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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:interleukin-6 signaling pathway
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Accession:PW:0000516 term browser browse the term
Definition:Interleukin-6 signaling is involved in a wide range of biological processes such as immune regulation, inflammation, hematopoiesis and oncogenesis. A signal transducer common to all family members, gp130 activates Jak-Stat and Raf/Mek/Erk signaling pathways.
Synonyms:exact_synonym: Il-6 signaling pathway
 related_synonym: Interleukin-6 signaling;   interleukin-6-mediated signaling pathway
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interleukin-6 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO PID PID:200146 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:156,569,860...156,619,868 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 ISO RGD PMID:21145125 RGD:5686846 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO RGD PMID:22029668 PMID:21145125 RGD:5686834, RGD:5686846 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200146 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta ISO PID PID:200146 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta ISO PID PID:200146 NCBI chr11:98,268,856...98,269,994
Ensembl chr11:98,265,651...98,280,824 		JBrowse link
G Crp C-reactive protein ISO PID PID:200146 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Fgg fibrinogen gamma chain ISO PID PID:200146 NCBI chr 2:170,652,929...170,660,372
Ensembl chr 2:170,652,234...170,661,170 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Foxo1 forkhead box O1 ISO PID PID:200146 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419 		JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200146 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:44,035,063...44,143,617 		JBrowse link
G Gab2 GRB2-associated binding protein 2 ISO PID PID:200146 NCBI chr 1:160,841,066...161,036,940
Ensembl chr 1:160,841,066...161,036,940 		JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID
RGD		 PMID:22029668 PID:200146, RGD:5686834 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200146 NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO PID PID:200146 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293 		JBrowse link
G Il6 interleukin 6 ISO
IDA 		PID
RGD		 PMID:12773095 PMID:22029668 PMID:21881215 PMID:23825534 PMID:28186964 PID:200146, RGD:1580493, RGD:5686834, RGD:5686839, RGD:11062097, RGD:127229952 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Il6r interleukin 6 receptor ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:177,582,164...177,645,221 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer ISO
IMP 		PID
RGD		 PMID:22029668 PMID:21881215 PMID:18280048 PID:200146, RGD:5686834, RGD:5686839, RGD:5686900 NCBI chr 2:45,798,872...45,839,501
Ensembl chr 2:45,799,380...45,843,182 		JBrowse link
G Irf1 interferon regulatory factor 1 ISO PID PID:200146 NCBI chr10:38,417,935...38,424,946
Ensembl chr10:38,417,148...38,424,947 		JBrowse link
G Jak1 Janus kinase 1 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758 		JBrowse link
G Jak2 Janus kinase 2 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200146 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218 		JBrowse link
G Lbp lipopolysaccharide binding protein ISO PID PID:200146 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Lmo4 LIM domain only 4 ISO PID PID:200146 NCBI chr 2:235,924,574...235,941,609
Ensembl chr 2:235,924,403...235,941,275 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO PID PID:200146 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200146 NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,872,546...95,987,721 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200146 NCBI chr 7:122,098,120...122,105,023
Ensembl chr 7:122,098,121...122,105,038 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200146 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO PID PID:200146 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mitf melanocyte inducing transcription factor ISO PID PID:200146 NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:131,965,714...132,177,790 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200146 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 ISO PID PID:200146 NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:72,233,566...72,334,315 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 ISO PID PID:200146 NCBI chr 2:186,921,384...186,930,292
Ensembl chr 2:186,921,428...186,936,714 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200146 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200146 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200146 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID
RGD		 PMID:22029668 PID:200146, RGD:5686834 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:41,043,785...41,085,577 		JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200146 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO PID PID:200146 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID
RGD		 PMID:22029668 PMID:9815779 PID:200146, RGD:5686834, RGD:155631264 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 ISO RGD PMID:22029668 RGD:5686834 NCBI chr 6:93,778,971...93,892,161
Ensembl chr 6:93,778,971...93,892,811 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO PID
RGD		 PMID:22029668 PMID:21881215 PID:200146, RGD:5686834, RGD:5686839 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO PID PID:200146 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Tnfsf11 TNF superfamily member 11 ISO PID PID:200146 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479 		JBrowse link
G Tyk2 tyrosine kinase 2 ISO PID
RGD		 PMID:21881215 PID:200146, RGD:5686839 NCBI chr 8:27,918,054...27,943,319
Ensembl chr 8:27,916,496...27,943,278 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 ISO PID PID:200146 NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,248,914...2,296,922 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          Interleukin mediated signaling pathway 256
            interleukin-6 family mediated signaling pathway 48
              interleukin-6 signaling pathway 48
paths to the root