Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of MORC3 mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MORC3 mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MORC3 mRNA | CTD | PMID:21570461 | 2,4-dinitrotoluene | affects expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of MORC3 mRNA | CTD | PMID:21346803 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | 3 more ... | CTD | PMID:19467301 | 5-aza-2'-deoxycytidine | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Decitabine results in increased expression of MORC3 mRNA | CTD | PMID:19194470 | acrolein | multiple interactions | ISO | MORC3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MORC3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MORC3 mRNA | CTD | PMID:32699268 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of MORC3 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | MORC3 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of MORC3 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | increases methylation | ISO | MORC3 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of MORC3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of MORC3 mRNA | CTD | PMID:33167477 | alpha-pinene | multiple interactions | ISO | MORC3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MORC3 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of MORC3 mRNA | CTD | PMID:32699268 | arsenite(3-) | multiple interactions | ISO | MORC3 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to MORC3 mRNA] | CTD | PMID:32406909 | azoxystrobin | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MORC3 mRNA | CTD | PMID:33854195 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of MORC3 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | MORC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of MORC3 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of MORC3 mRNA | CTD | PMID:25181051 and PMID:30816183 | bisphenol A | decreases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of MORC3 mRNA | CTD | PMID:35192832 | bisphenol A | decreases methylation | ISO | MORC3 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of MORC3 gene | CTD | PMID:31601247 | bisphenol A | increases methylation | ISO | Morc3 (Rattus norvegicus) | 6480464 | bisphenol A results in increased methylation of MORC3 gene | CTD | PMID:28505145 | caffeine | decreases phosphorylation | ISO | MORC3 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of MORC3 protein | CTD | PMID:35688186 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlorpyrifos | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MORC3 mRNA | CTD | PMID:33854195 | cobalt dichloride | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of MORC3 mRNA | CTD | PMID:19376846 | copper(II) sulfate | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of MORC3 mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of MORC3 mRNA | CTD | PMID:20106945 | cyproconazole | increases expression | EXP | | 6480464 | cyproconazole results in increased expression of MORC3 mRNA | CTD | PMID:22334560 | dibenz[a,h]anthracene | increases expression | EXP | | 6480464 | 1 more ... | CTD | PMID:26377693 | dicrotophos | decreases expression | ISO | MORC3 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of MORC3 mRNA | CTD | PMID:28302478 | doxorubicin | decreases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of MORC3 mRNA | CTD | PMID:29803840 | epoxiconazole | increases expression | EXP | | 6480464 | epoxiconazole results in increased expression of MORC3 mRNA | CTD | PMID:22334560 | ethyl methanesulfonate | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of MORC3 mRNA | CTD | PMID:23649840 | flutamide | increases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of MORC3 mRNA | CTD | PMID:24136188 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of MORC3 mRNA | CTD | PMID:25629700 | formaldehyde | decreases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of MORC3 mRNA | CTD | PMID:20655997 | formaldehyde | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of MORC3 mRNA | CTD | PMID:23649840 | FR900359 | affects phosphorylation | ISO | MORC3 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of MORC3 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of MORC3 mRNA | CTD | PMID:22061828 | glyphosate | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MORC3 mRNA | CTD | PMID:33854195 | gold atom | decreases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Gold results in decreased expression of MORC3 mRNA | CTD | PMID:25523186 | gold(0) | decreases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Gold results in decreased expression of MORC3 mRNA | CTD | PMID:25523186 | imidacloprid | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MORC3 mRNA | CTD | PMID:33854195 | methyl methanesulfonate | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of MORC3 mRNA | CTD | PMID:23649840 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of MORC3 gene | CTD | PMID:33148267 | ozone | multiple interactions | ISO | MORC3 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of MORC3 mRNA more ... | CTD | PMID:32699268 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of MORC3 mRNA | CTD | PMID:17562736 | pentachlorophenol | increases expression | EXP | | 6480464 | Pentachlorophenol results in increased expression of MORC3 mRNA | CTD | PMID:23892564 | permethrin | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of MORC3 gene | CTD | PMID:33148267 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of MORC3 mRNA | CTD | PMID:19270015 | phenobarbital | affects expression | ISO | MORC3 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of MORC3 mRNA | CTD | PMID:19159669 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of MORC3 mRNA | CTD | PMID:28903501 | propiconazole | increases expression | EXP | | 6480464 | propiconazole results in increased expression of MORC3 mRNA | CTD | PMID:21278054 and PMID:22334560 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of MORC3 protein | CTD | PMID:25505154 | resveratrol | multiple interactions | ISO | MORC3 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of MORC3 mRNA | CTD | PMID:23557933 | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of MORC3 mRNA | CTD | PMID:36209798 | sunitinib | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of MORC3 mRNA | CTD | PMID:31533062 | tamoxifen | affects expression | EXP | | 6480464 | Tamoxifen affects the expression of MORC3 mRNA | CTD | PMID:20937368 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of MORC3 mRNA | CTD | PMID:27339419 and PMID:31919559 | tetrachloromethane | increases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in increased expression of MORC3 mRNA | CTD | PMID:31150632 | thiabendazole | multiple interactions | ISO | Morc3 (Rattus norvegicus) | 6480464 | [azoxystrobin co-treated with 2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide co-treated with Chlorpyrifos co-treated with Glyphosate co-treated with imidacloprid co-treated with Thiabendazole] results in increased expression of MORC3 mRNA | CTD | PMID:33854195 | urethane | increases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Urethane results in increased expression of MORC3 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | MORC3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of MORC3 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | MORC3 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of MORC3 mRNA | CTD | PMID:23179753 and PMID:27188386 | vinclozolin | decreases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of MORC3 mRNA | CTD | PMID:20566332 | vinclozolin | increases expression | ISO | Morc3 (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of MORC3 mRNA | CTD | PMID:23034163 | | 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Gene Ontology Annotations Click to see Annotation Detail View
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Phenotype Annotations Click to see Annotation Detail View
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | A gene expression map of human chromosome 21 orthologues in the mouse. | Gitton Y, etal., Nature 2002 Dec 5;420(6915):586-90. |
| 2. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 3. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 5. | Human chromosome 21 gene expression atlas in the mouse. | Reymond A, etal., Nature 2002 Dec 5;420(6915):582-6. |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11374901 | PMID:11567631 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:15368895 | PMID:16141072 |
| PMID:16141073 | PMID:17332504 | PMID:18799693 | PMID:20064376 | PMID:20501696 | PMID:21267068 | PMID:21873635 | PMID:27188231 | PMID:27528681 | PMID:27653685 | PMID:28190767 | PMID:28378742 |
| PMID:31162944 | PMID:32325033 | PMID:34650118 | PMID:34706774 |
Genomics
Comparative Map Data
| Morc3 (Mus musculus - house mouse) |
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| MORC3 (Homo sapiens - human) |
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| Morc3 (Rattus norvegicus - Norway rat) |
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| Morc3 (Chinchilla lanigera - long-tailed chinchilla) |
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| MORC3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| MORC3 (Canis lupus familiaris - dog) |
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| Morc3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| MORC3 (Sus scrofa - pig) |
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| MORC3 (Chlorocebus sabaeus - green monkey) |
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| Morc3 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Morc3
2164 total Variants 
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