| 1345145 | PML | PML nuclear body scaffold | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor an d tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] | 15 | 73994716 | 74047827 | Human | 517 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1557220 | Pml | promyelocytic leukemia | Enables SMAD binding activity. Involved in several processes, including defense response to other organism; regulation of macromolecule metabolic process; and signal transduction by p53 class mediator. Acts upstream of or within several processes, including apoptotic signaling pathway; cell surface receptor protein serine/threonine kinase signaling pathway; and cellular response to cytokine stimulus. Located in PML body; cytosol; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2025] | 9 | 58125359 | 58157077 | Mouse | 500 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1562602 | Pml | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN PML body organization; apoptotic process (ortholog); branching involved in mammary gland duct morphogenesis (o rtholog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; acute myeloid leukemia pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A; 6-propyl-2-thiouracil | 8 | 67523164 | 67557801 | Rat | 484 | symbol , PhenoGen , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8785931 | Pml | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN apoptotic process (ortholog); branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); PARTICIPATES IN mT OR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955450 | 3654854 | 3692057 | Chinchilla | 196 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 11678104 | PML | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ort holog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN cytosol (ortholog); nuclear membrane (ortholog); nucleolus (ortholog) | 15 | 52903874 | 52955151 | Bonobo | 232 | symbol , old_gene_name , name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12336741 | PML | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ort holog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN nuclear membrane (ortholog) | 30 | 37232337 | 37278434 | Dog | 226 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 12637195 | Pml | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ort holog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN nuclear membrane (ortholog) | NW_004936471 | 33135186 | 33173218 | Squirrel | 224 | symbol , name | gene, protein-coding, MODEL [RefSeq] |
| 13911106 | PML | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ort holog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN nuclear membrane (ortholog) | | | | Pig | 226 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18567715 | PML | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ort holog); PARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN nucleus; cytosol (ortholog); nuclear membrane (ortholog) | | | | Green Monkey | 225 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18916399 | Pml | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); cellular response to interleukin-4 (ortholog); P ARTICIPATES IN mTOR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytosol (ortholog); nuclear body (ortholog) | | | | Naked Mole-Rat | 213 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 626144887 | Pml | PML nuclear body scaffold | ENCODES a protein that exhibits cobalt ion binding (ortholog); identical protein binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN apoptotic process (ortholog); branching involved in mammary gland duct morphogenesis (ortholog); cell fate commitment (ortholog); PARTICIPATES IN mT OR signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); breast ductal carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 196 | symbol , old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 737203 | Fxyd1 | FXYD domain-containing ion transport regulator 1 | This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009] | 7 | 30751103 | 30758332 | Mouse | 171 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1604582 | PRAM1 | PML-RARA regulated adaptor molecule 1 | The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expre ssion of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008] | 19 | 8490056 | 8502640 | Human | 67 | old_gene_name , name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16572626 | AC013486.1 | novel transcript, antisense to PML | | | | | Human | | name | gene, lncrna |
| 1564330 | Pram1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetr achlorodibenzodioxine | 7 | 15125813 | 15142494 | Rat | 58 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 8764333 | Pram1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog) | NW_004955563 | 924365 | 933198 | Chinchilla | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 11699449 | PRAM1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog) | 19 | 7775887 | 7789657 | Bonobo | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12401260 | PRAM1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits lipid binding (inferred); protein kinase binding (inferred); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN plasma membrane (inferred); protein-containing complex (inferred) | 20 | 53035389 | 53047126 | Dog | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 12613570 | Pram1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits lipid binding (inferred); protein kinase binding (inferred); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN plasma membrane (inferred); protein-containing complex (inferred) | NW_004936588 | 5284001 | 5294900 | Squirrel | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 14021948 | PRAM1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits lipid binding (inferred); protein kinase binding (inferred); zinc ion binding (inferred); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN plasma membrane (inferred); protein-containing complex (in ferred) | | | | Pig | 17 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18480696 | PRAM1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Green Monkey | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18928081 | Pram1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Naked Mole-Rat | 16 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 20866418 | PRAM1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits lipid binding (inferred); protein kinase binding (inferred); INVOLVED IN integrin-mediated signaling pathway (inferred); protein localization to plasma membrane (inferred); T cell receptor signaling pathway (inferred); FOUND IN plasma membrane (inferred); protein-cont aining complex (inferred) | | | | Green Monkey | 9 | name | gene, protein-coding |
| 626109677 | Pram1 | PML-RARA regulated adaptor molecule 1 | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN integrin-mediated signaling pathway (ortholog); regulation of neutrophil degranulation (ortholog); FOUND IN protein-containing complex (ortholog) | | | | Black Rat | 9 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 1622820 | Pram1 | PML-RAR alpha-regulated adaptor molecule 1 | Predicted to enable protein kinase binding activity. Acts upstream of or within integrin-mediated signaling pathway and regulation of neutrophil degranulation. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in central nervous system; repro ductive system; and stomach. Orthologous to human PRAM1 (PML-RARA regulated adaptor molecule 1). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 33857030 | 33864680 | Mouse | 71 | old_gene_name , name , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1606654 | GOLGA6A | golgin A6 family member A | The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008] | 15 | 74069857 | 74082550 | Human | 17 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 733999 | RARA | retinoic acid receptor alpha | This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Tr anslocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010] | 17 | 40309180 | 40357643 | Human | 562 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 14374331 | PML1 | | | | | | Yeast | | symbol | gene, null |
| 736785 | PLLP | plasmolipin | Enables identical protein binding activity. Involved in myelin assembly and regulation of transcytosis. Located in myelin sheath and plasma membrane. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Jul 2025] | 16 | 57256097 | 57284672 | Human | 130 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1605941 | SNIP1 | Smad nuclear interacting protein 1 | This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signa ling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012] | 1 | 37534449 | 37554293 | Human | 143 | old_gene_name , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1346209 | GJC2 | gap junction protein gamma 2 | This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defec ts in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008] | 1 | 228149930 | 228159826 | Human | 479 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1348100 | SP100 | SP100 nuclear antigen | This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011] | 2 | 230416201 | 230545606 | Human | 196 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1316870 | THAP1 | THAP domain containing 1 | The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAW R to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] | 8 | 42836674 | 42843325 | Human | 181 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 18912781 | LOC101697682 | small ubiquitin-related modifier 2 | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | | | | Naked Mole-Rat | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 18908802 | LOC101703415 | small ubiquitin-related modifier 2-like | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | | | | Naked Mole-Rat | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 18903402 | LOC101706735 | small ubiquitin-related modifier 2 | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | | | | Naked Mole-Rat | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 18911766 | LOC101718438 | small ubiquitin-related modifier 3 | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | | | | Naked Mole-Rat | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 12614881 | LOC101961851 | small ubiquitin-related modifier 3-like | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | NW_004936619 | 824286 | 824976 | Squirrel | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 12679182 | LOC101970206 | small ubiquitin-related modifier 2-like | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | NW_004936722 | 753222 | 754138 | Squirrel | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 12442125 | LOC101975628 | small ubiquitin-related modifier 2-like | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | NW_004936641 | 3712478 | 3713686 | Squirrel | 2 | description | gene, pseudo, MODEL [RefSeq] |
| 12625937 | LOC101978414 | small ubiquitin-related modifier 3 | INVOLVED IN protein sumoylation (inferred); FOUND IN PML body (inferred) | NW_004936595 | 4681401 | 4682529 | Squirrel | 2 | description | gene, protein-coding, MODEL [RefSeq] |
