VPS35 (VPS35 retromer complex component) - Rat Genome Database

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Gene: VPS35 (VPS35 retromer complex component) Pan paniscus
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Symbol: VPS35
Name: VPS35 retromer complex component
RGD ID: 11729771
Description: ENCODES a protein that exhibits D1 dopamine receptor binding (inferred); INVOLVED IN lysosome organization (ortholog); modulation of chemical synaptic transmission (ortholog); negative regulation of gene expression (ortholog); PARTICIPATES IN altered retromer-mediated pathway; Parkinson's disease pathway; retromer-mediated pathway; ASSOCIATED WITH genetic disease (ortholog); glycogen storage disease IXB (ortholog); late onset Parkinson's disease (ortholog); FOUND IN cytoplasm (ortholog); dopaminergic synapse (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: vacuolar protein sorting 35 homolog; vacuolar protein sorting-associated protein 35; VPS35, retromer complex component
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21856,118,897 - 56,148,460 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11662,024,010 - 62,053,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01626,924,901 - 26,954,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11645,815,716 - 45,846,672 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1645,817,371 - 45,846,531 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
endocytic recycling  (IEA)
intracellular protein transport  (IEA)
lysosome organization  (ISO)
mitochondrial fragmentation involved in apoptotic process  (IEA)
mitochondrion to lysosome vesicle-mediated transport  (IEA)
modulation of chemical synaptic transmission  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of late endosome to lysosome transport  (IEA)
negative regulation of lysosomal protein catabolic process  (ISO)
negative regulation of protein homooligomerization  (ISO)
negative regulation of protein localization  (ISO)
neurotransmitter receptor transport, endosome to plasma membrane  (IEA)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of dopamine biosynthetic process  (ISO)
positive regulation of dopamine receptor signaling pathway  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of locomotion involved in locomotory behavior  (ISO)
positive regulation of mitochondrial fission  (IEA)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein localization to cell periphery  (IEA)
positive regulation of Wnt protein secretion  (ISO)
protein destabilization  (ISO)
protein localization to endosome  (IEA)
protein localization to organelle  (ISO)
protein transport  (IEA)
regulation of dendritic spine maintenance  (IEA)
regulation of mitochondrion organization  (IEA)
regulation of postsynapse assembly  (ISO)
regulation of protein metabolic process  (IEA)
regulation of protein stability  (IEA)
regulation of synapse maturation  (ISO)
regulation of terminal button organization  (IEA)
retrograde transport, endosome to Golgi  (IEA)
transcytosis  (IEA)
vesicle-mediated transport in synapse  (ISO)
voluntary musculoskeletal movement  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
VPS35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21856,118,897 - 56,148,460 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11662,024,010 - 62,053,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01626,924,901 - 26,954,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11645,815,716 - 45,846,672 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1645,817,371 - 45,846,531 (-)Ensemblpanpan1.1panPan2
VPS35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381646,656,132 - 46,689,178 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1646,656,132 - 46,689,518 (-)EnsemblGRCh38hg38GRCh38
GRCh371646,690,044 - 46,723,090 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,251,090 - 45,280,645 (-)NCBINCBI36Build 36hg18NCBI36
Build 341645,251,091 - 45,280,593NCBI
Celera1631,201,751 - 31,231,306 (-)NCBICelera
Cytogenetic Map16q11.2NCBI
HuRef1632,582,305 - 32,611,908 (-)NCBIHuRef
CHM1_11648,100,524 - 48,130,101 (-)NCBICHM1_1
T2T-CHM13v2.01652,452,996 - 52,486,052 (-)NCBIT2T-CHM13v2.0
Vps35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,987,014 - 86,026,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,987,021 - 86,026,431 (-)EnsemblGRCm39 Ensembl
GRCm38885,260,385 - 85,299,517 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,260,392 - 85,299,802 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,784,291 - 87,823,396 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36888,150,497 - 88,189,603 (-)NCBIMGSCv36mm8
Celera889,541,447 - 89,580,450 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.61NCBI
Vps35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81937,938,989 - 37,974,887 (+)NCBIGRCr8
