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G |
Bco1 |
beta-carotene oxygenase 1 |
increases expression |
ISO |
Ro 41-5253 results in increased expression of BCO1 mRNA; Ro 41-5253 results in increased expression of BCO1 protein |
CTD |
PMID:16186334 |
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NCBI chr19:45,149,250...45,186,102
Ensembl chr19:45,149,265...45,186,101
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G |
Ccnd3 |
cyclin D3 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [CPG-oligonucleotide results in increased expression of CCND3 protein]] |
CTD |
PMID:17209053 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNE1 protein]] |
CTD |
PMID:12421932 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cd1d1 |
CD1d1 molecule |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CD1D mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of CD1D mRNA] |
CTD |
PMID:17392484 |
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NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDKN1B protein]] |
CTD |
PMID:12421932 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cyp26a1 |
cytochrome P450, family 26, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)benzoic acid results in increased expression of CYP26A1 mRNA]; Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of CYP26A1 mRNA] |
CTD |
PMID:10953040 |
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NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
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G |
Fabp4 |
fatty acid binding protein 4 |
increases expression |
ISO |
Ro 41-5253 results in increased expression of FABP4 mRNA |
CTD |
PMID:17290005 |
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NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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G |
Fth1 |
ferritin heavy chain 1 |
multiple interactions |
EXP |
Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of FTH1 mRNA] |
CTD |
PMID:22154532 |
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NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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G |
Gja1 |
gap junction protein, alpha 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of GJA1 protein]; Ro 41-5253 inhibits the reaction [beta Carotene results in increased expression of GJA1 protein] |
CTD |
PMID:16091010 |
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NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of IFNG protein] |
CTD |
PMID:16007204 PMID:16872382 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ifngr1 |
interferon gamma receptor 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein] |
CTD |
PMID:16085646 |
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NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
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G |
Il10 |
interleukin 10 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL10 protein] |
CTD |
PMID:16872382 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:16872382 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:16872382 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il4 |
interleukin 4 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin results in increased secretion of IL4 protein] |
CTD |
PMID:16872382 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein |
CTD |
PMID:17290005 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Ireb2 |
iron responsive element binding protein 2 |
multiple interactions |
EXP |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of IREB2 mRNA] |
CTD |
PMID:22154532 |
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NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611
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G |
Irf1 |
interferon regulatory factor 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IRF1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of IRF1 protein] |
CTD |
PMID:16085646 PMID:16636311 |
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NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Muc4 |
mucin 4, cell surface associated |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [IFNG protein promotes the reaction [Tretinoin results in increased expression of MUC4 protein]]; Ro 41-5253 inhibits the reaction [IFNG protein results in increased expression of MUC4 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of MUC4 protein] |
CTD |
PMID:16007204 |
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NCBI chr11:68,008,245...68,053,242
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G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] |
CTD |
PMID:17291456 |
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NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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G |
Oas2 |
2'-5' oligoadenylate synthetase 2 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of OAS2 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of OAS2 mRNA] |
CTD |
PMID:16636311 |
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NCBI chr12:35,802,824...35,830,778
Ensembl chr12:35,806,759...35,829,371
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G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT] |
CTD |
PMID:7556191 |
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NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
affects binding multiple interactions |
ISO |
Ro 41-5253 binds to PPARD protein Ro 41-5253 inhibits the reaction [GW 2433 binds to PPARD protein] |
CTD |
PMID:17290005 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
[Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 binds to and results in increased activity of PPARG protein; Ro 41-5253 inhibits the reaction [pioglitazone results in increased activity of PPARG protein]; Ro 41-5253 inhibits the reaction [rosiglitazone binds to PPARG protein] [Dexamethasone co-treated with INS protein co-treated with Ro 41-5253] results in increased expression of PPARG protein; Ro 41-5253 results in increased activity of and results in decreased expression of PPARG protein |
CTD |
PMID:17290005 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Rara |
retinoic acid receptor, alpha |
multiple interactions increases response to substance decreases activity |
ISO |
Am 580 inhibits the reaction [Ro 41-5253 results in decreased activity of RARA protein]; Ro 41-5253 binds to and results in decreased activity of RARA protein; Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased expression of RARA mRNA] RARA protein results in increased susceptibility to Ro 41-5253 |
CTD |
PMID:7556191 PMID:8838863 PMID:10779427 PMID:17216566 PMID:17290005 PMID:25550158 More...