| 1312940 | Ankrd2 | ankyrin repeat domain 2 | Enables chromatin binding activity; protein kinase B binding activity; and titin binding activity. Involved in negative regulation of myoblast differentiation. Acts upstream of or within several processes, including negative regulation of myotube differentiation; regulation of intrinsic apoptotic si gnaling pathway by p53 class mediator; and skeletal muscle cell differentiation. Located in several cellular components, including PML body; euchromatin; and sarcomere. Colocalizes with I band. Is expressed in skeletal musculature; somite; and tongue. Orthologous to human ANKRD2 (ankyrin repeat domain 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 42024358 | 42033550 | Mouse | 114 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12101235 | ARK2N | arkadia (RNF111) N-terminal like PKA signaling regulator 2N | ENCODES a protein that exhibits metal ion binding (inferred); transcription corepressor activity (inferred); transferase activity (inferred); INVOLVED IN protein phosphorylation (ortholog); response to activity (ortholog); skeletal muscle fiber development (ortholog); FOUND IN chromatin (inferred); nucleus (inferred); PML body (inferred) | 7 | 44991197 | 45071723 | Dog | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 1553098 | Atrx | ATRX, chromatin remodeler | Enables chromatin binding activity and histone binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; cellular response to hydroxyurea; and positive regulation of DNA metabolic process. Acts upstream of or within several processes, including male gonad development; positive regulation of transcription by RNA polymerase II; and post-embryonic forelimb morphogenesis. Located in PML body and chromosome. Colocalizes with chromosome, telomeric region. Is expressed in several structures, including alimentary system; early embryo; egg cylinder; genitourinary system; and nervous system. Used to study alpha thalassemia-X-linked intellectual disability syndrome. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Jul 2025] | X | 104841221 | 104972978 | Mouse | 350 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1623116 | Calcoco2 | calcium binding and coiled-coil domain 2 | Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of autophagosome maturation; response to type II interferon; and xenophagy. Predicted to be located in cytosol; intracellular membrane-bounded organelle; and perinuclear region of cytoplasm. Predic ted to be active in PML body and autophagosome. Orthologous to human CALCOCO2 (calcium binding and coiled-coil domain 2). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 95990195 | 96015362 | Mouse | 85 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314006 | Casp8ap2 | caspase 8 associated protein 2 | Enables cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding activity; and protease binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in cytoplasm and nucleus. Pred icted to be active in PML body and mitochondrion. Is expressed in several structures, including brain ventricular layer; incisor; inner cell mass; renal calyx; and submandibular gland primordium. Orthologous to human CASP8AP2 (caspase 8 associated protein 2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 32615462 | 32653271 | Mouse | 138 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 621543 | Chek2 | checkpoint kinase 2 | ENCODES a protein that exhibits kinase activity; protein kinase activity; protein serine/threonine kinase activity; INVOLVED IN cellular response to bisphenol A; cellular response to xenobiotic stimulus; DNA damage checkpoint signaling; PARTICIPATES IN p53 signaling pathway; cell cycle pathway, mito tic; ASSOCIATED WITH Kidney Neoplasms; Metabolic Syndrome; urinary bladder cancer; FOUND IN chromosome, telomeric region (ortholog); nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene | 12 | 51448838 | 51481159 | Rat | 635 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732862 | Chek2 | checkpoint kinase 2 | Enables protein kinase activity. Acts upstream of or within several processes, including cellular response to gamma radiation; signal transduction by p53 class mediator; and thymocyte apoptotic process. Predicted to be located in Golgi apparatus and PML body. Pr edicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 110987668 | 111022006 | Mouse | 751 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8851058 | Chek2 | checkpoint kinase 2 | ENCODES a protein that exhibits identical protein binding (ortholog); kinase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (ortholog); nucleoplasm (ortholog); PML body (ortholog) | NW_004955455 | 2969113 | 3008004 | Chinchilla | 319 | description | gene, protein-coding, MODEL [RefSeq] |
| 11930300 | CHEK2 | checkpoint kinase 2 | ENCODES a protein that exhibits identical protein binding (ortholog); kinase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (ortholog); nucleoplasm (ortholog); PML body (ortholog) | 22 | 9757038 | 9811171 | Bonobo | 319 | description | gene, protein-coding, MODEL [RefSeq] |
| 12059651 | CHEK2 | checkpoint kinase 2 | ENCODES a protein that exhibits kinase activity (ortholog); protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (inferred); nucleoplasm (inferred); PML body (inferred) | 26 | 22052256 | 22145675 | Dog | 339 | description | gene, protein-coding, MODEL [RefSeq] |
| 14217497 | CHEK2 | checkpoint kinase 2 | ENCODES a protein that exhibits kinase activity (ortholog); protein kinase activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (inferred); nucleoplasm (inferred); PML body (inferred); INTERACTS WITH caffeine; deoxynivalenol | | | | Pig | 344 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18787250 | CHEK2 | checkpoint kinase 2 | ENCODES a protein that exhibits identical protein binding (ortholog); kinase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to bisphenol A (ortholog); cellular response to gamma radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); bone osteosarcoma (ortholog); breast cancer (ortholog); FOUND IN chromosome, telomeric region (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Green Monkey | 323 | description | gene, protein-coding, MODEL [RefSeq] |
| 1306360 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; cocaine; endosulfan | 12 | 52164214 | 52197860 | Rat | 103 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314933 | Chfr | checkpoint with forkhead and ring finger domains | Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein metabolic process; protein destabilization; and protein polyubiquitination. Predicted to be located in PML body. Predicted to be act ive in nucleus. Is expressed in embryo. Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 110283599 | 110319839 | Mouse | 126 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8924018 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | NW_004955482 | 233485 | 267064 | Chinchilla | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 12116810 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | 26 | 251369 | 324699 | Dog | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 12669488 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | NW_004936660 | 2725019 | 2754564 | Squirrel | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 14284993 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquitination (ortholog); PARTICIPATES IN ADP-ribosyla tion pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | | | | Pig | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 18691099 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | | | | Green Monkey | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 18932287 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and p oly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | | | | Naked Mole-Rat | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 32727218 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | 12 | 130318971 | 130366282 | Bonobo | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 625947373 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | | | | Black Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 1347816 | CIART | circadian associated repressor of transcription | Predicted to enable E-box binding activity. Predicted to be involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of DNA-templated transcription. Predicted to be located in PML body. Predicted to be active in nucleus. [pr ovided by Alliance of Genome Resources, Jul 2025] | 1 | 150282554 | 150287093 | Human | 120 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619813 | Ciita | class II, major histocompatibility complex, transactivator | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to electrical stimulus; cellular response to exogenous dsRNA; cellular response to type II interfe ron; PARTICIPATES IN antigen processing and presentation pathway; influenza A pathway; primary immunodeficiency pathway; ASSOCIATED WITH Experimental Autoimmune Encephalomyelitis; periapical periodontitis; acute kidney tubular necrosis (ortholog); FOUND IN cell surface; nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 5646854 | 5694393 | Rat | 202 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9036784 | Ciita | class II major histocompatibility complex transactivator | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to electrical stimulus (ortholog); cellular response to exogenous dsRNA (ortholog); cellular respo nse to type II interferon (ortholog); ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Addison's disease (ortholog); Albuminuria (ortholog); FOUND IN cell surface (ortholog); nucleoplasm (ortholog); PML body (ortholog) | NW_004955442 | 7600903 | 7647619 | Chinchilla | 69 | description | gene, protein-coding, MODEL [RefSeq] |
| 12726803 | Ciita | class II major histocompatibility complex transactivator | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to electrical stimulus (ortholog); cellular response to exogenous dsRNA (ortholog); cellular respo nse to type II interferon (ortholog); ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Addison's disease (ortholog); Albuminuria (ortholog); FOUND IN cell surface (ortholog); nucleoplasm (ortholog); PML body (ortholog) | NW_004936530 | 9033510 | 9073341 | Squirrel | 69 | description | gene, protein-coding, MODEL [RefSeq] |
| 625847286 | Ciita | class II major histocompatibility complex transactivator | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to electrical stimulus (ortholog); cellular response to exogenous dsRNA (ortholog); cellular respo nse to type II interferon (ortholog); ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Addison's disease (ortholog); Albuminuria (ortholog); FOUND IN cell surface (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Black Rat | 68 | description | gene, protein-coding, MODEL [RefSeq] |
| 731386 | Dapk3 | death-associated protein kinase 3 | Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including cellular response to type II interferon; protein phosphorylation; and regulation of myosin II filament organization. Acts upstream of or within apoptotic signaling pathway. Located in PML body. Is expressed in heart; mammary gland epithelium; and notochord. Orthologous to human DAPK3 (death associated protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 81018821 | 81029031 | Mouse | 233 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 732822 | Daxx | Fas death domain-associated protein | Enables histone binding activity and transcription coactivator activity. Involved in several processes, including nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic s ignaling pathway; negative regulation of DNA-templated transcription; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including early embryo; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 34128379 | 34134564 | Mouse | 315 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1323023 | EIF3E | eukaryotic translation initiation factor 3 subunit E | Enables RNA binding activity and cadherin binding activity. Contributes to translation initiation factor activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; positive regulation of translation; and translational initiation. Located in PML 0;'>PML body and cytosol. