Prkaa1 (protein kinase AMP-activated catalytic subunit alpha 1) - Rat Genome Database

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Gene: Prkaa1 (protein kinase AMP-activated catalytic subunit alpha 1) Ictidomys tridecemlineatus
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Symbol: Prkaa1
Name: protein kinase AMP-activated catalytic subunit alpha 1
RGD ID: 12551100
Description: ENCODES a protein that exhibits AMP-activated protein kinase activity (ortholog); ATP binding (ortholog); chromatin binding (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); bile acid signaling pathway (ortholog); CAMKK-AMPK signaling cascade (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; bile acid signaling pathway; vascular endothelial growth factor signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); amenorrhea (ortholog); breast cancer (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5'-AMP-activated protein kinase catalytic subunit alpha-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBI
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bile acid and bile salt transport  (ISO)
bile acid signaling pathway  (ISO)
CAMKK-AMPK signaling cascade  (ISO)
cellular response to calcium ion  (ISO)
cellular response to ethanol  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to nutrient levels  (ISO)
cellular response to organonitrogen compound  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
cold acclimation  (ISO)
energy homeostasis  (ISO)
fatty acid homeostasis  (ISO)
fatty acid oxidation  (ISO)
glucose homeostasis  (ISO)
glucose metabolic process  (ISO)
lipid biosynthetic process  (ISO)
motor behavior  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of lipid catabolic process  (ISO)
negative regulation of TOR signaling  (ISO)
negative regulation of tubulin deacetylation  (ISO)
neuron cellular homeostasis  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular protein localization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of mitochondrial transcription  (ISO)
positive regulation of peptidyl-lysine acetylation  (ISO)
positive regulation of protein targeting to mitochondrion  (ISO)
positive regulation of skeletal muscle tissue development  (ISO)
protein phosphorylation  (ISO)
regulation of bile acid secretion  (ISO)
regulation of circadian rhythm  (ISO)
regulation of gene expression  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of peptidyl-serine phosphorylation  (ISO)
regulation of stress granule assembly  (ISO)
regulation of vesicle-mediated transport  (ISO)
response to 17alpha-ethynylestradiol  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to camptothecin  (ISO)
response to gamma radiation  (ISO)
response to hydrogen peroxide  (ISO)
response to UV  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Prkaa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBI
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl540,759,379 - 40,798,374 (-)EnsemblGRCh38hg38GRCh38
GRCh38540,759,389 - 40,798,374 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37540,759,481 - 40,798,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36540,795,238 - 40,834,054 (-)NCBINCBI36hg18NCBI36
Build 34540,795,238 - 40,834,046NCBI
Celera540,648,066 - 40,686,889 (-)NCBI
Cytogenetic Map5p13.1NCBI
HuRef540,711,304 - 40,750,184 (-)NCBIHuRef
CHM1_1540,761,376 - 40,800,178 (-)NCBICHM1_1
Prkaa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39155,172,641 - 5,211,380 (+)NCBIGRCm39mm39
GRCm39 Ensembl155,173,343 - 5,211,380 (+)Ensembl
GRCm38155,143,861 - 5,181,899 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl155,143,861 - 5,181,899 (+)EnsemblGRCm38mm10GRCm38
MGSCv37155,093,861 - 5,131,899 (+)NCBIGRCm37mm9NCBIm37
MGSCv36155,091,090 - 5,129,114 (+)NCBImm8
Celera154,993,697 - 5,031,451 (+)NCBICelera
Cytogenetic Map15A1NCBI
Prkaa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2254,240,298 - 54,275,978 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl254,857,688 - 54,893,404 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0254,857,688 - 54,893,404 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0273,882,080 - 73,917,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4254,327,821 - 54,360,462 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1254,256,055 - 54,288,695 (+)NCBI
Celera249,888,577 - 49,923,847 (+)NCBICelera
Cytogenetic Map2q16NCBI
Prkaa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542625,079,718 - 25,102,090 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542625,079,718 - 25,102,090 (-)NCBIChiLan1.0ChiLan1.0
PRKAA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1574,627,844 - 74,666,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl574,627,830 - 74,666,505 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0569,581,748 - 69,620,721 (+)NCBIMhudiblu_PPA_v0panPan3
PRKAA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1468,579,061 - 68,614,548 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl468,579,037 - 68,611,841 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha468,255,490 - 68,291,515 (+)NCBI
ROS_Cfam_1.0469,085,598 - 69,121,628 (+)NCBI
UMICH_Zoey_3.1468,844,836 - 68,880,871 (+)NCBI
UNSW_CanFamBas_1.0468,957,934 - 68,993,962 (+)NCBI
UU_Cfam_GSD_1.0469,496,965 - 69,533,038 (+)NCBI
PRKAA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1625,745,321 - 25,783,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11625,745,902 - 25,783,524 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRKAA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1439,516,307 - 39,553,627 (-)NCBI
Vero_WHO_p1.0NW_02366607129,939,348 - 29,980,047 (-)NCBI
Prkaa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475914,143,439 - 14,174,971 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021726559   ⟹   XP_021582234
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049365181,818,876 - 1,843,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726560   ⟹   XP_021582235
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213229,528,457 - 229,554,778 (-)NCBI
SpeTri2.0NW_0049365181,817,131 - 1,843,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726561   ⟹   XP_021582236
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213229,528,457 - 229,554,782 (-)NCBI
SpeTri2.0NW_0049365181,817,051 - 1,843,376 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040272293   ⟹   XP_040128227
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213229,528,457 - 229,554,781 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_021582236   ⟸   XM_021726561
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_021582235   ⟸   XM_021726560
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021582234   ⟸   XM_021726559
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040128227   ⟸   XM_040272293
- Peptide Label: isoform X1
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008118 ENTREZGENE
Ensembl Protein ENSSTOP00000024036 ENTREZGENE
Ensembl Transcript ENSSTOT00000043160 ENTREZGENE
NCBI Gene Prkaa1 ENTREZGENE