PARK7 (Parkinsonism associated deglycase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PARK7 (Parkinsonism associated deglycase) Pan paniscus
Analyze
Symbol: PARK7
Name: Parkinsonism associated deglycase
RGD ID: 11719136
Description: ENCODES a protein that exhibits androgen receptor binding (ortholog); copper ion binding (ortholog); cupric ion binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); aging (ortholog); cellular detoxification of aldehyde (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); cerebral infarction (ortholog); FOUND IN axon (ortholog); cell body (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Parkinson disease protein 7; protein/nucleic acid deglycase DJ-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
aging  (ISO)
cellular detoxification of aldehyde  (ISO)
cellular detoxification of methylglyoxal  (ISO)
cellular response to glyoxal  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (ISO)
detection of oxidative stress  (ISO)
detoxification of copper ion  (ISO)
detoxification of mercury ion  (ISO)
DNA repair  (ISO)
dopamine uptake involved in synaptic transmission  (ISO)
glucose homeostasis  (ISO)
glutathione deglycation  (ISO)
glycolate biosynthetic process  (ISO)
glyoxal metabolic process  (ISO)
guanine deglycation  (ISO)
guanine deglycation, glyoxal removal  (ISO)
guanine deglycation, methylglyoxal removal  (ISO)
histone modification  (ISO)
hydrogen peroxide metabolic process  (ISO)
insulin secretion  (ISO)
lactate biosynthetic process  (ISO)
maternal process involved in female pregnancy  (ISO)
membrane depolarization  (ISO)
membrane hyperpolarization  (ISO)
methylglyoxal catabolic process to lactate  (ISO)
methylglyoxal metabolic process  (ISO)
mitochondrion organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of hydrogen peroxide-induced neuron death  (ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of oxidative stress-induced cell death  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein export from nucleus  (ISO)
negative regulation of protein K48-linked deubiquitination  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein sumoylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
negative regulation of ubiquitin-protein transferase activity  (ISO)
negative regulation of ubiquitin-specific protease activity  (ISO)
peptidyl-arginine deglycation  (ISO)
peptidyl-cysteine deglycation  (ISO)
peptidyl-lysine deglycation  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO)
positive regulation of androgen receptor activity  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of dopamine biosynthetic process  (ISO)
positive regulation of fertilization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of L-dopa biosynthetic process  (ISO)
positive regulation of L-dopa decarboxylase activity  (ISO)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (ISO)
positive regulation of NAD(P)H oxidase activity  (ISO)
positive regulation of oxidative phosphorylation uncoupler activity  (ISO)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of pyrroline-5-carboxylate reductase activity  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tyrosine 3-monooxygenase activity  (ISO)
protein deglycation, glyoxal removal  (ISO)
protein deglycation, methylglyoxal removal  (ISO)
protein deglycosylation  (ISO)
protein stabilization  (ISO)
regulation of androgen receptor signaling pathway  (ISO)
regulation of histone acetylation  (ISO)
regulation of histone ubiquitination  (ISO)
regulation of inflammatory response  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of TRAIL production  (ISO)
response to hydrogen peroxide  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
synaptic transmission, dopaminergic  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PARK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0panPan3
PARK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl17,954,291 - 7,985,505 (+)EnsemblGRCh38hg38GRCh38
GRCh3817,961,711 - 7,985,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3718,021,771 - 8,045,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,944,380 - 7,967,926 (+)NCBINCBI36hg18NCBI36
Build 3417,956,058 - 7,979,602NCBI
Celera17,128,771 - 7,152,398 (+)NCBI
Cytogenetic Map1p36.23NCBI
HuRef17,169,316 - 7,193,163 (+)NCBIHuRef
CHM1_118,009,469 - 8,033,097 (+)NCBICHM1_1
Park7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBImm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
Park7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,353,718 - 161,376,993 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5161,353,719 - 161,376,970 (-)Ensembl
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
Park7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
PARK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,576,219 - 61,592,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,576,069 - 61,592,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,584,413 - 61,601,125 (+)NCBI
ROS_Cfam_1.0561,791,984 - 61,808,701 (+)NCBI
UMICH_Zoey_3.1561,791,244 - 61,807,961 (+)NCBI
UNSW_CanFamBas_1.0561,656,017 - 61,672,730 (+)NCBI
UU_Cfam_GSD_1.0562,059,399 - 62,076,120 (+)NCBI
Park7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,937,508 - 31,951,577 (+)NCBI
SpeTri2.0NW_0049366232,422,780 - 2,436,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,629,214 - 68,645,520 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,629,327 - 68,645,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,023,779 - 63,033,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,776,084 - 123,808,031 (-)NCBI
ChlSab1.1 Ensembl20123,776,297 - 123,798,434 (-)Ensembl
Vero_WHO_p1.0NW_02366605427,810,002 - 27,834,129 (-)NCBI
Park7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248183,900,917 - 3,915,457 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000037208   ⟹   ENSPPAP00000014522
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037209   ⟹   ENSPPAP00000014523
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl17,969,289 - 7,993,271 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000037217   ⟹   ENSPPAP00000014531
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl17,970,397 - 7,993,043 (+)Ensembl
RefSeq Acc Id: XM_003822129   ⟹   XP_003822177
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.117,969,266 - 7,993,271 (+)NCBI
Mhudiblu_PPA_v016,722,264 - 6,745,914 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003822130   ⟹   XP_003822178
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.117,969,280 - 7,993,271 (+)NCBI
Mhudiblu_PPA_v016,722,285 - 6,745,915 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975659   ⟹   XP_008973907
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.117,969,289 - 7,993,271 (+)NCBI
Mhudiblu_PPA_v016,722,285 - 6,745,915 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008975660   ⟹   XP_008973908
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.117,969,265 - 7,993,271 (+)NCBI
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003822177 (Get FASTA)   NCBI Sequence Viewer  
  XP_003822178 (Get FASTA)   NCBI Sequence Viewer  
  XP_008973907 (Get FASTA)   NCBI Sequence Viewer  
  XP_008973908 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008973908   ⟸   XM_008975660
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003822177   ⟸   XM_003822129
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003822178   ⟸   XM_003822130
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008973907   ⟸   XM_008975659
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000014531   ⟸   ENSPPAT00000037217
RefSeq Acc Id: ENSPPAP00000014522   ⟸   ENSPPAT00000037208
RefSeq Acc Id: ENSPPAP00000014523   ⟸   ENSPPAT00000037209


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030409 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000014522 ENTREZGENE
  ENSPPAP00000014523 ENTREZGENE
  ENSPPAP00000014531 ENTREZGENE
NCBI Gene PARK7 ENTREZGENE