCTTTGCTGAGTGA
GATTTTTTTGATCTTCAGCTACATTCTTCCGCCTTTGTGAGGAACCTTATCAAACACGATGGCT
AGCAACGTTACCAACAAGACAGATCCACGCTCCATGAACTCCCGTGTATTCATTGGGAATCTAA
ACACTCTGGTGGTCAAGAAGTCTGATGTGGAAGCAATCTTCTCCAAGTATGGAAAAATTGTGGG
CTGCTCTGTCCATAAGGGCTTTGCCTTCGTCCAGTATGTTAATGAGAGAAATGCCCGGGCTGCT
GTAGCAGGAGAGGATGGCAGAATGATTGCTGGCCAGGTTTTAGATATTAATCTGGCTGCAGAGC
CAAAAGTGAACAGAGGAAAGGCAGGTGTGAAACGATCTGCAGCGGAGATGTACGGCTCCTCTTT
TGACTTGGACTATGATTTTCAACGTGATTATTATGACAGGATGTATAGTTACCCAGCACGAGTT
CCTCCTCCTCCTCCTATTGCTAGGGCTGTAGTGCCCTCTAAACGCCAGCGTGTTTCAGGAAACA
CCTCCCGAAGGGGCAAAAGTGGCTTCAATTCTAAGAGTGGACAGCGAGGATCTTCTTCCAAATC
TGGAAAGTTGAAAGGAGATGACCTTCAGGCCATTAAGAAGGAGCTGACCCAAATAAAACAAAAA
GTGGATTCTCTTCTGGAAAGTCTGGAAAAAATTGAAAAGGAGCAGAGCAAACAAGGGAAATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_021576613	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000029633.1
GenBank Protein	KAG3260825	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021576613 ⟸ XM_021720938

- UniProtKB:

A0A287D7X1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIVGCSVHKGFAFVQYVNERNAR
AAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAAEMYGSSFDLDYDFQRDYYDRMYSYPA
RVPPPPPIARAVVPSKRQRVSGNTSRRGKSGFNSKSGQRGSSSKSGKLKGDDLQAIKKELTQIK
QKVDSLLESLEKIEKEQSKQGK

hide sequence

Protein Domains

RRM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000030323	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000034759.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
InterPro	hnRNP_C	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
NCBI Gene	Hnrnpc	ENTREZGENE
PANTHER	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN	UniProtKB/TrEMBL
	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEINS C1/C2	UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/TrEMBL
PIRSF	hnRNP-C_Raly	UniProtKB/TrEMBL
PROSITE	RRM	UniProtKB/TrEMBL
SMART	RRM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A0A287D7X1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-07-16	Hnrnpc	heterogeneous nuclear ribonucleoprotein C	Hnrnpc	heterogeneous nuclear ribonucleoprotein C (C1/C2)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations