Sirt2 (sirtuin 2) - Rat Genome Database

Name: Sirt2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Sirt2 (sirtuin 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Sirt2

Name:

sirtuin 2

RGD ID:

12547045

Description:

ENCODES a protein that exhibits beta-tubulin binding (ortholog); NAD-dependent histone deacetylase activity (ortholog); tubulin deacetylase activity (ortholog); INVOLVED IN cellular response to hepatocyte growth factor stimulus (ortholog); cellular response to molecule of bacterial origin (ortholog); central nervous system development (ortholog); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; ASSOCIATED WITH genetic disease (ortholog); high grade glioma (ortholog); intermittent claudication (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); glial cell projection (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NAD-dependent protein deacetylase sirtuin-2

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT2 (sirtuin 2)	NCBI	Ortholog
Mus musculus (house mouse):	Sirt2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Sirt2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIRT2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt2 (sirtuin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,400,802 - 13,421,980 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	1,828,831 - 1,850,000 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936661	1,828,868 - 1,849,892 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

high grade glioma (ISO)

intermittent claudication (ISO)

maturity-onset diabetes of the young type 1 (ISO)

non-alcoholic fatty liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular lipid catabolic process (IEA)

cellular response to caloric restriction (IEA)

cellular response to epinephrine stimulus (IEA)

cellular response to hepatocyte growth factor stimulus (ISO)

cellular response to hypoxia (IEA)

cellular response to molecule of bacterial origin (ISO)

cellular response to oxidative stress (IEA)

central nervous system development (ISO)

chromatin organization (IEA,ISO)

chromatin remodeling (IEA)

epigenetic regulation of gene expression (IEA)

hepatocyte growth factor receptor signaling pathway (ISO)

histone deacetylation (ISO)

histone H3 deacetylation (ISO)

histone H4 deacetylation (ISO)

myelination in peripheral nervous system (IEA)

negative regulation of apoptotic process (ISO)

negative regulation of autophagy (IEA)

negative regulation of cell population proliferation (IEA)

negative regulation of defense response to bacterium (ISO)

negative regulation of DNA-templated transcription (IEA)

negative regulation of fat cell differentiation (IEA)

negative regulation of NLRP3 inflammasome complex assembly (IEA,ISO)

negative regulation of oligodendrocyte differentiation (ISO)

negative regulation of oligodendrocyte progenitor proliferation (ISO)

negative regulation of peptidyl-threonine phosphorylation (IEA)

negative regulation of protein catabolic process (IEA)

negative regulation of reactive oxygen species metabolic process (IEA)

negative regulation of striated muscle tissue development (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

negative regulation of transcription from RNA polymerase II promoter in response to hypoxia (IEA)

NLRP3 inflammasome complex assembly (IEA,ISO)

obsolete protein ADP-ribosylation (ISO)

peptidyl-lysine deacetylation (IEA)

phosphatidylinositol 3-kinase signaling (ISO)

positive regulation of attachment of spindle microtubules to kinetochore (IEA)

positive regulation of cell division (IEA)

positive regulation of DNA binding (IEA)

positive regulation of execution phase of apoptosis (IEA)

positive regulation of fatty acid biosynthetic process (IEA)

positive regulation of meiotic nuclear division (IEA)

positive regulation of oocyte maturation (IEA)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

post-translational protein modification (IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

protein deacetylation (IEA,ISO)

protein kinase B signaling (ISO)

regulation of cell cycle (IEA)

regulation of cell cycle (ISO)

regulation of fat cell differentiation (IEA,ISO)

regulation of myelination (IEA)

regulation of postsynaptic neurotransmitter receptor internalization (ISO)

substantia nigra development (ISO)

tubulin deacetylation (IEA,ISO)

Cellular Component

centriole (IEA)

centrosome (IEA)

chromosome (IEA)

cytoplasm (IEA)

cytoplasm (ISO)

cytosol (IEA)

cytosol (ISO)

glial cell projection (ISO)

glutamatergic synapse (ISO)

heterochromatin (ISO)

juxtaparanode region of axon (ISO)

lateral loop (ISO)

meiotic spindle (IEA)

microtubule (IEA)

midbody (IEA)

mitochondrion (IEA)

mitotic spindle (IEA)

myelin sheath (IEA)

myelin sheath abaxonal region (ISO)

nucleolus (IEA)

nucleolus (ISO)

nucleus (IEA)

nucleus (ISO)

paranodal junction (IEA,ISO)

paranode region of axon (ISO)

perikaryon (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

plasma membrane (ISO)

Schmidt-Lanterman incisure (IEA)

spindle (IEA)

spindle (ISO)

terminal loop (ISO)

Molecular Function

beta-tubulin binding (ISO)

chromatin binding (IEA)

DNA-binding transcription factor binding (IEA)

histone acetyltransferase binding (IEA)

histone deacetylase activity (IEA)

histone deacetylase binding (IEA)

metal ion binding (IEA)

NAD binding (IEA)

NAD+ ADP-ribosyltransferase activity (IEA)

NAD+ binding (IEA)

NAD-dependent histone deacetylase activity (IEA,ISO)

NAD-dependent histone H4K16 deacetylase activity (IEA)

NAD-dependent protein deacetylase activity (IEA)

NAD-dependent protein demyristoylase activity (IEA)

NAD-dependent protein depalmitoylase activity (IEA)

protein binding (ISO)

protein lysine deacetylase activity (IEA)

transferase activity (IEA)

tubulin deacetylase activity (IEA,ISO)

ubiquitin binding (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

Sirtuin mediated pathway (ISO)

References

Genomics

Comparative Map Data

Sirt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	13,400,802 - 13,421,980 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936661	1,828,831 - 1,850,000 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936661	1,828,868 - 1,849,892 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	38,878,555 - 38,899,618 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	19	38,878,555 - 38,899,862 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	39,369,195 - 39,390,258 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	44,061,040 - 44,082,201 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	44,061,039 - 44,082,193	NCBI
Celera	19	36,171,632 - 36,192,939 (-)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	35,815,856 - 35,837,294 (-)	NCBI		HuRef
CHM1_1	19	39,369,665 - 39,390,970 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	41,682,611 - 41,703,673 (-)	NCBI		T2T-CHM13v2.0

Sirt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	28,466,177 - 28,488,090 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	28,466,160 - 28,488,086 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	28,766,752 - 28,788,665 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	28,766,735 - 28,788,661 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	29,551,771 - 29,573,684 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	28,475,543 - 28,497,420 (+)	NCBI		MGSCv36	mm8
Celera	7	23,327,529 - 23,349,457 (+)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI

Sirt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	84,053,883 - 84,076,975 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	84,052,903 - 84,076,975 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	89,463,787 - 89,486,870 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	1	97,922,897 - 97,945,932 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	1	91,219,644 - 91,242,728 (+)	NCBI	Rnor_WKY
Rnor_6.0	1	86,948,866 - 86,971,954 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	86,948,918 - 86,971,952 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	88,130,012 - 88,153,086 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	83,873,578 - 83,896,121 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	78,446,589 - 78,469,133 (+)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Sirt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	626,365 - 644,441 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	626,365 - 644,441 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIRT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	44,533,965 - 44,554,838 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	44,533,965 - 44,554,799 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	35,984,453 - 36,005,582 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SIRT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	114,224,922 - 114,235,041 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	114,224,900 - 114,234,583 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	113,618,889 - 113,636,581 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	114,817,111 - 114,834,816 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	114,817,428 - 114,834,812 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	114,375,328 - 114,392,089 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	114,008,029 - 114,025,710 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	115,003,788 - 115,021,492 (+)	NCBI		UU_Cfam_GSD_1.0

SIRT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	47,682,429 - 47,703,384 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	47,682,427 - 47,703,408 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	43,218,298 - 43,228,967 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIRT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	33,493,106 - 33,518,793 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	33,493,079 - 33,518,647 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	11,514,410 - 11,540,709 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sirt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	12,235,263 - 12,259,276 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	12,239,363 - 12,259,561 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005336397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279603	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040279608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSSTOT00000020040 ⟹ ENSSTOP00000021109

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936661	1,828,831 - 1,850,000 (-)	Ensembl

RefSeq Acc Id:

ENSSTOT00000032528 ⟹ ENSSTOP00000026921

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936661	1,829,447 - 1,849,814 (-)	Ensembl

RefSeq Acc Id:

XM_005336397 ⟹ XP_005336454

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,401,203 - 13,421,848 (-)	NCBI
SpeTri2.0	NW_004936661	1,828,868 - 1,849,892 (-)	NCBI

Sequence:

show sequence

TCCCTGCCCCTCCTATTTCCGGTGCCGTCACGGGACAGAGCAGTCGGTGACAGCCCCGAGGGCC
CCCGCCCCGCGCCCATGGCCGAGCCGGACCCCTCTGACCCTCTGGAGAACCAGGCAGGGAAGGT
GCAGGAGGCTCAGGACTCCGACTCAGACCCTGAAGGAGGAGCCGCTGGCGGAGAAGCTGAGATG
GATTTCCTGCGGAACTTCTTCTCCCAGACCCTGGGCCTGGGCACCCAAAAGGAGCGTCTGCTGG
ATGAGCTAACCCTGGAAGGGGTGGCCCGCTACATGCAGAGTGAGCGCTGTCGCAGGGTCATCTG
TTTGGTGGGAGCCGGAATCTCCACAGCTGCGGGCATCCCCGACTTCCGCTCTCCATCCACCGGC
CTCTACGCCAACCTGGAGAAATACCATCTGCCCTACCCGGAGGCCATCTTTGAGATTGGCTACT
TTAAGAAACATCCAGAACCCTTCTTTGCCCTTGCCAAGGAACTCTATCCTGGGCAATTCAAGCC
GACCATCTGTCACTACTTCATTCGCCTGATGAAGGAGAAGGGGCTGCTCCTGCGCTGCTACACC
CAGAACATAGACACCCTGGAGCGCGTGGCAGGGCTGGAGCCCGAGGACCTGGTGGAGGCCCACG
GCACCTTCTACACCTCCCACTGCATCAGCCCCGTGTGCAGGCGCGAATACCCGCTGAGCTGGAT
GAAAGAGAAGCTCTTCACGGAGGTGACTCCACGGTGCGAGAAGTGCCAGAGCGTGGTGAAACCT
GACATCATTTTTTTTGGCGAGAACCTCCCGGCGCGGTTCTTCTCGTGCATGCAGTCAGACTTCC
TGAAGGTGGACCTGCTCATCATCATGGGCACCTCGCTGCAGGTGCAGCCCTTCGCCTCCCTCGT
CAGCAAGGCGCCCCTCTCCACCCCGCGCCTGCTCATCAACAAGGAGAAGACGGGCCAGACCGAC
CCCTTCCTGGGCATGATGATGGGCCTGGGAAGAGGCATGGACTTCGACTCCAAGAAGGCCTACA
GGGACGTGGCCTGGCTGGGTGACTGCGACCAGGGCTGCCTGGCCCTCGCTGACCTCCTCGGATG
GAAGAAAGAGCTGGAGGACCTCGTTCGGAAGGAGCACGCCAGCATCGATGCCCAGTCTGGGTCG
GGGGCCCCCAACCCCAACACCGTAGCTTCCCCCAGGAGGTCCCCACCTCCTGCCAAGGAGGGGG
CCAGGACCGCAGAGCCGGAAAAGCCCCAGTGACAGCCCCGACTCGCAGGCAGGACACCCAGACC
CTCCGGGACAGCGGAGCCCCAACCAGCACTGGCCCCTCTAACTCGCAGCTCTTCTCTGGGGAGA
GCCGTGCACCCCCCAGTCTCCTAACGACTCCCTCCTAAAACTGGGGTCCTAGCCACACCCCACT
TTATCCCAGCAAATCTCTAACATCCCCTTAAAGCCAAAGCCTAAGCAGCCTGACCTAACAGCCC
ACGCCCTCTAAGGAGCAGCCTCCCCTAACCTCTAACTGCTCCCAGGAGGCCAGGGGTGCCCCCA
AACTTCTGTCACCAAAGGGGGCCAAGGGCCCTCACTCTACTGCTTCAGTGACCTGTGGCCAAGC
AGATCCAACCAACCCACCCTAGACCAGGGTGTGGCCCTCCCAGTACGCTCCCACCTCCCACCGT
GGTTGGGGAGGGTCTGAGCCTGATAGGGCTCCTGGGTCTCCGCCTCCACCTCCCAAAGTAGGTG
CTGGGCCCCCTCCCTTGGGACCCACTGCCCACGTGGGGATGGGCAGAGGAGGTTGTTTGTTTGG
ACACAAATTAAAAAACCAAAACCAACTAACCGCCA

hide sequence

RefSeq Acc Id:

