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Gene: AGMAT (agmatinase (putative)) Pan paniscus

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Symbol:

AGMAT

Name:

agmatinase (putative)

RGD ID:

11926409

Description:

ENCODES a protein that exhibits agmatinase activity (inferred); arginase activity (inferred); guanidinobutyrase activity (inferred); INVOLVED IN putrescine biosynthetic process from arginine, via agmatine (inferred); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); Hereditary Pancreatitis (ortholog); FOUND IN mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

agmatinase; agmatinase, mitochondrial; guanidino acid hydrolase, mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AGMAT (agmatinase (putative))	NCBI	Ortholog
Mus musculus (house mouse):	Agmat (agmatinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Agmat (agmatinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Agmat (agmatinase (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AGMAT (agmatinase (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Agmat (agmatinase (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AGMAT (agmatinase (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AGMAT (agmatinase (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Agmat (agmatinase (putative))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	211,334,719 - 211,348,138 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	210,583,175 - 210,596,607 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	14,711,891 - 14,723,546 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	15,704,983 - 15,717,428 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	15,704,989 - 15,717,428 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

Hereditary Pancreatitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

putrescine biosynthetic process from arginine, via agmatine (IEA)

Cellular Component

mitochondrion (ISO)

Molecular Function

agmatinase activity (IEA)

arginase activity (IEA)

guanidinobutyrase activity (IEA)

guanidinopropionase activity (IEA)

hydrolase activity (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (IEA)

metal ion binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

AGMAT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	211,334,719 - 211,348,138 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	210,583,175 - 210,596,607 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	14,711,891 - 14,723,546 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	15,704,983 - 15,717,428 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	15,704,989 - 15,717,428 (-)	Ensembl	panpan1.1		panPan2

AGMAT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	15,571,699 - 15,585,051 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	15,571,699 - 15,585,051 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	15,898,194 - 15,911,546 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	15,771,739 - 15,784,192 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	15,644,457 - 15,656,911	NCBI
Celera	1	14,382,018 - 14,394,470 (-)	NCBI		Celera
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	14,417,633 - 14,431,067 (-)	NCBI		HuRef
CHM1_1	1	15,696,867 - 15,710,276 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	15,016,395 - 15,029,763 (-)	NCBI		T2T-CHM13v2.0

Agmat
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	141,473,986 - 141,486,574 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	141,473,983 - 141,486,574 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	141,746,675 - 141,759,263 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	141,746,672 - 141,759,263 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	141,302,590 - 141,315,178 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	141,018,751 - 141,031,339 (+)	NCBI		MGSCv36	mm8
Celera	4	143,570,879 - 143,584,214 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	74.75	NCBI

Agmat
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	159,326,680 - 159,357,300 (+)	NCBI		GRCr8
mRatBN7.2	5	154,043,665 - 154,074,278 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	154,060,151 - 154,074,276 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	156,745,200 - 156,759,284 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	158,518,486 - 158,532,576 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	158,507,648 - 158,521,740 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	160,306,754 - 160,321,951 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	160,306,727 - 160,321,066 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	164,019,284 - 164,033,407 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	160,646,314 - 160,660,437 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	160,656,515 - 160,670,614 (+)	NCBI
Celera	5	152,413,017 - 152,427,142 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Agmat
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955527	2,563,194 - 2,572,283 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955527	2,563,705 - 2,572,421 (+)	NCBI	ChiLan1.0	ChiLan1.0

AGMAT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	81,980,959 - 81,990,377 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	81,981,376 - 81,989,916 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	78,518,550 - 78,527,487 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	82,630,376 - 82,639,406 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	82,630,021 - 82,639,219 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	79,382,696 - 79,391,644 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	80,401,119 - 80,410,133 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	81,466,554 - 81,475,514 (+)	NCBI		UU_Cfam_GSD_1.0

Agmat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	37,417,396 - 37,427,642 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	3,238,447 - 3,252,272 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	3,242,185 - 3,252,231 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AGMAT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	74,773,324 - 74,784,457 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	74,773,359 - 74,784,486 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	69,199,980 - 69,211,320 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AGMAT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	116,710,261 - 116,721,997 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	116,710,578 - 116,722,125 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	20,250,544 - 20,262,209 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Agmat
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	1,843,227 - 1,853,350 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	1,839,667 - 1,853,344 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003806256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000031623 ⟹ ENSPPAP00000008983

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	15,704,989 - 15,717,428 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000031625 ⟹ ENSPPAP00000008985

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	15,705,327 - 15,717,290 (-)	Ensembl

RefSeq Acc Id:

XM_003806256 ⟹ XP_003806304

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	211,334,719 - 211,348,138 (+)	NCBI
NHGRI_mPanPan1	1	210,583,175 - 210,596,607 (+)	NCBI
Mhudiblu_PPA_v0	1	14,711,891 - 14,723,546 (-)	NCBI
PanPan1.1	1	15,704,983 - 15,717,428 (-)	NCBI

