Syne2 (spectrin repeat containing, nuclear envelope 2) - Rat Genome Database

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Gene: Syne2 (spectrin repeat containing, nuclear envelope 2) Mus musculus
Analyze
Symbol: Syne2
Name: spectrin repeat containing, nuclear envelope 2
RGD ID: 1615570
MGI Page MGI
Description: Enables actin binding activity. Involved in several processes, including centrosome localization; nuclear migration; and regulation of cilium assembly. Located in Z disc and nuclear membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant Emery-Dreifuss muscular dystrophy 5. Orthologous to human SYNE2 (spectrin repeat containing nuclear envelope protein 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6820443O06Rik; AW546258; Cpf; Cpfl8; D12Ertd777; D12Ertd777e; dic; dice; diminished cone electroretinogram; KASH domain-containing protein 2; KASH2; MGC96690; mKIAA1011; nes; Nesp2g; nesprin 2; nesprin-2; NUA; nuance; nuclear envelope spectrin repeat protein 2; nucleus and actin connecting element protein; synaptic nuclear envelope 2; synaptic nuclear envelope protein 2; syne; syne-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391275,865,092 - 76,157,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1275,864,908 - 76,157,700 (+)EnsemblGRCm39 Ensembl
GRCm381275,818,318 - 76,110,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1275,818,134 - 76,110,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv371276,919,305 - 77,211,915 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361276,772,909 - 77,029,768 (+)NCBIMGSCv36mm8
Celera1276,923,010 - 77,205,661 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7beta-aminocephalosporanic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium hexachloroplatinate  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clotrimazole  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epichlorohydrin  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glafenine  (ISO)
glycidol  (ISO)
hexamethylene diisocyanate  (ISO)
hydrogen peroxide  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
propylparaben  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tebufenpyrad  (ISO)
tetrachloromethane  (ISO)
tetraphene  (EXP)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
troglitazone  (EXP)
trovafloxacin  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiovascular system physiology  (IAGP)
abnormal cell nucleus morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart weight  (IAGP)
abnormal keratinocyte morphology  (IAGP)
abnormal locomotor behavior  (IEA)
abnormal Muller cell morphology  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal ocular fundus morphology  (IEA)
abnormal phrenic nerve morphology  (IAGP)
abnormal respiratory mechanics  (IAGP)
abnormal retina bipolar cell morphology  (IAGP)
abnormal retina blood vessel morphology  (IEA)
abnormal retina horizontal cell morphology  (IAGP)
abnormal retina outer plexiform layer morphology  (IAGP)
abnormal retina photoreceptor layer morphology  (IEA)
abnormal rod electrophysiology  (IAGP)
abnormal synapse morphology  (IAGP)
cardiac fibrosis  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased fibroblast cell migration  (IAGP)
decreased mean corpuscular volume  (IEA)
decreased retina cone cell number  (IAGP)
decreased total body fat amount  (IEA)
decreased total retina thickness  (IEA)
increased cardiomyocyte apoptosis  (IAGP)
increased grip strength  (IEA)
increased lean body mass  (IEA)
increased retina apoptosis  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
respiratory failure  (IAGP)
short photoreceptor inner segment  (IAGP)
short photoreceptor outer segment  (IAGP)
thick epidermis  (IAGP)
thin retina inner nuclear layer  (IAGP)
thin retina outer nuclear layer  (IAGP)
thin retina outer plexiform layer  (IAGP)
thin ventricular wall  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat. Barthold JS, etal., Mol Hum Reprod. 2016 Jan;22(1):18-34. doi: 10.1093/molehr/gav060. Epub 2015 Oct 26.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10878022   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11792814   PMID:12118075   PMID:12465718   PMID:12466851   PMID:12477932  
PMID:14610273   PMID:14681479   PMID:15671068   PMID:16079285   PMID:16141072   PMID:16141073   PMID:16380439   PMID:16648470   PMID:17267447   PMID:18396275   PMID:18477613   PMID:18827015  
