RGD Reference Report - Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development. - Rat Genome Database

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Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development.

Authors: Cannazza, G  Chiarugi, A  Parenti, C  Zanoli, P  Baraldi, M 
Citation: Cannazza G, etal., Neurochem Res. 2001 May;26(5):511-4.
RGD ID: 2290543
Pubmed: PMID:11513477   (View Abstract at PubMed)

Kynurenic, anthranilic, and quinolinic acid, brain tissue concentrations and indoleamine 2,3-dioxygenase [EC 1 13.11.17] activity were determined in rat brain, during pre- and postnatal development. Quinolinic acid brain tissue concentration was significantly increased at birth as compared with the prenatal level, then it declined rapidly in the postnatal period. By the contrary, kynurenic and anthranilic acids brain tissue concentrations in rat brain were significantly lower at birth as compared with those found prenatally; then kynurenic acid concentration decreased in the first postnatal week and increased thereafter, while anthranilic acid concentration increased in the first postnatal week and decreased thereafter. Indoleamine 2,3-dioxygenase [EC 1 13.11.17] activity were found unchanged in pre and post natal rat brain. The described opposite changes in quinolinic and kynurenic acids concentrations, occurring in pre- and postnatal period, despite the lack of knowledge on the precise role played by these compounds on the different neurotransmitter systems in the brain, could be involved in brain ontogenetic development.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
tryptophan catabolic process to kynurenine  IDA 2290543 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
amino acid binding  IDA 2290543 RGD 
indoleamine 2,3-dioxygenase activity  IDA 2290543 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ido1  (indoleamine 2,3-dioxygenase 1)


Additional Information