Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tazarotene
go back to main search page
Accession:CHEBI:32184 term browser browse the term
Definition:The ethyl ester of tazarotenic acid. A prodrug for tazarotenic acid, it is used for the treatment of psoriasis, acne, and sun-damaged skin.
Synonyms:exact_synonym: ethyl 6-[(4,4-dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinate
 related_synonym: Avage;   Formula=C21H21NO2S;   InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18(13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3;   InChIKey=OGQICQVSFDPSEI-UHFFFAOYSA-N;   SMILES=CCOC(=O)c1ccc(nc1)C#Cc1ccc2SCCC(C)(C)c2c1;   Tazorac;   Zorac;   tazaroteno;   tazarotenum
 xref: Beilstein:8159145;   CAS:118292-40-3;   DrugBank:DB00799;   Drug_Central:2571;   HMDB:HMDB0014937;   KEGG:C12531;   KEGG:D01132
 xref_mesh: MESH:C086827
 xref: Patent:EP284288;   Patent:US5089509;   Wikipedia:Tazarotene


show annotations for term's descendants           Sort by:
 
tazarotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tazarotene results in increased expression of BAX protein CTD PMID:16109552, PMID:16196285 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tazarotene results in decreased expression of BCL2 protein CTD PMID:16109552, PMID:16196285 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 increases activity ISO tazarotene results in increased activity of CASP3 protein CTD PMID:16196285 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tazarotene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:143,840,739...143,863,206
Ensembl chr 7:143,839,980...143,863,186
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression ISO tazarotene results in increased expression of SLC5A5 mRNA CTD PMID:16954431 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sts steroid sulfatase increases activity
multiple interactions
ISO tazarotene metabolite results in increased activity of STS protein; tazarotene results in increased activity of STS protein
wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]
CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      application 19363
        pro-agent 8820
          prodrug 8609
            tazarotene 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic group 18488
                              organic divalent group 18481
                                organodiyl group 18481
                                  carbonyl group 18384
                                    carbonyl compound 18384
                                      carboxylic acid 18054
                                        monocarboxylic acid 17396
                                          tazarotenic acid 11
                                            tazarotene 11
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.