Tnfaip6 (TNF alpha induced protein 6)

Gene: Tnfaip6 (TNF alpha induced protein 6) Ictidomys tridecemlineatus

Analyze

Symbol:

Tnfaip6

Name:

TNF alpha induced protein 6

RGD ID:

12503679

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); carboxylesterase activity (inferred); fibronectin binding (inferred); INVOLVED IN positive regulation of cell migration (ortholog); ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); Arsenic Poisoning (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	115,472,309 - 115,488,387 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	26,129,331 - 26,145,422 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	26,129,339 - 26,145,464 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Lung Injury (ISO)

allergic contact dermatitis (ISO)

Arsenic Poisoning (ISO)

atopic dermatitis (ISO)

conjunctival disease (ISO)

corneal neovascularization (ISO)

Corneal Opacity (ISO)

genetic disease (ISO)

Human Influenza (ISO)

Inflammation (ISO)

juvenile rheumatoid arthritis (ISO)

middle cerebral artery infarction (ISO)

Peritoneal Fibrosis (ISO)

skin disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

fibronectin fibril organization (IEA)

hyaluronan metabolic process (IEA)

negative regulation of BMP signaling pathway (IEA)

negative regulation of inflammatory response (IEA)

negative regulation of neutrophil chemotaxis (IEA)

negative regulation of osteoblast differentiation (IEA)

negative regulation of osteoclast differentiation (IEA)

ovarian cumulus expansion (IEA)

positive regulation of cell migration (ISO)

positive regulation of receptor clustering (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA,ISO)

Molecular Function

calcium ion binding (IEA)

carboxylesterase activity (IEA)

fibronectin binding (IEA)

hyaluronic acid binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Tnfaip6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	115,472,309 - 115,488,387 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	26,129,331 - 26,145,422 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	26,129,339 - 26,145,464 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TNFAIP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	151,357,592 - 151,381,340 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	151,357,592 - 151,380,046 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	152,214,106 - 152,236,560 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	151,922,351 - 151,944,806 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	152,039,612 - 152,062,067	NCBI
Celera	2	145,828,376 - 145,850,827 (+)	NCBI		Celera
Cytogenetic Map	2	q23.3	NCBI
HuRef	2	144,110,453 - 144,133,100 (+)	NCBI		HuRef
CHM1_1	2	152,219,924 - 152,242,420 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	151,809,346 - 151,833,086 (+)	NCBI		T2T-CHM13v2.0

Tnfaip6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	51,928,125 - 51,946,693 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	51,928,021 - 51,946,698 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	52,038,113 - 52,056,681 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	52,038,009 - 52,056,686 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	51,893,633 - 51,912,201 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	51,860,122 - 51,878,690 (+)	NCBI		MGSCv36	mm8
Celera	2	53,762,777 - 53,783,057 (+)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	29.98	NCBI

Tnfaip6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	56,911,398 - 56,930,797 (+)	NCBI		GRCr8
mRatBN7.2	3	36,502,250 - 36,521,652 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	36,502,188 - 36,521,649 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	39,888,035 - 39,907,355 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	48,472,812 - 48,492,136 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	46,257,353 - 46,276,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	37,545,238 - 37,564,704 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	37,545,238 - 37,564,699 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	42,649,266 - 42,663,190 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	3	34,646,103 - 34,665,498 (+)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

Tnfaip6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	16,916,055 - 16,944,190 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	16,915,952 - 16,944,375 (+)	NCBI	ChiLan1.0	ChiLan1.0

TNFAIP6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	54,047,676 - 54,070,133 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	54,062,655 - 54,085,417 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	38,669,652 - 38,692,037 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	155,933,842 - 155,956,382 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	155,933,842 - 155,956,382 (+)	Ensembl	panpan1.1		panPan2

TNFAIP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	52,607,598 - 52,623,799 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	52,607,713 - 52,623,811 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	52,770,629 - 52,786,812 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	54,118,538 - 54,134,777 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	54,118,552 - 54,135,260 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	52,832,140 - 52,848,316 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	52,902,916 - 52,919,491 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	54,369,113 - 54,385,510 (+)	NCBI		UU_Cfam_GSD_1.0

TNFAIP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	862,015 - 881,461 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	862,013 - 881,352 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	157,132,380 - 157,151,740 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TNFAIP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	36,792,505 - 36,814,271 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	36,792,514 - 36,814,494 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	162,729,309 - 162,750,857 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tnfaip6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624866	5,706,850 - 5,728,771 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624866	5,706,483 - 5,758,666 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005315809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000016317 ⟹ ENSSTOP00000014608

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936469	26,129,331 - 26,145,422 (-)	Ensembl

RefSeq Acc Id:

XM_005315809 ⟹ XP_005315866

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	115,472,309 - 115,488,387 (+)	NCBI
SpeTri2.0	NW_004936469	26,129,339 - 26,145,464 (-)	NCBI

