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Gene: SP100 (SP100 nuclear antigen) Homo sapiens
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Symbol: SP100
Name: SP100 nuclear antigen
Description: This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686E07254; FLJ00340; FLJ34579; lysp100b; nuclear autoantigen Sp-100; nuclear dot-associated Sp100 protein; SP100-HMG nuclear autoantigen; speckled 100 kDa
Orthologs:
Mus musculus (house mouse) : Sp100 (nuclear antigen Sp100)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sp100 (SP100 nuclear antigen)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp100 (SP100 nuclear antigen)
Pan paniscus (bonobo/pygmy chimpanzee) : SP100 (SP100 nuclear antigen)
Canis lupus familiaris (dog) : SP100 (SP100 nuclear antigen)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp100 (SP100 nuclear antigen)
Sus scrofa (pig) : LOC100517129 (nuclear body protein SP140-like protein)
more info ...
Related Pseudogenes: HMGB1P37  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,416,156 - 230,545,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,280,871 - 231,410,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,989,115 - 231,118,561 (+)NCBINCBI36hg18NCBI36
Build 342231,106,485 - 231,206,745NCBI
Celera2225,057,025 - 225,186,692 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2223,121,005 - 223,250,289 (+)NCBIHuRef
CHM1_12231,286,764 - 231,416,096 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SP100
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348100
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.