XM_040279603 ⟹ XP_040135537

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,400,802 - 13,421,616 (-)	NCBI

RefSeq Acc Id:

XM_040279604 ⟹ XP_040135538

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,401,203 - 13,421,851 (-)	NCBI

RefSeq Acc Id:

XM_040279605 ⟹ XP_040135539

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,401,203 - 13,421,616 (-)	NCBI

RefSeq Acc Id:

XM_040279606 ⟹ XP_040135540

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,401,203 - 13,421,818 (-)	NCBI

RefSeq Acc Id:

XM_040279607 ⟹ XP_040135541

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,401,203 - 13,421,980 (-)	NCBI

RefSeq Acc Id:

XM_040279608 ⟹ XP_040135542

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	13,401,203 - 13,421,677 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_005336454	(Get FASTA)	NCBI Sequence Viewer
	XP_040135537	(Get FASTA)	NCBI Sequence Viewer
	XP_040135538	(Get FASTA)	NCBI Sequence Viewer
	XP_040135539	(Get FASTA)	NCBI Sequence Viewer
	XP_040135540	(Get FASTA)	NCBI Sequence Viewer
	XP_040135541	(Get FASTA)	NCBI Sequence Viewer
	XP_040135542	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	KAG3256000	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_005336454 ⟸ XM_005336397
- Peptide Label:	isoform X4
- UniProtKB:	I3N9R2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAEPDPSDPLENQAGKVQEAQDSDSDPEGGAAGGEAEMDFLRNFFSQTLGLGTQKERLLDELTL EGVARYMQSERCRRVICLVGAGISTAAGIPDFRSPSTGLYANLEKYHLPYPEAIFEIGYFKKHP EPFFALAKELYPGQFKPTICHYFIRLMKEKGLLLRCYTQNIDTLERVAGLEPEDLVEAHGTFYT SHCISPVCRREYPLSWMKEKLFTEVTPRCEKCQSVVKPDIIFFGENLPARFFSCMQSDFLKVDL LIIMGTSLQVQPFASLVSKAPLSTPRLLINKEKTGQTDPFLGMMMGLGRGMDFDSKKAYRDVAW LGDCDQGCLALADLLGWKKELEDLVRKEHASIDAQSGSGAPNPNTVASPRRSPPPAKEGARTAE PEKPQ hide sequence

RefSeq Acc Id:	XP_040135537 ⟸ XM_040279603
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040135541 ⟸ XM_040279607
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_040135538 ⟸ XM_040279604
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040135540 ⟸ XM_040279606
- Peptide Label:	isoform X5
- UniProtKB:	A0A287D072 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_040135542 ⟸ XM_040279608
- Peptide Label:	isoform X6

RefSeq Acc Id:	XP_040135539 ⟸ XM_040279605
- Peptide Label:	isoform X3

RefSeq Acc Id:

ENSSTOP00000021109 ⟸ ENSSTOT00000020040

RefSeq Acc Id:

ENSSTOP00000026921 ⟸ ENSSTOT00000032528

Protein Domains

Deacetylase sirtuin-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000020829	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSTOP00000021109	ENTREZGENE
	ENSSTOP00000021109.1	UniProtKB/TrEMBL
	ENSSTOP00000026921.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000020040.2	UniProtKB/TrEMBL
	ENSSTOT00000032528.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1600.10	UniProtKB/TrEMBL
	TPP-binding domain	UniProtKB/TrEMBL
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/TrEMBL
	Sirtuin	UniProtKB/TrEMBL
	Sirtuin_cat_small_dom_sf	UniProtKB/TrEMBL
	Sirtuin_class_I	UniProtKB/TrEMBL
	Ssirtuin_cat_dom	UniProtKB/TrEMBL
NCBI Gene	Sirt2	ENTREZGENE
PANTHER	NAD-DEPENDENT HISTONE DEACETYLASE HST4	UniProtKB/TrEMBL
	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2	UniProtKB/TrEMBL
Pfam	SIR2	UniProtKB/TrEMBL
PIRSF	SIR2_euk	UniProtKB/TrEMBL
PROSITE	SIRTUIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52467	UniProtKB/TrEMBL
UniProt	A0A287D072	ENTREZGENE, UniProtKB/TrEMBL
	I3N9R2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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