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Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development.

Authors: Cannazza, G  Chiarugi, A  Parenti, C  Zanoli, P  Baraldi, M 
Citation: Cannazza G, etal., Neurochem Res. 2001 May;26(5):511-4.
Pubmed: (View Article at PubMed) PMID:11513477

Kynurenic, anthranilic, and quinolinic acid, brain tissue concentrations and indoleamine 2,3-dioxygenase [EC 1 13.11.17] activity were determined in rat brain, during pre- and postnatal development. Quinolinic acid brain tissue concentration was significantly increased at birth as compared with the prenatal level, then it declined rapidly in the postnatal period. By the contrary, kynurenic and anthranilic acids brain tissue concentrations in rat brain were significantly lower at birth as compared with those found prenatally; then kynurenic acid concentration decreased in the first postnatal week and increased thereafter, while anthranilic acid concentration increased in the first postnatal week and decreased thereafter. Indoleamine 2,3-dioxygenase [EC 1 13.11.17] activity were found unchanged in pre and post natal rat brain. The described opposite changes in quinolinic and kynurenic acids concentrations, occurring in pre- and postnatal period, despite the lack of knowledge on the precise role played by these compounds on the different neurotransmitter systems in the brain, could be involved in brain ontogenetic development.


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RGD Object Information
RGD ID: 2290543
Created: 2008-03-18
Species: All species
Last Modified: 2008-03-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.