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025] | 8 | 108201216 | 108248717 | Human | 163 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1558337 | Elf4 | E74 like ETS transcription factor 4 | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including lymphocyte proliferation; negative regulation of cytokine production; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human ELF4 (E74 like ETS transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025] | X | 47499926 | 47552009 | Mouse | 168 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1560743 | Elf4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN natural killer cell proliferati on (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of interleukin-1 beta production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (ortholog); PML body (ortholog); INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine | X | 132465290 | 132508175 | Rat | 150 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8926699 | Elf4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN natural killer cell proliferati on (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of interleukin-1 beta production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (ortholog); PML body (ortholog) | NW_004955473 | 4934770 | 4986283 | Chinchilla | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 11678087 | ELF4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell differentiation (inferred); DNA-templated transcription (inferred); natural killer cell proliferation (inferred); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (inferred); nucleus (inferred); PML body (inferred) | X | 119191921 | 119237548 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12395946 | ELF4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN natural killer cell proliferati on (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of interleukin-1 beta production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (ortholog); PML body (ortholog) | X | 101220524 | 101268050 | Dog | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12579308 | Elf4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell differentiation (inferred); DNA-templated transcription (inferred); natural killer cell proliferation (inferred); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (inferred); nucleus (inferred); PML body (inferred) | NW_004936479 | 1519663 | 1534510 | Squirrel | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 14112167 | ELF4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); natural killer cell proliferation (inferred); negativ e regulation of inflammatory response (inferred); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 18707157 | ELF4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell differentiation (inferred); DNA-templated transcription (inferred); natural killer cell proliferation (inferred); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (inferred); nucleus (inferred); PML body (inferred) | | | | Green Monkey | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 18928895 | Elf4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell differentiation (inferred); DNA-templated transcription (inferred); natural killer cell proliferation (inferred); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (inferred); nucleus (inferred); PML body (inferred) | | | | Naked Mole-Rat | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 626082039 | Elf4 | E74 like ETS transcription factor 4 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN natural killer cell proliferati on (ortholog); negative regulation of inflammatory response (ortholog); negative regulation of interleukin-1 beta production (ortholog); ASSOCIATED WITH autistic disorder (ortholog); AUTOINFLAMMATORY SYNDROME, FAMILIAL, X-LINKED, BEHCET-LIKE 2 (ortholog); FOUND IN nuclear body (ortholog); PML body (ortholog) | | | | Black Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 1346265 | GCNA | germ cell nuclear acidic peptidase | Enables SUMO polymer binding activity. Involved in protein-DNA covalent cross-linking repair. Located in PML body. Implicated in X-linked spermatogenic failure 4. [provided by Alliance of Genome Resources, Jul 2025] | X | 71578437 | 71613583 | Human | 76 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8908110 | Gcna | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (orthol og); PML body (ortholog) | NW_004955475 | 11111151 | 11145474 | Chinchilla | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 11960253 | GCNA | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (inferred); INVOLVED IN DNA damage response (inferred); protein-DNA covalent cross-linking repair (inferred); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleop lasm (inferred); nucleus (inferred); PML body (inferred) | X | 60843078 | 60878840 | Bonobo | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12307020 | GCNA | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (orthol og); PML body (ortholog) | X | 55859750 | 55881164 | Dog | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12560837 | Gcna | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (orthol og); PML body (ortholog) | NW_004936762 | 71719 | 96816 | Squirrel | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 14205577 | GCNA | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (orthol og); PML body (ortholog) | | | | Pig | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 15017606 | Gcna | predicted gene, 52429 | INVOLVED IN DNA damage response; DNA integrity checkpoint signaling; homologous chromosome pairing at meiosis; FOUND IN condensed chromosome; PML body | X | 100739442 | 100749805 | Mouse | 14 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18632763 | GCNA | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (orthol og); PML body (ortholog) | | | | Green Monkey | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 18923738 | Gcna | germ cell nuclear acidic peptidase | ENCODES a protein that exhibits SUMO polymer binding (ortholog); INVOLVED IN protein-DNA covalent cross-linking repair (ortholog); ASSOCIATED WITH azoospermia (ortholog); spermatogenic failure 3 (ortholog); X-linked spermatogenic failure 4 (ortholog); FOUND IN nucleoplasm (ortholog); PML nt-weight:700;'>PML body (ortholog) | | | | Naked Mole-Rat | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 1306486 | Habp4 | hyaluronan binding protein 4 | ENCODES a protein that exhibits ribosome binding (ortholog); SUMO binding (ortholog); translation elongation factor binding (ortholog); INVOLVED IN cellular response to mechanical stimulus; PML body organization (ortholog); positive regulation of RNA splicing (o rtholog); FOUND IN cytoplasm; nucleus; sarcomere; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil | 17 | 940672 | 963358 | Rat | 126 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1315131 | HABP4 | hyaluronan binding protein 4 | Enables SUMO binding activity. Involved in PML body organization; positive regulation of RNA splicing; and positive regulation of translational initiation. Located in several cellular components, including cytoplasmic stress granule; nuclear lumen; and nuclear m embrane. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 96450102 | 96491336 | Human | 110 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315132 | Habp4 | hyaluronic acid binding protein 4 | Predicted to enable several functions, including SUMO binding activity; hyaluronic acid binding activity; and translation elongation factor binding activity. Predicted to be involved in PML body organization; cellular response to mechanical stimulus; and regulat ion of gene expression. Predicted to act upstream of or within hyaluronan metabolic process. Located in cytoplasm. Is active in synapse. Is expressed in central nervous system; ovary; retina; and white fat. Orthologous to human HABP4 (hyaluronan binding protein 4). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 64309680 | 64334351 | Mouse | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8702316 | Habp4 | hyaluronan binding protein 4 | ENCODES a protein that exhibits SUMO binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); PML body organization (ortholog); positive regulation of RNA splicing (ortholog); FOUND IN Cajal body (ortholog); cytoplasm (ortholog); cyto plasmic stress granule (ortholog) | NW_004955422 | 23449175 | 23475919 | Chinchilla | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 12565965 | Habp4 | hyaluronan binding protein 4 | ENCODES a protein that exhibits SUMO binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); PML body organization (ortholog); positive regulation of RNA splicing (ortholog); FOUND IN Cajal body (ortholog); cytoplasm (ortholog); cyto plasmic stress granule (ortholog) | NW_004936487 | 402701 | 424399 | Squirrel | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 18915372 | Habp4 | hyaluronan binding protein 4 | ENCODES a protein that exhibits SUMO binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); PML body organization (ortholog); FOUND IN cytosol (ortholog); Gemini of Cajal bodies (ortholog); nuclear membrane (ortholog) | | | | Naked Mole-Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 625902155 | Habp4 | hyaluronan binding protein 4 | ENCODES a protein that exhibits SUMO binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); PML body organization (ortholog); positive regulation of RNA splicing (ortholog); FOUND IN Cajal body (ortholog); cytoplasm (ortholog); cyto plasmic stress granule (ortholog) | | | | Black Rat | 25 | description | gene, protein-coding, MODEL [RefSeq] |
| 1312672 | Hipk1 | homeodomain interacting protein kinase 1 | Predicted to enable protein serine/threonine kinase activity; protein tyrosine kinase activity; and transcription corepressor activity. Involved in adherens junction assembly; camera-type eye morphogenesis; and neuron differentiation. Acts upstream of or within several processes, including anterior/ posterior pattern specification; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and smoothened signaling pathway. Located in PML body; cytoplasm; and nuclear speck. Is expressed in several structures, including forebrain ventricular layer and future forebrain. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 103647131 | 103699210 | Mouse | 163 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 731501 | Hipk3 | homeodomain interacting protein kinase 3 | Enables protein serine/threonine kinase activity. Involved in negative regulation of JUN kinase activity; peptidyl-serine phosphorylation; and peptidyl-threonine phosphorylation. Located in PML body and cytoplasm. Is expressed in diaphragm; heart; limb segment; paraxial mesenchyme; and skeletal musculature. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 104256826 | 104324834 | Mouse | 140 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 12060104 | HIPK3 | homeodomain interacting protein kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN negative regulation of JUN kinase activity (ortholog); peptidyl-serine phosphorylation (ortholog); peptidyl-threonine phosphorylation (ortholog); FOUND IN PML weight:700;'>PML body (ortholog) | 18 | 34305208 | 34397593 | Dog | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 14025920 | HIPK3 | homeodomain interacting protein kinase 3 | ENCODES a protein that exhibits ATP binding (inferred); DNA binding (inferred); kinase activity (inferred); INVOLVED IN negative regulation of JUN kinase activity (ortholog); peptidyl-serine phosphorylation (ortholog); peptidyl-threonine phosphorylation (ortholog); FOUND IN PML 700;'>PML body (ortholog) | | | | Pig | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 1318073 | Ikbke | inhibitor of kappaB kinase epsilon | Enables IkappaB kinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to virus; interleukin-17-mediated signaling pathway; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in PML body and mitochondrial membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including future brain; sensory organ; submandibular gland primordium; thymus primordium; and turbinate bone primordium. Orthologous to human IKBKE (inhibitor of nuclear factor kappa B kinase subunit epsilon). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 131182337 | 131207339 | Mouse | 209 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 18908585 | Isg20 | interferon stimulated exonuclease gene 20 | ENCODES a protein that exhibits 3'-5'-RNA exonuclease activity (ortholog); single-stranded DNA 3'-5' DNA exonuclease activity (ortholog); U1 snRNA binding (ortholog); INVOLVED IN response to virus (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN Cajal body (ortholog); cy toplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 18930960 | Kat6a | lysine acetyltransferase 6A | ENCODES a protein that exhibits acetyltransferase activity (ortholog); DNA-binding transcription factor binding (ortholog); histone H3K14 acetyltransferase activity (ortholog); INVOLVED IN aorta morphogenesis (ortholog); cellular senescence (ortholog); embryonic hemopoiesis (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Arboleda-Tham syndrome (ortholog); FOUND IN nuclear speck (ortholog); nucleolus (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 74 | description | gene, protein-coding, MODEL [RefSeq] |
