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ONTOLOGY REPORT - ANNOTATIONS

Term:biogenic amine metabolic process
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Accession:GO:0006576 term browser browse the term
Definition:The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
Synonyms:exact_synonym: biogenic amine metabolism;   cellular biogenic amine metabolic process


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biogenic amine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MECP2 methyl-CpG binding protein 2 acts_upstream_of_or_within ISO (PMID:15975715) MGI PMID:15975715 NCBI chr  X:143,571,864...143,647,192
Ensembl chr  X:153,465,204...153,527,854 		JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase involved_in IEA UniProt GO_REF:0000104 NCBI chr17:72,265,365...72,285,764
Ensembl chr17:77,816,908...77,835,905 		JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr2A:42,857,216...42,882,738
Ensembl chr2A:43,704,468...43,729,887 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:39,149,045...39,209,671
Ensembl chr 8:36,665,240...36,717,420 		JBrowse link
G KMO kynurenine 3-monooxygenase involved_in IEA UniProt GO_REF:0000104 NCBI chr 1:217,094,037...217,157,827
Ensembl chr 1:222,075,268...222,138,866 		JBrowse link
G KYNU kynureninase involved_in IEA UniProt GO_REF:0000104 NCBI chr2B:16,792,401...16,947,766
Ensembl chr2B:146,975,995...147,132,634 		JBrowse link
catecholamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHR2 corticotropin releasing hormone receptor 2 ISO RGD PMID:17194738 RGD:5131263 NCBI chr 7:31,265,619...31,313,902
Ensembl chr 7:31,386,026...31,434,220 		JBrowse link
G DBH dopamine beta-hydroxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697 		JBrowse link
G DDC dopa decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:51,101,169...51,206,031
Ensembl chr 7:51,345,228...51,449,710 		JBrowse link
G HDC histidine decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr15:29,188,296...29,212,327
Ensembl chr15:47,510,629...47,534,577 		JBrowse link
G PNMT phenylethanolamine N-methyltransferase involved_in IEA UniProt GO_REF:0000043 NCBI chr17:17,618,399...17,620,691
Ensembl chr17:17,835,277...17,837,180 		JBrowse link
G TH tyrosine hydroxylase involved_in ISO
IEA		 RGD
InterPro
UniProt		 PMID:20025246 GO_REF:0000002 GO_REF:0000043 RGD:4139888 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433 		JBrowse link
catecholamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase involved_in IEA Ensembl
UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G LOC100967430 leucine-rich repeat-containing protein 51 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:67,160,599...67,189,746
Ensembl chr11:70,392,081...70,412,641 		JBrowse link
catecholamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of
acts_upstream_of_or_within		 ISO (PMID:17511) MGI PMID:17511 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G COMT catechol-O-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11849292) InterPro
MGI
Ensembl
UniProt		 PMID:11849292 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G DDC dopa decarboxylase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:51,101,169...51,206,031
Ensembl chr 7:51,345,228...51,449,710 		JBrowse link
G LOC100967430 leucine-rich repeat-containing protein 51 involved_in IEA UniProt GO_REF:0000043 NCBI chr11:67,160,599...67,189,746
Ensembl chr11:70,392,081...70,412,641 		JBrowse link
G LOC100969764 sulfotransferase 1A1 ISO RGD PMID:6959650 RGD:2301075
G LOC129397680 sulfotransferase 1 family member D1-like involved_in IEA UniProt GO_REF:0000043
G MAOA monoamine oxidase A involved_in IEA UniProt GO_REF:0000043 NCBI chr  X:36,106,680...36,197,907
Ensembl chr  X:43,931,044...44,022,199 		JBrowse link
G MTPN myotrophin ISO RGD PMID:12051753 RGD:625450 NCBI chr 7:127,896,148...127,947,122
Ensembl chr 7:140,392,620...140,443,591 		JBrowse link
dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR1 angiotensin II receptor type 1 ISO RGD PMID:20097214 RGD:6903884 NCBI chr 3:145,722,475...145,767,550
Ensembl chr 3:153,341,947...153,345,380 		JBrowse link
G AGTR2 angiotensin II receptor type 2 ISO RGD PMID:20097214 RGD:6903884 NCBI chr  X:105,252,903...105,257,171
Ensembl chr  X:115,671,594...115,672,685 		JBrowse link
G DAO D-amino acid oxidase involved_in ISO (PMID:17303072)
(PMID:17042912)		 UniProt PMID:17042912 PMID:17303072 NCBI chr12:106,453,807...106,475,409
Ensembl chr12:109,849,995...109,870,065 		JBrowse link
G DDC dopa decarboxylase involved_in ISO
IEA		 RGD
Ensembl		 PMID:12703659 GO_REF:0000107 RGD:4139893 NCBI chr 7:51,101,169...51,206,031
Ensembl chr 7:51,345,228...51,449,710 		JBrowse link
