Gene: Pias1 (protein inhibitor of activated STAT 1) Mus musculus
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Symbol:
Pias1
Name:
protein inhibitor of activated STAT 1
Description:
Exhibits transcription factor binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Localizes to the nucleus. Colocalizes with the PML body. Is expressed in several structures, including branchial arch; genitourinary system; sensory organ; tooth; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1); PARTICIPATES IN aldosterone signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; Hedgehog signaling pathway; INTERACTS WITH 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
2900068C24Rik; Ddxbp1; DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1; DEAD/H box-binding protein 1; E3 SUMO-protein ligase PIAS1; GBP; protein inhibitor of activated STAT protein 1; RING-type E3 ubiquitin transferase PIAS1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PIAS1 (protein inhibitor of activated STAT 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Pias1 (protein inhibitor of activated STAT, 1) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pias1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PIAS1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PIAS1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pias1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PIAS1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
PIAS1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Pias1 (protein inhibitor of activated STAT 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PIAS3 (protein inhibitor of activated STAT 3) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Pias1 (protein inhibitor of activated STAT, 1)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Homo sapiens (human):
PIAS1 (protein inhibitor of activated STAT 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
pias1b (protein inhibitor of activated STAT, 1b)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam, ZFIN)
Danio rerio (zebrafish):
pias1a (protein inhibitor of activated STAT, 1a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
NFI1
Alliance
DIOPT (Ensembl Compara, Hieranoid, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Su(var)2-10
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
gei-17
Alliance
DIOPT (Ensembl Compara, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Saccharomyces cerevisiae (baker's yeast):
SIZ1
Alliance
DIOPT (Ensembl Compara, Hieranoid, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 9 62,878,368 - 62,987,924 (-) Ensembl GRCm38 9 62,878,366 - 62,980,879 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 9 62,727,884 - 62,828,686 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 9 62,678,083 - 62,778,885 (-) NCBI mm8 Celera 9 60,099,154 - 60,199,601 (-) NCBI Celera Cytogenetic Map 9 B NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
nephronophthisis ISO RGD:1317273 8554872 ClinVar Annotator: match by term: Nephronophthisis ClinVar PMID:26489029
Imported Annotations - CTD
Arsenic Poisoning ISO RGD:1317273 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16835338 skin disease ISO RGD:1317273 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16835338
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1317273 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PIAS1 mRNA CTD PMID:22079256 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expression EXP 6480464 1-Methyl-4-phenyl-1 more ... CTD PMID:28801915 17alpha-ethynylestradiol increases expression ISO RGD:1307843 6480464 Ethinyl Estradiol results in increased expression of PIAS1 mRNA CTD PMID:29097150 17beta-estradiol multiple interactions ISO RGD:1317273 6480464 Estradiol promotes the reaction [PIAS1 protein binds to ESR1 protein] CTD PMID:15666801 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression ISO RGD:1317273 6480464 Metribolone results in increased expression of PIAS1 mRNA CTD PMID:16751804 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1317273 6480464 Dihydrotestosterone results in increased expression of PIAS1 mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1317273 6480464 Tetrachlorodibenzodioxin results in decreased expression of PIAS1 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of PIAS1 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression ISO RGD:1307843 6480464 2, 6-dinitrotoluene affects the expression of PIAS1 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1317273 6480464 beta-methylcholine affects the expression of PIAS1 mRNA CTD PMID:21179406 