AOC1 (amine oxidase copper containing 1) - Rat Genome Database

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Gene: AOC1 (amine oxidase copper containing 1) Pan paniscus
Analyze
Symbol: AOC1
Name: amine oxidase copper containing 1
RGD ID: 11903129
Description: ENCODES a protein that exhibits calcium ion binding (inferred); copper ion binding (inferred); diamine oxidase activity (inferred); INVOLVED IN amine metabolic process (inferred); putrescine metabolic process (inferred); response to antibiotic (inferred); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); Cardiomegaly (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN bicellular tight junction (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ABP1; amiloride binding protein 1 (amine oxidase (copper-containing)); amiloride-sensitive amine oxidase [copper-containing]; amine oxidase, copper containing 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,267,472 - 187,277,116 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,278,074 - 39,286,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,434,732 - 142,443,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,586,931 - 154,595,248 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,563,523 - 154,595,248 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AOC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,267,472 - 187,277,116 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,278,074 - 39,286,395 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,434,732 - 142,443,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,586,931 - 154,595,248 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,563,523 - 154,595,248 (+)Ensemblpanpan1.1panPan2
AOC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,852,120 - 150,861,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,824,627 - 150,861,504 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,549,605 - 150,558,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,180,506 - 150,189,312 (+)NCBINCBI36Build 36hg18NCBI36
Build 347149,987,239 - 149,996,025NCBI
Celera7145,106,596 - 145,115,402 (+)NCBICelera
Cytogenetic Map7q36.1ENTREZGENE
HuRef7144,361,610 - 144,370,427 (+)NCBIHuRef
CHM1_17150,557,803 - 150,566,593 (+)NCBICHM1_1
T2T-CHM13v2.07152,025,287 - 152,034,270 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,878,851 - 149,887,665 (+)NCBI
Aoc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,872,189 - 48,886,122 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,849,830 - 48,886,122 (+)EnsemblGRCm39 Ensembl
GRCm38648,895,255 - 48,909,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,872,896 - 48,909,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv37648,845,254 - 48,859,186 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36648,824,840 - 48,838,774 (+)NCBIMGSCv36mm8
Celera649,405,009 - 49,418,946 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.78NCBI
Aoc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,143,126 - 79,162,705 (+)NCBIGRCr8
mRatBN7.2477,812,260 - 77,831,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,812,260 - 77,831,840 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx483,019,777 - 83,039,389 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,795,250 - 78,814,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,235,544 - 77,255,152 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,496,043 - 78,515,582 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,496,043 - 78,515,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04143,183,686 - 143,203,225 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4476,957,477 - 76,977,643 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1477,247,444 - 77,253,779 (+)NCBI
Celera472,749,277 - 72,768,814 (+)NCBICelera
Cytogenetic Map4q24NCBI
Aoc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,316,476 - 5,326,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,316,482 - 5,326,262 (+)NCBIChiLan1.0ChiLan1.0
AOC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,955,528 - 14,963,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1614,958,658 - 15,036,651 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,563,706 - 15,571,546 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,671,139 - 16,678,130 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11615,049,911 - 15,057,763 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,631,448 - 15,639,287 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,681,981 - 15,689,844 (+)NCBIUU_Cfam_GSD_1.0
Aoc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,590,547 - 6,597,512 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,308,682 - 6,312,815 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,309,210 - 6,312,869 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AOC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,309,594 - 6,320,974 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,309,583 - 6,321,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,738,053 - 6,749,392 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AOC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,037,498 - 119,046,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,038,356 - 119,047,279 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,014,229 - 15,018,767 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aoc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,739,034 - 5,749,608 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,739,076 - 5,749,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000047956   ⟹   ENSPPAP00000025130
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7154,563,523 - 154,595,248 (+)Ensembl
RefSeq Acc Id: XM_003815059   ⟹   XP_003815107
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26187,267,472 - 187,277,116 (+)NCBI
NHGRI_mPanPan1739,278,074 - 39,286,395 (+)NCBI
Mhudiblu_PPA_v07142,434,732 - 142,443,050 (+)NCBI
PanPan1.17154,586,931 - 154,595,248 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063606416   ⟹   XP_063462486
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v26187,271,790 - 187,277,116 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003815107 (Get FASTA)   NCBI Sequence Viewer  
  XP_063462486 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000025130.1
RefSeq Acc Id: XP_003815107   ⟸   XM_003815059
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BA23 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000025130   ⟸   ENSPPAT00000047956
RefSeq Acc Id: XP_063462486   ⟸   XM_063606416
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BA23 (UniProtKB/TrEMBL)

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035701 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047956.1 UniProtKB/TrEMBL
Gene3D-CATH 2.70.98.20 UniProtKB/TrEMBL
  3.10.450.40 UniProtKB/TrEMBL
InterPro Cu_Am_Ox_Cu-bd UniProtKB/TrEMBL
  Cu_Am_ox_TPQ-bd UniProtKB/TrEMBL
  Cu_amine_oxidase UniProtKB/TrEMBL
  Cu_amine_oxidase_C UniProtKB/TrEMBL
  Cu_amine_oxidase_C_sf UniProtKB/TrEMBL
  Cu_amine_oxidase_N-reg UniProtKB/TrEMBL
  Cu_amine_oxidase_N2 UniProtKB/TrEMBL
  Cu_amine_oxidase_N3 UniProtKB/TrEMBL
KEGG Report pps:100973977 UniProtKB/TrEMBL
NCBI Gene AOC1 ENTREZGENE
PANTHER AMILORIDE-SENSITIVE AMINE OXIDASE [COPPER-CONTAINING] UniProtKB/TrEMBL
  PTHR10638 UniProtKB/TrEMBL
Pfam Cu_amine_oxid UniProtKB/TrEMBL
  Cu_amine_oxidN2 UniProtKB/TrEMBL
  Cu_amine_oxidN3 UniProtKB/TrEMBL
PRINTS CUDAOXIDASE UniProtKB/TrEMBL
PROSITE COPPER_AMINE_OXID_1 UniProtKB/TrEMBL
  COPPER_AMINE_OXID_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF49998 UniProtKB/TrEMBL
  SSF54416 UniProtKB/TrEMBL
UniProt A0A2R9BA23 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-22 AOC1  amine oxidase copper containing 1    amine oxidase, copper containing 1  Symbol and/or name change 5135510 APPROVED