PMID:19596800   PMID:19843581   PMID:19874786   PMID:20108321   PMID:20356461   PMID:20457914   PMID:20724637   PMID:20801886   PMID:21177258   PMID:21267068   PMID:21327095   PMID:21862448  
PMID:21873635   PMID:22198684   PMID:22349700   PMID:22826121   PMID:23071752   PMID:23336069   PMID:23707952   PMID:24586179   PMID:24880667   PMID:25516977   PMID:26066746   PMID:26506308  
PMID:26688217   PMID:26745407   PMID:27565344   PMID:28533284   PMID:28595999   PMID:28671696   PMID:29844364   PMID:29868845   PMID:30054381   PMID:30220251   PMID:30667166   PMID:31614616  
PMID:32290105   PMID:32325033   PMID:32790861   PMID:33013468   PMID:34174788   PMID:37067297   PMID:38355793   PMID:38569934  


Genomics

Comparative Map Data
Syne2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391275,865,092 - 76,157,702 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1275,864,908 - 76,157,700 (+)EnsemblGRCm39 Ensembl
GRCm381275,818,318 - 76,110,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1275,818,134 - 76,110,926 (+)EnsemblGRCm38mm10GRCm38
MGSCv371276,919,305 - 77,211,915 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361276,772,909 - 77,029,768 (+)NCBIMGSCv36mm8
Celera1276,923,010 - 77,205,661 (+)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.11NCBI
SYNE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381463,761,596 - 64,226,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1463,761,899 - 64,226,433 (+)EnsemblGRCh38hg38GRCh38
GRCh371464,319,722 - 64,693,167 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,389,436 - 63,762,920 (+)NCBINCBI36Build 36hg18NCBI36
Build 341463,612,085 - 63,762,903NCBI
Celera1444,377,022 - 44,750,869 (+)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1444,548,587 - 44,865,749 (+)NCBIHuRef
CHM1_11464,258,594 - 64,632,989 (+)NCBICHM1_1
T2T-CHM13v2.01457,969,282 - 58,434,164 (+)NCBIT2T-CHM13v2.0
Syne2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,272,729 - 100,586,364 (+)NCBIGRCr8
mRatBN7.2694,537,088 - 94,848,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,537,088 - 94,848,064 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0698,884,269 - 99,153,551 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl698,844,926 - 99,153,551 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.06108,300,643 - 108,565,625 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4698,457,147 - 98,601,686 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1698,460,902 - 98,605,226 (+)NCBI
Celera693,001,776 - 93,273,770 (+)NCBICelera
Cytogenetic Map6q24NCBI
Syne2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554665,646,516 - 5,926,382 (-)NCBIChiLan1.0ChiLan1.0
SYNE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21564,969,228 - 65,338,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,185,749 - 64,554,042 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01444,438,851 - 44,807,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11462,694,928 - 63,064,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1462,751,560 - 63,064,136 (+)Ensemblpanpan1.1panPan2
SYNE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,373,900 - 38,643,544 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,373,964 - 38,643,240 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha838,066,748 - 38,335,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0838,601,180 - 38,866,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,550,295 - 38,866,628 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,217,742 - 38,486,813 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,289,976 - 38,558,948 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,650,638 - 38,919,080 (+)NCBIUU_Cfam_GSD_1.0
Syne2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,242,282 - 66,512,354 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364957,658,250 - 7,949,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYNE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,911,965 - 194,264,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11193,909,563 - 194,352,550 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,795,839 - 216,243,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYNE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,054,609 - 41,443,067 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,054,621 - 41,443,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605329,245,733 - 29,619,251 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syne2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473436,832,490 - 37,167,438 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Syne2