| 40909002 | KIAA1586 | KIAA1586 ortholog | ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymerase II (inferred); negative regulation of tr ansforming growth factor beta receptor signaling pathway (inferred); ASSOCIATED WITH schizophrenia (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 1550848 | Klhl20 | kelch-like 20 | Predicted to enable type II interferon binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Golgi to endosome transport; proteasome-mediated ubiquitin-depende nt protein catabolic process; and protein K33-linked ubiquitination. Predicted to be located in Golgi apparatus and cytosol. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in PML body and trans-Golgi network. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and thymus primordium. Orthologous to human KLHL20 (kelch like family member 20). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 160915945 | 160959078 | Mouse | 107 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 13891809 | LOC100737265 | small ubiquitin-related modifier 1-like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN PML body organization (ortholog); FOUND IN nucleus (ortholog) | | | | Pig | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 11827640 | LOC100993046 | E3 ubiquitin-protein ligase RNF4-like | ENCODES a protein that exhibits DNA binding (inferred); metal ion binding (inferred); transferase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); positive regulation of transcription by RNA polymerase II (inferred); FOUND IN cytoplasm (inferred); nucleus (inferred); PML yle='font-weight:700;'>PML body (inferred) | 1 | 206570482 | 206574574 | Bonobo | 13 | description | gene, protein-coding, MODEL [RefSeq] |
| 12164803 | LOC491788 | small ubiquitin-related modifier 1-like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN PML body organization (ortholog); FOUND IN nucleus (inferred) | X | 21742066 | 21743108 | Dog | 12 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1306145 | Lrch4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (ortholog); positive regulation of toll-like receptor signaling pathway (ortholog); FOUND IN plasma membrane (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; Cuprizon; paracetamol | 12 | 24694364 | 24709354 | Rat | 52 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8771502 | Lrch4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (ortholog); positive regulation of toll-like receptor signaling pathway (ortholog); FOUND IN plasma membrane (ortholog); PML body (ortholog) | NW_004955573 | 315764 | 327833 | Chinchilla | 9 | description | gene, protein-coding, MODEL [RefSeq] |
| 11848500 | LRCH4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (inferred); positive regulation of toll-like receptor signaling pathway (inferred); FOUND IN cytoplasm (inferred); plasma membrane (inferred); PML body (inferred) | 7 | 92601158 | 92613274 | Bonobo | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 12083380 | LRCH4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (inferred); positive regulation of toll-like receptor signaling pathway (inferred); FOUND IN plasma membrane (inferred); PML body (inferred) | 6 | 9088815 | 9113629 | Dog | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 12704399 | Lrch4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (inferred); positive regulation of toll-like receptor signaling pathway (inferred); FOUND IN cytoplasm (inferred); plasma membrane (inferred); PML body (inferred) | NW_004936543 | 632255 | 643639 | Squirrel | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 14296928 | LRCH4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (inferred); positive regulation of toll-like receptor signaling pathway (inferred); FOUND IN plasma membrane (inferred); PML body (inferred) | | | | Pig | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 18728161 | LRCH4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (inferred); positive regulation of toll-like receptor signaling pathway (inferred); FOUND IN cytoplasm (inferred); plasma membrane (inferred); PML body (inferred) | | | | Green Monkey | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 18922325 | Lrch4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (ortholog); positive regulation of toll-like receptor signaling pathway (ortholog); FOUND IN PML body (ortholog) | | | | Naked Mole-Rat | 10 | description | gene, protein-coding, MODEL [RefSeq] |
| 626071111 | Lrch4 | leucine rich repeats and calponin homology domain containing 4 | INVOLVED IN membrane raft assembly (ortholog); positive regulation of toll-like receptor signaling pathway (ortholog); FOUND IN plasma membrane (ortholog); PML body (ortholog) | | | | Black Rat | 9 | description | gene, protein-coding, MODEL [RefSeq] |
| 1550675 | Lrrc28 | leucine rich repeat containing 28 | Predicted to be active in PML body. Orthologous to human LRRC28 (leucine rich repeat containing 28). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 67163158 | 67295084 | Mouse | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1622052 | Magea10 | MAGE family member A10 | Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML >PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Apr 2025] | X | 71425476 | 71430464 | Mouse | 30 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1622395 | Magea2 | MAGE family member A2 | Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML >PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; heart; liver; and reproductive system. Orthologous to several human genes including MAGEA10 (MAGE family member A10) and MAGEA8 (MAGE family member A8). [provided by Alliance of Genome Resources, Apr 2025] | X | 153810197 | 153816309 | Mouse | 12 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 32728742 | MAGEA2B | MAGE family member A2B | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); histone deacetylase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular senescence (ortholog); negative regulation of protein acetylation (ortholog); negative regulation of protein sumoylation (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | X | 142314688 | 142316495 | Bonobo | 21 | description | gene, protein-coding, MODEL [RefSeq] |
| 1622394 | Magea3 | MAGE family member A3 | Predicted to enable DNA-binding transcription factor binding activity and enzyme binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body; cytosol; and endoplasmic reticulum. Pre dicted to be active in nucleus. Is expressed in testis. Orthologous to human MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Apr 2025] | X | 153731176 | 153742027 | Mouse | 37 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1622393 | Magea4 | MAGE family member A4 | Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML >PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10) and MAGEA8 (MAGE family member A8). [provided by Alliance of Genome Resources, Apr 2025] | X | 71264599 | 71266611 | Mouse | 41 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1622392 | Magea5 | MAGE family member A5 | Predicted to enable DNA-binding transcription factor binding activity and enzyme binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body; cytosol; and endoplasmic reticulum. Pre dicted to be active in nucleus. Is expressed in early conceptus and testis. Orthologous to several human genes including MAGEA10 (MAGE family member A10) and MAGEA8 (MAGE family member A8). [provided by Alliance of Genome Resources, Jul 2025] | X | 153836057 | 153846147 | Mouse | 56 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 621101 | Max | MYC associated transcriptional regulator X | ENCODES a protein that exhibits DNA-binding transcription factor activity; identical protein binding; protein-containing complex binding; INVOLVED IN cellular response to peptide hormone stimulus; cellular response to starvation; negative regulation of gene expression; PARTICIPATES IN mitogen activa ted protein kinase signaling pathway; small cell lung carcinoma pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Hereditary Paraganglioma-Pheochromocytoma Syndromes (ortholog); lung small cell carcinoma (ortholog); FOUND IN dendrite; nucleus; PML body; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 6 | 101369989 | 101395333 | Rat | 158 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1315218 | MLIP | muscular LMNA interacting protein | Predicted to enable lamin binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of cardiac muscle hypertrophy in response to stress; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymeras e II. Predicted to be located in PML body; nuclear envelope; and sarcolemma. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 54018970 | 54266280 | Human | 105 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1618346 | Mlip | muscular LMNA-interacting protein | Enables lamin binding activity and transcription corepressor activity. Involved in negative regulation of cardiac muscle hypertrophy in response to stress. Acts upstream of or within negative regulation of cardiac muscle hypertrophy and negative regulation of transcription by RNA polymerase II. Loca ted in PML body; nuclear envelope; and sarcolemma. Is expressed in frontal suture frontal osteogenic front. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 77009366 | 77260062 | Mouse | 80 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552838 | Morc3 | microrchidia 3 | Predicted to enable DNA binding activity; methylated histone binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within post-embryonic development. Located in PML body. Is expressed in several structures, including alimentary system ; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 93629009 | 93672964 | Mouse | 139 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11859504 | MORC3 | MORC family CW-type zinc finger 3 | ENCODES a protein that exhibits ATP hydrolysis activity (inferred); DNA binding (inferred); histone H3K4me3 reader activity (inferred); INVOLVED IN maintenance of protein location in nucleus (ortholog); negative regulation of fibroblast proliferation (ortholog); peptidyl-serine phosphorylation (orth olog); FOUND IN PML body (ortholog) | 21 | 22690055 | 22747067 | Bonobo | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 12737883 | Morc3 | MORC family CW-type zinc finger 3 | ENCODES a protein that exhibits ATP hydrolysis activity (inferred); DNA binding (inferred); histone H3K4me3 reader activity (inferred); INVOLVED IN maintenance of protein location in nucleus (ortholog); negative regulation of fibroblast proliferation (ortholog); peptidyl-serine phosphorylation (orth olog); FOUND IN PML body (ortholog) | NW_004936500 | 6293084 | 6336091 | Squirrel | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 18543679 | MORC3 | MORC family CW-type zinc finger 3 | ENCODES a protein that exhibits ATP hydrolysis activity (inferred); DNA binding (inferred); histone H3K4me3 reader activity (inferred); INVOLVED IN maintenance of protein location in nucleus (ortholog); negative regulation of fibroblast proliferation (ortholog); peptidyl-serine phosphorylation (orth olog); FOUND IN PML body (ortholog) | | | | Green Monkey | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 18909293 | Morc3 | MORC family CW-type zinc finger 3 | ENCODES a protein that exhibits ATP hydrolysis activity (inferred); DNA binding (inferred); histone H3K4me3 reader activity (inferred); INVOLVED IN maintenance of protein location in nucleus (ortholog); negative regulation of fibroblast proliferation (ortholog); peptidyl-serine phosphorylation (orth olog); FOUND IN PML body (ortholog) | | | | Naked Mole-Rat | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 735478 | Mre11a | MRE11A homolog A, double strand break repair nuclease | Enables nuclease activity. Involved in DNA strand resection involved in replication fork processing; chromosome organization; and double-strand break repair via homologous recombination. