Nr2c1 (nuclear receptor subfamily 2, group C, member 1) - Rat Genome Database

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Gene: Nr2c1 (nuclear receptor subfamily 2, group C, member 1) Rattus norvegicus
Analyze
Symbol: Nr2c1
Name: nuclear receptor subfamily 2, group C, member 1
RGD ID: 3200
Description: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of retinoic acid receptor signaling pathway. Predicted to be located in PML body. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group H, member 1; orphan nuclear receptor TR2; orphan receptor; orphan receptor, TR2-11; pregnancy specific beta-1-glycoprotein 4; Psg4; testicular receptor 2; Tr2; TR2-11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,602,338 - 30,655,610 (+)NCBIGRCr8
mRatBN7.2728,715,347 - 28,768,624 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,715,562 - 28,767,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx730,713,646 - 30,765,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,875,895 - 32,927,468 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,646,428 - 32,698,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0735,069,807 - 35,122,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl735,069,814 - 35,122,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0735,137,598 - 35,189,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4731,293,180 - 31,345,189 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1731,313,973 - 31,365,460 (+)NCBI
Celera725,816,321 - 25,858,083 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Original Reference(s)
Nr2c1RatContracture  ISONR2C1 (Homo sapiens)8554872ClinVar Annotator: match by term: ContracturesClinVar 
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Original Reference(s)
Nr2c1Ratendometriosis  ISONR2C1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22138541

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Original Reference(s)
Nr2c1Rat(1->4)-beta-D-glucan multiple interactionsISONr2c1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of NR2C1 mRNACTDPMID:36331819
Nr2c1Rat1,2-dichloroethane decreases expressionISONr2c1 (Mus musculus)6480464ethylene dichloride results in decreased expression of NR2C1 mRNACTDPMID:28960355
Nr2c1Rat1,2-dimethylhydrazine affects expressionISONr2c1 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of NR2C1 mRNACTDPMID:22206623
Nr2c1Rat17alpha-ethynylestradiol affects expressionISONr2c1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of NR2C1 mRNACTDPMID:17555576
Nr2c1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISONr2c1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of NR2C1 mRNACTDPMID:21570461 and PMID:24058054
Nr2c1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of NR2C1 mRNACTDPMID:33387578
Nr2c1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISONr2c1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of NR2C1 mRNACTDPMID:18796159 more ...
Nr2c1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONr2c1 (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of NR2C1 mRNA and [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of NR2C1 mRNACTDPMID:16214954 and PMID:25975270
Nr2c1Rat4,4'-sulfonyldiphenol increases expressionISONr2c1 (Mus musculus)6480464bisphenol S results in increased expression of NR2C1 mRNACTDPMID:39298647
Nr2c1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of NR2C1 mRNACTDPMID:30047161
Nr2c1Ratacrylamide decreases expressionISONR2C1 (Homo sapiens)6480464Acrylamide results in decreased expression of NR2C1 mRNACTDPMID:32763439
Nr2c1RatAflatoxin B2 alpha decreases methylationISONR2C1 (Homo sapiens)6480464aflatoxin B2 results in decreased methylation of NR2C1 intronCTDPMID:30157460
Nr2c1Ratall-trans-retinoic acid multiple interactionsISONr2c1 (Mus musculus)6480464NR2C1 protein affects the reaction [Tretinoin results in increased expression of MYC protein] more ...CTDPMID:17389641
Nr2c1Ratall-trans-retinoic acid decreases expressionISONR2C1 (Homo sapiens)6480464Tretinoin results in decreased expression of NR2C1 mRNACTDPMID:33167477
Nr2c1Ratall-trans-retinoic acid increases expressionISONr2c1 (Mus musculus)6480464Tretinoin results in increased expression of NR2C1 mRNA and Tretinoin results in increased expression of NR2C1 proteinCTDPMID:17389641
Nr2c1Ratall-trans-retinoic acid decreases expressionISONr2c1 (Mus musculus)6480464Tretinoin results in decreased expression of NR2C1 mRNA and Tretinoin results in decreased expression of NR2C1 proteinCTDPMID:17389641
Nr2c1Ratamitrole decreases expressionEXP 6480464Amitrole results in decreased expression of NR2C1 mRNACTDPMID:30047161
Nr2c1Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of NR2C1 mRNACTDPMID:16483693
Nr2c1Rataristolochic acid A decreases expressionISONR2C1 (Homo sapiens)6480464aristolochic acid I results in decreased expression of NR2C1 mRNACTDPMID:33212167
Nr2c1Ratarsane multiple interactionsISONR2C1 (Homo sapiens)6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of NR2C1 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NR2C1 mRNACTDPMID:39836092