12089 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2913
Count of miRNA genes:756
Interacting mature miRNAs:1009
Transcripts:ENSMUST00000044217, ENSMUST00000085280, ENSMUST00000124685, ENSMUST00000126903, ENSMUST00000131480, ENSMUST00000132161, ENSMUST00000133623, ENSMUST00000139204, ENSMUST00000142864, ENSMUST00000143031, ENSMUST00000148324, ENSMUST00000148825, ENSMUST00000150317, ENSMUST00000151286, ENSMUST00000154509, ENSMUST00000154762, ENSMUST00000157033
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse

Markers in Region
AW546258  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381276,110,447 - 76,110,567UniSTSGRCm38
MGSCv371277,211,434 - 77,211,554UniSTSGRCm37
Celera1277,205,183 - 77,205,303UniSTS
Cytogenetic Map12C3UniSTS
cM Map1233.0UniSTS
Whitehead/MRC_RH12712.16UniSTS
D12Mit128  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381276,051,661 - 76,051,774UniSTSGRCm38
MGSCv371277,152,648 - 77,152,761UniSTSGRCm37
Celera1279,315,305 - 79,315,414UniSTS
Cytogenetic Map12C3UniSTS
cM Map1232.0UniSTS
Whitehead Genetic1227.3UniSTS
Whitehead/MRC_RH12702.51UniSTS
Whitehead_YAC12 UniSTS
D12Mit192  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381276,048,091 - 76,048,206UniSTSGRCm38
MGSCv371277,149,078 - 77,149,193UniSTSGRCm37
Celera1279,318,868 - 79,318,983UniSTS
Cytogenetic Map12C3UniSTS
cM Map1232.0UniSTS
Whitehead Genetic1227.3UniSTS
Whitehead/MRC_RH12702.51UniSTS
Whitehead_YAC12 UniSTS
D12Mit252  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381275,976,038 - 75,976,122UniSTSGRCm38
MGSCv371277,077,025 - 77,077,109UniSTSGRCm37
Celera1277,080,953 - 77,081,037UniSTS
Cytogenetic Map12C3UniSTS
cM Map1232.0UniSTS
Whitehead Genetic1227.3UniSTS
Whitehead_YAC12 UniSTS
Syne2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C3UniSTS
cM Map1233.0UniSTS
BI301410  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381276,012,168 - 76,012,324UniSTSGRCm38
MGSCv371277,113,155 - 77,113,311UniSTSGRCm37
Celera1277,117,035 - 77,117,191UniSTS
Cytogenetic Map12C3UniSTS
cM Map1233.0UniSTS
D12Ertd777e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381276,110,580 - 76,110,780UniSTSGRCm38
MGSCv371277,211,567 - 77,211,767UniSTSGRCm37
Celera1277,205,316 - 77,205,516UniSTS
Cytogenetic Map12C3UniSTS
cM Map1233.0UniSTS
D12Mit3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381275,980,519 - 75,980,640UniSTSGRCm38
MGSCv371277,081,506 - 77,081,627UniSTSGRCm37
Celera1277,085,434 - 77,085,555UniSTS
Cytogenetic Map12C3UniSTS
cM Map1232.0UniSTS
Whitehead Genetic1227.3UniSTS
Whitehead_YAC12 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB093279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC115714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC164121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC166991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF435012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC076568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ848978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000044217   ⟹   ENSMUSP00000047697
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,865,092 - 76,157,674 (+)Ensembl
GRCm38.p6 Ensembl1275,818,318 - 76,110,900 (+)Ensembl
Ensembl Acc Id: ENSMUST00000085280   ⟹   ENSMUSP00000082383
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,078,388 - 76,157,694 (+)Ensembl
GRCm38.p6 Ensembl1276,031,614 - 76,110,920 (+)Ensembl
Ensembl Acc Id: ENSMUST00000124685
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,955,992 - 75,960,661 (+)Ensembl
GRCm38.p6 Ensembl1275,909,218 - 75,913,887 (+)Ensembl
Ensembl Acc Id: ENSMUST00000126903   ⟹   ENSMUSP00000115053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,128,713 - 76,144,755 (+)Ensembl
GRCm38.p6 Ensembl1276,081,939 - 76,097,981 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131480   ⟹   ENSMUSP00000114364
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,118,790 - 76,141,210 (+)Ensembl