G GCH1 GTP cyclohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:35,428,676...35,489,359
Ensembl chr14:53,706,723...53,767,393 		JBrowse link
G GPR37 G protein-coupled receptor 37 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15218106) Ensembl
MGI		 PMID:15218106 GO_REF:0000107 NCBI chr 7:116,727,912...116,751,647
Ensembl chr 7:129,410,458...129,430,292 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 ISO RGD PMID:12438507 RGD:704388 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G LOC100988273 cytochrome P450 2D6-like ISO RGD PMID:19818757 RGD:5143981 NCBI chr22:23,022,449...23,031,627 JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16782508), (PMID:9608532) Ensembl
MGI		 PMID:9608532 PMID:16782508 GO_REF:0000107 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9520487) Ensembl
MGI		 PMID:9520487 GO_REF:0000107 Ensembl chr 5:1,437,567...1,488,829 JBrowse link
G SNCA synuclein alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10707987) MGI
Ensembl		 PMID:10707987 GO_REF:0000107 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600 		JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (PMID:16257223) UniProt PMID:16257223 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl
UniProt		 GO_REF:0000041 GO_REF:0000107 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433 		JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:9520487)
(PMID:7592982), (PMID:7715703)		 RGD
TreeGrafter
MGI
Ensembl		 PMID:2427363 PMID:7592982 PMID:7715703 PMID:9520487 PMID:19584816 GO_REF:0000107 GO_REF:0000118 RGD:1580046 RGD:5130972 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433 		JBrowse link
dopamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9520487) Ensembl
MGI		 PMID:9520487 GO_REF:0000107 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G DBH dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10051631) Ensembl
TreeGrafter
MGI		 PMID:10051631 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697 		JBrowse link
G MAOA monoamine oxidase A acts_upstream_of_or_within ISO (PMID:9520487) MGI PMID:9520487 NCBI chr  X:36,106,680...36,197,907
Ensembl chr  X:43,931,044...44,022,199 		JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:130,073,802...130,177,753
Ensembl chr 6:134,179,412...134,285,995 		JBrowse link
G PDE1B phosphodiesterase 1B acts_upstream_of_positive_effect ISO (PMID:17559891) MGI PMID:17559891 NCBI chr12:34,167,801...34,198,049 JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9520487) Ensembl
MGI		 PMID:9520487 GO_REF:0000107 Ensembl chr 5:1,437,567...1,488,829 JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 involved_in ISO (PMID:23207770) CAFA PMID:23207770
dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:1752214), (PMID:8174230) MGI PMID:1752214 PMID:8174230 MGI:71923 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G COMT catechol-O-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23863468)
(PMID:11849292), (PMID:17881525), (PMID:19770404), (PMID:22169008), (PMID:24591155)
(PMID:27388330)		 Ensembl
UniProt
TreeGrafter
MGI		 PMID:11849292 PMID:17881525 PMID:19770404 PMID:22169008 PMID:23863468 More... GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G DRD2 dopamine receptor D2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7925842) Ensembl
MGI		 PMID:7925842 GO_REF:0000107 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G GNAT2 G protein subunit alpha transducin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:32049342) Ensembl
MGI		 PMID:32049342 GO_REF:0000107 NCBI chr 1:111,980,855...111,990,686
Ensembl chr 1:111,208,510...111,225,808 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11160454) Ensembl
MGI		 PMID:11160454 GO_REF:0000107 NCBI chr16:8,682,169...9,105,581
Ensembl chr16:9,919,143...10,336,167 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:1432691), (PMID:7509865), (PMID:9886073) MGI
Ensembl		 PMID:1432691 PMID:7509865 PMID:9886073 GO_REF:0000107 NCBI chr  X:123,609,248...123,650,102
Ensembl chr  X:133,916,681...133,948,197 		JBrowse link
G LOC100967430 leucine-rich repeat-containing protein 51 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:67,160,599...67,189,746
Ensembl chr11:70,392,081...70,412,641 		JBrowse link
G LOC100988273 cytochrome P450 2D6-like ISO RGD PMID:10945868 RGD:1599723 NCBI chr22:23,022,449...23,031,627 JBrowse link
G MYO5A myosin VA ISO RGD PMID:29217155 RGD:42721980 NCBI chr15:31,246,192...31,470,040
Ensembl chr15:49,578,491...49,704,319 		JBrowse link
G NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 acts_upstream_of_or_within ISO (PMID:28327638) MGI PMID:28327638 NCBI chr 5:60,344,363...60,467,008
