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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tazarotenic acid
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Accession:CHEBI:73129 term browser browse the term
Definition:A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene.
Synonyms:exact_synonym: 6-[(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]nicotinic acid
 related_synonym: 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-3-pyridinecarboxylic acid;   6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid;   Agn 190299;   Formula=C19H17NO2S;   InChI=1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22);   InChIKey=IQIBKLWBVJPOQO-UHFFFAOYSA-N;   SMILES=CC1(C)CCSc2ccc(cc12)C#Cc1ccc(cn1)C(O)=O
 xref: CAS:118292-41-4
 xref_mesh: MESH:C090766
 xref: PMID:11807455;   PMID:12642475;   PMID:7981424;   Patent:US2006020037;   Patent:WO2006022964;   Reaxys:9718318


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tazarotenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rarb retinoic acid receptor, beta multiple interactions ISO AGN 190299 binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO AGN 190299 binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Sts steroid sulfatase increases activity ISO AGN 190299 results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
tazarotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tazarotene results in increased expression of BAX protein CTD PMID:16109552 PMID:16196285 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tazarotene results in decreased expression of BCL2 protein CTD PMID:16109552 PMID:16196285 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity ISO tazarotene results in increased activity of CASP3 protein CTD PMID:16196285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tazarotene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression ISO tazarotene results in increased expression of SLC5A5 mRNA CTD PMID:16954431 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Sts steroid sulfatase increases activity
multiple interactions		 ISO tazarotene metabolite results in increased activity of STS protein; tazarotene results in increased activity of STS protein
wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]		 CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        aetiopathogenetic role 19180
          teratogenic agent 16149
            tazarotenic acid 11
              tazarotene 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            organic hydride 18674
                              organic fundamental parent 18674
                                hydrocarbon 18410
                                  terpene 14029
                                    diterpene 13033
                                      diterpenoid 13033
                                        retinoid 10281
                                          tazarotenic acid 11
                                            tazarotene 11
paths to the root