Sequence:

show sequence

GGAGAGCACTTGCTGACCTCACAGTTGAAAAAAACTATTTAAAAGATGTGCAAACCAGATGTTT
CAGTCACATTTCAGCCGCTGTTCTGAGAATTTATCGTGAGCAGCCTCTGCCGGGCTGTTAACTT
CACTATAACTGAAGATATGATCATCTTAATTTACTTATTCGTCTTGCTGTGGGAAGAGGCTCAA
GGATGGGGATTCAAGAATGGAATTTTTCATAACTCCATATGGCTTGAACAAGCAGCAGGCGTGT
ACCACAGAGAAGCCCGGTCTGGCAAGTACAAGCTCACCTACGCAGAAGCTAAGGCGGTGTGTGA
ATTTGAGGGCGGTCGTCTTGCCACCTACAAGCAGCTAGAGGCAGCCAGAAAAATTGGATTTCAT
GTCTGTGCTGCTGGATGGATGGCCAAGGGCAGAGTTGGCTACCCCATTGTGAAGCCAGGGCCCA
ACTGTGGATTTGGAAAAACTGGAATTATTGATTATGGAGTCCGTCTCAATAGGAGTGAAAGATG
GGATGCCTACTGCTTCAACCCACATGCAAAGGAATGTGGTGGTGTCTTTACAGATCCAAAGCGA
ATTTTTAAATCTCCAGGTTTTCCAAATGAGTATGAAGATAACCAGGTATGCTACTGGCACATTA
GACTCAAGTATGGTCAGCGTATTCACCTGAGTTTTTTGGACTTTGACATTGAAGATGACCCAGG
TTGCTTGGCTGACTATGTTGAAATATATGACAGTTACGATGACATCCATGGCTTTGTGGGAAGG
TACTGTGGTGATGAGCTTCCAGAAGACATCATTAGCACAGGAAATGTCATGACCTTGAAGTTTC
TGAGTGATGCTTCAGTAACAGCAGGAGGTTTCCAAATCAAATATGTTGCAGTGGATCCTGTATC
CAAATCCAGTCAAGGAAAAAATACAAGTACTACTACTGGAAATAAAAACTTTTTAGCTGGAAGA
TTTAGCCATTTATAAAATAAAACAAAAAGGATACTCAAATTATACAATGTTACATCTTTTGGAA
ACCCTTTGATCTCACTTTTGTATTATTATTGTTGTTATTGTTAATGTTTATTTATTATTTTTCT
AAATGTGAAAGCAATACATAATTTTGGAGAAAATTGAAAAATACAGAAAACTTCAAATGAAAAT
CTCTTATACTCTCACTACATAGAGATAACTAGTGTTAACATTTTTATATATTTTTCTTTCATTT
TTTTTTTACTTGTGGTATATGTATATATGTATCTATGTGTGTTTGTATTTGAAGTTTGGAATCC
TACTCTATGTACAGTTTTATATGCTGTTTTCTTTAACCTTAAACTTTATAGCCTAAGCATTTTC
CCAAATCATTGTGTATTCTAGAAAATCATTATTTTGAACAGCTGTAAAATTTCCCATGGTATGA
TTATTTCATACTTTATTTAAACCTCTCTATTGTTGGAATTTTAGATTGTTTTCATAAATATTGC
TGAATAAATATTCTTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005315866	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014608.2
GenBank Protein	KAG3274463	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005315866 ⟸ XM_005315809

- UniProtKB:

I3MRB5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIILIYLFVLLWEEAQGWGFKNGIFHNSIWLEQAAGVYHREARSGKYKLTYAEAKAVCEFEGGR
LATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGVRLNRSERWDAYCF
NPHAKECGGVFTDPKRIFKSPGFPNEYEDNQVCYWHIRLKYGQRIHLSFLDFDIEDDPGCLADY
VEIYDSYDDIHGFVGRYCGDELPEDIISTGNVMTLKFLSDASVTAGGFQIKYVAVDPVSKSSQG
KNTSTTTGNKNFLAGRFSHL

hide sequence

RefSeq Acc Id:

ENSSTOP00000014608 ⟸ ENSSTOT00000016317

Protein Domains

CUB Link

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016314	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016317.3	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.290	UniProtKB/TrEMBL
	3.10.100.10	UniProtKB/TrEMBL
InterPro	C-type_lectin-like/link_sf	UniProtKB/TrEMBL
	CTDL_fold	UniProtKB/TrEMBL
	CUB_dom	UniProtKB/TrEMBL
	Link_dom	UniProtKB/TrEMBL
	Sperma_CUB_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Tnfaip6	ENTREZGENE
PANTHER	CUBILIN-LIKE PROTEIN	UniProtKB/TrEMBL
	TUMOR NECROSIS FACTOR-INDUCIBLE GENE 6 PROTEIN	UniProtKB/TrEMBL
Pfam	CUB	UniProtKB/TrEMBL
	Xlink	UniProtKB/TrEMBL
PRINTS	LINKMODULE	UniProtKB/TrEMBL
PROSITE	CUB	UniProtKB/TrEMBL
	LINK_1	UniProtKB/TrEMBL
	LINK_2	UniProtKB/TrEMBL
SMART	CUB	UniProtKB/TrEMBL
	LINK	UniProtKB/TrEMBL
Superfamily-SCOP	SSF49854	UniProtKB/TrEMBL
	SSF56436	UniProtKB/TrEMBL
UniProt	I3MRB5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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