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Gene: SP100 (SP100 nuclear antigen) Homo sapiens
Symbol: SP100
Name: SP100 nuclear antigen
Description: This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp686E07254; FLJ00340; FLJ34579; lysp100b; nuclear autoantigen Sp-100; nuclear dot-associated Sp100 protein; SP100-HMG nuclear autoantigen; speckled 100 kDa
Mus musculus (house mouse) : Sp100 (nuclear antigen Sp100)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sp100 (SP100 nuclear antigen)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp100 (SP100 nuclear antigen)
Pan paniscus (bonobo/pygmy chimpanzee) : SP100 (SP100 nuclear antigen)
Canis lupus familiaris (dog) : SP100 (SP100 nuclear antigen)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp100 (SP100 nuclear antigen)
Sus scrofa (pig) : LOC100517129 (nuclear body protein SP140-like protein)
more info ...
Related Pseudogenes: HMGB1P37  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382230,416,156 - 230,545,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372231,280,871 - 231,410,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,989,115 - 231,118,561 (+)NCBINCBI36hg18NCBI36
Build 342231,106,485 - 231,206,745NCBI
Celera2225,057,025 - 225,186,692 (+)NCBI
Cytogenetic Map2q37.1NCBI
HuRef2223,121,005 - 223,250,289 (+)NCBIHuRef
CHM1_12231,286,764 - 231,416,096 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SP100
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348100
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.