Ensembl chr 5:61,966,124...62,088,375 		JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO RGD PMID:15544851 RGD:1580153 NCBI chr 1:129,034,972...129,050,439
Ensembl chr 1:132,664,948...132,679,327 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12385813) Ensembl
MGI		 PMID:12385813 GO_REF:0000107 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within		 IEA
ISO		 (PMID:12915482)
(PMID:15684050)		 Ensembl
MGI		 PMID:12915482 PMID:15684050 GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase acts_upstream_of_or_within ISO (PMID:21178975) MGI PMID:21178975 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
G SLC1A1 solute carrier family 1 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,323,124...4,420,193
Ensembl chr 9:4,511,491...4,608,337 		JBrowse link
G SNCA synuclein alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15465911) MGI
Ensembl		 PMID:15465911 GO_REF:0000107 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600 		JBrowse link
G SNCAIP synuclein alpha interacting protein acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14506261) MGI
Ensembl		 PMID:14506261 GO_REF:0000107 NCBI chr 5:117,692,836...117,847,221
Ensembl chr 5:123,555,073...123,630,921 		JBrowse link
G SNCB synuclein beta involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15465911) Ensembl
MGI		 PMID:15465911 GO_REF:0000107 NCBI chr 5:171,918,297...171,928,672
Ensembl chr 5:178,988,439...178,998,800 		JBrowse link
G SPR sepiapterin reductase acts_upstream_of_or_within ISO (PMID:16532389) MGI PMID:16532389 NCBI chr2A:72,939,621...72,944,669
Ensembl chr2A:74,433,056...74,438,105 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 involved_in ISO (PMID:24136195) CAFA PMID:24136195
epinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:7914070 RGD:4139902 NCBI chr17:17,618,399...17,620,691
Ensembl chr17:17,835,277...17,837,180 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433 		JBrowse link
epinephrine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:1752214) MGI PMID:1752214 MGI:71923 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase acts_upstream_of_or_within ISO (PMID:21178975) MGI PMID:21178975 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
ethanolamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHKA choline kinase alpha ISO RGD PMID:1577786 RGD:61551 NCBI chr11:63,134,776...63,202,516
Ensembl chr11:66,444,406...66,510,221 		JBrowse link
G GDE1 glycerophosphodiester phosphodiesterase 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:18,789,681...18,809,783
Ensembl chr16:19,602,611...19,623,041 		JBrowse link
histamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDC histidine decarboxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11478947) Ensembl
TreeGrafter
MGI		 PMID:11478947 GO_REF:0000107 GO_REF:0000118 NCBI chr15:29,188,296...29,212,327
Ensembl chr15:47,510,629...47,534,577 		JBrowse link
G PRG3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,617,688...52,622,058
Ensembl chr 3:160,108,051...160,112,421 		JBrowse link
histamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNMT histamine N-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315 		JBrowse link
histamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDC histidine decarboxylase ISO RGD PMID:5898 PMID:4449071 PMID:7075603 PMID:9525922 RGD:2303726 RGD:2303727 RGD:2303728 RGD:2303735 NCBI chr15:29,188,296...29,212,327
Ensembl chr15:47,510,629...47,534,577 		JBrowse link
G HNMT histamine N-methyltransferase involved_in IEA
ISO		 Ensembl
RGD		 PMID:15739896 GO_REF:0000107 RGD:152985534 NCBI chr2B:21,840,342...21,892,744
Ensembl chr2B:142,036,321...142,088,315 		JBrowse link
G TRH thyrotropin releasing hormone involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:17760865 GO_REF:0000118 RGD:7241067 NCBI chr 3:127,037,069...127,041,299
Ensembl chr 3:134,383,016...134,387,736 		JBrowse link
N-acylethanolamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD4 abhydrolase domain containing 4, N-acyl phospholipase B acts_upstream_of_or_within ISO (PMID:16818490) MGI PMID:16818490 NCBI chr14:3,434,357...3,448,471
Ensembl chr14:21,535,753...21,549,856 		JBrowse link
G GDE1 glycerophosphodiester phosphodiesterase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25596343) Ensembl
TreeGrafter
MGI		 PMID:25596343 GO_REF:0000107 GO_REF:0000118 NCBI chr16:18,789,681...18,809,783
Ensembl chr16:19,602,611...19,623,041 		JBrowse link
G GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:25596343) MGI
TreeGrafter
Ensembl		 PMID:25596343 GO_REF:0000107 GO_REF:0000118 NCBI chr17:53,290,496...53,345,584
Ensembl chr17:58,138,432...58,191,986 		JBrowse link
G GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:30,479,684...30,488,868 JBrowse link