GRCm38.p6 Ensembl1276,072,016 - 76,094,436 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132161   ⟹   ENSMUSP00000122781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,134,534 - 76,157,700 (+)Ensembl
GRCm38.p6 Ensembl1276,087,760 - 76,110,926 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133623
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,865,097 - 75,937,823 (+)Ensembl
GRCm38.p6 Ensembl1275,818,323 - 75,891,049 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139204   ⟹   ENSMUSP00000118921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,095,352 - 76,157,674 (+)Ensembl
GRCm38.p6 Ensembl1276,048,578 - 76,110,900 (+)Ensembl
Ensembl Acc Id: ENSMUST00000142864   ⟹   ENSMUSP00000119268
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,864,908 - 75,927,280 (+)Ensembl
GRCm38.p6 Ensembl1275,818,134 - 75,880,506 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143031   ⟹   ENSMUSP00000119120
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,865,092 - 76,157,700 (+)Ensembl
GRCm38.p6 Ensembl1275,818,318 - 76,110,926 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148324   ⟹   ENSMUSP00000121517
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,899,504 - 75,927,102 (+)Ensembl
GRCm38.p6 Ensembl1275,852,730 - 75,880,328 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148825   ⟹   ENSMUSP00000120371
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,069,074 - 76,074,589 (+)Ensembl
GRCm38.p6 Ensembl1276,022,300 - 76,027,815 (+)Ensembl
Ensembl Acc Id: ENSMUST00000150317   ⟹   ENSMUSP00000118142
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,865,103 - 75,955,651 (+)Ensembl
GRCm38.p6 Ensembl1275,818,329 - 75,908,877 (+)Ensembl
Ensembl Acc Id: ENSMUST00000151286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,147,675 - 76,152,766 (+)Ensembl
GRCm38.p6 Ensembl1276,100,901 - 76,105,992 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154509   ⟹   ENSMUSP00000116718
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,128,430 - 76,141,820 (+)Ensembl
GRCm38.p6 Ensembl1276,081,656 - 76,095,046 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154762
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1276,106,448 - 76,113,290 (+)Ensembl
GRCm38.p6 Ensembl1276,059,674 - 76,066,516 (+)Ensembl
Ensembl Acc Id: ENSMUST00000157033
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1275,865,124 - 75,952,677 (+)Ensembl
GRCm38.p6 Ensembl1275,818,350 - 75,905,903 (+)Ensembl
RefSeq Acc Id: NM_001005510   ⟹   NP_001005510
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391275,865,092 - 76,157,702 (+)NCBI
GRCm381275,818,318 - 76,110,928 (+)ENTREZGENE
MGSCv371276,919,305 - 77,211,915 (+)RGD
Celera1279,314,213 - 79,337,041 (-)NCBI
Celera1276,923,010 - 77,205,661 (+)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001005510   ⟸   NM_001005510
- UniProtKB: Q6ZWQ0 (UniProtKB/Swiss-Prot),   Q640M5 (UniProtKB/Swiss-Prot),   E9QP46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000118142   ⟸   ENSMUST00000150317
Ensembl Acc Id: ENSMUSP00000118921   ⟸   ENSMUST00000139204
Ensembl Acc Id: ENSMUSP00000082383   ⟸   ENSMUST00000085280
Ensembl Acc Id: ENSMUSP00000119120   ⟸   ENSMUST00000143031
Ensembl Acc Id: ENSMUSP00000115053   ⟸   ENSMUST00000126903
Ensembl Acc Id: ENSMUSP00000122781   ⟸   ENSMUST00000132161
Ensembl Acc Id: ENSMUSP00000114364   ⟸   ENSMUST00000131480
Ensembl Acc Id: ENSMUSP00000116718   ⟸   ENSMUST00000154509
Ensembl Acc Id: ENSMUSP00000121517   ⟸   ENSMUST00000148324
Ensembl Acc Id: ENSMUSP00000120371   ⟸   ENSMUST00000148825
Ensembl Acc Id: ENSMUSP00000047697   ⟸   ENSMUST00000044217
Ensembl Acc Id: ENSMUSP00000119268   ⟸   ENSMUST00000142864
Protein Domains
Calponin-homology (CH)   KASH

Promoters
RGD ID:8678550
Promoter ID:EPDNEW_M17306
Type:initiation region
Name:Syne2_1
Description:Mus musculus spectrin repeat containing, nuclear envelope 2 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17307  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381275,818,323 - 75,818,383EPDNEW
RGD ID:8678554
Promoter ID:EPDNEW_M17307
Type:multiple initiation site
Name:Syne2_2
Description:Mus musculus spectrin repeat containing, nuclear envelope 2 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M17306  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381276,081,905 - 76,081,965EPDNEW