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1317273 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PIAS1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1317273 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PIAS1 mRNA CTD PMID:28628672 aflatoxin B1 decreases methylation ISO RGD:1317273 6480464 Aflatoxin B1 results in decreased methylation of PIAS1 gene CTD PMID:27153756 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PIAS1 mRNA CTD PMID:23650126 arsane decreases expression ISO RGD:1317273 6480464 Arsenic results in decreased expression of PIAS1 mRNA CTD PMID:16835338 arsane affects methylation ISO RGD:1317273 6480464 Arsenic affects the methylation of PIAS1 gene CTD PMID:25304211 arsenic atom decreases expression ISO RGD:1317273 6480464 Arsenic results in decreased expression of PIAS1 mRNA CTD PMID:16835338 arsenic atom affects methylation ISO RGD:1317273 6480464 Arsenic affects the methylation of PIAS1 gene CTD PMID:25304211 arsenous acid multiple interactions ISO RGD:1317273 6480464 PIAS1 protein promotes the reaction [Arsenic Trioxide results in increased degradation of PML protein] CTD PMID:22406621 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of PIAS1 mRNA CTD PMID:22228805 benzo[a]pyrene affects methylation ISO RGD:1317273 6480464 Benzo(a)pyrene affects the methylation of PIAS1 intron CTD PMID:30157460 bilirubin IXalpha decreases expression ISO RGD:1317273 6480464 Bilirubin results in decreased expression of PIAS1 mRNA CTD PMID:20196124 bisphenol A increases expression ISO RGD:1307843 6480464 bisphenol A results in increased expression of PIAS1 mRNA CTD PMID:30816183 bisphenol A increases methylation ISO RGD:1307843 6480464 bisphenol A results in increased methylation of PIAS1 gene CTD PMID:28505145 butanal decreases expression ISO RGD:1317273 6480464 butyraldehyde results in decreased expression of PIAS1 mRNA CTD PMID:26079696 calcitriol increases expression ISO RGD:1317273 6480464 Calcitriol results in increased expression of PIAS1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1317273 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of PIAS1 mRNA CTD PMID:21592394 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon affects the expression of PIAS1 mRNA CTD PMID:25554681 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of PIAS1 mRNA, Nanotubes, Carbon results in decreased expression of PIAS1 mRNA CTD PMID:25554681 chlorpromazine increases expression EXP 6480464 Chlorpromazine results in increased expression of PIAS1 mRNA CTD PMID:21683644 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PIAS1 gene CTD PMID:20938992 clofibric acid multiple interactions ISO RGD:1307843 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PIAS1 mRNA CTD PMID:17602206 Colforsin dapropate hydrochloride decreases expression ISO RGD:1317273 6480464 Colforsin results in decreased expression of PIAS1 mRNA CTD PMID:16751804 crocidolite asbestos affects expression ISO RGD:1317273 6480464 Asbestos, Crocidolite affects the expression of PIAS1 mRNA CTD PMID:17331233 cyclosporin A decreases expression ISO RGD:1317273 6480464 Cyclosporine results in decreased expression of PIAS1 mRNA CTD PMID:20106945 cyclosporin A increases expression ISO RGD:1317273 6480464 Cyclosporine results in increased expression of PIAS1 mRNA CTD PMID:25562108 dexamethasone multiple interactions ISO RGD:1317273 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PIAS1 mRNA CTD PMID:28628672 diarsenic trioxide multiple interactions ISO RGD:1317273 6480464 PIAS1 protein promotes the reaction [Arsenic Trioxide results in increased degradation of PML protein] CTD PMID:22406621 dichloromethane decreases expression EXP 6480464 Methylene Chloride results in decreased expression of PIAS1 mRNA CTD PMID:28392392 dorsomorphin multiple interactions ISO RGD:1317273 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PIAS1 gene CTD PMID:20938992 formaldehyde decreases expression ISO RGD:1317273 6480464 Formaldehyde results in decreased expression of PIAS1 mRNA CTD PMID:20655997 hydrogen peroxide multiple interactions ISO RGD:1317273 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS1 protein CTD PMID:18951874 indometacin multiple interactions ISO RGD:1317273 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PIAS1 mRNA CTD PMID:28628672 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PIAS1 gene CTD PMID:20938992 manganese(II) chloride decreases expression ISO RGD:1307843 6480464 manganese chloride results in decreased expression of PIAS1 mRNA CTD PMID:28801915 manganese(II) chloride decreases expression EXP 6480464 manganese chloride results in