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Part of Mre11 complex. Colocalizes with chromosome, telomeric region. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 14695971 | 14748421 | Mouse | 318 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68534 | Mtor | mechanistic target of rapamycin kinase | Enables protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; T-helper 1 cell lineage commitment; and TORC2 signaling. Acts upstream of or within several processes, including heart develo pment; positive regulation of cellular component biogenesis; and protein phosphorylation. Located in cytosol; dendrite; and nucleus. Part of TORC1 complex and TORC2 complex. Colocalizes with PML body. Is expressed in several structures, including central nervous system; early conceptus; eye; oocyte; and respiratory system. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Apr 2025] | 4 | 148533039 | 148642142 | Mouse | 1704 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1313053 | N4bp1 | NEDD4 binding protein 1 | Predicted to enable RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV; negative regulation of macromolecule metabolic process; and regulation of innate immune response. Located in PML body; cytosol; and nucleolus. Orthologous to human N4BP1 (NEDD4 binding protein 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 87567764 | 87612489 | Mouse | 139 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605706 | N4BP1 | NEDD4 binding protein 1 | Enables RNA nuclease activity; mRNA binding activity; and ubiquitin binding activity. Involved in cellular response to UV and negative regulation of viral genome replication. Predicted to be located in cytosol and nucleolus. Predicted to be active in PML body. [ provided by Alliance of Genome Resources, Jul 2025] | 16 | 48538726 | 48610180 | Human | 122 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 732723 | Nbn | nibrin | Enables chromatin-protein adaptor activity and damaged DNA binding activity. Involved in DNA metabolic process and blastocyst growth. Acts upstream of or within intracellular signal transduction; neuroblast proliferation; and neuromuscular process controlling balance. Located in PML ight:700;'>PML body and replication fork. Part of Mre11 complex. Colocalizes with chromosome, telomeric region. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Nijmegen breakage syndrome and T-cell acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; rectum cancer; and reproductive organ cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 15955388 | 15992589 | Mouse | 479 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 3200 | Nr2c1 | nuclear receptor subfamily 2, group C, member 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of retinoic acid receptor signaling pathway (ortholog); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole | 7 | 30602338 | 30655610 | Rat | 134 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731685 | Nr2c1 | nuclear receptor subfamily 2, group C, member 1 | Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of retinoic acid r eceptor signaling pathway. Located in PML body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 93983491 | 94033078 | Mouse | 124 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8874366 | Nr2c1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of retinoic acid receptor signaling pathway (ortholog); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog) | NW_004955405 | 31637832 | 31693621 | Chinchilla | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 11820928 | NR2C1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (i nferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 12 | 92611459 | 92664405 | Bonobo | 33 | description | gene, protein-coding, MODEL [RefSeq] |
| 12565549 | Nr2c1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (i nferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | NW_004936507 | 11266408 | 11319642 | Squirrel | 31 | description | gene, protein-coding, MODEL [RefSeq] |
| 14059828 | NR2C1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); intracellular receptor signaling pathway (inferred); negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18771083 | NR2C1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of DNA-templated transcription (i nferred); negative regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Green Monkey | 32 | description | gene, protein-coding, MODEL [RefSeq] |
| 18903683 | Nr2c1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of retinoic acid receptor signaling pathway (ortholog); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 30 | description | gene, protein-coding, MODEL [RefSeq] |
| 625889915 | Nr2c1 | nuclear receptor subfamily 2 group C member 1 | ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); histone deacetylase binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of retinoic acid receptor signaling pathway (ortholog); ASSOCIATED WITH Contracture (ortholog); endometriosis (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog) | | | | Black Rat | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 1331905 | Nsmce2 | NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase | Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predic ted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in brain; cerebral cortex ventricular layer; spermatocyte; and testis. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 59246047 | 59473538 | Mouse | 159 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1317274 | Pias1 | protein inhibitor of activated STAT 1 | Enables several functions, including SUMO ligase activity; transcription cis-regulatory region binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including fat cell differentiation; protein sumoylation; and regulation of primary metabolic process. Located in nuclear periphery. Is active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Colocalizes with PML body. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; sensory organ; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 62785648 | 62888161 | Mouse | 237 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1603852 | RD3 | RD3 regulator of GUCY2D | This gene encodes a retinal protein that is associated with promyelocytic leukemia-gene product (PML) bodies in the nucleus. Mutations in this gene cause Leber congenital amaurosis type 12, a disease that results in retinal degeneration. Alternative splicing res ults in multiple transcript variants. [provided by RefSeq, Sep 2009] | 1 | 211476522 | 211492162 | Human | 167 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 3583 | Rnf4 | ring finger protein 4 | ENCODES a protein that exhibits DNA binding; identical protein binding; nuclear androgen receptor binding; INVOLVED IN cellular response to arsenic-containing substance; cellular response to cytokine stimulus; cellular response to gamma radiation; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; ASSOCIATED WITH Angelman syndrome (ortholog); Testicular Neoplasms (ortholog); FOUND IN nucleoplasm; nucleus; PML body; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 14 | 80625864 | 80647138 | Rat | 198 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550389 | Rnf6 | ring finger protein (C3H2C3 type) 6 | Enables DNA binding activity and ubiquitin protein ligase activity. Involved in protein K48-linked ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of axon extension and positive regulation of DNA-templated transcription. Located in ... (more) an style='font-weight:700;'>PML body; axon; and cytoplasm. Is expressed in central nervous system and genitourinary system. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma and squamous cell carcinoma. Orthologous to human RNF6 (ring finger protein 6). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 146146003 | 146158267 | Mouse | 140 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 11682152 | RNF6 | ring finger protein 6 | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN negative regulation of axon extension (ortholog); positive regulation of DNA-templated transcription (ortholog); protein K48-linked ubiquitination (ortholog); ASSOCIATED WITH Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); hepatocellular carcinoma (ortholog); FOUND IN axon (ortholog); PML body (ortholog) | 13 | 7505669 | 7515542 | Bonobo | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 12187130 | RNF6 | ring finger protein 6 | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN negative regulation of axon extension (ortholog); positive regulation of DNA-templated transcription (ortholog); protein K48-linked ubiquitination (ortholog); ASSOCIATED WITH Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); hepatocellular carcinoma (ortholog); FOUND IN axon (ortholog); PML body (ortholog) | 25 | 13199201 | 13240347 | Dog | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 14116325 | RNF6 | ring finger protein 6 | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN negative regulation of axon extension (ortholog); positive regulation of DNA-templated transcription (ortholog); protein K48-linked ubiquitination (ortholog); ASSOCIATED WITH Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); hepatocellular carcinoma (ortholog); FOUND IN axon (ortholog); PML body (ortholog) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 18755615 | RNF6 | ring finger protein 6 | ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN negative regulation of axon extension (ortholog); positive regulation of DNA-templated transcription (ortholog); protein K48-linked ubiquitination (ortholog); ASSOCIATED WITH Esophageal Neoplasms (ortholog); esophagus squamous cell carcinoma (ortholog); hepatocellular carcinoma (ortholog); FOUND IN axon (ortholog); PML body (ortholog) | | | | Green Monkey | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 734242 | Rpa2 | replication protein A2 | Enables DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and regulation of double-strand break repair via homologous recombination. Predicted to be located in PML bod y and chromatin. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Is expressed in blastocyst; brain; compacted morula; heart; and spermatocyte. Orthologous to human RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 132495671 | 132506057 | Mouse | 214 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1308492 | Rpain | RPA interacting protein | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 4 ,4'-sulfonyldiphenol; bisphenol A; bisphenol F | 10 | 56190975 | 56198490 | Rat | 74 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1331906 | Rpain | RPA interacting protein | Predicted to enable zinc ion binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within DNA metabolic process and response to UV. Predicted to be located in PML body; cytoplasm; and fibrillar center. Predict ed to be active in nucleus. Is expressed in several structures, including cerebral cortex ventricular layer; egg cylinder; and oocyte. Orthologous to human RPAIN (RPA interacting protein). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 70860403 | 70868759 | Mouse | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604268 | RPAIN | RPA interacting protein | Predicted to enable zinc ion binding activity. Acts upstream of or within protein import into nucleus and response to UV. Located in PML body; cytoplasm; and fibrillar center. [provided by Alliance of Genome Resources, Jul 2025] | 17 | 5420182 | 5432877 | Human | 75 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8888524 | Rpain | RPA interacting protein | INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | NW_004955467 | 10780818 | 10788137 | Chinchilla | 6 | description | gene, protein-coding, MODEL [RefSeq] |