G NAAA N-acylethanolamine acid amidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:48,264,567...48,294,872
Ensembl chr 4:54,102,384...54,128,776 		JBrowse link
G NAPEPLD N-acyl phosphatidylethanolamine phospholipase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16818490)
(PMID:14634025)		 Ensembl
TreeGrafter
MGI		 PMID:14634025 PMID:16818490 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:95,074,084...95,123,936
Ensembl chr 7:107,923,960...107,973,269 		JBrowse link
negative regulation of catecholamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:17511) MGI PMID:17511 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G NT5DC2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr 3:52,466,032...52,475,396
Ensembl chr 3:53,694,113...53,706,537 		JBrowse link
negative regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5DC2 5'-nucleotidase domain containing 2 involved_in ISO PMID:31279527 UniProt PMID:31279527 RGD:408345212 NCBI chr 3:52,466,032...52,475,396
Ensembl chr 3:53,694,113...53,706,537 		JBrowse link
negative regulation of dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase ISO RGD PMID:15190105 RGD:2289786 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:17018023 RGD:1625003 NCBI chr  X:103,673,172...103,999,133
Ensembl chr  X:114,199,485...114,503,201 		JBrowse link
G ITGAM integrin subunit alpha M involved_in ISO (PMID:18981141) ARUK-UCL PMID:18981141 NCBI chr16:23,634,476...23,707,147
Ensembl chr16:31,630,146...31,702,406 		JBrowse link
G SNCA synuclein alpha involved_in ISO PMID:11943812 BHF-UCL PMID:11943812 RGD:5129111 NCBI chr 4:82,018,585...82,132,938
Ensembl chr 4:92,737,608...92,850,600 		JBrowse link
nor-spermidine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,657,166...7,658,773
Ensembl chr17:7,643,490...7,645,127 		JBrowse link
norepinephrine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:4405722)
(PMID:4858102)		 MGI PMID:4405722 PMID:4858102 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G DBH dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:10051631), (PMID:9603211) RGD
TreeGrafter
MGI
Ensembl
UniProt		 PMID:9603211 PMID:10051631 PMID:10573542 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 RGD:1625403 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10835639) Ensembl
MGI		 PMID:10835639 GO_REF:0000107 NCBI chr10:8,075,951...8,105,573
Ensembl chr10:8,064,207...8,086,272 		JBrowse link
G HAND2 heart and neural crest derivatives expressed 2 acts_upstream_of_positive_effect ISO (PMID:19008477) BHF-UCL PMID:19008477 NCBI chr 4:165,755,000...165,758,735 JBrowse link
G INSM1 INSM transcriptional repressor 1 involved_in ISO (PMID:18094025) UniProt PMID:18094025 NCBI chr20:20,317,060...20,320,051 JBrowse link
G KL klotho ISO RGD PMID:20086041 RGD:10403068 NCBI chr13:14,272,463...14,321,122
Ensembl chr13:32,702,336...32,751,458 		JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:130,073,802...130,177,753
Ensembl chr 6:134,179,412...134,285,995 		JBrowse link
G TH tyrosine hydroxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,204,820...2,212,750
Ensembl chr11:2,231,248...2,242,433 		JBrowse link
norepinephrine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B1 aldo-keto reductase family 1 member B ISO RGD PMID:10424772 RGD:8548769 NCBI chr 7:126,400,861...126,417,756
Ensembl chr 7:138,912,953...138,924,095 		JBrowse link
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:4147174) MGI PMID:4147174 MGI:71923 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G COMT catechol-O-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11849292), (PMID:24591155) Ensembl
MGI		 PMID:11849292 PMID:24591155 GO_REF:0000107 NCBI chr22:2,704,015...2,731,326
Ensembl chr22:18,375,434...18,402,387 		JBrowse link
G EDNRA endothelin receptor type A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:139,815,336...139,879,600
Ensembl chr 4:151,476,356...151,536,497 		JBrowse link
G EPAS1 endothelial PAS domain protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9808618) Ensembl
MGI		 PMID:9808618 GO_REF:0000107 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560 		JBrowse link
G LY6E lymphocyte antigen 6 family member E acts_upstream_of_or_within ISO (PMID:11784869) MGI PMID:11784869
G PNMT phenylethanolamine N-methyltransferase ISO RGD PMID:3945626 RGD:5130757 NCBI chr17:17,618,399...17,620,691
Ensembl chr17:17,835,277...17,837,180 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15249681) Ensembl
MGI		 PMID:15249681 GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G RNF180 ring finger protein 180 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23926250) Ensembl
TreeGrafter
