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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thiram
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Accession:CHEBI:9495 term browser browse the term
Definition:An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.
Synonyms:exact_synonym: [disulfanediylbis(carbonothioylnitrilo)]tetramethane
 related_synonym: Arasan;   Bis(dimethyl-thiocarbamoyl)-disulfid;   Formula=C6H12N2S4;   InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3;   InChIKey=KUAZQDVKQLNFPE-UHFFFAOYSA-N;   N(1),N(1),N(3),N(3)-tetramethyl-2-dithioperoxy-1,3-dithiodicarbonic diamide;   N,N'-(dithiodicarbonothioyl)bis(N-methylmethanamine);   N,N-tetramethylthiuram disulfide;   Nomersan;   Pomarsol;   Rezifilm;   SMILES=CN(C)C(=S)SSC(=S)N(C)C;   TMTD;   Tetramethyl-thiram disulfid;   Tetramethylthioperoxydicarbonic diamide;   [Me2NC(S)S]2;   alpha,alpha'-dithiobis(dimethylthio)formamide;   bis((dimethylamino)carbonothioyl) disulfide;   bis(dimethyl thiocarbamoyl)disulfide;   bis(dimethylthiocarbamoyl) disulfide;   disulfure de tetramethylthiourame;   tetramethylenethiuram disulfide;   tetramethylthiuram disulfide;   tetramethylthiurane disulfide;   tetrathiuram disulfide;   thirame;   thiramum;   thiuram;   tiramo
 xref: CAS:137-26-8;   Drug_Central:3601;   KEGG:C11160;   KEGG:D06114
 xref_mesh: MESH:D013893
 xref: PMID:14587840;   PMID:1842585;   PMID:20940038;   PMID:3055654;   PMID:3176026;   PPDB:642;   Pesticides:thiram;   Reaxys:1725821;   Wikipedia:Thiram


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thiram term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c21 aldo-keto reductase family 1, member C21 increases activity ISO Thiram results in increased activity of AKR1C2 promoter CTD PMID:21195160 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO Thiram results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 7:110,367,291...110,411,612
Ensembl chr 7:110,367,413...110,411,612 		JBrowse link
G Anxa10 annexin A10 increases expression ISO Thiram results in increased expression of ANXA10 mRNA CTD PMID:32194361 NCBI chr 8:62,510,076...62,576,227
Ensembl chr 8:62,510,076...62,576,184 		JBrowse link
G Arg1 arginase, liver decreases expression ISO Thiram results in decreased expression of ARG1 mRNA CTD PMID:32194361 NCBI chr10:24,791,105...24,803,368
Ensembl chr10:24,791,119...24,803,382 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thiram results in increased expression of ATF3 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236 		JBrowse link
G Casp1 caspase 1 affects expression EXP Thiram affects the expression of CASP1 protein CTD PMID:25929180 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression ISO Thiram results in decreased expression of CCR2 mRNA CTD PMID:19371601 NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594 		JBrowse link
G Cd86 CD86 antigen increases expression ISO Thiram results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO Thiram results in increased expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Thiram results in increased expression of CREM mRNA CTD PMID:19371601 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
multiple interactions
increases secretion		 ISO Thiram results in increased expression of CXCL8 mRNA
SB 203580 affects the reaction [Thiram results in increased secretion of CXCL8 protein]		 CTD PMID:18494145 PMID:19878716 PMID:21920952 PMID:27965148 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Thiram results in increased expression of CYP1A1 mRNA; Thiram results in increased expression of CYP1A1 protein CTD PMID:32194361 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases expression ISO Thiram results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases metabolic processing
multiple interactions		 ISO CYP2E1 protein results in increased metabolism of Thiram
Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]		 CTD PMID:12458634 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO Thiram results in decreased expression of CYP7A1 mRNA CTD PMID:32194361 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Thiram results in increased expression of DNAJB4 mRNA CTD PMID:23999411 PMID:27965148 NCBI chr 3:151,887,217...151,915,720
Ensembl chr 3:151,884,148...151,915,939 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 increases expression ISO Thiram results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462 		JBrowse link
G Ftl1 ferritin light polypeptide 1 increases expression ISO Thiram results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 7:45,107,368...45,109,310
Ensembl chr 7:45,107,368...45,109,308 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Thiram results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO Thiram results in increased expression of GCLM mRNA CTD PMID:23999411 PMID:24211530 PMID:27965148 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Gm40318 predicted gene, 40318 increases expression ISO Thiram results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO		 Thiram results in increased expression of HMOX1 mRNA CTD PMID:23445166 PMID:24211530 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
decreases activity		 ISO Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein]; Thiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone] CTD PMID:12901862 PMID:16857225 PMID:22796344 NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
decreases activity		 ISO Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD3B1 protein] CTD PMID:36965607 NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO Thiram promotes the reaction [TNF protein results in increased expression of ICAM1 protein]
Thiram results in increased expression of ICAM1 protein		 CTD PMID:25752435 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma increases expression EXP Thiram results in increased expression of IFNG protein CTD PMID:12062936 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il18 interleukin 18 increases expression ISO Thiram results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Thiram results in increased expression of IL1A mRNA CTD PMID:33715048 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO Thiram results in increased secretion of IL1B protein CTD PMID:33715048 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 increases expression EXP Thiram results in increased expression of IL4 protein CTD PMID:12062936 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Lep leptin multiple interactions ISO [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein CTD PMID:29321614 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lepr leptin receptor multiple interactions ISO [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA CTD PMID:29321614 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO Thiram results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Thiram results in increased expression of NAMPT mRNA CTD PMID:19371601 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO Thiram results in decreased expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 affects expression EXP Thiram affects the expression of NLRP3 protein CTD PMID:25929180 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nmb neuromedin B multiple interactions ISO [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA CTD PMID:29321614 NCBI chr 7:80,551,975...80,554,810
