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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GnRH antagonist
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Accession:CHEBI:59229 term browser browse the term
Definition:A chemical substance which inhibits the function of gonadotrophin-releasing hormone (GnRH).
Synonyms:related_synonym: GnRH antagonists;   gonadotrophin-releasing hormone antagonist;   gonadotrophin-releasing hormone antagonists


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cetrorelix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO cetrorelix results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of APOE mRNA CTD PMID:18160741 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP		 cetrorelix results in increased expression of BAX mRNA; cetrorelix results in increased expression of BAX protein CTD PMID:17268770 PMID:18829022 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP		 cetrorelix results in decreased expression of BCL2 protein
cetrorelix results in decreased expression of BCL2 mRNA		 CTD PMID:18829022 PMID:21062912 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cetrorelix results in decreased expression of BCL2L1 protein CTD PMID:21062912 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP		 cetrorelix results in increased activity of CASP3 protein CTD PMID:17268770 PMID:21062912 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO
EXP		 cetrorelix results in increased activity of CASP9 protein CTD PMID:17268770 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CCN5 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CCN5 mRNA CTD PMID:18160741 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cetrorelix results in increased expression of CDKN1A protein CTD PMID:21062912 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chga chromogranin A multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CHGA mRNA CTD PMID:18160741 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 decreases expression ISO cetrorelix results in decreased expression of CLCF1 mRNA CTD PMID:21062912 NCBI chr 1:201,507,763...201,517,607
Ensembl chr 1:201,507,859...201,517,605 		JBrowse link
G Cst9l cystatin 9-like multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of CST9L mRNA CTD PMID:18160741 NCBI chr 3:136,288,093...136,290,906
Ensembl chr 3:136,288,093...136,290,906 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO cetrorelix results in decreased expression of CXCL12 mRNA CTD PMID:21062912 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYB5A mRNA CTD PMID:18160741 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP11A1 mRNA CTD PMID:18160741 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP17A1 mRNA CTD PMID:18160741 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of DDR1 mRNA CTD PMID:18160741 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DHCR24 mRNA CTD PMID:18160741 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dpep3 dipeptidase 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DPEP3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DPEP3 mRNA CTD PMID:18160741 NCBI chr19:33,868,229...33,876,609
Ensembl chr19:33,868,242...33,873,896 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP		 cetrorelix results in increased expression of FAS mRNA; cetrorelix results in increased expression of FAS protein CTD PMID:17268770 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO
EXP		 cetrorelix results in decreased expression of FSHB protein CTD PMID:10077358 PMID:17638707 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of GSTA2 mRNA CTD PMID:18160741 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP cetrorelix results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hcrtr2 hypocretin receptor 2 decreases expression EXP cetrorelix results in decreased expression of HCRTR2 mRNA CTD PMID:17638707 NCBI chr 8:76,989,834...77,105,953
Ensembl chr 8:76,989,834...77,105,893 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HMGCS2 mRNA CTD PMID:18160741 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HSD17B6 mRNA CTD PMID:18160741 NCBI chr 7:422,466...442,008
Ensembl chr 7:422,480...442,425 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO cetrorelix results in decreased expression of IGF1 mRNA CTD PMID:21062912 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 decreases expression ISO cetrorelix results in decreased expression of IL6 mRNA CTD PMID:21062912 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of INSL3 mRNA CTD PMID:18160741 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
decreases secretion
multiple interactions		 EXP
ISO		 cetrorelix results in decreased expression of LHB protein
cetrorelix results in decreased secretion of LHB protein
cypermethrin inhibits the reaction [cetrorelix results in decreased secretion of LHB protein]		 CTD PMID:10077358 PMID:16914592 PMID:17638707 PMID:28731686 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of MAPK1 protein CTD PMID:21062912 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of MAPK3 protein CTD PMID:21062912 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of MSMO1 mRNA CTD PMID:18160741 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016 		JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PAPSS2 mRNA CTD PMID:18160741 NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PGRMC1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PGRMC1 mRNA CTD PMID:18160741 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682 		JBrowse link
G Prl prolactin decreases expression EXP cetrorelix results in decreased expression of PRL protein CTD PMID:17638707 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prok1 prokineticin 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PROK1 mRNA CTD PMID:18160741 NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250 		JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PRPS2 mRNA CTD PMID:18160741 NCBI chr  X:26,975,915...27,013,184
Ensembl chr  X:26,976,061...27,013,181 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO cetrorelix results in decreased phosphorylation of and results in decreased activity of RELA protein CTD PMID:21062912 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of RHOB mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of RHOB mRNA CTD PMID:18160741 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of STAR mRNA CTD PMID:18160741 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of STAT3 protein CTD PMID:21062912 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sycp1 synaptonemal complex protein 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of SYCP1 mRNA CTD PMID:18160741 NCBI chr 2:190,296,688...190,456,687
Ensembl chr 2:190,296,954...190,456,737 		JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TAF4B mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TAF4B mRNA CTD PMID:18160741 NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307 		JBrowse link
G Tex19.2 testis expressed gene 19.2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TEX19 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TEX19 mRNA CTD PMID:18160741 NCBI chr10:106,379,757...106,382,344
Ensembl chr10:106,379,757...106,382,344 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO cetrorelix results in decreased expression of TGFB1 mRNA CTD PMID:21062912 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression ISO cetrorelix results in decreased expression of TNFSF13 mRNA CTD PMID:21062912 NCBI chr10:54,400,054...54,403,723
Ensembl chr10:54,400,065...54,403,042 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO cetrorelix results in increased expression of TP53 protein CTD PMID:21062912 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO cetrorelix results in decreased expression of VEGFA mRNA CTD PMID:21062912 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        pharmacological role 19122
          antagonist 17266
            hormone antagonist 13549
              GnRH antagonist 49
                cetrorelix + 49
                cetrorelix acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        pharmaceutical 19573
          drug 19573
            receptor modulator 18989
              hormone receptor modulator 18981
                hormone antagonist 13549
                  GnRH antagonist 49
                    cetrorelix + 49
                    cetrorelix acetate 0
paths to the root