MGI		 PMID:23926250 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:49,624,452...49,841,741
Ensembl chr 5:51,280,064...51,454,750 		JBrowse link
G RNLS renalase, FAD dependent amine oxidase acts_upstream_of_or_within ISO (PMID:21178975) MGI PMID:21178975 NCBI chr10:84,996,999...85,304,240
Ensembl chr10:88,503,683...88,808,990 		JBrowse link
G RTL4 retrotransposon Gag like 4 acts_upstream_of_or_within ISO (PMID:26402067) MGI PMID:26402067 NCBI chr  X:101,191,619...101,570,815 JBrowse link
G SLITRK1 SLIT and NTRK like family member 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:36085162) MGI
Ensembl		 PMID:36085162 GO_REF:0000107 NCBI chr13:65,081,844...65,087,135
Ensembl chr13:84,253,287...84,256,069 		JBrowse link
G SPR sepiapterin reductase acts_upstream_of_or_within ISO (PMID:16532389) MGI PMID:16532389 NCBI chr2A:72,939,621...72,944,669
Ensembl chr2A:74,433,056...74,438,105 		JBrowse link
octopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697 		JBrowse link
G MOXD1 monooxygenase DBH like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:130,073,802...130,177,753
Ensembl chr 6:134,179,412...134,285,995 		JBrowse link
octopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBH dopamine beta-hydroxylase ISO RGD PMID:11521740 RGD:1625401 NCBI chr 9:104,761,504...104,784,445
Ensembl chr 9:133,371,821...133,393,697 		JBrowse link
phenylethylamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAOB monoamine oxidase B ISO RGD PMID:18539264 RGD:2316732 NCBI chr  X:36,217,710...36,333,516
Ensembl chr  X:44,042,000...44,157,941 		JBrowse link
phenylethylamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAOA monoamine oxidase A ISO Y402A, Y407A, Y410A had an impact on the properties of the protein while Y402F, Y410F had little effect; the residues are near the C406 FAD binding site RGD PMID:11754741 RGD:1600709 NCBI chr  X:36,106,680...36,197,907
Ensembl chr  X:43,931,044...44,022,199 		JBrowse link
polyamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AZIN1 antizyme inhibitor 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:99,483,027...99,521,151
Ensembl chr 8:101,639,950...101,678,604 		JBrowse link
G AZIN2 antizyme inhibitor 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:32,365,430...32,404,880
Ensembl chr 1:33,550,140...33,589,402 		JBrowse link
G LOC100993236 spermidine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr17:1,320,610...1,321,800 JBrowse link
G LOC129398401 spermine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104
G OAZ1 ornithine decarboxylase antizyme 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:1,279,139...1,283,079
Ensembl chr19:2,250,678...2,254,179 		JBrowse link
G ODC1 ornithine decarboxylase 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr2A:10,443,308...10,451,412
Ensembl chr2A:10,598,125...10,607,152 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:16,382,735...16,385,790
Ensembl chr  X:23,756,691...23,760,349 		JBrowse link
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in ISO (PMID:15283699) UniProt PMID:15283699 NCBI chr17:7,657,166...7,658,773
Ensembl chr17:7,643,490...7,645,127 		JBrowse link
G SMS spermine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr  X:14,571,432...14,625,601
Ensembl chr  X:21,949,830...21,980,209 		JBrowse link
G SRM spermidine synthase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chr 1:9,817,765...9,823,244 JBrowse link
polyamine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAOX polyamine oxidase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12660232) RGD
MGI
Ensembl		 PMID:12660232 PMID:15541750 GO_REF:0000107 RGD:7244190 Ensembl chr10:134,294,760...134,307,179 JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:15541750 RGD:7244190 NCBI chr  X:16,382,735...16,385,790
Ensembl chr  X:23,756,691...23,760,349 		JBrowse link
G SMOX spermine oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:4,167,417...4,206,956
Ensembl chr20:3,965,616...4,004,468 		JBrowse link
polyamine deacetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC10 histone deacetylase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:30,473,753...30,481,369
Ensembl chr22:49,473,369...49,479,216 		JBrowse link
G HDAC6 histone deacetylase 6 NOT|involved_in ISO (PMID:28516954) UniProt PMID:28516954 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642 		JBrowse link
polyamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 ISO RGD PMID:10430362 RGD:1578320 NCBI chr 6:108,678,741...108,699,695
Ensembl chr 6:112,761,072...112,782,074 		JBrowse link
G LOC100993236 spermidine synthase involved_in IEA InterPro GO_REF:0000002 NCBI chr17:1,320,610...1,321,800 JBrowse link