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Biological Process
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Original Reference(s)
Nr2c1Ratcell differentiation involved_inIBAFB:FBgn0003651 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr2c1Ratintracellular receptor signaling pathway involved_inIEAGO:00048791600115GO_REF:0000108GOCGO_REF:0000108
Nr2c1Ratnegative regulation of DNA-templated transcription involved_inIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Ratnegative regulation of DNA-templated transcription involved_inISONr2c1 (Mus musculus)1624291 PMID:8858600 more ...RGDPMID:8858600 more ...
Nr2c1Ratnegative regulation of transcription by RNA polymerase II involved_inISONR2C1 (Homo sapiens)1624291UniProtKB:P49116 and PMID:17974920RGDPMID:17974920
Nr2c1Ratnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P13056 and ensembl:ENSP000003332751600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Ratnegative regulation of transcription by RNA polymerase II involved_inISONr2c1 (Mus musculus)1624291 PMID:8858600 more ...RGDPMID:8858600 more ...
Nr2c1Ratnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Ratpositive regulation of retinoic acid receptor signaling pathway involved_inIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Ratpositive regulation of retinoic acid receptor signaling pathway involved_inISONr2c1 (Mus musculus)1624291 PMID:16130175RGDPMID:16130175
Nr2c1Ratregulation of DNA-templated transcription involved_inIEAInterPro:IPR001628 and InterPro:IPR0130881600115GO_REF:0000002InterProGO_REF:0000002
Nr2c1Ratregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0003720 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
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Original Reference(s)
Nr2c1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Nr2c1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Nr2c1Ratnucleus located_inIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Ratnucleus located_inISONr2c1 (Mus musculus)1624291 PMID:9795341RGDPMID:9795341
Nr2c1RatPML body located_inISONr2c1 (Mus musculus)1624291 PMID:18682553RGDPMID:18682553
Nr2c1RatPML body located_inIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1RatPML body located_inIEAUniProtKB-SubCell:SL-04651600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function
1 to 20 of 23 rows

  
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Original Reference(s)
Nr2c1RatDNA binding enablesISONr2c1 (Mus musculus)1624291 PMID:9071982 more ...RGDPMID:9071982 more ...
Nr2c1RatDNA binding enablesIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nr2c1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR0016281600115GO_REF:0000002InterProGO_REF:0000002
Nr2c1RatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISONr2c1 (Mus musculus)1624291 PMID:9369481RGDPMID:9369481
Nr2c1RatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Rathistone deacetylase binding enablesIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Rathistone deacetylase binding enablesISONr2c1 (Mus musculus)1624291UniProtKB:P56524 and PMID:11463856RGDPMID:11463856
Nr2c1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Nr2c1Ratnuclear receptor activity enablesIBAFB:FBgn0015239 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr2c1Ratprotein binding enablesISONr2c1 (Mus musculus)1624291PR:Q8CBD1 more ...RGDPMID:17187077 more ...
Nr2c1Ratprotein binding enablesISONR2C1 (Homo sapiens)1624291UniProtKB:P03372 more ...RGDPMID:12093804 and PMID:17974920
Nr2c1Ratprotein binding enablesISONR2C1 (Homo sapiens) and UniProtKB:P13056-21624291UniProtKB:P10276 and PMID:32296183RGDPMID:32296183
Nr2c1Ratprotein homodimerization activity enablesISONr2c1 (Mus musculus)1624291UniProtKB:Q505F1 and PMID:9369481RGDPMID:9369481
Nr2c1Ratprotein homodimerization activity enablesIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISONr2c1 (Mus musculus)1624291 PMID:9369481RGDPMID:9369481
Nr2c1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAMGI:109128 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nr2c1RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q505F1 and ensembl:ENSMUSP000001009271600115GO_REF:0000107EnsemblGO_REF:0000107
Nr2c1Ratsequence-specific DNA binding enablesIEAInterPro:IPR0016281600115GO_REF:0000002InterProGO_REF:0000002
Nr2c1Ratsequence-specific double-stranded DNA binding enablesISONR2C1 (Homo sapiens)1624291 PMID:28473536RGDPMID:28473536
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:7794280   PMID:8858600   PMID:9071982   PMID:9369481   PMID:9774688   PMID:9795341   PMID:11463856   PMID:12477932   PMID:16130175   PMID:17974920   PMID:18682553  