| 12317477 | RPAIN | RPA interacting protein | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); PML body (ortholog) | 5 | 31359735 | 31366108 | Dog | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 14078094 | RPAIN | RPA interacting protein | ENCODES a protein that exhibits metal ion binding (inferred); zinc ion binding (inferred); INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); PML body (ortholog) | | | | Pig | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 625892843 | Rpain | RPA interacting protein | INVOLVED IN protein import into nucleus (ortholog); response to UV (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Black Rat | 6 | description | gene, protein-coding, MODEL [RefSeq] |
| 733308 | Senp2 | SUMO/sentrin specific peptidase 2 | Enables deSUMOylase activity. Involved in fat cell differentiation and protein desumoylation. Acts upstream of or within several processes, including embryonic placenta development; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle process. Located in nuclear bo dy. Colocalizes with PML body. Is expressed in several structures, including blastocyst; central nervous system; early embryo; extraembryonic component; and retina. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 21828182 | 21868019 | Mouse | 165 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 619907 | Serbp1 | Serpine1 mRNA binding protein 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); ribosome binding (ortholog); RNA binding (ortholog); INVOLVED IN regulation of apoptotic process; negative regulation of translation (ortholog); PML body organization (ortholog); ASSOCIATED WITH Dis ease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine | 4 | 97731200 | 97748438 | Rat | 170 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606807 | SERBP1 | SERPINE1 mRNA binding protein 1 | Enables several functions, including SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization and ribosome hibernation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 20 25] | 1 | 67407810 | 67430402 | Human | 156 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9011212 | Serbp1 | SERPINE1 mRNA binding protein 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); ribosome binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of translation (ortholog); PML body organization (ortholog); regulation of apoptotic process (ortholog); ASSOCIAT ED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | NW_004955423 | 23763356 | 23774816 | Chinchilla | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 12423766 | SERBP1 | SERPINE1 mRNA binding protein 1 | ENCODES a protein that exhibits ribosome binding (ortholog); SUMO binding (ortholog); translation elongation factor binding (ortholog); INVOLVED IN negative regulation of translation (ortholog); PML body organization (ortholog); regulation of apoptotic process ( ortholog); ASSOCIATED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | 5 | 43170553 | 43187281 | Dog | 27 | description | gene, protein-coding, MODEL [RefSeq] |
| 18912087 | Serbp1 | SERPINE1 mRNA binding protein 1 | ENCODES a protein that exhibits ribosome binding (ortholog); SUMO binding (ortholog); translation elongation factor binding (ortholog); INVOLVED IN negative regulation of translation (ortholog); PML body organization (ortholog); regulation of apoptotic process ( ortholog); ASSOCIATED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 26 | description | gene, protein-coding, MODEL [RefSeq] |
| 625866352 | Serbp1 | SERPINE1 mRNA binding protein 1 | ENCODES a protein that exhibits mRNA 3'-UTR binding (ortholog); ribosome binding (ortholog); RNA binding (ortholog); INVOLVED IN negative regulation of translation (ortholog); PML body organization (ortholog); regulation of apoptotic process (ortholog); ASSOCIAT ED WITH Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog) | | | | Black Rat | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 1604161 | SIMC1 | SUMO interacting motifs containing 1 | Enables SUMO polymer binding activity and peptidase inhibitor activity. Located in PML body and sarcomere. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 176238424 | 176345989 | Human | 57 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614077 | Simc1 | SUMO-interacting motifs containing 1 | Predicted to enable SUMO polymer binding activity and peptidase inhibitor activity. Predicted to be located in PML body and sarcomere. Orthologous to human SIMC1 (SUMO interacting motifs containing 1). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 54651539 | 54699103 | Mouse | 60 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 2319689 | Simc1 | SUMO-interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); SUMO polymer binding (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearal anol | 17 | 10066855 | 10112010 | Rat | 54 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8884648 | Simc1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); SUMO polymer binding (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | NW_004955408 | 28562372 | 28630420 | Chinchilla | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 11738112 | SIMC1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); SUMO polymer binding (inferred); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); PML body (inferred) | 5 | 171543624 | 171643253 | Bonobo | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12123626 | SIMC1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); SUMO polymer binding (inferred); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); PML body (inferred) | 4 | 36980710 | 37058032 | Dog | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 12524353 | Simc1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | NW_004936597 | 493387 | 574174 | Squirrel | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 14180632 | SIMC1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); SUMO polymer binding (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Pig | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 18703114 | SIMC1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (inferred); SUMO polymer binding (inferred); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); PML body (inferred) | | | | Green Monkey | 12 | description | gene, protein-coding, MODEL [RefSeq] |
| 18902251 | Simc1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 626060892 | Simc1 | SUMO interacting motifs containing 1 | ENCODES a protein that exhibits peptidase inhibitor activity (ortholog); SUMO polymer binding (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Black Rat | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 12425642 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); PML body (ortholog) | 34 | 34871770 | 34898681 | Dog | 64 | description | gene, protein-coding, MODEL [RefSeq] |
| 12542248 | Skil | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); PML body (ortholog) | NW_004936593 | 2109414 | 2132871 | Squirrel | 63 | description | gene, protein-coding, MODEL [RefSeq] |
| 14148873 | SKIL | SKI like proto-oncogene | ENCODES a protein that exhibits identical protein binding (ortholog); protein domain specific binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (ortholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); PML body (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 65 | description | gene, protein-coding, MODEL [RefSeq] |
| 18915127 | Skil | SKI like proto-oncogene | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); INVOLVED IN blastocyst formation (ortholog); lens fiber cell differentiation (ortholog); lymphocyte homeostasis (or tholog); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Arsenic Poisoning (ortholog); Experimental Liver Cirrhosis (ortholog); Paraquat Lung (ortholog); FOUND IN acrosomal vesicle (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 61 | description | gene, protein-coding, MODEL [RefSeq] |
| 1349080 | SLF2 | SMC5/6 complex localization factor 2 | Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in PML L body; chromatin; and site of double-strand break. Implicated in mosaic variegated aneuploidy syndrome. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 100912963 | 100965134 | Human | 127 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1614178 | Slf2 | SMC5-SMC6 complex localization factor 2 | Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Predicted to be located in PML body and chromatin. Predicted to be active in nucleus and site of double-strand break. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SLF2 (SMC5-SMC6 complex localization factor 2). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 44906948 | 44972225 | Mouse | 95 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316719 | Smc5 | structural maintenance of chromosomes 5 | Predicted to enable DNA secondary structure binding activity and single-stranded DNA binding activity. Acts upstream of or within several processes, including internal peptidyl-lysine acetylation; mitotic cell cycle phase transition; and protein localization to chromosome, centromeric region. Locate d in PML body; chromosome; and cytoplasm. Part of Smc5-Smc6 complex. Is expressed in ovary; secondary spermatocyte; and testis. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome. Orthologous to human SMC5 (structural maintenance of chromosomes 5). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 23183817 | 23251286 | Mouse | 178 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1312269 | SPTBN4 | spectrin beta, non-erythrocytic 4 | Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | 19 | 40467001 | 40576464 | Human | 219 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1315808 | Sumo1 | small ubiquitin-like modifier 1 | Predicted to enable enzyme binding activity; potassium channel regulator activity; and protein tag activity. Involved in several processes, including positive regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of cardiac muscle cell contraction; and regulation of pro tein stability. Acts upstream of or within several processes, including PML body organization; protein localization to nuclear pore; and protein sumoylation. Located in XY body and nuclear body. Is active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to human SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 59678593 | 59709993 | Mouse | 260 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1601685 | SUMO1P1 | SUMO1 pseudogene 1 | Enables identical protein binding activity. Involved in PML body organization and protein sumoylation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 20 | 53874498 | 53875709 | Human | 21 | description | gene, pseudo, PROVISIONAL [RefSeq] |
