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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:vasopressin signaling pathway via receptor type 2
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Accession:PW:0000713 term browser browse the term
Definition:Vasopressin signaling via receptor type 2 plays a central role in water homeostasis by regulating the translocation of Aqp2 channel. The receptor couples to Gs alpha subunit leading to activation of adenylyl cyclase, production of cyclic AMP and triggering of protein kinase A (PKA) signaling pathway. PKA regulates both the translocation and the expression of the channel.
Synonyms:related_synonym: KEGG:04962;   SMP:00322
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vasopressin signaling pathway via receptor type 2 term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy2 adenylate cyclase 2 ISO SMPDB SMP:00322 NCBI chr 1:36,204,054...36,650,645
Ensembl chr 1:36,204,054...36,650,645 		JBrowse link
G Adcy3 adenylate cyclase 3 IEA KEGG rno:04962 NCBI chr 6:32,819,602...32,923,174
Ensembl chr 6:32,843,961...32,923,173 		JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IDA
IMP
IEA 		KEGG
RGD		 PMID:18431594 PMID:15579502 PMID:18971210 rno:04962, RGD:2312656, RGD:2313211, RGD:2312654 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:131,621,860...131,642,770 		JBrowse link
G Adcy9 adenylate cyclase 9 IEA KEGG rno:04962 NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,645,282...11,765,792 		JBrowse link
G Akap7 A-kinase anchoring protein 7 ISO
IDA 		RGD PMID:18431594 PMID:15037626 RGD:2312656, RGD:1303982 NCBI chr 1:21,906,503...22,168,663
Ensembl chr 1:21,906,676...22,037,090 		JBrowse link
G Aqp2 aquaporin 2 TAS
IDA
IMP
IEA 		KEGG
RGD		 PMID:18431594 PMID:15579502 PMID:18971210 PMID:15037626 rno:04962, RGD:2312656, RGD:2313211, RGD:2312654, RGD:1303982 NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:132,590,225...132,595,319 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) IEA KEGG rno:04962 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685 		JBrowse link
G Aqp4 aquaporin 4 IEA KEGG rno:04962 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha IEA KEGG rno:04962 NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347 		JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta IEA KEGG rno:04962 NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:171,554,140...171,573,068 		JBrowse link
G Avp arginine vasopressin TAS
ISO
IEA 		KEGG
RGD		 PMID:18431594 PMID:14624682 rno:04962, RGD:2312656, RGD:1579891 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 TAS
ISO
IMP
IEA 		KEGG
SMPDB
RGD		 PMID:18431594 PMID:14624682 PMID:18971210 SMP:00322 rno:04962, RGD:2312656, RGD:1579891, RGD:2312654 NCBI chr  X:156,785,009...156,787,477
Ensembl chr  X:156,785,139...156,787,477 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 IEA KEGG rno:04962 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 IEA KEGG rno:04962 NCBI chr 3:98,408,240...98,449,104
Ensembl chr 3:98,408,058...98,449,104 		JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 IEA KEGG rno:04962 NCBI chr 4:66,874,623...66,990,962
Ensembl chr 4:66,387,126...66,990,832 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 IEA KEGG rno:04962 NCBI chr 7:9,273,320...9,281,755
Ensembl chr 7:9,273,338...9,281,778 		JBrowse link
G Creb3l4 cAMP responsive element binding protein 3-like 4 IEA KEGG rno:04962 NCBI chr 2:177,987,981...177,994,568
Ensembl chr 2:177,987,981...177,993,485 		JBrowse link
G Dctn1 dynactin subunit 1 IEA KEGG rno:04962 NCBI chr 4:117,228,722...117,261,528
Ensembl chr 4:117,219,349...117,261,528 		JBrowse link
G Dctn2 dynactin subunit 2 IEA KEGG rno:04962 NCBI chr 7:64,977,338...64,992,875
Ensembl chr 7:64,977,363...64,992,873 		JBrowse link
G Dctn4 dynactin subunit 4 IEA KEGG rno:04962 NCBI chr18:56,251,187...56,279,844
Ensembl chr18:56,252,780...56,279,842 		JBrowse link
G Dctn5 dynactin subunit 5 IEA KEGG rno:04962 NCBI chr 1:186,120,415...186,137,146
Ensembl chr 1:186,119,913...186,137,146 		JBrowse link
G Dctn6 dynactin subunit 6 IEA KEGG rno:04962 NCBI chr16:64,780,759...64,799,766
Ensembl chr16:64,780,735...64,801,060 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 IEA KEGG rno:04962 NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116 		JBrowse link
G Dync1i1 dynein cytoplasmic 1 intermediate chain 1 IEA KEGG rno:04962 NCBI chr 4:34,819,313...35,132,647