RGD ID:6823484
Promoter ID:MM_KWN:11954
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:NM_001005510,   OTTMUST00000082377,   OTTMUST00000082456,   OTTMUST00000082562,   UC007NXM.1,   UC007NXN.1,   UC007NXO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361276,919,131 - 76,919,631 (+)MPROMDB
RGD ID:6823455
Promoter ID:MM_KWN:11956
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000082563
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361276,953,399 - 76,953,899 (+)MPROMDB
RGD ID:6823460
Promoter ID:MM_KWN:11958
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000082569
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,123,161 - 77,123,661 (+)MPROMDB
RGD ID:6823463
Promoter ID:MM_KWN:11959
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000044217,   UC007NXR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,131,661 - 77,132,412 (+)MPROMDB
RGD ID:6823464
Promoter ID:MM_KWN:11963
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC007NXT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,162,156 - 77,162,656 (+)MPROMDB
RGD ID:6823459
Promoter ID:MM_KWN:11964
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Lung
Transcripts:OTTMUST00000082567
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,173,026 - 77,173,526 (+)MPROMDB
RGD ID:6823458
Promoter ID:MM_KWN:11965
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000082565,   OTTMUST00000082566
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,181,961 - 77,183,007 (+)MPROMDB
RGD ID:6823453
Promoter ID:MM_KWN:11966
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung,   Spleen
Transcripts:OTTMUST00000082543
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,187,791 - 77,188,577 (+)MPROMDB
RGD ID:6823457
Promoter ID:MM_KWN:11967
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000082564
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361277,201,594 - 77,202,094 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2449316 AgrOrtholog
Ensembl Genes ENSMUSG00000063450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000044217 ENTREZGENE
  ENSMUST00000044217.16 UniProtKB/Swiss-Prot
  ENSMUST00000085280.12 UniProtKB/TrEMBL
  ENSMUST00000126903.2 UniProtKB/TrEMBL
  ENSMUST00000131480.8 UniProtKB/TrEMBL
  ENSMUST00000132161.2 UniProtKB/TrEMBL
  ENSMUST00000139204.8 UniProtKB/TrEMBL
  ENSMUST00000142864.8 UniProtKB/TrEMBL
  ENSMUST00000143031.8 UniProtKB/TrEMBL
  ENSMUST00000148324.2 UniProtKB/TrEMBL
  ENSMUST00000148825.2 UniProtKB/TrEMBL
  ENSMUST00000150317.8 UniProtKB/TrEMBL
  ENSMUST00000154509.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anc-1-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KASH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:319565 UniProtKB/Swiss-Prot
MGD MGI:2449316 ENTREZGENE
NCBI Gene Syne2 ENTREZGENE
PANTHER SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPECTRIN REPEAT-CONTAINING NUCLEAR ENVELOPE PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam KASH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Syne2 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KASH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART KASH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YVK9_MOUSE UniProtKB/TrEMBL
  D3Z2J8_MOUSE UniProtKB/TrEMBL
  D3Z2P5_MOUSE UniProtKB/TrEMBL
  D3Z412_MOUSE UniProtKB/TrEMBL
  D5FT67_MOUSE UniProtKB/TrEMBL
  D6RH38_MOUSE UniProtKB/TrEMBL
  E9QP46 ENTREZGENE, UniProtKB/TrEMBL
  F6VTU3_MOUSE UniProtKB/TrEMBL
  F6W8R9_MOUSE UniProtKB/TrEMBL
  F7BX34_MOUSE UniProtKB/TrEMBL
  Q640M5 ENTREZGENE
  Q6DFZ2_MOUSE UniProtKB/TrEMBL
  Q6PI66_MOUSE UniProtKB/TrEMBL
  Q6ZWN0_MOUSE UniProtKB/TrEMBL
  Q6ZWQ0 ENTREZGENE
  Q76KB5_MOUSE UniProtKB/TrEMBL
  Q7TPP1_MOUSE UniProtKB/TrEMBL
  Q8K147_MOUSE UniProtKB/TrEMBL
  Q8VHN9_MOUSE UniProtKB/TrEMBL
  SYNE2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q640M5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-21 Syne2  spectrin repeat containing, nuclear envelope 2  Syne2  synaptic nuclear envelope 2  Symbol and/or name change 5135510 APPROVED
2024-08-21 Syne2  synaptic nuclear envelope 2  Syne2  spectrin repeat containing, nuclear envelope 2  Symbol and/or name change 5135510 APPROVED
2012-11-27 Syne2  spectrin repeat containing, nuclear envelope 2    synaptic nuclear envelope 2  Symbol and/or name change 5135510 APPROVED