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:10430362 RGD:1578320 NCBI chr2A:10,443,308...10,451,412
Ensembl chr2A:10,598,125...10,607,152 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 ISO RGD PMID:11172929 RGD:1599544 NCBI chr  X:16,382,735...16,385,790
Ensembl chr  X:23,756,691...23,760,349 		JBrowse link
G SRM spermidine synthase involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:9,817,765...9,823,244 JBrowse link
positive regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EPAS1 endothelial PAS domain protein 1 ISO RGD PMID:19457096 RGD:5128877 NCBI chr2A:46,403,411...46,492,734
Ensembl chr2A:47,332,308...47,421,560 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
G VPS35 VPS35 retromer complex component involved_in ISO (PMID:26203154) ParkinsonsUK-UCL PMID:26203154 NCBI chr16:26,924,901...26,954,443
Ensembl chr16:45,817,371...45,846,531 		JBrowse link
positive regulation of dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABAT 4-aminobutyrate aminotransferase ISO RGD PMID:11239920 RGD:10047061 NCBI chr16:7,609,282...7,718,049
Ensembl chr16:8,888,178...8,958,420 		JBrowse link
G GPR37 G protein-coupled receptor 37 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15218106) Ensembl
MGI		 PMID:15218106 GO_REF:0000107 NCBI chr 7:116,727,912...116,751,647
Ensembl chr 7:129,410,458...129,430,292 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:123,609,248...123,650,102
Ensembl chr  X:133,916,681...133,948,197 		JBrowse link
G MAOB monoamine oxidase B ISO RGD PMID:12175458 RGD:2316765 NCBI chr  X:36,217,710...36,333,516
Ensembl chr  X:44,042,000...44,157,941 		JBrowse link
G NPY neuropeptide Y ISO RGD PMID:19579268 RGD:10448966 NCBI chr 7:24,963,056...24,970,803
Ensembl chr 7:24,568,041...24,574,657 		JBrowse link
positive regulation of spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAOX polyamine oxidase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:134,294,760...134,307,179 JBrowse link
putrescine acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,657,166...7,658,773
Ensembl chr17:7,643,490...7,645,127 		JBrowse link
putrescine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ODC1 ornithine decarboxylase 1 ISO RGD PMID:1415709 PMID:10430362 RGD:1578320 RGD:7242912 NCBI chr2A:10,443,308...10,451,412
Ensembl chr2A:10,598,125...10,607,152 		JBrowse link
G PAOX polyamine oxidase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:134,294,760...134,307,179 JBrowse link
putrescine biosynthetic process from arginine, via agmatine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGMAT agmatinase (putative) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:14,711,891...14,723,546
Ensembl chr 1:15,704,989...15,717,428 		JBrowse link
putrescine biosynthetic process from arginine, via ornithine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AZIN1 antizyme inhibitor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:99,483,027...99,521,151
Ensembl chr 8:101,639,950...101,678,604 		JBrowse link
G AZIN2 antizyme inhibitor 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:32,365,430...32,404,880
Ensembl chr 1:33,550,140...33,589,402 		JBrowse link
G ODC1 ornithine decarboxylase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2A:10,443,308...10,451,412
Ensembl chr2A:10,598,125...10,607,152 		JBrowse link
putrescine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAOX polyamine oxidase involved_in IEA Ensembl GO_REF:0000107 Ensembl chr10:134,294,760...134,307,179 JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr  X:16,382,735...16,385,790
Ensembl chr  X:23,756,691...23,760,349 		JBrowse link
putrescine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:142,434,732...142,443,050
Ensembl chr 7:154,563,523...154,595,248 		JBrowse link
regulation of catecholamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VHL von Hippel-Lindau tumor suppressor ISO RGD PMID:11912140 RGD:619592 NCBI chr 3:10,077,630...10,089,499
Ensembl chr 3:10,430,143...10,440,234 		JBrowse link
regulation of dopamine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH2 aldehyde dehydrogenase 2 family member involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:109,343,020...109,385,060
Ensembl chr12:112,734,243...112,776,471 		JBrowse link
regulation of dopamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11282258) MGI PMID:11282258 NCBI chr 1:129,922,740...129,931,582
Ensembl chr 1:133,535,023...133,547,361 		JBrowse link
G DRD1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11438590) Ensembl
MGI		 PMID:11438590 GO_REF:0000107 NCBI chr 5:170,787,115...170,792,383
Ensembl chr 5:177,688,917...177,690,257 		JBrowse link
G DRD4 dopamine receptor D4 acts_upstream_of_or_within ISO (PMID:9323127) MGI PMID:9323127 NCBI chr11:640,401...646,775 JBrowse link