Nr2c1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,602,338 - 30,655,610 (+)NCBIGRCr8
mRatBN7.2728,715,347 - 28,768,624 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,715,562 - 28,767,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx730,713,646 - 30,765,220 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,875,895 - 32,927,468 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,646,428 - 32,698,239 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0735,069,807 - 35,122,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl735,069,814 - 35,122,796 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0735,137,598 - 35,189,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4731,293,180 - 31,345,189 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1731,313,973 - 31,365,460 (+)NCBI
Celera725,816,321 - 25,858,083 (+)NCBICelera
Cytogenetic Map7q13NCBI
NR2C1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,020,229 - 95,073,618 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,020,229 - 95,073,628 (-)EnsemblGRCh38hg38GRCh38
GRCh371295,414,005 - 95,467,394 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361293,939,802 - 93,991,487 (-)NCBINCBI36Build 36hg18NCBI36
Build 341293,918,138 - 93,969,676NCBI
Celera1295,085,340 - 95,138,686 (-)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1292,481,137 - 92,534,428 (-)NCBIHuRef
CHM1_11295,378,558 - 95,432,374 (-)NCBICHM1_1
T2T-CHM13v2.01295,000,934 - 95,054,323 (-)NCBIT2T-CHM13v2.0
Nr2c1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,983,491 - 94,033,078 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,983,885 - 94,033,073 (+)EnsemblGRCm39 Ensembl
GRCm381094,147,542 - 94,197,216 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1094,148,023 - 94,197,211 (+)EnsemblGRCm38mm10GRCm38
MGSCv371093,610,676 - 93,659,959 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361093,586,085 - 93,625,150 (+)NCBIMGSCv36mm8
Celera1096,123,279 - 96,172,755 (+)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.81NCBI
Nr2c1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540531,635,113 - 31,691,465 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540531,637,832 - 31,693,621 (-)NCBIChiLan1.0ChiLan1.0
NR2C1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210103,094,441 - 103,146,827 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112103,090,832 - 103,144,945 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01292,611,459 - 92,664,405 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,007,293 - 96,060,878 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,007,293 - 96,060,878 (-)Ensemblpanpan1.1panPan2
NR2C1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,003,658 - 35,049,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,005,066 - 35,038,968 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1535,390,524 - 35,436,592 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01535,668,122 - 35,714,259 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1535,668,136 - 35,714,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11534,941,455 - 34,987,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,036,660 - 35,082,732 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01535,299,269 - 35,345,360 (-)NCBIUU_Cfam_GSD_1.0
Nr2c1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,915,800 - 24,968,872 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650711,264,737 - 11,319,642 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650711,266,408 - 11,319,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2C1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl588,231,274 - 88,277,997 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1588,231,180 - 88,278,803 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2592,480,138 - 92,527,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NR2C1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11190,430,307 - 90,481,269 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1190,430,194 - 90,481,493 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037154,685,782 - 154,738,815 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr2c1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,981,783 - 12,023,282 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475011,972,826 - 12,022,603 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Nr2c1
331 total Variants