| 13970885 | SUMO2 | small ubiquitin like modifier 2 | ENCODES a protein that exhibits nuclear retinoid X receptor binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular protein localization (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regulation of protein sumoylation (ortholog) ; FOUND IN PML body (ortholog) | | | | Pig | 53 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 32729023 | SUMO3 | small ubiquitin like modifier 3 | ENCODES a protein that exhibits protein tag activity (ortholog); INVOLVED IN regulation of protein localization to nucleus (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog); PML body (ortholog) | 21 | 31098812 | 31112286 | Bonobo | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 620959 | Tdg | thymine-DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding; protein domain specific binding; ATP binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II; base-excision repair (ortholog); epigenetic regulation of gene expression (ortholog); PARTICIPATES IN base excision repair pathway; ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH (+)-pilocarpine; 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine | 7 | 22965388 | 22990311 | Rat | 166 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1617602 | Tdg | thymine DNA glycosylase | Enables several functions, including SUMO binding activity; protein kinase C binding activity; and transcription coregulator activity. Involved in base-excision repair; epigenetic regulation of gene expression; and regulation of embryonic development. Acts upstream of or within negative regulation o f transcription by RNA polymerase II. Located in PML body. Is expressed in several structures, including epithelium; genitourinary system; nervous system; retina; and skin. Orthologous to human TDG (thymine DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 82465649 | 82486633 | Mouse | 193 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8989915 | Tdg | thymine DNA glycosylase | ENCODES a protein that exhibits ATP binding (ortholog); chloride ion binding (ortholog); DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); epigenetic regulation of gene expression (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Exp erimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog) | NW_004955405 | 38661687 | 38680138 | Chinchilla | 44 | description | gene, protein-coding, MODEL [RefSeq] |
| 12032703 | TDG | thymine DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); nucleic acid binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of embryonic development (ortholog); ASSOCIAT ED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN PML body (ortholog) | 12 | 101543945 | 101567035 | Bonobo | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 12425200 | TDG | thymine DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); nucleic acid binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of embryonic development (ortholog); ASSOCIAT ED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN PML body (ortholog) | 15 | 42493593 | 42516868 | Dog | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 12641945 | Tdg | thymine DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); nucleic acid binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | NW_004936492 | 10476472 | 10506144 | Squirrel | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 14221109 | TDG | thymine DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); nucleic acid binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog ); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 57 | description | gene, protein-coding, MODEL [RefSeq] |
| 18585633 | TDG | thymine DNA glycosylase | ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); nucleic acid binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of embryonic development (ortholog); ASSOCIAT ED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN PML body (ortholog) | | | | Green Monkey | 55 | description | gene, protein-coding, MODEL [RefSeq] |
| 18919762 | Tdg | thymine DNA glycosylase | ENCODES a protein that exhibits ATP binding (ortholog); chloride ion binding (ortholog); DNA-binding transcription factor binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); regulation of embryonic development (ortholog); ASSOCIATED WITH Experimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN PML body (ortholog) | | | | Naked Mole-Rat | 48 | description | gene, protein-coding, MODEL [RefSeq] |
| 625872612 | Tdg | thymine DNA glycosylase | ENCODES a protein that exhibits ATP binding (ortholog); chloride ion binding (ortholog); DNA binding (ortholog); INVOLVED IN base-excision repair (ortholog); epigenetic regulation of gene expression (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Exp erimental Mammary Neoplasms (ortholog); hereditary breast ovarian cancer syndrome (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML body (ortholog) | | | | Black Rat | 44 | description | gene, protein-coding, MODEL [RefSeq] |
| 1557333 | Tdp2 | tyrosyl-DNA phosphodiesterase 2 | Predicted to enable several functions, including metal ion binding activity; phosphoric diester hydrolase activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair and neuron development. Predicted to be located in aggresome and nuclear body. Predicte d to be active in PML body and cytoplasm. Is expressed in several structures, including hemolymphoid system; limb; submandibular gland primordium; telencephalon; and testis. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 23. Orthologous to human TDP2 (tyrosyl-DNA phosphodiesterase 2). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 25015642 | 25026136 | Mouse | 123 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 736748 | Tenm2 | teneurin transmembrane protein 2 | Enables protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of filopodium assembly; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Predicted to be located in several cellular components, including PML body; dendritic spine; and postsynaptic membrane. Predicted to be active in glutamatergic synapse and neuron projection. Predicted to be extrinsic component of postsynaptic membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human TENM2 (teneurin transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2025] | 11 | 35897483 | 37881486 | Mouse | 175 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1309320 | Top3a | DNA topoisomerase III alpha | ENCODES a protein that exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN chromosome separation (ortholog); DNA topological change (ortholog); double-strand break repair via homologous recombination (ortholo g); PARTICIPATES IN homologous recombination pathway of double-strand break repair; ASSOCIATED WITH autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (ortholog); genetic disease (ortholog); Microcephaly, Growth Restriction, and Increased Sister Chromatid Exchange 2 (ortholog); FOUND IN mitochondrion (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; paracetamol; (S)-colchicine (ortholog) | 10 | 45915625 | 45956856 | Rat | 88 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1319605 | Top3a | topoisomerase (DNA) III alpha | Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity and single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process and chromosome separation. Predicted to be located in PML body. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5. Orthologous to human TOP3A (DNA topoisomerase III alpha). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 60629014 | 60668099 | Mouse | 107 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8796399 | Top3a | DNA topoisomerase III alpha | ENCODES a protein that exhibits DNA topoisomerase type I (single strand cut, ATP-independent) activity (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN chromosome separation (ortholog); DNA topological change (ortholog); double-strand break repair via homologous recombination (ortholo g); ASSOCIATED WITH autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (ortholog); genetic disease (ortholog); Microcephaly, Growth Restriction, and Increased Sister Chromatid Exchange 2 (ortholog); FOUND IN mitochondrion (ortholog); PML body (ortholog); RecQ family helicase-topoisomerase III complex (ortholog) | NW_004955478 | 11015378 | 11045717 | Chinchilla | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 18902614 | Top3a | DNA topoisomerase III alpha | ENCODES a protein that exhibits single-stranded DNA binding (ortholog); INVOLVED IN chromosome separation (ortholog); double-strand break repair via homologous recombination (ortholog); mitochondrial DNA metabolic process (ortholog); ASSOCIATED WITH autosomal recessive progressive external ophthalmo plegia with mitochondrial DNA deletions 5 (ortholog); genetic disease (ortholog); Microcephaly, Growth Restriction, and Increased Sister Chromatid Exchange 2 (ortholog); FOUND IN mitochondrion (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 3889 | Tp53 | tumor protein p53 | ENCODES a protein that exhibits MDM2/MDM4 family protein binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; INVOLVED IN apoptotic signaling pathway; cellular response to heat; cellular response to hypoxia; PARTICIPATES IN altered p53 signalin g pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; ASSOCIATED WITH abnormal vacuole morphology; decreased body weight; decreased testis weight; ASSOCIATED WITH bronchiolo-alveolar adenocarcinoma; bronchopulmonary dysplasia; colorectal cancer; FOUND IN chromatin; nucleus; PML body; INTERACTS WITH (+)-catechin; (+)-dexrazoxane; (+)-schisandrin B | 10 | 54798871 | 54810300 | Rat | 4013 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 1309749 | Trim16 | tripartite motif-containing 16 | ENCODES a protein that exhibits DNA binding (ortholog); interleukin-1 binding (ortholog); NACHT domain binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of keratinocyte d ifferentiation (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); PML body (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; aflatoxin B1 | 10 | 47985235 | 48008242 | Rat | 144 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 9010540 | Trim16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (ortholog); interleukin-1 binding (ortholog); NACHT domain binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of keratinocyte d ifferentiation (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); PML body (ortholog) | NW_004955467 | 2059793 | 2084221 | Chinchilla | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 11863337 | TRIM16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (ortholog); interleukin-1 binding (ortholog); NACHT domain binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of keratinocyte d ifferentiation (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); PML body (ortholog) | 17 | 35973775 | 36028767 | Bonobo | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 12081128 | TRIM16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (inferred); interleukin-1 binding (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of interleukin-1 beta production (inferred); positive regulation of keratinocyte diff erentiation (inferred); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); PML body (inferred) | 5 | 39146505 | 39167857 | Dog | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 12589325 | Trim16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (inferred); interleukin-1 binding (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of interleukin-1 beta production (inferred); positive regulation of keratinocyte diff erentiation (inferred); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); PML body (inferred) | NW_004936724 | 2101942 | 2122747 | Squirrel | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 13914107 | TRIM16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (inferred); interleukin-1 binding (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of DNA-templated transcription (inferred); positive regulation of interleukin-1 beta production (inferred); positive regulation of keratinocyte diff erentiation (inferred); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); PML body (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 24 | description | gene, protein-coding, MODEL [RefSeq] |