G HTR1A 5-hydroxytryptamine receptor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:50,045,266...50,049,636
Ensembl chr 5:51,692,416...51,693,684 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12915123) Ensembl
MGI		 PMID:12915123 GO_REF:0000107 NCBI chr2B:43,584,835...43,593,118
Ensembl chr2B:160,826,091...160,837,162 		JBrowse link
G PNKD PNKD metallo-beta-lactamase domain containing involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22214848) Ensembl
MGI		 PMID:22214848 GO_REF:0000107 NCBI chr2B:105,529,775...105,606,207
Ensembl chr2B:224,127,504...224,204,046 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:159,293,016...160,679,106
Ensembl chr 6:164,314,990...165,678,770 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9247269), (PMID:9520487) Ensembl
MGI		 PMID:9247269 PMID:9520487 GO_REF:0000107 Ensembl chr 5:1,437,567...1,488,829 JBrowse link
G TACR3 tachykinin receptor 3 ISO RGD PMID:8574643 RGD:2305963 NCBI chr 4:96,022,788...96,162,249
Ensembl chr 4:106,644,943...106,776,172 		JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100988273 cytochrome P450 2D6-like ISO RGD PMID:23098818 RGD:11353778 NCBI chr22:23,022,449...23,031,627 JBrowse link
spermidine acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SAT1 spermidine/spermine N1-acetyltransferase 1 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:15541750 GO_REF:0000107 GO_REF:0000118 RGD:7244190 NCBI chr  X:16,382,735...16,385,790
Ensembl chr  X:23,756,691...23,760,349 		JBrowse link
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 NOT|involved_in ISO
IEA		 (PMID:15283699) UniProt
Ensembl		 PMID:15283699 GO_REF:0000107 NCBI chr17:7,657,166...7,658,773
Ensembl chr17:7,643,490...7,645,127 		JBrowse link
G SATL1 spermidine/spermine N1-acetyl transferase like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:74,163,746...74,314,004 JBrowse link
spermidine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro		 PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000043 GO_REF:0000118 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr 6:108,678,741...108,699,695
Ensembl chr 6:112,761,072...112,782,074 		JBrowse link
G LOC100993236 spermidine synthase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:1,320,610...1,321,800 JBrowse link
G SRM spermidine synthase involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:8494549 PMID:12843627 PMID:16931179 GO_REF:0000118 RGD:1359042 RGD:7242920 RGD:7242928 NCBI chr 1:9,817,765...9,823,244 JBrowse link
spermidine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHPS deoxyhypusine synthase ISO RGD PMID:7721768 RGD:2316236 NCBI chr19:12,237,882...12,243,903
Ensembl chr19:12,983,106...12,989,193 		JBrowse link
G PAOX polyamine oxidase involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl		 PMID:7560898 GO_REF:0000107 GO_REF:0000118 RGD:7244191 Ensembl chr10:134,294,760...134,307,179 JBrowse link
spermidine deacetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC10 histone deacetylase 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:30,473,753...30,481,369
Ensembl chr22:49,473,369...49,479,216 		JBrowse link
G HDAC6 histone deacetylase 6 NOT|involved_in ISO (PMID:28516954) UniProt PMID:28516954 NCBI chr  X:41,099,539...41,122,650
Ensembl chr  X:48,960,430...48,982,642 		JBrowse link
spermidine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHPS deoxyhypusine synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:12,237,882...12,243,903
Ensembl chr19:12,983,106...12,989,193 		JBrowse link
spermine acetylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SAT2 spermidine/spermine N1-acetyltransferase family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,657,166...7,658,773
Ensembl chr17:7,643,490...7,645,127 		JBrowse link
spermine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMD1 adenosylmethionine decarboxylase 1 involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:1415709 PMID:10430362 PMID:10712236 GO_REF:0000002 GO_REF:0000118 RGD:1578320 RGD:7242911 RGD:7242912 NCBI chr 6:108,678,741...108,699,695
Ensembl chr 6:112,761,072...112,782,074 		JBrowse link
G LOC129398401 spermine synthase involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118
G SMS spermine synthase involved_in ISO
IEA		 RGD
TreeGrafter
InterPro		 PMID:8494549 GO_REF:0000002 GO_REF:0000118 RGD:7242928 NCBI chr  X:14,571,432...14,625,601
Ensembl chr  X:21,949,830...21,980,209 		JBrowse link
spermine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAOX polyamine oxidase involved_in ISO
IEA		 RGD
Ensembl		 PMID:7560898 GO_REF:0000107 RGD:7244191 Ensembl chr10:134,294,760...134,307,179 JBrowse link