Ensembl chr 7:80,551,975...80,554,824 		JBrowse link
G Nmbr neuromedin B receptor multiple interactions ISO [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA CTD PMID:29321614 NCBI chr10:14,634,894...14,647,202
Ensembl chr10:14,581,335...14,646,594 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 multiple interactions ISO [2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA CTD PMID:29321614 NCBI chr 8:67,149,595...67,159,452
Ensembl chr 8:67,149,844...67,159,444 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 increases expression ISO Thiram results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]; Thiram inhibits the reaction [Hydrocortisone binds to NR3C1 protein] CTD PMID:16857225 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Park7 Parkinson disease (autosomal recessive, early onset) 7 decreases activity ISO Thiram results in decreased activity of PARK7 protein CTD PMID:36842454 NCBI chr 4:150,981,590...150,994,378
Ensembl chr 4:150,981,590...150,998,894 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 multiple interactions ISO Thiram inhibits the reaction [TNF protein results in decreased expression of PECAM1 protein] CTD PMID:25752435 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Prkca protein kinase C, alpha decreases activity ISO Thiram results in decreased activity of PRKCA protein CTD PMID:15998240 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Prkcb protein kinase C, beta decreases activity ISO Thiram results in decreased activity of PRKCB protein CTD PMID:15998240 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prkcd protein kinase C, delta increases activity ISO Thiram results in increased activity of PRKCD protein CTD PMID:15998240 NCBI chr14:30,317,310...30,348,637
Ensembl chr14:30,317,311...30,348,167 		JBrowse link
G Prkce protein kinase C, epsilon decreases activity ISO Thiram results in decreased activity of PRKCE protein CTD PMID:15998240 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Prkcg protein kinase C, gamma decreases activity ISO Thiram results in decreased activity of PRKCG protein CTD PMID:15998240 NCBI chr 7:3,352,038...3,379,615
Ensembl chr 7:3,337,704...3,379,615 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Thiram results in increased expression of PTGS2 mRNA CTD PMID:19371601 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Sel1l3 sel-1 suppressor of lin-12-like 3 (C. elegans) increases expression ISO Thiram results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr 5:53,264,425...53,370,794
Ensembl chr 5:53,264,425...53,371,269 		JBrowse link
G Sftpa1 surfactant associated protein A1 multiple interactions ISO Thiram inhibits the reaction [Dexamethasone results in decreased expression of SFTPA1 mRNA] CTD PMID:16857225 NCBI chr14:40,853,745...40,858,330
Ensembl chr14:40,853,739...40,858,409 		JBrowse link
G Sftpb surfactant associated protein B multiple interactions ISO Thiram inhibits the reaction [Dexamethasone results in increased expression of SFTPB mRNA] CTD PMID:16857225 NCBI chr 6:72,281,594...72,291,354
Ensembl chr 6:72,281,594...72,291,354 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO Thiram results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Thiram results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Syne2 spectrin repeat containing, nuclear envelope 2 decreases expression ISO Thiram results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr12:75,865,092...76,157,702
Ensembl chr12:75,864,908...76,157,700 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO Thiram results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Thiram results in increased expression of TNF mRNA
Thiram inhibits the reaction [TNF protein results in decreased expression of PECAM1 protein]; Thiram inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Thiram promotes the reaction [TNF protein results in increased expression of ICAM1 protein]		 CTD PMID:20385217 PMID:25752435 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnnt2 troponin T2, cardiac decreases expression ISO Thiram results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr 1:135,763,933...135,780,006
Ensembl chr 1:135,764,092...135,779,998 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression EXP
ISO		 Thiram results in increased expression of TXNRD1 mRNA CTD PMID:23445166 PMID:24211530 NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Thiram results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:20,524,660...20,549,420
Ensembl chr  X:20,524,565...20,549,418 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Thiram inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:25752435 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22182
    role 22167
      application 21752
        pesticide 18831
          antifungal agrochemical 11007
            thiram 61
Path 2
Term Annotations click to browse term
  CHEBI ontology 22182
    subatomic particle 22174
      composite particle 22174
        hadron 22174
          baryon 22174
            nucleon 22174
              atomic nucleus 22174
                atom 22174
                  main group element atom 22108
                    p-block element atom 22108
                      carbon group element atom 21909
                        carbon atom 21835
                          organic molecular entity 21835
                            heteroorganic entity 21490
                              organochalcogen compound 20980
                                organosulfur compound 18099
                                  thiocarbonyl compound 7801
                                    dithiocarbamic acids 426
                                      dimethyldithiocarbamic acid 145
                                        thiram 61
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