LOC100988273 (cytochrome P450 2D6-like) - Rat Genome Database

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Gene: LOC100988273 (cytochrome P450 2D6-like) Pan paniscus
Analyze
Symbol: LOC100988273
Name: cytochrome P450 2D6-like
RGD ID: 11703292
Description: ENCODES a protein that exhibits arachidonate monooxygenase activity (ortholog); heme binding (ortholog); monooxygenase activity (ortholog); INVOLVED IN alkaloid catabolic process (ortholog); alkaloid metabolic process (ortholog); arachidonate metabolic process (ortholog); PARTICIPATES IN celecoxib pharmacodynamics pathway; celecoxib pharmacokinetics pathway; citalopram pharmacodynamics pathway; ASSOCIATED WITH acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Cholesterol 25-hydroxylase; CYP2D6; CYPIID6; cytochrome P450 2D6; Cytochrome P450-DB1; Debrisoquine 4-hydroxylase
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,959,870 - 51,969,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12254,654,160 - 54,664,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,022,449 - 23,031,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC100988273
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22351,959,870 - 51,969,146 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12254,654,160 - 54,664,840 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02223,022,449 - 23,031,627 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CYP2D6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382242,126,499 - 42,130,810 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2242,126,499 - 42,130,865 (-)EnsemblGRCh38hg38GRCh38
GRCh372242,522,501 - 42,526,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362240,852,445 - 40,856,827 (-)NCBINCBI36Build 36hg18NCBI36
Build 342240,847,000 - 40,851,379NCBI
Celera2226,328,694 - 26,333,076 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2225,488,519 - 25,492,901 (-)NCBIHuRef
CHM1_12242,482,242 - 42,486,624 (-)NCBICHM1_1
T2T-CHM13v2.02242,605,990 - 42,610,301 (-)NCBIT2T-CHM13v2.0
Cyp2d22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391582,254,728 - 82,264,461 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1582,254,728 - 82,264,461 (-)EnsemblGRCm39 Ensembl
GRCm381582,370,527 - 82,380,260 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1582,370,527 - 82,380,260 (-)EnsemblGRCm38mm10GRCm38
MGSCv371582,200,957 - 82,210,690 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361582,199,236 - 82,207,926 (-)NCBIMGSCv36mm8
Celera1584,494,227 - 84,513,082 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1538.57NCBI
Cyp2d4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87115,762,662 - 115,771,832 (-)NCBIGRCr8
mRatBN7.27113,882,584 - 113,891,754 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7113,881,618 - 113,891,759 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7115,638,375 - 115,646,935 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07117,861,892 - 117,871,066 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07117,831,341 - 117,840,516 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07123,599,264 - 123,608,436 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7123,599,266 - 123,608,436 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07123,583,983 - 123,593,008 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47120,742,273 - 120,752,274 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17120,775,536 - 120,786,502 (-)NCBI
Celera7110,197,422 - 110,206,650 (-)NCBICelera
Cytogenetic Map7q34NCBI
CYP2D15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11023,255,259 - 23,259,380 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1023,255,249 - 23,259,298 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1023,190,268 - 23,194,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01024,000,262 - 24,004,211 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1024,000,212 - 24,004,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11023,717,484 - 23,721,432 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01024,037,966 - 24,041,898 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01024,212,712 - 24,216,661 (+)NCBIUU_Cfam_GSD_1.0
LOC101961588
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049456,804,025 - 6,843,868 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936718153,340 - 157,966 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2D6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl56,538,907 - 6,543,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.156,539,021 - 6,543,643 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,810,426 - 3,815,068 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2D6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11924,667,207 - 24,672,580 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1924,667,282 - 24,671,513 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045100,727,530 - 100,732,209 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_034949302   ⟹   XP_034805193
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22351,959,870 - 51,964,162 (-)NCBI
NHGRI_mPanPan12254,654,160 - 54,660,832 (-)NCBI
Mhudiblu_PPA_v02223,022,449 - 23,031,344 (-)NCBI
RefSeq Acc Id: XM_063603332   ⟹   XP_063459402
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22351,959,870 - 51,969,146 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034805193 (Get FASTA)   NCBI Sequence Viewer  
  XP_063459402 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABB77910 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000005501.1
  ENSPPAP00000005502.1
GenBank Protein Q2XNC9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_034805193   ⟸   XM_034949302
- Peptide Label: isoform X1
- UniProtKB: Q2XNC9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063459402   ⟸   XM_063603332
- Peptide Label: isoform X2
- UniProtKB: Q2XNC9 (UniProtKB/Swiss-Prot)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000022794 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000025011.1 UniProtKB/TrEMBL
  ENSPPAT00000025015.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2D-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cytochrome_P450_fam2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene LOC100988273 ENTREZGENE
PANTHER CYTOCHROME P450 2D6-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EP450ICYP2D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8ZKK9_PANPA UniProtKB/TrEMBL
  A0A2R8ZRN9_PANPA UniProtKB/TrEMBL
  CP2D6_PANPA UniProtKB/Swiss-Prot, ENTREZGENE