mRatBN7.21921,765,771 - 21,801,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1921,765,749 - 21,801,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1923,455,852 - 23,491,776 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01928,650,370 - 28,686,295 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01931,613,200 - 31,649,098 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01927,464,937 - 27,500,636 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1927,464,937 - 27,500,636 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01938,430,733 - 38,466,263 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41923,124,790 - 23,161,655 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1921,625,446 - 21,661,413 (+)NCBICelera
Cytogenetic Map19q11NCBI
Vps35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955448204,991 - 240,160 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955448207,582 - 240,264 (-)NCBIChiLan1.0ChiLan1.0
VPS35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,428,073 - 8,454,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,428,172 - 8,454,049 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,581,899 - 8,608,418 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,544,407 - 8,570,955 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,544,515 - 8,571,199 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,373,461 - 8,399,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,454,130 - 8,480,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,469,932 - 8,496,696 (+)NCBIUU_Cfam_GSD_1.0
Vps35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934959,511,247 - 59,538,597 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647550,321 - 78,097 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647550,476 - 77,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VPS35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl637,944,127 - 37,986,171 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1637,944,099 - 37,977,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VPS35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,509,037 - 32,539,371 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl532,508,580 - 32,539,343 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604744,064,261 - 44,095,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vps35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624914160,483 - 188,490 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624914160,483 - 188,534 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000023567   ⟹   ENSPPAP00000005164
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1645,817,371 - 45,846,531 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000023594   ⟹   ENSPPAP00000005172
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1645,818,172 - 45,840,904 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000023617   ⟹   ENSPPAP00000005176
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1645,818,172 - 45,838,138 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000023629   ⟹   ENSPPAP00000005178
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1645,824,039 - 45,840,904 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000023636   ⟹   ENSPPAP00000005180
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1645,839,941 - 45,840,904 (-)Ensembl
RefSeq Acc Id: XM_003819788   ⟹   XP_003819836
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21856,118,897 - 56,148,460 (-)NCBI
NHGRI_mPanPan11662,024,010 - 62,053,586 (-)NCBI
Mhudiblu_PPA_v01626,924,901 - 26,954,443 (-)NCBI
PanPan1.11645,815,716 - 45,846,531 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003819836 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000005164
  ENSPPAP00000005164.1
  ENSPPAP00000005172.1
  ENSPPAP00000005176.1
  ENSPPAP00000005178.1
  ENSPPAP00000005180.1
RefSeq Acc Id: XP_003819836   ⟸   XM_003819788
- UniProtKB: A0A2R8ZKL0 (UniProtKB/TrEMBL),   A0A2R8ZJN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000005164   ⟸   ENSPPAT00000023567
RefSeq Acc Id: ENSPPAP00000005172   ⟸   ENSPPAT00000023594
RefSeq Acc Id: ENSPPAP00000005178   ⟸   ENSPPAT00000023629
RefSeq Acc Id: ENSPPAP00000005176   ⟸   ENSPPAT00000023617
RefSeq Acc Id: ENSPPAP00000005180   ⟸   ENSPPAT00000023636


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000021221 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000023567.1 UniProtKB/TrEMBL
  ENSPPAT00000023594.1 UniProtKB/TrEMBL
  ENSPPAT00000023617.1 UniProtKB/TrEMBL
  ENSPPAT00000023629.1 UniProtKB/TrEMBL
  ENSPPAT00000023636.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.660 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Vps35 UniProtKB/TrEMBL
  Vps35_C UniProtKB/TrEMBL
KEGG Report pps:100973777 UniProtKB/TrEMBL
NCBI Gene VPS35 ENTREZGENE
PANTHER PTHR11099 UniProtKB/TrEMBL
  VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35 UniProtKB/TrEMBL
Pfam Vps35 UniProtKB/TrEMBL
PIRSF Retromer_Vps35 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A2R8ZJM4_PANPA UniProtKB/TrEMBL
  A0A2R8ZJN7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZKL0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZMK9_PANPA UniProtKB/TrEMBL
  A0A2R8ZQR9_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 VPS35  VPS35 retromer complex component    VPS35, retromer complex component  Symbol and/or name change 5135510 APPROVED