G SMOX spermine oxidase involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:12141946) RGD
TreeGrafter
MGI
Ensembl		 PMID:12141946 PMID:15541750 GO_REF:0000107 GO_REF:0000118 RGD:7244190 NCBI chr20:4,167,417...4,206,956
Ensembl chr20:3,965,616...4,004,468 		JBrowse link
spermine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SMS spermine synthase acts_upstream_of_or_within ISO (PMID:9467015) MGI PMID:9467015 NCBI chr  X:14,571,432...14,625,601
Ensembl chr  X:21,949,830...21,980,209 		JBrowse link
tryptophan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase ISO RGD PMID:11802786 RGD:70243 NCBI chr2B:24,958,661...25,019,901
Ensembl chr2B:138,918,281...138,978,407 		JBrowse link
G AFMID arylformamidase involved_in IEA UniProt GO_REF:0000043 NCBI chr17:72,265,365...72,285,764
Ensembl chr17:77,816,908...77,835,905 		JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA UniProt GO_REF:0000104 NCBI chr2A:42,857,216...42,882,738
Ensembl chr2A:43,704,468...43,729,887 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 involved_in IEA UniProt GO_REF:0000043 GO_REF:0000117 NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 involved_in IEA UniProt GO_REF:0000043 GO_REF:0000117 NCBI chr 8:39,149,045...39,209,671
Ensembl chr 8:36,665,240...36,717,420 		JBrowse link
G IL4I1 interleukin 4 induced 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,902,656...46,942,213
Ensembl chr19:55,819,080...55,858,389 		JBrowse link
G KMO kynurenine 3-monooxygenase involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 1:217,094,037...217,157,827
Ensembl chr 1:222,075,268...222,138,866 		JBrowse link
G KYNU kynureninase involved_in IEA Ensembl
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 NCBI chr2B:16,792,401...16,947,766
Ensembl chr2B:146,975,995...147,132,634 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase involved_in IEA UniProt GO_REF:0000043 GO_REF:0000117 NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266 		JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYNU kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chr2B:16,792,401...16,947,766
Ensembl chr2B:146,975,995...147,132,634 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:7236232 GO_REF:0000118 RGD:2303721 NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266 		JBrowse link
tryptophan catabolic process to indole-3-acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4I1 interleukin 4 induced 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,902,656...46,942,213
Ensembl chr19:55,819,080...55,858,389 		JBrowse link
tryptophan catabolic process to kynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15866519) InterPro
UniProt
MGI		 PMID:15866519 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 NCBI chr17:72,265,365...72,285,764
Ensembl chr17:77,816,908...77,835,905 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:11751753), (PMID:2419335) RGD
TreeGrafter
UniProt
MGI
InterPro
Ensembl		 PMID:2419335 PMID:10719243 PMID:11513477 PMID:11751753 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:2290190 RGD:2290543 NCBI chr 8:39,108,310...39,123,611
Ensembl chr 8:36,617,312...36,632,352 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17671174)
(PMID:17499941)		 Ensembl
TreeGrafter
UniProt
MGI
InterPro		 PMID:17499941 PMID:17671174 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:39,149,045...39,209,671
Ensembl chr 8:36,665,240...36,717,420 		JBrowse link
G KYNU kynureninase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:16,792,401...16,947,766
Ensembl chr2B:146,975,995...147,132,634 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase involved_in IEA InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266 		JBrowse link
tryptophan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:4147174) MGI PMID:4147174 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G TDO2 tryptophan 2,3-dioxygenase ISO RGD PMID:3400092 PMID:3899109 PMID:10719243 RGD:2290190 RGD:2290313 RGD:2291804 NCBI chr 4:148,269,097...148,285,533
Ensembl chr 4:160,085,645...160,102,266 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16644
    cellular process 16207
      metabolic process 10770
        amine metabolic process 117
          biogenic amine metabolic process 106
            biogenic amine biosynthetic process + 42
            catecholamine metabolic process + 67
            ethanolamine-containing compound metabolic process + 9
            histamine metabolic process + 4
            indolalkylamine metabolic process + 11
            nicotianamine metabolic process + 0
            phenylethylamine metabolic process + 2
            polyamine metabolic process + 19
paths to the root