decreased expression of PIAS1 mRNA CTD PMID:28801915 manganese(II) chloride increases methylation ISO RGD:1307843 6480464 manganese chloride results in increased methylation of PIAS1 gene CTD PMID:28801915 methylmercury chloride decreases expression ISO RGD:1317273 6480464 methylmercuric chloride results in decreased expression of PIAS1 mRNA CTD PMID:28001369 motexafin gadolinium multiple interactions ISO RGD:1317273 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA] CTD PMID:16357179 motexafin gadolinium increases expression ISO RGD:1317273 6480464 motexafin gadolinium results in increased expression of PIAS1 mRNA CTD PMID:16357179 N-methyl-4-phenylpyridinium increases methylation ISO RGD:1307843 6480464 1-Methyl-4-phenylpyridinium results in increased methylation of PIAS1 gene CTD PMID:28801915 N-methyl-4-phenylpyridinium decreases expression ISO RGD:1307843 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of PIAS1 mRNA CTD PMID:28801915 N-nitrosodiethylamine multiple interactions ISO RGD:1307843 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PIAS1 mRNA CTD PMID:17602206 oxaliplatin multiple interactions ISO RGD:1307843 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PIAS1 mRNA CTD PMID:25729387 paracetamol increases expression ISO RGD:1317273 6480464 Acetaminophen results in increased expression of PIAS1 mRNA CTD PMID:21420995 , PMID:22230336 paracetamol decreases expression ISO RGD:1317273 6480464 Acetaminophen results in decreased expression of PIAS1 mRNA CTD PMID:29067470 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of PIAS1 mRNA CTD PMID:23091169 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of PIAS1 mRNA CTD PMID:21318169 pirinixic acid multiple interactions EXP 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of PIAS1 mRNA] CTD PMID:21318169 potassium chromate multiple interactions ISO RGD:1317273 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PIAS1 mRNA CTD PMID:22079256 potassium chromate decreases expression ISO RGD:1317273 6480464 potassium chromate(VI) results in decreased expression of PIAS1 mRNA CTD PMID:22079256 rifampicin multiple interactions ISO RGD:1317273 6480464 Rifampin inhibits the reaction [trichostatin A inhibits the reaction [[PIAS1 co-treated with SUMO3] inhibits the reaction [NCOR2 protein promotes the reaction [NR1I2 protein binds to HDAC3 protein]]]] CTD PMID:26883953 SB 431542 multiple interactions ISO RGD:1317273 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of PIAS1 mRNA CTD PMID:19073995 sodium arsenate decreases expression EXP 6480464 sodium arsenate results in decreased expression of PIAS1 mRNA CTD PMID:30953684 tert-butyl hydroperoxide decreases expression ISO RGD:1317273 6480464 tert-Butylhydroperoxide results in decreased expression of PIAS1 mRNA CTD PMID:15336504 testosterone multiple interactions ISO RGD:1317273 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of PIAS1 mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:1317273 6480464 Testosterone results in increased expression of PIAS1 mRNA CTD PMID:21592394 theophylline multiple interactions ISO RGD:1317273 6480464 [Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIAS1 protein CTD PMID:18951874 topotecan multiple interactions ISO RGD:1307843 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PIAS1 mRNA CTD PMID:25729387 topotecan decreases expression ISO RGD:1307843 6480464 Topotecan results in decreased expression of PIAS1 mRNA CTD PMID:25729387 trichostatin A decreases expression ISO RGD:1317273 6480464 trichostatin A results in decreased expression of PIAS1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1317273 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:26883953 , PMID:27188386 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of PIAS1 mRNA CTD PMID:28973697 urethane multiple interactions EXP 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of PIAS1 mRNA CTD PMID:12400877 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of PIAS1 mRNA CTD PMID:21427059 valproic acid multiple interactions ISO RGD:1317273 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIAS1 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1317273 6480464 Valproic Acid results in decreased expression of PIAS1 mRNA CTD PMID:23179753 more ... vitamin E decreases expression ISO RGD:1317273 6480464 Vitamin E results in decreased expression of PIAS1 mRNA CTD PMID:19244175 zinc acetate multiple interactions ISO RGD:1317273 6480464 motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA] CTD PMID:16357179 zinc acetate increases expression ISO RGD:1317273 6480464 Zinc Acetate results in increased expression of PIAS1 mRNA CTD PMID:16357179