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:21
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000009578
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000009578   ⟹   ENSRNOP00000009578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl728,716,093 - 28,767,160 (+)Ensembl
Rnor_6.0 Ensembl735,070,284 - 35,121,346 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089228   ⟹   ENSRNOP00000071901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl728,715,562 - 28,767,071 (+)Ensembl
Rnor_6.0 Ensembl735,069,814 - 35,122,796 (+)Ensembl
RefSeq Acc Id: NM_145780   ⟹   NP_665723
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,607 - 30,654,148 (+)NCBI
mRatBN7.2728,715,616 - 28,767,162 (+)NCBI
Rnor_6.0735,069,807 - 35,121,348 (+)NCBI
Rnor_5.0735,137,598 - 35,189,641 (+)NCBI
RGSC_v3.4731,293,180 - 31,345,189 (+)RGD
Celera725,816,321 - 25,858,083 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594671   ⟹   XP_017450160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,794 - 30,655,610 (+)NCBI
mRatBN7.2728,715,802 - 28,768,624 (+)NCBI
Rnor_6.0735,069,973 - 35,122,810 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078458   ⟹   XP_038934386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,338 - 30,655,610 (+)NCBI
mRatBN7.2728,715,347 - 28,768,624 (+)NCBI
RefSeq Acc Id: XM_039078459   ⟹   XP_038934387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,953 - 30,655,610 (+)NCBI
mRatBN7.2728,715,990 - 28,768,624 (+)NCBI
RefSeq Acc Id: XR_005486547
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,602,338 - 30,648,237 (+)NCBI
mRatBN7.2728,715,347 - 28,761,249 (+)NCBI
RefSeq Acc Id: NP_665723   ⟸   NM_145780
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450160   ⟸   XM_017594671
- Peptide Label: isoform X1
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071901   ⟸   ENSRNOT00000089228
Ensembl Acc Id: ENSRNOP00000009578   ⟸   ENSRNOT00000009578
RefSeq Acc Id: XP_038934386   ⟸   XM_039078458
- Peptide Label: isoform X1
- UniProtKB: Q8VIJ4 (UniProtKB/Swiss-Prot),   A0A8L2R4T2 (UniProtKB/TrEMBL)
NR LBD   Nuclear receptor

Name Modeler Protein Id AA Range Protein Structure
AF-Q8VIJ4-F1-model_v2 AlphaFold Q8VIJ4 1-590 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695154
Promoter ID:EPDNEW_R5678
Type:initiation region
Name:Nr2c1_1
Description:nuclear receptor subfamily 2, group C, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0735,069,816 - 35,069,876EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34372 BioCyc
Ensembl Genes ENSRNOG00000006983 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009578 ENTREZGENE
  ENSRNOT00000009578.5 UniProtKB/Swiss-Prot
  ENSRNOT00000089228 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599041 IMAGE-MGC_LOAD
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR2C1/2-like_DBD UniProtKB/Swiss-Prot
  NR2C1/2-like_LBD UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR2 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:252924 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72289 IMAGE-MGC_LOAD
NCBI Gene Nr2c1 ENTREZGENE
PANTHER NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr2c1 PhenoGen
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006983 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A0A8L2R4T2 ENTREZGENE, UniProtKB/TrEMBL
  A6IG09_RAT UniProtKB/TrEMBL
  NR2C1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-06 Nr2c1  nuclear receptor subfamily 2, group C, member 1  Psg4  pregnancy specific beta-1-glycoprotein 4  Data merged from RGD:628790 737654 APPROVED
2003-02-27 Psg4  pregnancy specific beta-1-glycoprotein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2001-06-20 Tr2  Orphan receptor, TR2-11      Symbol withdrawn, duplicate of Nr2c1 (RGD:3200) 67952 WITHDRAWN
2001-06-20 Nr2c1  Nuclear receptor subfamily 2, group C, member 1      Name updated 67952 APPROVED

Note Type Note Reference
gene_homology mouse Nr2c1 exhibits transcription factor, subtilase, ligand-dependent nuclear receptor and steroid hormone activities 704405