| 18936637 | Trim16 | tripartite motif containing 16 | ENCODES a protein that exhibits DNA binding (ortholog); interleukin-1 binding (ortholog); NACHT domain binding (ortholog); INVOLVED IN positive regulation of DNA-templated transcription (ortholog); positive regulation of interleukin-1 beta production (ortholog); positive regulation of keratinocyte d ifferentiation (ortholog); ASSOCIATED WITH Ovarian Neoplasms (ortholog); FOUND IN cytosol (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 18928876 | Trim8 | tripartite motif containing 8 | ENCODES a protein that exhibits identical protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN canonical NF-kappaB signal transduction (ortholog); host-mediated suppression of symbiont invasion (ortho log); negative regulation of viral transcription (ortholog); ASSOCIATED WITH electroclinical syndrome (ortholog); epilepsy (ortholog); Focal Segmental Glomerulosclerosis and Neurodevelopmental Syndrome (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 37 | description | gene, protein-coding, MODEL [RefSeq] |
| 1318027 | UBA7 | ubiquitin like modifier activating enzyme 7 | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008] | 3 | 49805209 | 49813953 | Human | 162 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 18910898 | Zbed1 | zinc finger BED-type containing 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); identical protein binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN host-mediated suppression of viral genome replicati on (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Prostatic Neoplasms (ortholog); FOUND IN nuclear membrane (ortholog); nucleoplasm (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 1359439 | Zcchc12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate | X | 120299138 | 120302465 | Rat | 90 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1552702 | Zcchc12 | zinc finger, CCHC domain containing 12 | Enables SUMO binding activity and transcription coactivator activity. Acts upstream of or within BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Located in PML body and nuclear speck. Is expressed in several structures, inclu ding central nervous system; gut; paravertebral ganglion; retina; and skeletal musculature. Orthologous to several human genes including ZCCHC12 (zinc finger CCHC-type containing 12). [provided by Alliance of Genome Resources, Jul 2025] | X | 35459553 | 35462817 | Mouse | 83 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8910553 | Zcchc12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); nucleus (ortholog); PML body (ortholog) | NW_004955534 | 1131585 | 1133382 | Chinchilla | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 11980120 | ZCCHC12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); PML body (ortholog) | X | 107831784 | 107834964 | Bonobo | 17 | description | gene, protein-coding, MODEL [RefSeq] |
| 12324307 | ZCCHC12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); nucleus (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A | X | 91004777 | 91008019 | Dog | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 12592781 | Zcchc12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); PML body (ortholog) | NW_004936479 | 11021502 | 11024612 | Squirrel | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 18749464 | ZCCHC12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); PML body (ortholog) | | | | Green Monkey | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 18916978 | Zcchc12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); PML body (ortholog) | | | | Naked Mole-Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 626133429 | Zcchc12 | zinc finger CCHC-type containing 12 | ENCODES a protein that exhibits SUMO binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN BMP signaling pathway (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH esophagus squamous cell carcinoma (ortholog); FOUND IN nuclear s peck (ortholog); nucleus (ortholog); PML body (ortholog) | | | | Black Rat | 15 | description | gene, protein-coding, MODEL [RefSeq] |
| 1305865 | Zfp451 | zinc finger protein 451 | ENCODES a protein that exhibits SUMO ligase activity (ortholog); transcription corepressor activity (ortholog); transcription regulator inhibitor activity (ortholog); INVOLVED IN negative regulation of transcription initiation by RNA polymerase II (ortholog); negative regulation of transforming grow th factor beta receptor signaling pathway (ortholog); protein sumoylation (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; bisphenol A; chloroprene | 9 | 43481395 | 43546103 | Rat | 95 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314153 | Zfp451 | zinc finger protein 451 | Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; SUMO ligase activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; and metanephros. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 33800622 | 33854683 | Mouse | 112 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1593255 | Zmym2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); PML yle='font-weight:700;'>PML body (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; oxaliplatin | 15 | 35151356 | 35224528 | Rat | 94 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8894626 | Zmym2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog); PML ML body (ortholog) | NW_004955497 | 778641 | 895376 | Chinchilla | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 11729672 | ZMYM2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin conjugating enzyme binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FO UND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 13 | 1281220 | 1411390 | Bonobo | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 12419552 | ZMYM2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin conjugating enzyme binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FO UND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 25 | 18040081 | 18158241 | Dog | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 12699852 | Zmym2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin conjugating enzyme binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FO UND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | NW_004936720 | 1643711 | 1726124 | Squirrel | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 14278527 | ZMYM2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin conjugating enzyme binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FO UND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 18646554 | ZMYM2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits metal ion binding (inferred); ubiquitin conjugating enzyme binding (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of DNA-templated transcription (inferred); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FO UND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Green Monkey | 20 | description | gene, protein-coding, MODEL [RefSeq] |
| 18900091 | Zmym2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog); PML ML body (ortholog) | | | | Naked Mole-Rat | 19 | description | gene, protein-coding, MODEL [RefSeq] |
| 626028027 | Zmym2 | zinc finger MYM-type containing 2 | ENCODES a protein that exhibits ubiquitin conjugating enzyme binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH CAKUT (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog); PML ML body (ortholog) | | | | Black Rat | 16 | description | gene, protein-coding, MODEL [RefSeq] |
| 1314152 | ZNF451 | zinc finger protein 451 | Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylati on. Located in PML body. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 57090188 | 57170305 | Human | 93 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 8723366 | Znf451 | zinc finger protein 451 | ENCODES a protein that exhibits SUMO ligase activity (ortholog); transcription corepressor activity (ortholog); transcription regulator inhibitor activity (ortholog); INVOLVED IN negative regulation of transcription initiation by RNA polymerase II (ortholog); negative regulation of transforming grow th factor beta receptor signaling pathway (ortholog); protein sumoylation (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | NW_004955502 | 3003822 | 3087529 | Chinchilla | 9 | description | gene, protein-coding, MODEL [RefSeq] |
| 11902202 | ZNF451 | zinc finger protein 451 | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); sequence-specific DNA binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymer ase II (inferred); negative regulation of transforming growth factor beta receptor signaling pathway (inferred); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 6 | 56647589 | 56728231 | Bonobo | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 12173554 | ZNF451 | zinc finger protein 451 | ENCODES a protein that exhibits metal ion binding (inferred); SUMO ligase activity (inferred); transcription corepressor activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymerase II (inferred); negative regulation of tr ansforming growth factor beta receptor signaling pathway (inferred); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | 12 | 24260862 | 24350890 | Dog | 22 | description | gene, protein-coding, MODEL [RefSeq] |
| 12488754 | Znf451 | zinc finger protein 451 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); transcription regulator inhibitor activity (ortholog); INVOLVED IN negative regulation of transcription initiation by RNA polymerase II (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | NW_004936476 | 4133803 | 4268834 | Squirrel | 11 | description | gene, protein-coding, MODEL [RefSeq] |
| 14035890 | ZNF451 | zinc finger protein 451 | ENCODES a protein that exhibits ligase activity (inferred); metal ion binding (inferred); SUMO ligase activity (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymerase II (inferred); negative regulation of transforming growth f actor beta receptor signaling pathway (inferred); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 18606986 | ZNF451 | zinc finger protein 451 | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); sequence-specific DNA binding (inferred); INVOLVED IN DNA-templated transcription (inferred); negative regulation of transcription initiation by RNA polymer ase II (inferred); negative regulation of transforming growth factor beta receptor signaling pathway (inferred); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferred) | | | | Green Monkey | 23 | description | gene, protein-coding, MODEL [RefSeq] |
| 18908724 | Znf451 | zinc finger protein 451 | ENCODES a protein that exhibits transcription regulator inhibitor activity (ortholog); INVOLVED IN negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); PML body (inferr ed) | | | | Naked Mole-Rat | 18 | description | gene, protein-coding, MODEL [RefSeq] |
| 625880624 | Znf451 | zinc finger protein 451 | ENCODES a protein that exhibits SUMO ligase activity (ortholog); transcription corepressor activity (ortholog); transcription regulator inhibitor activity (ortholog); INVOLVED IN negative regulation of transcription initiation by RNA polymerase II (ortholog); negative regulation of transforming grow th factor beta receptor signaling pathway (ortholog); protein sumoylation (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | | | | Black Rat | 9 | description | gene, protein-coding, MODEL [RefSeq] |
| 14204285 | ZNF605 | zinc finger protein 605 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN cell division (inferred); chromatin remodeling (inferred); DNA-templated transcription (inferred); FOUND IN nucleopla sm (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 36 | description | gene, protein-coding, MODEL [RefSeq] |
| 16556958 | AL020989.1 | transmembrane 4 superfamily member 11 (plasmolipin) (PMLP) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