Sequence:

show sequence

TCCCAGGGCGCCCCTGACCTTTGAGCCGGCTCGGGTTCCGGCTCTGGCGCGTGCACACTCGCCT
CGCCGTTCGGGACCAGCCAGATCGCGGCGGCCTCGCGGGCGGTCTGGTCGGTGAGGTCTTGGCC
GCGCGCGGCAATGCTGAGGCTGCTGGCGTCCGGGTGCGCCCGGGGCCCGGGCCCCGGCGTGGGC
GCGCGTCCTGCCGCAGGGCTCTTTCACCCGGGGCGCCGCCAGAGCCGCCAGGCTTCCGACGCGC
CCCGGAACCAGCCCCCCAGCCCCGAGTTCGTGGCCCGGCCGGTGGGCGTCTGCTCCATGATGCG
CCTGCCGGTGCAGACCTCCCCCGAGGGGCTGGACGCTGCCTTCATCGGGGTGCCCCTGGATACT
GGGACCTCCAACCGGCCTGGGGCGAGATTCGGACCTCGCCGCATCCGGGAAGAATCAGTGATGC
TTCGGACAGTCAATCCTAGCACGGGGGCCCTCCCCTTCCAGTCCCTCATGGTTGCAGACCTAGG
CGATGTGAATGTCAATCTTTACAACCTTCAGGACAGCTGCCGGCGAATTCAAGAGGCCTATGAG
AAAATTGTAGCAGCTGGCTGTATTCCTCTGACCTTGGGTGGAGATCACACAATCACATATCCCA
TATTGCAAGCGATGGCAAAAAAGCATGGCCCAGTGGGGCTGCTGCATGTGGACGCACACACGGA
CACGACCGACAAGGCCCTAGGAGAGAAGCTCTACCACGGGGCGCCCTTCCGCCGGTGTGTGGAT
GAGGGTCTCCTGGACTGTAAGCGTGTGGTGCAGATTGGCATCCGGGGCTCTTCCACGACCTTGG
ATCCCTACAGATACAACCGGAGCCAGGGCTTCCGGGTAGTCCTGGCTGAAGACTGCTGGATGAA
GTCGTTGGTTCCTCTGATGGGGGAAGTCAGGCAGCAGATGGGAGGCAAACCCATTTATATCAGC
TTTGATATTGACGCTCTGGATCCTGCCTATGCGCCAGGGACAGGGACACCTGAAATTGCTGGTC
TCACTCCTAGTCAGGCTCTGGAGATCATCAGGGGTTGTCAAGGCCTGAACGTGGTGGGCTGTGA
TCTTGTCGAAGTTTCACCACCGTATGATCTTTCTGGGAACACAGCCCTGCTGGCGGCTAACCTG
CTGTTTGAGATGCTGTGTGCTCTCCCCAAAGTGACAACCGTCTGAGTCTTGTGCTCTTCAAGAC
AAAACAGATTGCGTCGCTCACAAGTTCTCAAGAAGAACTTATGAGTAAGCAGTCTGAGAACTAA
AGAGTTTATGCCAAGAAAACTTTCTGCTGAAAGTGTCATTGCTGGCTGTGAAGTCGGGATAGTC
AGTAGAATTCTCACCCAAACGGCAACATTTCTAAGGAACTTGGATTAATTGGGGGAAAAAAAAA
AAAAGGAGTACTTGTACTGCTTTGATTTTTTTTTCCTTTGATGAAAGATGGAGGATAAAGGGGA
AGTGAGGAGAATTTCTTTCAAGATTATCTAAACATTAGAAACATGACATTTAAAAAAACTATGA
AATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003806304	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008983.1
	ENSPPAP00000008985.1

RefSeq Acc Id:

XP_003806304 ⟸ XM_003806256

- UniProtKB:

A0A2R9A166 (UniProtKB/TrEMBL), A0A2R8ZVK2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQPPSPEFVARPVGVCSMMRLPV
QTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESVMLRTVNPSTGALPFQSLMVADLGDVN
VNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKHGPVGLLHVDAHTDTTD
KALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCWMKSLV
PLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVE
VSPPYDLSGNTALLAANLLFEMLCALPKVTTV

hide sequence

Ensembl Acc Id:

ENSPPAP00000008985 ⟸ ENSPPAT00000031625

Ensembl Acc Id:

ENSPPAP00000008983 ⟸ ENSPPAT00000031623

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027720	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000031623.1	UniProtKB/TrEMBL
	ENSPPAT00000031625.1	UniProtKB/TrEMBL
Gene3D-CATH	Ureohydrolase domain	UniProtKB/TrEMBL
InterPro	Agmatinase-rel	UniProtKB/TrEMBL
	Ureohydrolase	UniProtKB/TrEMBL
	Ureohydrolase_dom_sf	UniProtKB/TrEMBL
	Ureohydrolase_Mn_BS	UniProtKB/TrEMBL
KEGG Report	pps:100992228	UniProtKB/TrEMBL
NCBI Gene	AGMAT	ENTREZGENE
PANTHER	AGMATINASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR11358	UniProtKB/TrEMBL
Pfam	Arginase	UniProtKB/TrEMBL
PIRSF	Arginase	UniProtKB/TrEMBL
PRINTS	ARGINASE	UniProtKB/TrEMBL
PROSITE	ARGINASE_1	UniProtKB/TrEMBL
	ARGINASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52768	UniProtKB/TrEMBL
UniProt	A0A2R8ZVK2	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9A166	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-06	AGMAT	agmatinase (putative)	AGMAT	agmatinase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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