Ensembl chr 4:34,819,430...35,142,319 		JBrowse link
G Dync1i2 dynein cytoplasmic 1 intermediate chain 2 IEA KEGG rno:04962 NCBI chr 3:76,441,621...76,492,782
Ensembl chr 3:76,424,469...76,492,782 		JBrowse link
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 IEA KEGG rno:04962 NCBI chr 8:123,254,823...123,288,496
Ensembl chr 8:123,254,859...123,289,167 		JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 IEA KEGG rno:04962 NCBI chr19:538,207...561,110
Ensembl chr19:538,211...561,107 		JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 IEA KEGG rno:04962 NCBI chr 8:12,473,955...12,697,075
Ensembl chr 8:12,473,955...12,697,058 		JBrowse link
G Dync2li1 dynein cytoplasmic 2 light intermediate chain 1 IEA KEGG rno:04962 NCBI chr 6:15,745,350...15,778,166
Ensembl chr 6:15,745,350...15,778,166 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 IEA KEGG rno:04962 NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861 		JBrowse link
G Dynll2 dynein light chain LC8-type 2 IEA KEGG rno:04962 NCBI chr10:73,264,260...73,283,042
Ensembl chr10:73,264,261...73,272,285 		JBrowse link
G Fshr follicle stimulating hormone receptor ISO SMPDB SMP:00322 NCBI chr 6:10,952,329...11,160,288
Ensembl chr 6:10,952,329...11,160,288 		JBrowse link
G Gnas GNAS complex locus ISO
IDA
IMP
IEA 		KEGG
SMPDB
RGD		 PMID:18431594 PMID:14624682 PMID:15579502 PMID:18971210 SMP:00322 rno:04962, RGD:2312656, RGD:1579891, RGD:2313211, RGD:2312654 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Gnb1 G protein subunit beta 1 ISO SMPDB SMP:00322 NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488 		JBrowse link
G Gng12 G protein subunit gamma 12 ISO SMPDB SMP:00322 NCBI chr 4:97,340,830...97,464,422
Ensembl chr 4:97,340,472...97,464,476 		JBrowse link
G Myo5b myosin Vb TAS RGD PMID:18431594 RGD:2312656 NCBI chr18:70,313,717...70,613,918
Ensembl chr18:70,311,990...70,613,918 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase IEA KEGG rno:04962 NCBI chr10:89,227,937...89,357,383
Ensembl chr10:89,227,937...89,367,621 		JBrowse link
G Pde4d phosphodiesterase 4D ISO RGD PMID:18431594 RGD:2312656 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha IEA KEGG rno:04962 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta IEA
ISO 		KEGG
SMPDB		 SMP:00322 rno:04962 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit IEA KEGG rno:04962 NCBI chr  X:45,701,747...45,745,210
Ensembl chr  X:45,701,747...45,745,066 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO
IEA 		KEGG
RGD		 PMID:18431594 rno:04962, RGD:2312656 NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:74,118,922...74,141,837 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756 		JBrowse link
G Rab11fip2 RAB11 family interacting protein 2 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:268,908,825...269,080,691
Ensembl chr 1:268,909,413...269,079,661 		JBrowse link
G Rab5a RAB5A, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 9:6,720,057...6,749,456
Ensembl chr 9:6,721,122...6,749,447 		JBrowse link
G Rab5b RAB5B, member RAS oncogene family IEA KEGG rno:04962 NCBI chr 7:1,693,971...1,712,936
Ensembl chr 7:1,693,989...1,712,780 		JBrowse link
G Rab5c RAB5C, member RAS oncogene family IEA KEGG rno:04962 NCBI chr10:86,142,872...86,166,449
Ensembl chr10:86,142,873...86,166,449 		JBrowse link
G Sipa1 signal-induced proliferation-associated 1 ISO RGD PMID:18431594 RGD:2312656 NCBI chr 1:212,367,867...212,379,952
Ensembl chr 1:212,367,867...212,377,497 		JBrowse link
G Snap23 synaptosome associated protein 23 TAS RGD PMID:18431594 RGD:2312656 NCBI chr 3:127,966,184...127,999,929
Ensembl chr 3:127,967,886...127,998,067 		JBrowse link
G Stx4 syntaxin 4 IEA KEGG rno:04962 NCBI chr 1:191,880,549...191,890,333
Ensembl chr 1:191,881,559...191,896,774 		JBrowse link
G Vamp2 vesicle-associated membrane protein 2 ISO
IEA 		KEGG
RGD		 PMID:18431594 rno:04962, RGD:2312656 NCBI chr10:54,292,423...54,296,657
Ensembl chr10:54,292,806...54,296,654 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3864
      homeostasis pathway 1772
        cardiovascular system homeostasis pathway 422
          vasopressin signaling pathway 55
            vasopressin signaling pathway via receptor type 2 51
              altered vasopressin signaling pathway via receptor type 2 0
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