RGD Reference Report - Regulation of the adrenomedullary catecholaminergic system after mild, acute stress. - Rat Genome Database

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Regulation of the adrenomedullary catecholaminergic system after mild, acute stress.

Authors: Betito, K  Mitchell, JB  Bhatnagar, S  Boksa, P  Meaney, MJ 
Citation: Betito K, etal., Am J Physiol. 1994 Jul;267(1 Pt 2):R212-20.
RGD ID: 4139902
Pubmed: (View Article at PubMed) PMID:7914070

The time course of regulation of rat adrenomedullary phenylethanolamine N-methyltransferase (PNMT) and tyrosine hydroxylase (TH) activity was studied after a single episode of 20-min restraint stress. Significant increases in PNMT and TH activity were observed 18 h after the beginning of the stress. The time course of acute stress-induced regulation of PNMT and TH was examined for the influence of neural and hormonal input. Unilateral denervation was performed, and the animals were exposed to a single episode of restraint. PNMT activity increased similarly in both the innervated and denervated adrenals, with a significant increase observed at 36 h after the stress. TH activity was similar in both denervated and innervated adrenals, with a significant increase observed at 24 and 36 h after stress. Finally, suppression of endogenous corticosterone with dexamethasone delayed the stress-induced increase in activity of PNMT but not TH. The present study indicates that increases in catecholamine biosynthetic enzymes can be observed after a single episode of mild, acute stress. In addition, glucocorticoids appear to be important in the time course of the stress-induced increase in PNMT but not TH activity, whereas neural input does not seem to affect the time course of these increases.

Annotation

Gene Ontology Annotations    

Biological Process

Molecular Function

Molecular Pathway Annotations    
Objects Annotated

Genes (Rattus norvegicus)
Pnmt  (phenylethanolamine-N-methyltransferase)

Genes (Mus musculus)
Pnmt  (phenylethanolamine-N-methyltransferase)

Genes (Homo sapiens)
PNMT  (phenylethanolamine N-methyltransferase)


Additional Information