Biological Process fat cell differentiation IDA 2290270 (MGI:MGI:5619430, PMID:24061474) UniProtKB MGI:MGI:5619430 , PMID:24061474 G1/S transition of mitotic cell cycle ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of apoptotic process ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 negative regulation of transcription by RNA polymerase II IMP 2290270 (MGI:MGI:3604169, PMID:16127449) BHF-UCL MGI:MGI:3604169 , PMID:16127449 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 2290270 (MGI:MGI:5487503, PMID:22406621) UniProtKB MGI:MGI:5487503 , PMID:22406621 positive regulation of protein sumoylation ISO UniProtKB:O75925 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 positive regulation of protein sumoylation ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of smooth muscle cell differentiation ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 positive regulation of transcription, DNA-templated ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein sumoylation ISO UniProtKB:O75925 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 protein sumoylation IBA MGI:MGI:1096566 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein sumoylation IDA 2290270 (MGI:MGI:5487503 more ... UniProtKB MGI:MGI:5487503 more ... protein-DNA complex assembly ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 receptor signaling pathway via JAK-STAT ISO EMBL:AF077951 2290270 (MGI:MGI:1339355, PMID:9724754) MGI MGI:MGI:1339355 , PMID:9724754 regulation of cell population proliferation IMP 2290270 (MGI:MGI:5487503, PMID:22406621) UniProtKB MGI:MGI:5487503 , PMID:22406621 regulation of transcription by RNA polymerase II IBA MGI:MGI:1096566 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 visual learning ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 Cellular Component nucleus IDA 2290270 (MGI:MGI:3663197, PMID:16522640) MGI MGI:MGI:3663197 , PMID:16522640 nucleus IBA FB:FBgn0003612 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 nucleus ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO UniProtKB:O75925 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 PML body colocalizes_with IDA 2290270 (MGI:MGI:5487503, PMID:22406621) UniProtKB MGI:MGI:5487503 , PMID:22406621 Molecular Function DNA binding IEA UniProtKB-KW:KW-0238 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 enzyme binding ISO UniProtKB:O75925 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 metal ion binding IEA UniProtKB-KW:KW-0479 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 protein binding IPI UniProtKB:P29037 2290270 (MGI:MGI:3663197, PMID:16522640) MGI MGI:MGI:3663197 , PMID:16522640 protein binding IPI UniProtKB:P29590-12 2290270 (MGI:MGI:5487503, PMID:22406621) UniProtKB MGI:MGI:5487503 , PMID:22406621 protein binding IPI UniProtKB:Q9Z0P7 2290270 (MGI:MGI:5009176, PMID:14611647) IntAct MGI:MGI:5009176 , PMID:14611647 protein binding IPI UniProtKB:Q505F1 2290270 (MGI:MGI:5919259, PMID:17187077) IntAct MGI:MGI:5919259 , PMID:17187077 protein binding IPI UniProtKB:P37238 2290270 (MGI:MGI:3604169, PMID:16127449) BHF-UCL MGI:MGI:3604169 , PMID:16127449 protein C-terminus binding ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 protein domain specific binding ISO RGD:1307843 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 RNA polymerase II transcription factor binding IBA PANTHER:PTN001324782 , WB:WBGene00001574 2290270 (PMID:21873635) GO_Central PMID:21873635 SUMO ligase activity ISO UniProtKB:O75925 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SUMO ligase activity IBA MGI:MGI:2136940 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 SUMO transferase activity ISO UniProtKB:O75925 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 SUMO transferase activity ISO RGD:1307843 2290270 MGI GO_REF:0000096, MGI:MGI:4417868 transcription coregulator activity IBA MGI:MGI:2136940 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 transcription corepressor activity ISO EMBL:AF077951 2290270 (MGI:MGI:1339355, PMID:9724754) MGI MGI:MGI:1339355 , PMID:9724754 transcription factor binding IPI UniProtKB:P28033 2290270 (MGI:MGI:5619430, PMID:24061474) UniProtKB MGI:MGI:5619430 , PMID:24061474 transferase activity IEA UniProtKB-KW:KW-0808 2290270 UniProtKB GO_REF:0000004, MGI:MGI:1354194 ubiquitin protein ligase binding IPI UniProtKB:Q8CH72 2290270 (MGI:MGI:5009403, PMID:16816390) BHF-UCL MGI:MGI:5009403 , PMID:16816390 zinc ion binding IEA InterPro:IPR004181 2290270 UniProtKB GO_REF:0000002, MGI:MGI:2152098
Gene-Chemical Interaction Annotations