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NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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G |
Rarb |
retinoic acid receptor, beta |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] |
CTD |
PMID:25550158 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarg |
retinoic acid receptor, gamma |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] |
CTD |
PMID:25550158 |
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NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RB1 protein]] |
CTD |
PMID:12421932 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Rxra |
retinoid X receptor alpha |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] |
CTD |
PMID:25550158 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Slc10a1 |
solute carrier family 10 member 1 |
multiple interactions decreases expression increases response to substance |
ISO |
Ro 41-5253 inhibits the reaction [[RARA protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARB protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA]; Ro 41-5253 inhibits the reaction [[RARG protein co-treated with RXRA protein] results in increased expression of SLC10A1 mRNA] Ro 41-5253 results in decreased expression of SLC10A1 mRNA; Ro 41-5253 results in decreased expression of SLC10A1 protein SLC10A1 protein results in increased susceptibility to Ro 41-5253 |
CTD |
PMID:25550158 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions decreases expression |
ISO |
Ro 41-5253 inhibits the reaction [Am 580 results in increased phosphorylation of and results in increased activity of STAT1 protein]; Ro 41-5253 inhibits the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of STAT1 protein] Ro 41-5253 results in decreased expression of STAT1 protein |
CTD |
PMID:16007204 PMID:16085646 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Tfrc |
transferrin receptor |
multiple interactions |
EXP |
Ro 41-5253 inhibits the reaction [Tretinoin results in decreased expression of TFRC mRNA] |
CTD |
PMID:22154532 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
Ro 41-5253 inhibits the reaction [Tretinoin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; Ro 41-5253 inhibits the reaction [tributyltin inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]] |
CTD |
PMID:17291456 |
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NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
tazarotene results in increased expression of BAX protein |
CTD |
PMID:16109552 PMID:16196285 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
tazarotene results in decreased expression of BCL2 protein |
CTD |
PMID:16109552 PMID:16196285 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
tazarotene results in increased activity of CASP3 protein |
CTD |
PMID:16196285 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
tazarotene results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
[tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein |
CTD |
PMID:15383624 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
[tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein |
CTD |
PMID:15383624 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Rarb |
retinoic acid receptor, beta |
multiple interactions |
ISO |
tazarotene metabolite binds to and results in increased activity of RARB protein |
CTD |
PMID:16178010 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarg |
retinoic acid receptor, gamma |
multiple interactions |
ISO |
tazarotene metabolite binds to and results in increased activity of RARG protein |
CTD |
PMID:16178010 |
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NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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G |
Rb1 |
RB transcriptional corepressor 1 |
multiple interactions |
ISO |
[tazarotene co-treated with Retinoids] results in decreased phosphorylation of RB1 protein |
CTD |
PMID:15383624 |
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NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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G |
Slc5a5 |
solute carrier family 5 member 5 |
increases expression |
ISO |
tazarotene results in increased expression of SLC5A5 mRNA |
CTD |
PMID:16954431 |
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NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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G |
Sts |
steroid sulfatase |
increases activity multiple interactions |
ISO |
tazarotene metabolite results in increased activity of STS protein; tazarotene results in increased activity of STS protein wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein] |
CTD |
PMID:16178010 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Rarb |
retinoic acid receptor, beta |
multiple interactions |
ISO |
AGN 190299 binds to and results in increased activity of RARB protein |
CTD |
PMID:16178010 |
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NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
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G |
Rarg |
retinoic acid receptor, gamma |
multiple interactions |
ISO |
AGN 190299 binds to and results in increased activity of RARG protein |
CTD |
PMID:16178010 |
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NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
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G |
Sts |
steroid sulfatase |
increases activity |
ISO |
AGN 190299 results in increased activity of STS protein |
CTD |
PMID:16178010 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
EXP |
tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]; tertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine] |
CTD |
PMID:8539317 |
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NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr1b |
5-hydroxytryptamine receptor 1B |
affects binding |
EXP |
tertatolol binds to HTR1B protein |
CTD |
PMID:11888550 |
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NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
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