Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of RPAIN mRNA | CTD | PMID:23649840 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of RPAIN mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of RPAIN mRNA | CTD | PMID:17555576 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of RPAIN mRNA | CTD | PMID:16214954 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RPAIN mRNA | CTD | PMID:21570461 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Rpain (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RPAIN mRNA | CTD | PMID:36041667 | all-trans-retinoic acid | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of RPAIN mRNA | CTD | PMID:33167477 | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of RPAIN mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of RPAIN mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of RPAIN mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | Rpain (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RPAIN mRNA | CTD | PMID:36041667 | bisphenol A | decreases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of RPAIN mRNA | CTD | PMID:30816183 | bisphenol F | multiple interactions | ISO | Rpain (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RPAIN mRNA | CTD | PMID:36041667 | cannabidiol | multiple interactions | ISO | RPAIN (Homo sapiens) | 6480464 | [Cannabidiol co-treated with moringin] results in decreased expression of RPAIN mRNA | CTD | PMID:30096889 | carbon nanotube | increases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | chlorpyrifos | increases expression | EXP | | 6480464 | Chlorpyrifos results in increased expression of RPAIN mRNA | CTD | PMID:37019170 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of RPAIN mRNA | CTD | PMID:23811191 | cyclosporin A | increases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of RPAIN mRNA | CTD | PMID:20106945 | dicrotophos | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of RPAIN mRNA | CTD | PMID:28302478 | dorsomorphin | multiple interactions | ISO | RPAIN (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPAIN mRNA | CTD | PMID:27188386 | entinostat | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | entinostat results in decreased expression of RPAIN mRNA | CTD | PMID:27188386 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of RPAIN mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in decreased expression of RPAIN mRNA | CTD | PMID:23649840 | formaldehyde | increases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of RPAIN mRNA | CTD | PMID:23649840 | FR900359 | decreases phosphorylation | ISO | RPAIN (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of RPAIN protein | CTD | PMID:37730182 | gentamycin | decreases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of RPAIN mRNA | CTD | PMID:33387578 | indinavir | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA | CTD | PMID:16931933 | lamivudine | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA more ... | CTD | PMID:16931933 | methyl methanesulfonate | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of RPAIN mRNA | CTD | PMID:23649840 | methylmercury chloride | increases expression | ISO | RPAIN (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of RPAIN mRNA | CTD | PMID:23179753 | methylmercury chloride | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of RPAIN mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Nickel results in increased expression of RPAIN mRNA | CTD | PMID:25583101 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of RPAIN mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of RPAIN mRNA | CTD | PMID:33387578 | pirinixic acid | multiple interactions | ISO | RPAIN (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of RPAIN mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of RPAIN mRNA | CTD | PMID:20813756 and PMID:23811191 | resveratrol | multiple interactions | ISO | RPAIN (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RPAIN mRNA | CTD | PMID:23557933 | saquinavir | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of RPAIN mRNA | CTD | PMID:16931933 | SB 431542 | multiple interactions | ISO | RPAIN (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPAIN mRNA | CTD | PMID:27188386 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of RPAIN mRNA | CTD | PMID:30953684 | temozolomide | increases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Temozolomide results in increased expression of RPAIN mRNA | CTD | PMID:31758290 | thioacetamide | decreases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of RPAIN mRNA | CTD | PMID:34492290 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of RPAIN mRNA | CTD | PMID:23409001 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of RPAIN mRNA | CTD | PMID:33045310 | trovafloxacin | decreases expression | EXP | | 6480464 | trovafloxacin results in decreased expression of RPAIN mRNA | CTD | PMID:35537566 | tungsten | increases expression | EXP | | 6480464 | Tungsten results in increased expression of RPAIN mRNA | CTD | PMID:30912803 | valproic acid | increases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RPAIN mRNA | CTD | PMID:29154799 | valproic acid | multiple interactions | ISO | RPAIN (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RPAIN mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of RPAIN mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | RPAIN (Homo sapiens) | 6480464 | Valproic Acid affects the expression of RPAIN mRNA | CTD | PMID:25979313 | vinclozolin | decreases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | vinclozolin results in decreased expression of RPAIN mRNA | CTD | PMID:23555832 | vinclozolin | increases expression | ISO | Rpain (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of RPAIN mRNA | CTD | PMID:23034163 | vincristine | decreases expression | ISO | RPAIN (Homo sapiens) | 6480464 | Vincristine results in decreased expression of RPAIN mRNA | CTD | PMID:23649840 | zidovudine | multiple interactions | EXP | | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of RPAIN mRNA more ... | CTD | PMID:16931933 | |