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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tazarotenic acid
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Accession:CHEBI:73129 term browser browse the term
Definition:A thiochromane that is acetylene in which the hydrogens are replaced by 5-carboxypyridin-2-yl and 4,4-dimethylthiochroman-6-yl groups. It is the active form of the prodrug tazarotene.
Synonyms:exact_synonym: 6-[(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]nicotinic acid
 related_synonym: 6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl)-3-pyridinecarboxylic acid;   6-(2-(4,4-dimethylthiochroman-6-yl)ethynyl)nicotinic acid;   Agn 190299;   Formula=C19H17NO2S;   InChI=1S/C19H17NO2S/c1-19(2)9-10-23-17-8-4-13(11-16(17)19)3-6-15-7-5-14(12-20-15)18(21)22/h4-5,7-8,11-12H,9-10H2,1-2H3,(H,21,22);   InChIKey=IQIBKLWBVJPOQO-UHFFFAOYSA-N;   SMILES=CC1(C)CCSc2ccc(cc12)C#Cc1ccc(cn1)C(O)=O
 xref: CAS:118292-41-4
 xref_mesh: MESH:C090766
 xref: PMID:11807455;   PMID:12642475;   PMID:7981424;   Patent:US2006020037;   Patent:WO2006022964;   Reaxys:9718318



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tazarotenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rarb retinoic acid receptor, beta multiple interactions ISO AGN 190299 binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO AGN 190299 binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Sts steroid sulfatase increases activity ISO AGN 190299 results in increased activity of STS protein CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
tazarotene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO tazarotene results in increased expression of BAX protein CTD PMID:16109552 PMID:16196285 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO tazarotene results in decreased expression of BCL2 protein CTD PMID:16109552 PMID:16196285 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity ISO tazarotene results in increased activity of CASP3 protein CTD PMID:16196285 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tazarotene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:15383624 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tazarotene co-treated with Retinoids] results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:15383624 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARB protein CTD PMID:16178010 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rarg retinoic acid receptor, gamma multiple interactions ISO tazarotene metabolite binds to and results in increased activity of RARG protein CTD PMID:16178010 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [tazarotene co-treated with Retinoids] results in decreased phosphorylation of RB1 protein CTD PMID:15383624 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Slc5a5 solute carrier family 5 member 5 increases expression ISO tazarotene results in increased expression of SLC5A5 mRNA CTD PMID:16954431 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Sts steroid sulfatase increases activity
multiple interactions
ISO tazarotene metabolite results in increased activity of STS protein; tazarotene results in increased activity of STS protein
wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]
CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        aetiopathogenetic role 19302
          teratogenic agent 15957
            tazarotenic acid 11
              tazarotene 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        monocarboxylic acid 17843
                                          tazarotenic acid 11
                                            tazarotene 11
paths to the root