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ONTOLOGY REPORT - ANNOTATIONS


Term:tazarotenic acid
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Accession:CHEBI:73129 term browser browse the term
Definition:A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene.
Synonyms:exact_synonym: 6-[(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]nicotinic acid
 related_synonym: 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-3-pyridinecarboxylic acid;   6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid;   Agn 190299;   Formula=C19H17NO2S;   InChI=1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22);   InChIKey=IQIBKLWBVJPOQO-UHFFFAOYSA-N;   SMILES=CC1(C)CCSc2ccc(cc12)C#Cc1ccc(cn1)C(O)=O
 xref: CAS:118292-41-4 "ChemIDplus"
 xref_mesh: MESH:C090766
 xref: PMID:11807455 "Europe PMC";   PMID:12642475 "Europe PMC";   PMID:7981424 "Europe PMC";   Patent:US2006020037;   Patent:WO2006022964;   Reaxys:9718318 "Reaxys"


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tazarotenic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6480464
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
tazarotene term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Rarb retinoic acid receptor, beta JBrowse link 15 9,915,223 10,262,599 RGD:6480464
G Rarg retinoic acid receptor, gamma JBrowse link 7 143,840,739 143,863,206 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Slc5a5 solute carrier family 5 member 5 JBrowse link 16 20,297,414 20,307,401 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        aetiopathogenetic role 18766
          teratogenic agent 15864
            tazarotenic acid 11
              tazarotene 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          tazarotenic acid 11
                                            tazarotene 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.